scholarly journals Analysis of Serum and Urinal Copper and Zinc in Chinese Northeast Population with the Prediabetes or Diabetes with and without Complications

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Jiancheng Xu ◽  
Qi Zhou ◽  
Gilbert Liu ◽  
Yi Tan ◽  
Lu Cai
Keyword(s):  
Serum Zinc ◽  
Zinc Level ◽  
Serum Copper ◽  
Copper Level ◽  
Simvastatin Treatment ◽  
Copper And Zinc ◽  
Urinary Copper ◽  
Zinc Levels

This study investigated the association of copper and zinc levels in the serum or urine of patients living in northeast China, with either prediabetes or diabetes. From January 2010 to October 2011, patients with type 1 diabetes (T1D,n=25), type 2 diabetes (T2D,n=137), impaired fasting glucose (IFG,n=12) or impaired glucose tolerance (IGT,n=15), and age/gender matched controls (n=50) were enrolled. In the T2D group, there were 24 patients with nephropathy, 34 with retinopathy, and 50 with peripheral neuropathy. Serum copper levels were significantly higher in IFG, IGT, and T2D groups. Serum zinc level was dramatically lower, and urinary zinc level was significantly higher in both T1D and T2D subjects compared with controls. The serum zinc/copper ratio was significantly lower in all the patients with IFG, ITG, T1D, and T2D. The serum copper level was positively associated with HbA1c in T2D subjects. Simvastatin treatment in T2D patients had no significant effect on serum and urinary copper and zinc. These results suggest the need for further studies of the potential impact of the imbalanced serum copper and zinc levels on metabolic syndrome, diabetes, and diabetic complications.

Diurnal Variation of Serum Copper and Zinc in Epileptics Receiving Anti-Convulsants

1986 ◽  
Vol 5 (3) ◽  
pp. 195-200 ◽  
Author(s):  
A. Taylor ◽  
K. Ghose
Keyword(s):  
Diurnal Variation ◽  
Reference Range ◽  
Serum Zinc ◽  
Serum Copper ◽  
Copper Level ◽  
Copper And Zinc ◽  
Urinary Copper ◽  
Zinc Concentrations ◽  
Zinc Levels ◽  
Patients With Epilepsy

1 Serial measurements of copper and zinc concentrations in serum were made at 06.00, 14.00, 22.00 and again at 06.00 hours in 37 male patients with epilepsy, aged between 9 and 19 years. Anti-convulsant drugs were administered at 08.00 and 20.00 hours, and standard hospital meals were allowed at 07.30, 12.00, 16.00 and 19.00 hours. 2 Similar to our previous results, eight patients (21.6%) had serum copper levels greater than the reference range (11.0–20.5 μmol/l) and this hypercupraemia was associated with carbamazapine and/or phenytoin medication. 3 No diurnal variation in serum copper level was observed. Serum copper concentration had no correlation with either 24 h urinary copper excretion or serum anti-convulsant drug levels. 4 Serum zinc concentrations were within the reference range (10–16.5 μmol/l), confirming our previous report. No relation with anti-convulsant medication or serum copper levels was found. 5 Diurnal variations in serum zinc levels with peak and trough concentrations at 06.00 and 14.00 hours, respectively, were observed. 6 It is proposed that these variations in serum zinc concentrations are a normal physiological process and is unlikely to be related to anti-convulsant drugs or epilepsy.

Hypercupraemia Induced by Antiepileptic Drugs

1983 ◽  
Vol 2 (3) ◽  
pp. 519-529 ◽  
Author(s):  
K. Ghose ◽  
A. Taylor
Keyword(s):  
Antiepileptic Drugs ◽  
Spectroscopic Method ◽  
Serum Zinc ◽  
Zinc Level ◽  
Serum Copper ◽  
High Serum ◽  
Copper Level ◽  
Upper Level ◽  
Zinc Levels ◽  
Male Subjects

