scholarly journals Seroprevalence of Dengue Infection in a Tertiary Care Hospital in Assam

2018 ◽  
Vol 7 (1) ◽  
pp. 1582 ◽  
Author(s):  
Liza Goswami ◽  
Chowdhury Runumi ◽  
Elmy S. Rasul
Keyword(s):  
Dengue Infection ◽  
Tertiary Care ◽  
Age Groups ◽  
Hemorrhagic Fever ◽  
Health Concern ◽  
Care Hospital ◽  
Serum Samples ◽  
Igm Antibody ◽  
Ns1 Antigen ◽  
Antibody Elisa

<p><strong>Background:</strong> Dengue fever (DF) and dengue hemorrhagic fever (DHF) are important arthropod borne viral diseases. Dengue in India has dramatically expanded over the last few decades, with rapidly changing epidemiology. Dengue is emerging as major public health concern in northeast India and spreading with increased morbidity.</p><p><strong>Objective:</strong>This study was carried out to determine the seroprevalence of Dengue infection among patients attending in Fakhruddin Ali Ahmed Medical College and Hospital, Barpeta, Assam during the period 2013-2016.</p><p><strong>Methods:</strong> A retrospective study was done from the year 2013 to 2016. A total of 340 serum samples received in the department of microbiology FAAMCH, were tested for the confirmation of suspected cases of dengue. Dengue NS1 antigen and Dengue IgM antibody ELISA tests were performed for the confirmation of dengue cases. We estimated the incidence by applying age, sex and season adjusted dengue positivity.</p><p><strong>Results:</strong> Out of 340 samples tested, 68 were positive either by NS1 antigen or for IgM antibody ELISA tests. These comprised all age groups of both sexes with higher incidence of cases in young males aged 26– 60 years.</p><p><strong>Conclusion:</strong> From this study, it is apparent that dengue surveillance and control should be enhanced by wider use of laboratory testing to confirm dengue as a cause of fever of unknown origin, especially during the local dengue transmission season.</p>

scholarly journals THE STUDY OF DETECTION OF DENGUE CASES BY NS1 ANTIGEN AND IGM ANTIBODY IN RIMS, ADILABAD, INDIA.

2019 ◽  
Vol 3 (11) ◽  
Author(s):  
Dr. Tanajee Zade ◽  
Dr. K. Srinivas ◽  
Dr. Akshay Berad
Keyword(s):  
Early Diagnosis ◽  
Dengue Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
High Morbidity ◽  
Care Hospital ◽  
Serum Samples ◽  
Igg Antibody ◽  
Igm Antibody ◽  
Ns1 Antigen

Dengue fever is an acute febrile arboviral disease affecting tropical & subtropical regions of the world. Dengue infection produces a spectrum of clinical illness, ranging from an asymptomatic to its most severe form like dengue haemorrhagic fever and dengue shock syndrome. In view of high morbidity and mortality, it is imperative to have a rapid and sensitive laboratory assay for early detection of the dengue infection. The newer parameter NS1 antigen has gained a lot of interest for early diagnosis of the disease. Detection of non-structural antigen (NS1 Ag), IgM and IgG antibody may help in the early diagnosis. The present study was conducted in a RIMS Adilabad, tertiary care hospital & medical college in the Department of  General Medicine. A total of 100 serum samples were processed from suspected cases of dengue fever by using dengue test for detection of NS1 antigen and IgG antibodies. Platelet counts of all these cases were noted. . Of these 100 subjects 85 were serologically proved to have dengue illness, 57 patients were NS1 antigen positive, 28 patients were IgM antibody positive patients. As the NS1 antigen is detectable in blood from day one after onset of fever, its assay is an effective tool for early diagnosis of dengue infection so as to avoid complications. Key words:  Dengue, NS1 Antigen, IgM antibody, Platelet

scholarly journals Dengue IgM antibody sero-status assessment: a current experience in a teaching institution

2017 ◽  
Vol 4 (3) ◽  
pp. 661
Author(s):  
Deepti Kiran ◽  
Balvinder Singh Arora ◽  
Arun Gogna ◽  
K. C. Aggarwal
Keyword(s):  
Dengue Infection ◽  
Tertiary Care ◽  
P Value ◽  
New Delhi ◽  
Care Hospital ◽  
Serum Samples ◽  
Igm Antibody ◽  
Elisa Testing ◽  
Status Assessment ◽  
And Gender

