scholarly journals Study on parameters of severity in Dengue infection with both NS1 Antigen and Dengue IgM reactive on the same day, in a tertiary care hospital, Kolkata.

2021 ◽  
Vol 39 ◽  
pp. S128-S129
Author(s):  
Soumodip Dutta ◽  
Chayanika Banerjee ◽  
Anindya Ghosh ◽  
Kabita Choudhury ◽  
Swagata Ganguly Bhattacharjee
Keyword(s):  
Tertiary Care Hospital ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Care Hospital ◽  
Ns1 Antigen

scholarly journals Clinico-Laboratory Observations and Outcome of Dengue Infection In a Tertiary Care Hospital of Western Nepal: An Observational Cross-Sectional Study

2018 ◽  
Vol 5 (2) ◽  
pp. 3-7
Author(s):  
Niraj Kumar Jaiswal ◽  
Shatdal Chaudhary ◽  
Nagendra Chaudhary
Keyword(s):  
Tertiary Care Hospital ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Severe Thrombocytopenia ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Rapid Urbanization ◽  
South West

INTRODUCTION: Dengue fever (DF) is highly prevalent in tropical and subtropical countries all over the world. This study was done to study the clinico-laboratory profile of DF patients and their outcomes in a tertiary care hospital of western Nepal.MATERIAL & METHODS:  A prospective observational cross-sectional study conducted over 6 months (October 2016 to March 2017) in patients admitted to medical inpatient ward of a tertiary care referral hospital located at south west Nepal. All febrile patients underwent dengue antibody (IgM) testing. Patient details, clinical manifestations and laboratory parameters were recorded. Descriptive analysis was done as mean and percentage.RESULTS: Out of total 2653 hospital admissions, 1274 patients (male: 780, female: 494) presented with fever. Forty patients between 17 years to 84 years (Mean age ± SD: 40.3±17 years) were diagnosed as DF. All the age groups were almost equally affected. The average duration of hospital stay was 5.4±3.2 days. Fever (n=40, 100%), body ache (n=29, 74.4%) and headache (n=28, 70%) were three leading complaints in dengue patients. Only 22.5% (n=9) of the patients had thrombocytopenia (mild and moderate). Severe thrombocytopenia was not noticed. Only 10% of total dengue cases received platelet transfusion. The mean platelet count increased from day one to day seven gradually. All the patients recovered.CONCLUSION: DF is a well-established vector-borne disease in south west Nepal; may be due to rapid urbanization and poor hygiene facility. Appropriate disease control programme emphasizing on vector surveillance and control, early clinical diagnosis and treatment reduces the dengue-related deaths.Journal of Universal College of Medical Sciences (2017)Vol.05 No.02 Issue 16, page: 3-7

scholarly journals Drug utilization study in dengue infection in a tertiary care hospital

2019 ◽  
Vol 8 (3) ◽  
pp. 569
Author(s):  
Smita Bhandare ◽  
Santoshkumar R. Jeevangi
Keyword(s):  
Drug Utilization ◽  
Leaf Extract ◽  
Tertiary Care Hospital ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Specific Treatment ◽  
Public Health Problem ◽  
Rational Approach ◽  
Care Hospital ◽  
Utilization Pattern

Background: Dengue fever (DF) is a serious public health problem, gaining global attention because of its morbidity and mortality. Less studies on Drug utilization pattern of DF in India. The present study was undertaken to analyze Drug utilization pattern of dengue infection in a tertiary care hospital.Methods: A prospective cross-sectional study was conducted for a period of 2 months in a tertiary care hospital and the data was analyzed by using various drug use indicators.Results: A total of 52 prescriptions were analyzed. Male and female were (46.16%, 53.84%), A total of 330 drugs were prescribed. 86 (26.06%) antibiotics, 70 (21.21%) antipyretics, 51 (15.46%) antacids, 19 (5.76%) multivitamins, 52 (15.76%) anti-emetics and 52 (15.76%) papaya leaf extract was prescribed. 84 (25.46%) oral and 246 (74.54%) injectable drugs. IV-fluids given to all patients. 10 (19.24%) were given blood transfusion. 6.17 drugs per prescription. 96% drugs were prescribed by brand names. High DDD for drugs like diclofenac (184), doxycycline (115), metronidazole (2.5), pantoprazole (161.5), rabeprazole (34.6), ondansetron (200) was observed.Conclusions: Most commonly used drugs are antipyretics, antibiotics, antacids, antiemetic, papaya leaf extract. As the incidence of DF is increasing with epidemics, demand for specific treatment guidelines is in great need. Early recognition of the disease, with a rational approach in case management leads good clinical outcome.

scholarly journals Serum lipid profile as predictor of clinical outcome in pediatric patients with dengue infection at a tertiary care hospital