1 Serum copper and zinc levels were measured in 84 treated male epileptics, aged between 6 and 18 years, by an atomic absorption spectroscopic method. These patients were selected randomly from a residential special school. Twenty drug-free healthy but educationally subnormal (ESN) male subjects of similar age group from the same school acted as controls. 2 No abnormality in serum zinc level was observed. 3 In nineteen (22.6%) epileptics, copper levels were above the upper level of normal range (20.5 μmol/l), whereas this was only marginally elevated (20.8 μmol/l) in one (5%) ESN subject. 4 The mean copper level in all epileptics was higher than the controls ( P<0.01), but there was no difference between the epileptics treated with sodium valproate alone and the ESN group. 5 The patients who were receiving carbamazepine either as monotherapy or in combination with other drugs except phenytoin, had higher mean copper levels than the controls ( P<0.01). A similar observation was made in relation with phenytoin polytherapy (but excluding carbamazepine). 6 There also appeared to be an association between the high serum copper levels and diffuse/generalized electroencephalographic changes ( P < 0.001). Some antiepileptic drugs, particularly carbamazepine, can produce such electroencephalographic abnormalities. 7 It is concluded that hypercupraemia observed in these treated epileptics were related to the induction of caeruloplasmin synthesis by phenytoin and carbamazepine.

scholarly journals Serum zinc, copper and ferritin levels in transfusion dependent thalassemia patients with iron chelator therapy

2019 ◽  
Vol 14 (1) ◽  
pp. 38-42
Author(s):  
Fatema Tuz Munira ◽  
Shelina Begum
Keyword(s):  
Ferritin Level ◽  
Colorimetric Method ◽  
Serum Zinc ◽  
Study Groups ◽  
Iron Chelator ◽  
Zinc Level ◽  
Serum Copper ◽  
Copper Level ◽  
Serum Zinc Level ◽  
Cross Sectional

Background: Transfusion dependent thalassemia (TDT) patients require regular blood transfusion and iron chelator therapy to maintain their life. Iron chelator may alter serum zinc and copper level in TDT patients. Objective: To observe serum zinc and copper and ferritin levels in transfusion dependent thalassemic patients treated with iron chelator. Method: The present cross sectional study was carried out in the department of Physiology, BSMMU, Dhaka between September 2017 to February 2019. Thirty cases of TDT, aged 5-40 year were included in the study group. Age and sex matched 30 healthy subjects were also studied as control. All the TDT patients were selected from the outpatient Department of Hematology and Transfusion Medicine, BSMMU, Dhaka. Serum zinc was measured by Spectrophotometric method and serum copper and ferritin levels were measured by colorimetric method. For statistical analysis independent sample t test was used. Result: The mean serum zinc level was significantly (p<0.05) lower and serum ferritin level was significantly (p<0.001) higher in TDT compared to control. Again, mean serum copper level and Zn/Cu ratio were not significantly (p>0.05) different in study groups compared to that of control. In addition, 3.3 % TDT patients had hypozincemia and 13.3% TDT patients had hypercupremia. Conclusion: This study may conclude that low serum zinc level and high copper level may be associated with TDT patients treated by combined deferoxamine (DFO) & deferiprone (DFP) iron chelator. J Bangladesh Soc Physiol. 2019, June; 14(1): 38-42

ESTIMATION OF SERUM COPPER AND ZINC IN ANAEMIC PATIENTS

2016 ◽  
Vol 9 (5) ◽  
pp. 162
Author(s):  
Aishwarya Swaminathan ◽  
Sohara Parveen ◽  
Vishnupriya V ◽  
Gayathri R
Keyword(s):  
Study Design ◽  
Clinical Laboratory ◽  
Serum Zinc ◽  
Serum Copper ◽  
Healthy Individuals ◽  
Adequate Amount ◽  
Rich Food ◽  
Copper And Zinc ◽  
Group 2 ◽  
Zinc Levels