Background: In 2015, Delhi city experienced the worst outbreak of dengue infection since 1996 and our laboratory received a very high number of cases for IgM ELISA testing following clinicians’ referrals. The present study intends to correlate IgM antibody response with duration of fever, platelets counts and ‘with age and gender distribution’ of such cases attending OPDs and subsequently admitted to the medicine and pediatric wards in our tertiary care hospital, New Delhi, albeit, with some useful conclusions and suggestions.Methods: A hospital based observational study was conducted enrolling a total of 500 cases, clinically suspected of DF/DHF/DSS that either reported directly or were referred to Safdarjung Hospital from region in and around Delhi and NCR and subsequently admitted to Emergency Medicine and Paediatrics wards. A total of 500 cases and 50 controls were tested for IgM antibody by ‘IgM antibody capture ELISA (MAC ELISA).Results: Of total 500 serum samples tested, 169 i.e. 33.8% were found to be sero positive. Seropositivity was more among the males 99/169 (58.57%) than the females 70/169 (41.43%). The highest numbers of cases were seen in the age group 41-60 years (46.15%). Amongst seropositive cases, 146 (86.39%) cases had fever of >5 days duration while remaining 23 (13.60%) presented with fever of <5 days. Low platelet count between 20,000-1L cells/mm3 was a feature in all the seropositive cases and statistically it was found significant (p-value 0.001).Conclusions: Detection of IgM specific antibodies by MAC ELISA in cases with high index of clinical suspicion continues to be an effective tool providing a supportive criterion to clinical diagnosis, especially during outbreak periods.

scholarly journals Clinical profile of dengue fever in children: analysis of 2017 outbreak from Central Kerala, India

2018 ◽  
Vol 5 (6) ◽  
pp. 2265 ◽  
Author(s):  
Senthil Kumar K. ◽  
Rajendran N. K. ◽  
Ajith Brabhukumar C.
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Hemorrhagic Fever ◽  
Warning Signs ◽  
Clinical Profile ◽  
Severe Dengue ◽  
High Morbidity ◽  
Care Hospital ◽  
High Grade Fever

Background: In India, dengue epidemics are becoming more frequent (WHO, 2008). The majority of dengue viral infections are self-limiting, but complications may cause high morbidity and mortality. The objective of this study is to assess the clinical profile of the dengue infection in children less than 15 years of age and to evaluate the outcomes of dengue fever from March 2017 to July 2017 at the Pediatric Department of Karuna Medical College, the tertiary care hospital in Palakkad.Methods: In this retrospective study, medical records were reviewed and analyzed. Patients with suspected dengue infection were classified further into 2 groups, Dengue fever (probable dengue, dengue with warning signs) and ‘Severe Dengue’ (dengue hemorrhagic fever and/or dengue shock syndrome (DHF/DSS) according to WHO.Results: A total of 77 cases were classified into 67 (87%) non-severe and 10 (13%) severe dengue cases. The most common age of presentation was above 10 yrs. The mean age of admission was 8.9 yrs. The most common presenting symptom was fever seen in 93% followed by vomiting in 68%. Elevation in Aspartate transaminase (SGOT) and thrombocytopenia were found in 32.4 %.Conclusions: High grade fever, vomiting, abdominal pain and skin rash with normal or low platelet count were the presenting features. Early diagnosis, monitoring and prompt supportive management can reduce mortality.

scholarly journals Dengue Viral Augmentation among the Population of Few Districts of Assam and Neighbourhood Visiting Tezpur Medical College & Hospital

2021 ◽  
Vol 6 (2) ◽  
pp. 25-36
Author(s):  
Samrat Biswas ◽  
Jyoti Hazarika ◽  
Mihirjyoti Pathak
Keyword(s):  
Tertiary Care ◽  
Febrile Illness ◽  
Hemorrhagic Fever ◽  
Severe Bleeding ◽  
Care Hospital ◽  
Serum Samples ◽  
Epidemic Disease ◽  
College Hospital ◽  
Diagnostic Laboratory ◽  
Medical College

Dengue virus (DENV) has rapidly expanded its range through tropical and subtropical regions in recent years. This pathogen causes acute febrile illness (dengue fever, DF) and severe bleeding disease (dengue hemorrhagic fever, DHF) in humans. In this study we are trying to analyze the data obtained from the diagnosis conducted upon the Dengue suspected patients visiting tertiary care hospital, Sonitpur, Assam and to give a scientific evaluation to the pattern or spread of this epidemic disease. A total of 361 serum samples are analysed from suspected dengue cases during this study period. This study basically gives our research team to go more investigating the dengue viral expansion in coming days as we were able to discriminate among the patients on the basis of primary and secondary infections, what they were previously not examined for. Significant clue for the presence of secondary dengue viral infections (17.3%) among 10 different districts is found. Keywords: Dengue, Viral Research and Diagnostic Laboratory (VRDL), Tezpur Medical College & Hospital (TMCH).

scholarly journals Serum lipid profile as predictor of clinical outcome in pediatric patients with dengue infection at a tertiary care hospital

