SIGNIFICANCE OF SERUM COPPER AND ZINC LEVEL IN GASTROINTESTINAL CANCER

This study investigated the association of copper and zinc levels in the serum or urine of patients living in northeast China, with either prediabetes or diabetes. From January 2010 to October 2011, patients with type 1 diabetes (T1D,n=25), type 2 diabetes (T2D,n=137), impaired fasting glucose (IFG,n=12) or impaired glucose tolerance (IGT,n=15), and age/gender matched controls (n=50) were enrolled. In the T2D group, there were 24 patients with nephropathy, 34 with retinopathy, and 50 with peripheral neuropathy. Serum copper levels were significantly higher in IFG, IGT, and T2D groups. Serum zinc level was dramatically lower, and urinary zinc level was significantly higher in both T1D and T2D subjects compared with controls. The serum zinc/copper ratio was significantly lower in all the patients with IFG, ITG, T1D, and T2D. The serum copper level was positively associated with HbA1c in T2D subjects. Simvastatin treatment in T2D patients had no significant effect on serum and urinary copper and zinc. These results suggest the need for further studies of the potential impact of the imbalanced serum copper and zinc levels on metabolic syndrome, diabetes, and diabetic complications.

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Determination of Serum Copper and Zinc Level of Bangladeshi Breast Cancer Patient

ARC Journal of Cancer Science ◽

10.20431/2455-6009.0402002 ◽

2018 ◽

Vol 4 (2) ◽

Keyword(s):

Breast Cancer ◽

Cancer Patient ◽

Breast Cancer Patient ◽

Zinc Level ◽

Serum Copper ◽

Copper And Zinc

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Oğlaklarda Organik Bakır ve Çinko İz Minerallerinin Canlı Ağırlık ile Bu Minerallerin Birikim ve Atılma Düzeyleri Üzerine Etkisi

Turkish Journal of Agriculture - Food Science and Technology ◽

10.24925/turjaf.v6i10.1334-1338.1813 ◽

2018 ◽

Vol 6 (10) ◽

pp. 1334

Author(s):

Vadullah Eren

Keyword(s):

Live Weight ◽

Zinc Level ◽

Serum Copper ◽

Copper Chelate ◽

Mean Values ◽

Organic Group ◽

Average Value ◽

Copper And Zinc ◽

Hair Copper ◽

Organic Copper

This study was carried out to evaluate the effects of diet with organic copper (Cu) and zinc (Zn) which supplemented at the amount of 50% of recommendation levels for these minerals instead of its inorganic forms on live weight gain, accumulation levels of minerals in serum and hair and elimination levels of these minerals in faeces of goat kids. Kids were allocated equally two groups offered rations supplemented with organic (treatment, n=12) and inorganic (control, n=12) copper and zinc. It was offered 3.5 mg/kg DM copper chelate (2-hydroxy–4-methylthiobutyrate) and 10 mg/kg DM zinc chelate (2-hydroxy–4-methylthiobutyrate) to organic group. Seven mg/kg DM copper sulphate and 20 mg/kg DM zinc sulphate were supplemented to the ration of inorganic group kids. At the end of the experiment, average values of serum copper and zinc and hair copper and zinc were found higher than that of the beginning of the experiment in both groups. The differences between groups with regard to the mean values of live body weight, serum copper and zinc, hair copper and zinc were not statistically significant. The averages values of serum copper and zinc and hair copper in the organic group and the average value of the hair zinc level in the inorganic group were found to be numerically higher than that of another group. The averages copper and zinc levels in the faeces of the organic group were lower than that of the inorganic group. As a conclusion, although the supplementation of organic copper and zinc to the kid rations at level of 50% less than recommended levels it was determined that organic group had have similar growth performances, serum and hair values to that of the inorganic group. These values showed that organic minerals were better absorbed than inorganic ones. Furthermore, lower levels of faecal copper and faecal zinc values in the organic mineral group suggested that wastes of these minerals were scattered to the environment in lesser amounts and thus lead to lesser pollution.

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Status of Serum Copper and Zinc in Pre-Eclampsia

Bangladesh Journal of Medical Biochemistry ◽

10.3329/bjmb.v8i2.33279 ◽

2017 ◽

Vol 8 (2) ◽

pp. 49-54

Author(s):

FZ Muna ◽

ASMM Sirazi ◽

M Majumder ◽

K Serajuddin ◽

BC Debnath ◽

...

Keyword(s):

Pregnant Women ◽

Serum Zinc ◽

Lipid Peroxides ◽

Normal Pregnancy ◽

Zinc Level ◽

Serum Copper ◽

Medical College ◽

Copper And Zinc ◽

Significant Difference ◽

The Status

Pre-eclampsia is a multisystem and multifactorial disease that affects both mother and fetus by endothelial dysfunction and intrauterine growth retardation. It is thought that pre-eclampsia is associated with an imbalance of increased lipid peroxides and decreased antioxidants. Dietary deficiency or excess of copper, zinc or other micronutrients play important role in the pathogenesis of pre-eclampsia because nutrients can modulate oxidative stress by increasing or decreasing free radicals or antioxidants and providing substrates for formation of free radicals.This study was carried out in the Department of Biochemistry, Sylhet MAG Osmani Medical College during the period from July 2014 to June 2015 to evaluate the status of serum copper and zinc in pre-eclamptic patients. For this study 85 age-matched women were selected and grouped as 30 pre-eclamptic patients, 27 normal pregnant and 28 nonpregnant women. serum copper and zinc level were measured in all study subjects by AAS. Data were analyzed with the help of SPSS version 17.0. Mean (±SD) level of serum copper and zinc were 1.43±0.49 mg/l and 2.43±2.89 mg/l in pre-eclamptics, while in normal pregnant women the levels were 1.51±0.47 mg/l and 2.87±2.23 mg/l and in non-pregnant women these were 0.85±0.28 mg/l and 3.70±2.61 mg/l respectively. Serum copper significantly increased in pre-eclamptics and normal pregnant women when compared with that of non-pregnant women [F (2, 82) =19.763; p<0.001], but there was no significant difference between pre-eclamptic and normal pregnant group. No significant difference of serum zinc among three groups were observed [F (2, 82) =1.774; p=0.176]. The study showed increased trend of serum copper and decreased trend of serum zinc in pregnancy (both preeclampsia and without pre-eclampsia) compared with non-pregnant women, and both were reduced in pre-eclampsia compared to normal pregnancy. As our study did not show any significant difference in copper and zinc level in pre-eclamptics and normal pregnant women hence it can be concluded that there may not be any significant association of serum copper and zinc level with pre-eclampsia.Bangladesh J Med Biochem 2015; 8(2): 49-54

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