ABSTRACTObjective: Estimation of serum zinc and copper levels in anemic patients.Methods: The study design included 30 subjects presenting to clinical laboratory, global hospitals. The subjects were divided into 2 groups. TheGroup 1 consists of 15 healthy individuals and Group 2 consists of 15 anemic patients.Results: The serum copper and zinc levels were evaluated in anemic patients. The serum copper and zinc were found to be significantly lower inanemic patients when compared with normal individuals.Conclusion: Thus, the study concludes that the serum zinc and copper in anemic patients is significantly less when compared to the control individuals.Hence, it is important to add adequate amount of zinc and copper rich food in their diet to control the prevalence of anemia.Keywords: Anemia, Zinc, Copper, Hemoglobin.

scholarly journals Study on serum zinc and copper levels in pulmonary tuberculosis patients before starting Directly Observed Treatment, Short-course

Mediscope ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 122-127
Author(s):  
Prithwy Shankar Biswas ◽  
Abu Md Mayeenuddin Al Amin ◽  
Syed Didarul Haque
Keyword(s):  
Serum Zinc ◽  
Zinc Level ◽  
Serum Copper ◽  
Copper Level ◽  
Control Group ◽  
Case Group ◽  
Serum Zinc Level ◽  
Mean Values ◽  
Short Course ◽  
Directly Observed Treatment

Background: Tuberculosis is a major public health concern throughout the world including Bangladesh. The prevalence of tuberculosis (TB) is increasing day by day. Around one-third of world population is infected with M. tuberculosis. Still pulmonary tuberculosis (PTB) remains one of the important causes of mortality throughout the world with economic burden. Objective: To evaluate levels of the serum zinc and serum copper in smear positive PTB patients before starting Directly Observed Treatment, Short-course (DOTs) therapy. Methods: This was a cross-sectional type of observational study. A total of 100 subjects were included in this study. Among them 50 were smear positive PTB patients denoted as case group and 50 were apparently healthy individuals denoted as control group. Biochemical tests were carried out in the department of biochemistry of Mymensingh Medical College, Mymensingh. All the statistical analyses were performed by using SPSS version 21. Results were evaluated by using Student’s t-test. Results: After careful evaluation there was significant decrease in serum zinc level along with significant increase in serum copper level among the case group when compared with the control group. The mean values of serum zinc level were 93.96±10.04 μg/dl and 72.84±7.73 μg/dl in control and case group respectively. Serum zinc level decreased significantly (p <0.001) in PTB patients. The mean values of serum copper were 111.81±21.26 μg/dl and 125.99±27.93 μg/dl in control and case group respectively. There was significant (p <0.001) rise of serum copper level in PTB patients. Mediscope 2021;8(2): 122-127

Serum Copper and Zinc Levels of Oral Submucous Fibrosis Patients Using Areca Nut Products Reported at Isra University Hospital Hyderabad

2021 ◽  
Vol 15 (9) ◽  
pp. 3034-3036
Author(s):  
Uzma Tariq ◽  
Waqas Iqbal ◽  
Surwaich Ali Channa ◽  
Bhunesha Devi ◽  
Arhama Surwaich ◽  
...  
Keyword(s):  
Oral Submucous Fibrosis ◽  
Serum Zinc ◽  
Serum Copper ◽  
University Hospital ◽  
Areca Nut ◽  
Healthy Individuals ◽  
Copper And Zinc ◽  
Submucous Fibrosis ◽  
Zinc Levels ◽  
One Year