2019 ◽  
Vol 7 (1) ◽  
pp. 1
Author(s):  
Mohd. Saeed S. Siddiqui ◽  
Amruta Kailash Loya ◽  
Udaykumar Kanumala ◽  
Jagannath R. Kakade
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Tertiary Care Hospital ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Serum Lipid Profile ◽  
Health Concern ◽  
Care Hospital ◽  
Disease Category ◽  
Dengue Disease

Background: Dengue is a serious mosquito-borne viral disease which in recent years has become a major international public health concern. Early detection of individuals at risk of developing severe forms of dengue could be possible with the identification of an ideal biomarker, which has been the focus of several research studies. Changes in lipoprotein profile during infection probably are primarily cytokine induced Interactions between microorganisms and lipoproteins occur in viral infections. There have been very few studies that address and elucidate a correlation between dengue fever severity and changes in the lipid profile.Methods: This study was conducted in paediatric patients with dengue infection of age group between 1 to 18 years MGM Medical College and Tertiary Care Hospital of Aurangabad City.Results: There was statistically significant association between TG (mg/dl) level and dengue disease category (DF vs DHS+DSS) among the patients. Overall the combine lipids were significantly predicting dengue disease category (DF, DHS and DSS). Serum lipids (triglycerides, LDL and cholesterol) among the patients significantly predict dengue disease category (DF, DHS and DSS). There was negative correlation between triglycerides level and HDL and hospital Stay which was found to be statistically significant.Conclusions: Reduced serum lipid profile can be used as a cost-effective laboratory investigation prompting a high suspicion of severe dengue infection especially in resource poor setting where serological tests may not be available.

scholarly journals CLINICAL AND HEMATOLOGICAL PROFILE OF PATIENTS WITH DENGUE FEVER AT A TERTIARY CARE HOSPITAL – AN OBSERVATIONAL STUDY

2018 ◽  
Vol 10 (1) ◽  
pp. e2018021 ◽  
Author(s):  
Vishal Vishnu Tewari ◽  
Kunal Tewari ◽  
Ritu Mehta
Keyword(s):  
Dengue Fever ◽  
Tertiary Care ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Annual Data ◽  
Care Hospital ◽  
Igg Antibody ◽  
Hematological Profile ◽  
Ns1 Antigen ◽  
Duration Of Hospitalization

AbstractBackground: Dengue is a major health issue with seasonal rise in dengue fever cases imposing an additional burden on hospitals, necessitating bolstering of services in the emergency department, laboratory with creation of additional dengue fever wards.Objectives: To study the clinical and hematological profile of dengue fever cases presenting to a hospital.Methods: Patients with fever and other signs of dengue with either positive NS1 antigen test or IgM or IgG antibody were included. Age, gender, clinical presentation, platelet count and hematocrit were noted and patients classified as dengue fever (DF), dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Duration of hospitalization, bleeding manifestations, requirement for platelet component support and mortality were recorded.Results: There were 443 adults and 57 children between 6 months to 77 year age. NS1 was positive in 115 patients (23%). Fever (99.8%) and severe bodyache (97.4%) were the commonest presentation. DF was seen in 484 (96.8 %), DHF in 10 (2%) and DSS in 6 cases (1.2%). OPD treatment was needed in 412 (82%) and hospitalization in 88 (18%). Intravenous fluid resuscitation was needed in 16 (3.2%) patients. Thrombocytopenia was seen in 335 (67%) patients at presentation. Platelet transfusion was needed in 46 (9.2%). PRC transfusion was given in 3 patients with DF and 10 of DHF. Death occurred in 03 DSS and 2 DHF patients. Conclusions: Majority of DF cases can be managed on OPD basis. DHF and DSS carry high mortality. Hospitals can analyze annual data for resource allocation for capacity expansion.

scholarly journals Importance of Platelet Count and Hematocrit in Dengue Fever in Children

2021 ◽  
Vol 44 (2) ◽  
pp. 74-77
Author(s):  
Farhana Rahat ◽  
Morsheda Khanam ◽  
Kazi Iman ◽  
UK Ghosh ◽  
NK Ghosh
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Warning Signs ◽  
Care Hospital ◽  
Pediatric Age Group

