scholarly journals Effect of Iron Supplementation in Anaemic Children with Breath Holding Spells at a Tertiary Care Hospital (KGH - Visakhapatnam) in Southern India

2021 ◽  
Vol 8 (31) ◽  
pp. 2870-2874
Author(s):  
Ramadevi Devagudi ◽  
Ramu Pedada ◽  
Annapurna Dumpala
Keyword(s):  
Iron Deficiency ◽  
Iron Supplementation ◽  
Ferrous Sulphate ◽  
Tertiary Care ◽  
Complete Response ◽  
Iron Therapy ◽  
Breath Holding ◽  
Care Hospital ◽  
Total Period ◽  
Rbc Indices

BACKGROUND Breath holding spells (BHS) are common, non-epileptic paroxysmal events that occur in children below 6 years, whose diagnosis is made many times clinically. Exact aetiology is not known, but iron deficiency was one among many proposed aetiological factors. Very few studies were published till date to determine role and effect of iron supplementation in children with breath holding spells. Hence the present study was taken up to assess the presence of iron deficiency and the effect of iron supplementation in children with breath holding spells. METHODS This prospective interventional study was performed from May 2012 to April 2017. 125 children below six years of age brought with the complaint of breath holding spells were screened for presence of anaemia and other systemic illnesses. Ten children were excluded with other organic causes and only 85 children were found to have anaemia and were supplemented with 6 mg/kg/day of ferrous sulphate for 3 months and followed up for a total period of 6 months. Response to iron supplementation was assessed in these children by measuring total number of attacks of BHS before starting iron supplementation, after supplementation of iron for three months and also at the end of follow-up period. The results were analysed by using Microsoft Office Excel. RESULTS 76.52 % (85/115) of patients had anaemia and were supplemented with 6 mg/kg/day of ferrous sulphate for 3 months. The remaining 27 cases had normal Hb % & red blood cells (RBC) indices and were not included. Response to iron therapy was assessed in anaemic children with breath holding spells and we found complete response in 78.41 %, partial response in 15.91 % and no response in 5.7 %. CONCLUSIONS This study proved the role of iron therapy in anaemic children with breath holding spells. KEYWORDS Breath Holding Spells (BHS), Iron Deficiency, Anaemia, Haemoglobin

scholarly journals Role of ferric carboxymaltose in the treatment of postpartum anemia in a tertiary care hospital in Andhra Pradesh

2021 ◽  
Vol 10 (10) ◽  
pp. 3889
Author(s):  
Kirtan Krishna ◽  
Achint Krishna ◽  
Divya Teja G. N.
Keyword(s):  
Iron Deficiency ◽  
Patient Compliance ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Deficiency Anemia ◽  
Ferric Carboxymaltose ◽  
Care Hospital ◽  
Parenteral Iron

Background: Postpartum iron deficiency anemia is common in India as a consequence of postpartum hemorrhage.  Recent studies have evaluated the use of parenteral iron as a better tolerated treatment modality. Compared with oral iron supplements, parenteral iron is associated with a rapid rise in serum ferritin and hemoglobin and improved maternal fatigue scores in the postpartum period.  Parenteral iron may be considered for the treatment of postpartum anemia. The objective of the study was to evaluate the efficacy, safety, and tolerability of intravenous ferric carboxymaltose, in women with postpartum anemia.Methods: A clinical observational study was undertaken in a tertiary care hospital,  50 women within six weeks of delivery with Hb ≥6 gm/dl and ≤10 gm/dl received 1000 mg/week,  over 15 minutes or less, repeated weekly to a calculated replacement dose (maximum 2500 mg) . Hemoglobin and serum ferritin levels were recorded prior to treatment and on day 21 after completion of treatment.Results: Ferric carboxymaltose-treated subjects achieved a hemoglobin greater than 12 gm/dL in a short time period (21 days), achieve a hemoglobin rise of ≥3 gm/dL more quickly, and attain higher serum ferritin levels. It is also associated with better patient compliance, and shorter treatment period. Drug-related adverse events occurred less frequently with ferric carboxymaltose. The only noted disadvantage was that it is more expensive when compared to other iron preperations.Conclusions: Intravenous ferric carboxymaltose was safe and well tolerated with good efficacy and better patient compliance in the treatment of postpartum iron deficiency anemia.