2019 ◽  
Vol 7 (1) ◽  
pp. 1
Author(s):  
Mohd. Saeed S. Siddiqui ◽  
Amruta Kailash Loya ◽  
Udaykumar Kanumala ◽  
Jagannath R. Kakade
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Tertiary Care Hospital ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Serum Lipid Profile ◽  
Health Concern ◽  
Care Hospital ◽  
Disease Category ◽  
Dengue Disease

Background: Dengue is a serious mosquito-borne viral disease which in recent years has become a major international public health concern. Early detection of individuals at risk of developing severe forms of dengue could be possible with the identification of an ideal biomarker, which has been the focus of several research studies. Changes in lipoprotein profile during infection probably are primarily cytokine induced Interactions between microorganisms and lipoproteins occur in viral infections. There have been very few studies that address and elucidate a correlation between dengue fever severity and changes in the lipid profile.Methods: This study was conducted in paediatric patients with dengue infection of age group between 1 to 18 years MGM Medical College and Tertiary Care Hospital of Aurangabad City.Results: There was statistically significant association between TG (mg/dl) level and dengue disease category (DF vs DHS+DSS) among the patients. Overall the combine lipids were significantly predicting dengue disease category (DF, DHS and DSS). Serum lipids (triglycerides, LDL and cholesterol) among the patients significantly predict dengue disease category (DF, DHS and DSS). There was negative correlation between triglycerides level and HDL and hospital Stay which was found to be statistically significant.Conclusions: Reduced serum lipid profile can be used as a cost-effective laboratory investigation prompting a high suspicion of severe dengue infection especially in resource poor setting where serological tests may not be available.

scholarly journals Outcome of Dengue infection in pregnancy at a tertiary care hospital in India

2020 ◽  
Vol 9 (3) ◽  
pp. 970
Author(s):  
Naimah Raza ◽  
Nitin P. Dhungat
Keyword(s):  
Clinical Laboratory ◽  
Tertiary Care Hospital ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Perinatal Outcomes ◽  
Severe Dengue ◽  
Care Hospital ◽  
Laboratory Findings ◽  
Bleeding Manifestation ◽  
In Pregnancy

Background: Dengue is one of the most important mosquito-borne diseases in India. This study was done to study the course of dengue infection in pregnant women, its effects, foeto-maternal outcome, and associated complications.Methods: Clinical, laboratory findings, and maternal/foetal outcome were collected from patients with confirmed dengue infections in pregnancy treated at a tertiary care hospital in India, during a 6-month period.Results: A total 12 seropositive cases of dengue infection in pregnancy were diagnosed during the study period. Thrombocytopenia coupled with rising haematocrit were seen in all cases. Prophylactic platelet transfusion was not necessary in any of the cases without bleeding manifestation. Three patients developed severe dengue with some complication requiring extra measures, including a case of dengue encephalitis which responded to supportive treatment. One case of intra-uterine foetal demise and multi-organ failure leading to maternal death was seen. Perinatal outcomes of the other cases were satisfactory.Conclusions: Dengue in pregnancy requires early diagnosis and treatment. A high index of clinical suspicion is essential in any pregnant woman with fever, especially in endemic areas. Further studies are necessary as evidence-based data in the management of dengue in pregnancy is inadequate.

scholarly journals Association of clinical features, comorbidities and laboratory profile with outcomes among dengue patients admitted in a tertiary care hospital, Delhi NCR

2021 ◽  
Vol 9 (7) ◽  
pp. 1918
Author(s):  
Mohit Tiwari ◽  
Abhishek Tibrewal ◽  
Varun S. Pichika ◽  
Narinder P. Singh ◽  
Pankaj N. Choudhary ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Clinical Features ◽  
Tertiary Care Hospital ◽  
Wide Spectrum ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Clinical Manifestations ◽  
Chronic Obstructive ◽  
Care Hospital ◽  
Laboratory Profile

Background: Dengue fever is an endemic disease across multiple countries. Dengue infection results in a wide spectrum of non-specific clinical manifestations with unpredictable clinical course and outcome. Objective of the study was to understand the association of different clinical features, comorbidities and laboratory profile with outcomes (ICU use, ventilation use and blood transfusion) among dengue patients admitted in a tertiary care hospital in Delhi, National Capital Region.Methods This cross-sectional study included 75 dengue patients with fever <1 week confirmed based on NS-1 antigen and/or IgM antibody positivity. Descriptive analysis was used.Results: Gender was not significantly associated with the outcomes. The duration of fever was significantly higher among those with ICU use (median: 6 versus 4 days; p=0.005), ventilator use (median: 5.5 versus 4.0 days; p=0.049] and blood transfusion (median: 6 versus 4 days; p=0.013). Dengue patients with co-morbidities (diabetes, hypertension, or chronic obstructive pulmonary disease) or co-infection had a significantly higher odds of the outcomes. The platelet level was significantly lower while liver enzymes were significantly higher among those with the outcomes.Conclusions: The clinical features, comorbidities and laboratory profile can help in identifying critical patients for ICU admission and timely intervention to improve outcome.

