scholarly journals Clinical, biochemical and genetic risk factors for 30-day and 5-year mortality in 518 adult patients subjected to cardiopulmonary bypass during cardiac surgery - the INFLACOR study.

2018 ◽  
Vol 65 (2) ◽  
pp. 241-250 ◽  
Author(s):  
Maciej Michał Kowalik ◽  
Romuald Lango ◽  
Piotr Siondalski ◽  
Magdalena Chmara ◽  
Maciej Brzeziński ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Genetic Association ◽  
Biochemical Parameters ◽  
Cox Regression ◽  
Association Studies ◽  
Nyha Class ◽  
Genetic Association Studies ◽  
Chronic Obstructive

There is increasing evidence that genetic variability influence patients’ early morbidity after cardiac surgery performed using cardiopulmonary bypass (CPB). The use of mortality as an outcome measure in cardiac surgical genetic association studies is rare. We publish the 30-day and 5-year survival analyses with focus on pre-, intra-, postoperative variables, biochemical parameters, and genetic variants in the INFLACOR (INFlAmmation in Cardiac OpeRations) cohort.In a series of prospectively recruited 518 adult Polish Caucasians who underwent cardiac surgery in which CPB was used, the clinical data, biochemical parameters, IL-6, soluble ICAM-1, TNFa, soluble E-selectin, and 10 single nucleotide polymorphisms were evaluated for their associations with 30-day and 5-year mortality.The 30-day mortality was associated with: pre-operative prothrombin international normalized ratio, intra-operative blood lactate, postoperative serum creatine phosphokinase, and acute kidney injury requiring renal replacement therapy (AKI-RRT) in logistic regression. Factors that determined the 5-year survival included: pre-operative NYHA class, history of peripheral artery disease and severe chronic obstructive pulmonary disease, intra-operative blood transfusion; and postoperative peripheral hypothermia, myocardial infarction, infection, and AKI-RRT in Cox regression. The serum levels of IL-6 and ICAM-1 measured three hours after operation were associated with 30-day and 5-year mortality, respectively. The ICAM1 rs5498 was associated with 30-day and 5-year survival with borderline significance.Different risk factors determined the early (30-day) and late (5-year) survival after adult cardiac surgery in which cardiopulmonary bypass was used. Future genetic association studies in cardiac surgical patients should adjust for the identified chronic and acute postoperative risk factors.

P1395The role of hyponatremia in the development of atrial fibrillation after cardiac surgery

EP Europace ◽  
2020 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
A Pavlikova ◽  
A Shevelyok ◽  
N Vatutin
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Serum Sodium ◽  
Sodium Level ◽  
Cox Regression ◽  
Serum Sodium Level ◽  
History Of ◽  
The Impact

Abstract Background. Atrial fibrillation (AF) is one of the most common complication after cardiac surgeries. Age, valvular heart disease, heart failure, chronic obstructive pulmonary disease and a history of AF are well known risk factors for postoperative AF. On the other hand, hyponatremia is also a frequent disorder in patients undergoing cardiac surgery but its relationship with AF has not been studied. Purpose. We evaluated the impact of hyponatremia on the incidence of postoperative AF in patients undergoing cardiac surgery with cardiopulmonary bypass. Methods. The retrospective study included case history of 222 patients (174 men and 48 women, median age 64.5 [range 58.0; 69.0] years) who underwent cardiac surgery with cardiopulmonary bypass between January 2015 and December 2018.  In all patients intraoperative sodium level was analyzed. Hyponatremia was defined as serum sodium level < 135 mmol/l. Primary outcome was the episode of AF in postoperative period. Results. The incidence of postoperative AF was 18.9% (95% confidence interval (CI) 14.1-24.3 P = 0.05). Patients with AF more often had obesity, diabetes mellitus and a history of myocardial infarction and were more likely to perform combined surgery compared to non-AF patients (all Ps < 0.05). The prevalence of hyponatremia was significantly higher among AF group compared with non-AF (95.2% versus 77.8%, P = 0.017). Hyponatremia was the independent risk factors of postoperative AF in Cox regression models adjusted for covariates (odds ratio 5.31; 95% CI 1.42-18.7; P = 0.017). Conclusion.  In this analysis serum sodium level was closely associated with the risk of AF. These findings suggest that hyponatremia may cause the development of postoperative AF in patients undergoing cardiac surgery with cardiopulmonary bypass.

scholarly journals Incidence, Indications, and Risk Factors of Reopening After Cardiac Surgery in Tertiary Cardiac Center, Sudan: Retrospective Observational Study

2020 ◽  
pp. 1-7
Author(s):  
Fatimah Azhari Gasmalla Gadeltayeb ◽  
◽  
Elfatih M Malik ◽  
Elamin E Elnur ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Observational Study ◽  
Nyha Class ◽  
Postoperative Bleeding ◽  
Retrospective Observational Study ◽  
Increased Risk ◽  
Cardiac Center