Background: Dengue fever has become one of the most important public health concerns now a day due to increasing complications and fatal outcomes. Dengue hemorrhagic fever and dengue shock syndrome are life threatening but reversible complications of dengue fever. Objectives: This study was performed to evaluate the relationship between platelet count and hematocrit with the severity of dengue infection in pediatric age group. Materials & Methods: This was a prospective observational study which included 280 dengue seropositive children of 1 month to 15 years, conducted during 1st June to 30th November, 2018 in a tertiary care hospital of Dhaka. Results: Out of 280 dengue cases, 187(66.78%) had thrombocytopenia and 88(47%) had raised hematocrit. Among the thrombocytopenic patients 44% had dengue fever, 47% had dengue hemorrhagic fever and 9% dengue shock syndrome. A significant co-relation was observed between the severities of thrombocytopenia and raised hematocrit with the appearance of dengue warning signs in case of dengue hemorrhagic fever. Conclusion: Thrombocytopenia and raised hematocrit were related to the severity of dengue hemorrhagic fever. Bangladesh J Child Health 2020; VOL 44 (2) :74-77

scholarly journals Study on parameters of severity in Dengue infection with both NS1 Antigen and Dengue IgM reactive on the same day, in a tertiary care hospital, Kolkata.

2021 ◽  
Vol 39 ◽  
pp. S128-S129
Author(s):  
Soumodip Dutta ◽  
Chayanika Banerjee ◽  
Anindya Ghosh ◽  
Kabita Choudhury ◽  
Swagata Ganguly Bhattacharjee
Keyword(s):  
Tertiary Care Hospital ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Care Hospital ◽  
Ns1 Antigen

Diagnosis of Bacterial Vaginosis by Conventional Methods in the Patients at a Tertiary Care Hospital

2016 ◽  
Vol 1 (1) ◽  
pp. 1-3
Author(s):  
Ved Prakash ◽  
Prem P Mishra ◽  
Lata Agrawal ◽  
HK Premi
Keyword(s):  
Bacterial Vaginosis ◽  
Vaginal Discharge ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Age Groups ◽  
Health Concern ◽  
Care Hospital ◽  
Age Group ◽  
Vaginal Ph ◽  
Conventional Methods

ABSTRACT Background Bacterial vaginosis (BV) is highly prevalent among women especially in reproductive age group but it is found also in other age groups. Bacterial vaginosis is a great health concern in India because of its complications. Most of the healthcare centers in India are not well-versed in advance diagnostics for BV. Aim To assess the utility of conventional methods for diagnostic evaluation of BV in the patients of different age groups. Materials and methods In this 1 year cross-sectional study, the vaginal swabs were collected from women with signs and symptoms of BV like complaints of vaginal discharge, odor, itching, back ache, etc. attending the department of obstetrics and gynecology of a tertiary care hospital in Western UP. These specimens are subjected to vaginal pH determination and are sent to department of microbiology for Gram stain, wet-mount and whiff test. Amsel's criteria were used for confirming BV. Results A total of 206 women included in the study, n = 63 (29.61%) were found to be having BV based on Amsel's criteria. The mean age of the females were found to be 30.77 years. The most affected age group was found to be 26 to 35 years, n = 33 (54%). The vaginal pH was significantly higher in n = 61 (29.61%) women with BV. Vaginal discharge was prevalent in n = 108 (52.43%) women. Presence of clue cells and positive whiff test were found to be in n = 63 (30.58%) and n = 61(29.61%). Conclusion The characteristics of vaginal discharge, vaginal pH determination, clue cells and whiff test is relatively easier conventional methods for diagnosis of women with BV where better facilities are lacking. These tests are suitable for screening women with BV and in formulating the treatment to check the complications. How to cite this article Mishra PP, Prakash V, Agrawal L, Premi HK. Diagnosis of Bacterial Vaginosis by Conventional Methods in the Patients at a Tertiary Care Hospital. Int J Adv Integ Med Sci 2016;1(1):1-3.

scholarly journals Serological co-infection of dengue and COVID-19: case series in Bangladesh

2021 ◽  
Author(s):  
Tahmina Zahan ◽  
Morshed Nasir ◽  
Afzal Akhtar ◽  
A. F. M. Mohibur Rahman ◽  
Tanha E. Nahin
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Case Series ◽  
Health Concern ◽  
Care Hospital ◽  
Laboratory Findings ◽  
Ns1 Antigen ◽  
Serological Data ◽  
Antibody Tests ◽  
Positive Results

Parallel symptoms and laboratory findings between dengue and coronavirus disease 2019 (COVID-19) pretense a diagnostic contest in some dengue-endemic countries in Asia. In this study, we described ten cases of suspected COVID-19-dengue co-infection in a tertiary care hospital in Bangladesh. Serological data showed that patients with positive results for dengue virus (DENV) NS1 antigen and anti-dengue IgG and IgM were also reactive to COVID-19 rapid antibody tests, suggesting dengue with COVID-19 coinfection. The present study indicated a public health concern regarding COVID-19 and dengue detection in Bangladesh as well as in other dengue-endemic countries and it was important for these nations to manage both pathogens concurrently.

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