scholarly journals Seroprevalence of Dengue Infection in a Tertiary Care Hospital in Assam

2018 ◽  
Vol 7 (1) ◽  
pp. 1582 ◽  
Author(s):  
Liza Goswami ◽  
Chowdhury Runumi ◽  
Elmy S. Rasul
Keyword(s):  
Dengue Infection ◽  
Tertiary Care ◽  
Age Groups ◽  
Hemorrhagic Fever ◽  
Health Concern ◽  
Care Hospital ◽  
Serum Samples ◽  
Igm Antibody ◽  
Ns1 Antigen ◽  
Antibody Elisa

<p><strong>Background:</strong> Dengue fever (DF) and dengue hemorrhagic fever (DHF) are important arthropod borne viral diseases. Dengue in India has dramatically expanded over the last few decades, with rapidly changing epidemiology. Dengue is emerging as major public health concern in northeast India and spreading with increased morbidity.</p><p><strong>Objective:</strong>This study was carried out to determine the seroprevalence of Dengue infection among patients attending in Fakhruddin Ali Ahmed Medical College and Hospital, Barpeta, Assam during the period 2013-2016.</p><p><strong>Methods:</strong> A retrospective study was done from the year 2013 to 2016. A total of 340 serum samples received in the department of microbiology FAAMCH, were tested for the confirmation of suspected cases of dengue. Dengue NS1 antigen and Dengue IgM antibody ELISA tests were performed for the confirmation of dengue cases. We estimated the incidence by applying age, sex and season adjusted dengue positivity.</p><p><strong>Results:</strong> Out of 340 samples tested, 68 were positive either by NS1 antigen or for IgM antibody ELISA tests. These comprised all age groups of both sexes with higher incidence of cases in young males aged 26– 60 years.</p><p><strong>Conclusion:</strong> From this study, it is apparent that dengue surveillance and control should be enhanced by wider use of laboratory testing to confirm dengue as a cause of fever of unknown origin, especially during the local dengue transmission season.</p>

scholarly journals Clinical profile of dengue fever with severe thrombocytopenia and its complications: a retrospective study at a tertiary care hospital in South India

2017 ◽  
Vol 5 (5) ◽  
pp. 1751 ◽  
Author(s):  
Ch. Manoj Kumar ◽  
K. S. Keerthi Vyas ◽  
Y. Sai Krishna
Keyword(s):  
Retrospective Study ◽  
Dengue Fever ◽  
South India ◽  
Tertiary Care Hospital ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Clinical Profile ◽  
Severe Thrombocytopenia ◽  
Care Hospital ◽  
Haemorrhagic Fever

Background: Dengue haemorrhagic fever is a potentially lethal illness that is universally prevalent in the tropics and has become a major health concern globally in recent decades. The clinical manifestation of dengue infection varies from asymptomatic to severe life threatening illness in the form of DHF/DSS. Dengue haemorrhagic fever or DSS may be fatal in 40% to 50% of untreated patients. A hallmark of dengue infection is severe thrombocytopenia which causes concern for the patients and treating doctors. The objective of this study was to correlate clinical profile during the evolution of dengue fever with severe thrombocytopenia (platelets <10,000/mm3), and comparing frequencies between the different clinical forms in order to predict the severity of the disease.  The present study includes 40 individuals who were found to be seropositive with the detection of NS1Ag, IgM and IgG antibodies for dengue infection with severe thrombocytopenia. Early diagnosis and monitoring is largely dependent on haematological parameters. As no specific antiviral therapy is available, supportive therapy is of utmost importance.Methods: This is an observational, descriptive and retrospective study of 40 patients with clinical and serological diagnosis of dengue fever with severe thrombocytopenia (platelets<10,000/mm3), in the period from August 2015 to September 2016, who were admitted in a tertiary care hospital in South India. ELISA was performed for the detection of dengue NS1, Ig M and Ig G, haematological parameters by automated analyzer and peripheral smear, coagulation profile analysis were done.Results: Out of 40 cases with severe thrombocytopenia, 50% of the patients had classical dengue fever, 30% cases had DHF with bleeding manifests and 20% cases with DHF plasma leakage signs and 5% lead to DSS. There was lack of association studied between severe thrombocytopenia and bleeding manifestations as p value<0.065 was insignificant. However, the risk of complications increased with decreasing platelet counts in the present study.Conclusions: Thrombocytopenia was most predominant haematological discrepancy. There was no predilection for any age group or gender for thrombocytopenia or bleeding among the dengue patients. The results were relevant in assessing the severity of infection and can help by enabling the adaptation of the therapeutic conduct to the needs of individual patients.

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