Objective: To determine the copper and zinc levels in serum among oral submucous fibrosis patients using various areca nut products by taking healthy individuals as control at Isra University Hospital Hyderabad. Methodology: This descriptive case-control study was conducted on patients of oral submucosal fibrosis (OSMF) attending the Outpatient Department, Oral Surgery Isra Dental College, Isra university during a period of one year from November 2016 to October 2017. A total of 30 patients above 16 years of age and who were diagnosed cases of OSMF and gave history of areca nut and its commercial products consumption for more than one year were included as group (B)and in equal number healthy individuals were enrolled as control as group(A). The 6ml blood sample was collected in gel tube and then we centrifuged at 3000 rpm gravity for 10min to separate the serum from blood. The 4 to 5ml serum collected in this way was analyzed by spectrophotometric method on Hitachi 902(Roche Germany). The levels of copper and zinc were estimated from serum of both groups. All the data was collected via study proforma and analysis of the data was done by using SPSS version 20. Results: Mean age of the patients was 23.33±4.97 years and mean age of healthy controls was 22.80±4.61 years. The males were most common in both groups. Manipuri was commonest consumed areca nut (50.0%) followed by sweet scented areca nut and Gutkha 33.3% and 36.6% respectively. Mean of serum Cu in patients was lower 86±4.20 µg/dl in contrast to controls 114.0±13.8 µg/dl (p-0.0001). Average of serum Zinc was higher among patients 94.20±15.11 µg/dl as compared to controls as 68.06±17.10 µg/dl (p-0.0001). Conclusion: The average of serum copper level was observed to be significantly less and average of serum zinc significantly higher among OSMF patients using areca nut as compared to healthy individuals. These serum trace element levels could be used as potential prognostic and diagnostic markers in the OSMF patients. Key words: OSMF, Zinc, Copper, Areca nut

scholarly journals Serum Copper and Zinc Levels and Risk of Hepatocellular Carcinoma: A 1:1 Matched Case-Control Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1397-1397
Author(s):  
Aiping Fang ◽  
Huilian Zhu
Keyword(s):  
Serum Zinc ◽  
Serum Levels ◽  
Case Control ◽  
Serum Copper ◽  
Copper And Zinc ◽  
Copper Zinc ◽  
Matched Case ◽  
Zinc Levels ◽  
Control Study ◽  
Serum Zinc Levels

Abstract Objectives Copper and zinc have been involved in the development of liver cancer in laboratory models, yet data from epidemiological studies are limited. We investigated the association of serum levels of copper and zinc and their ratio with the risk of hepatocellular carcinoma (HCC) in a Chinese population. Methods This is a 1:1 matched case-control study conducted between September 2013 and February 2017. Each case with newly diagnosed HCC from the Guangdong Liver Cancer Cohort (GLCC) was matched to one healthy control from the Guangzhou Nutrition and Health Study by age (±1 years) and sex. Serum copper and zinc levels were quantified using inductively coupled plasma mass spectrometry. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for age, sex, body mass index, hepatitis infection, smoking status, alcohol drinking status, diabetes, and chronic inflammation. Serum levels of copper and zinc and their ratio were included in models in tertiles with cutpoints based on the distribution of the control participants. Results A total of 556 case-control pairs were included in this study. Mean (SD) age was 60.3 (7.1) years and 83.8% of the participants were men. HCC cases had significantly higher copper and lower zinc levels, and thus higher copper/zinc, than controls. Higher serum zinc levels were associated with a lower risk of HCC (ORT3 vs T1 = 0.21; 95% CI: 0.07–0.64, P for trend = 0.005). However, there was no association between serum copper levels and HCC risk (ORT3 vs T1 = 1.53; 95% CI: 0.62–3.76, P for trend = 0.375). Higher copper/zinc ratio was associated with increased risk of HCC (ORT3 vs T1 = 3.06; 95% CI: 1.08–8.70, P for trend = 0.049). Conclusions Serum zinc levels were inversely associated with the risk of HCC, suggesting a protective role of zinc in preventing HCC development. Funding Sources This work was supported by the National Natural Science Foundation of China.