Background: Chest re-opening after cardiac surgery is a surgical approach that is performed for diagnosis and management of some postoperative complications. The rate of reopening varies from 2% to 6% of patients undergoing cardiac surgery. The most frequent indication for reopening, followed by cardiac tamponade, cardiac arrest and redo surgery. Several risk factors have been associated with reopening such as, age, sex, BMI, NYHA class, diabetes mellitus, cardiopulmonary bypass and aortic cross clamp time. The aim of this study is to determine the incidence, indications, and risk factors of reopening after cardiac surgery. Methods: In this retrospective observational study, a total of consecutive 638 patients who underwent cardiac surgery in Ahmed Gasim cardiac center in 2017 were included. Results: The incidence of reopening was found to be 61 per 1000 in all age groups, 90 per 1000 in adults, and 34 per 1000 in paediatrics. Out of 39 reopening cases, Bleeding was found to be the most frequent indication of reopening. multivariate analysis by logistic regression revealed that, having NYHA class II odd ratio OR = 24.767 (95% confidence interval CI = 1.048 – 585.3), past cardiac surgery OR = 13.9(95% CI = 1.013 – 193.3), having diabetes mellitus OR = 4.885 (95% CI = 1.251 –19.056 ),longer cardiopulmonary bypass time OR = 1.012 (95% CI = 1.00 – 1.024), preoperative aspirin OR = 3.528 (95% CI = 1.062 – 11.720), and warfarin OR = 12.790 (95% CI = 1.594 – 102.3) all are associated with increased risk of reopening after cardiac surgery. Conclusion : Incidence of reopening in Sudan was relatively higher than the international records. Reopening was mostly performed for postoperative bleeding management. Cardiac failure assessed by NYHA classification, previous cardiac surgery, diabetes mellitus, anti thrombotic therapy and longer bypass time were associated with increased risk of reopening

Cardiovascular risk factors and Alzheimer's disease: Genetic association studies in a population aged 85+

2000 ◽  
Vol 21 ◽  
pp. 175
Author(s):  
Liisa Myllykangas ◽  
Tuomo Polvikoski ◽  
Raimo Sulkava ◽  
Auli Verkkoniemi ◽  
Pentti Tienari ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Genetic Association ◽  
Association Studies ◽  
Genetic Association Studies

scholarly journals Fine scale human genetic structure in three regions of Cameroon reveals episodic diversifying selection

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kevin K. Esoh ◽  
Tobias O. Apinjoh ◽  
Steven G. Nyanjom ◽  
Ambroise Wonkam ◽  
Emile R. Chimusa ◽  
...  
Keyword(s):  
Genetic Structure ◽  
Ethnic Groups ◽  
Genetic Association ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Genomic Region ◽  
Sub Saharan Africa ◽  
Genome Wide Association Studies ◽  
Fine Scale ◽  
Sub Saharan

AbstractInferences from genetic association studies rely largely on the definition and description of the underlying populations that highlight their genetic similarities and differences. The clustering of human populations into subgroups (population structure) can significantly confound disease associations. This study investigated the fine-scale genetic structure within Cameroon that may underlie disparities observed with Cameroonian ethnicities in malaria genome-wide association studies in sub-Saharan Africa. Genotype data of 1073 individuals from three regions and three ethnic groups in Cameroon were analyzed using measures of genetic proximity to ascertain fine-scale genetic structure. Model-based clustering revealed distinct ancestral proportions among the Bantu, Semi-Bantu and Foulbe ethnic groups, while haplotype-based coancestry estimation revealed possible longstanding and ongoing sympatric differentiation among individuals of the Foulbe ethnic group, and their Bantu and Semi-Bantu counterparts. A genome scan found strong selection signatures in the HLA gene region, confirming longstanding knowledge of natural selection on this genomic region in African populations following immense disease pressure. Signatures of selection were also observed in the HBB gene cluster, a genomic region known to be under strong balancing selection in sub-Saharan Africa due to its co-evolution with malaria. This study further supports the role of evolution in shaping genomes of Cameroonian populations and reveals fine-scale hierarchical structure among and within Cameroonian ethnicities that may impact genetic association studies in the country.

scholarly journals Evaluation of genome-wide power of genetic association studies based on empirical data from the HapMap project

2007 ◽  
Vol 16 (20) ◽  
pp. 2494-2505 ◽  
Author(s):  
Yasuhito Nannya ◽  
Kenjiro Taura ◽  
Mineo Kurokawa ◽  
Shigeru Chiba ◽  
Seishi Ogawa
Keyword(s):  
Genetic Association ◽  
Empirical Data ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Hapmap Project ◽  
Genome Wide
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