Utilization of lupin stubbles by merino sheep: studies of animal performance, rates and time of stocking, lupinosis, liver copper and zinc, and circulating plasma enzymes

1979 ◽  
Vol 30 (3) ◽  
pp. 551 ◽  
Author(s):  
KP Croker ◽  
JG Allen ◽  
DS Petterson ◽  
HG Masters ◽  
RF Frayne
Keyword(s):  
Liver Damage ◽  
Significant Negative Correlation ◽  
Zinc Level ◽  
Copper Level ◽  
Liver Copper ◽  
Plasma Enzymes ◽  
Copper And Zinc ◽  
Phomopsis Leptostromiformis ◽  
Zinc Levels ◽  
Stocking Rates

Three experiments were conducted in the West Midland region of Western Australia to evaluate the sheep-carrying capacity of dry narrow-leafed sweet lupin (Lupinus angustifolius cv. Uniharvest) stubbles. In addition, the effect of stocking rate on lupinosis, and the effect of lupinosis on circulating plasma enzymes and liver copper and zinc levels were determined. At low stocking rates (25 or less ha-1) sheep were grazed for up to 80 days with increases in liveweight. However, with higher stocking rates (50 or 75 ha-1) the maximum weights obtained were lower, and reached after a shorter period of time. Sheep grazed at the high stocking rates suffered more liver damage than those grazed at low rates, and it is suggested that outbreaks of clinical lupinosis might be precipitated by grazing sheep at high rates. Sheep that grazed the stubbles and suffered liver damage had higher liver copper levels than those that suffered no damage. Also, there was an indication that the degree of liver damage and the liver copper level were directly related. It is suggested that the toxins of Phomopsis leptostromiformis cause the liver to take up and store copper. A significant negative correlation between the degree of liver damage and the liver zinc level was found. However, it was not determined whether this diminishment of liver zinc was a direct effect of the toxins of P. leptostromiformis or due to displacement by copper which was actively being taken up. Plasma levels of ornithine carbamyl transferase, alkaline phosphatase and aspartate amino transferase, measured during or at the end of the experiments, were not related to the degree of terminal liver injury. They are not considered reliable indicators of the incidence or severity of lupinosis in the field.

scholarly journals Study of serum Zinc status among type 2 diabetes mellitus patients

2017 ◽  
Vol 4 (5) ◽  
pp. 1344 ◽  
Author(s):  
Ramesh Dasarathan ◽  
Senthil Kumar S. ◽  
Ganesh V. ◽  
Chenthil K. S.
Keyword(s):  
Fasting Blood Glucose ◽  
Serum Zinc ◽  
Zinc Level ◽  
Diabetic Group ◽  
Newly Diagnosed ◽  
Serum Zinc Level ◽  
Type 2 Diabetics ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: Both microvascular and macrovascular complications in diabetes are related to oxidative stress. Zinc which has antioxidant property, delays diabetic complications. The present study was conducted with the objective to study the relationship between serum Zinc level and HbA1C level in newly diagnosed type 2 diabetes mellitus and to compare serum Zinc level with its risk factors.Methods: The present study was a cross sectional study, conducted on 100 patients attending the outpatient department at Rajiv Gandhi Government General Hospital and Madras Medical College, Chennai during the period from May 2015 to October 2015. Of them 50 were newly diagnosed type 2 diabetics and considered as diabetic group and other 50 were considered as controls, who attended the master health check-up. All patients were subjected to thorough general and systemic examination. Under strict aseptic precautions blood sample was collected from all the patients and the serum was investigated for creatinine, urea, zinc, HbA1c, cholesterol, triglycerides and fasting blood glucose. The data obtained were analysed using Microsoft excel software. Correlation was found out in SPSS by using regression equation.Results: The body mass index (BMI) and mean systolic blood pressure (SBP) was significantly higher (p<0.001) in diabetic group as compared to controls. Serum levels of HbA1C and fasting blood glucose (FBG) levels were found to be significantly higher in diabetic group than in controls (p<0.001). Serum zinc levels were significantly higher in control group (p<0.001). Mean zinc value decreases with increase in HbA1c, FBG, BMI, SBP, DBP, triglycerides and cholesterol and the difference was statistically significant (p value <0.01). The relation between Pearson correlation coefficient for zinc and the above parameters were higher in diabetics than controls.Conclusions: Lower serum zinc levels were found to be responsible for the development of macrovascular complications in type-2 diabetics. Hence there is a need for zinc supplementation in diabetic patients to prevent long term complications associated with it.

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