scholarly journals Effect of anemia on pregnancy outcome: a prospective study at tertiary care hospital

2017 ◽  
Vol 6 (12) ◽  
pp. 5379
Author(s):  
Chintan Upadhyay ◽  
Nisha Upadhyay
Keyword(s):  
Iron Deficiency ◽  
Prospective Study ◽  
Iron Status ◽  
Tertiary Care ◽  
Subsequent Pregnancy ◽  
Care Hospital ◽  
Maternal Complications ◽  
Iron Deficient ◽  
Pregnancy And Postpartum ◽  
A Prospective Study

Background: Iron deficiency anaemia during pregnancy leads to preterm birth, low birth weight and small-for-gestational age babies and increases incidence of postpartum haemorrhage (PPH) and the reason for the incidence of PPH is higher in India compared with the rest of the world. The objective of this study was to find association between maternal anaemia and neonatal complications and to find long term morbidity and mortality of babies born to anaemic mothers.Methods: It is a prospective study done at Obstetrics and Gynecology Department, Dr. B. R. Ambedkar Medical College and Hospital, Bangalore during October 2009 to October 2011. All subjects were analyzed in full details and haemoglobin estimation done during 1st visit, at 30th week and 36th week of gestation.Results: Study observed moderate anaemia observed in almost 53.0% cases followed by mild (29.5%) and severe (17.5%) respectively. Risk factors present in 58.0% cases and maternal complications in puerperium observed in 14.5% cases. High incidence of adverse foetal outcome in the form of preterm (20%), IUGR (28%), NICU admission (25.5%) and IUD (3%) seen in present study. Study found association between space between pregnancy, LSCS and fetal outcome with severity of anaemia. Ensuring maternal iron sufficiency during gestation is the most cost-effective method of preventing perinatal iron deficiency and related morbidities.Conclusions: Iron supplementation during pregnancy in iron deficient mothers improves iron status during pregnancy and postpartum period, thus providing some protection against iron deficiency in the subsequent pregnancy. Proper antenatal care is the basic requirement for prevention, early detection and treatment of anaemia.

scholarly journals Vitamin A and Nutritional Anaemia

1996 ◽  
Vol 17 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Djoko Suharno ◽  
Muhilal
Keyword(s):  
Placebo Group ◽  
Iron Deficiency ◽  
Vitamin A ◽  
Pregnant Women ◽  
Iron Supplementation ◽  
Ferrous Sulphate ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Vitamin A Status

A cross-sectional study of the prevalence of iron and vitamin A deficiencies in 318 pregnant women revealed that 50.7% had iron deficiency and 21.3% had marginally deficient or deficient vitamin A status. Based on results, the influence of vitamin A and iron supplementation was studied in 305 anaemic pregnant women in west Java, in a randomized, doubleblind, placebo-controlled field trial. The women with a haemoglobin between 80 and 109 g/L were randomly allocated to four groups: vitamin A (2.4 mg retinol) and placebo iron tablets; iron (60 mg elemental iron as ferrous sulphate) and placebo vitamin A; vitamin A and iron; and both placebos, all daily for eight weeks. Maximum haemoglobin was achieved with both vitamin A and iron supplementation (12. 78 g/L, 95% Cl 10.86 to 14.70), with one-third of the response attributable to vitamin A (3.68 g/L, 2.03 to 5.33) and two-thirds to iron (771 g/L, 5.97 to 9.45). After supplementation, the proportion of women who became non-anaemic was 35 % in the vitamin Asupplemented group, 68% in the ironsupplemented group, 97% in the group supplemented with both, and 16% in the placebo group. We conclude that improvement in vitamin A status may contribute to the control of anaemia in pregnant women.

scholarly journals A prospective study to evaluate oral iron preparations in antenatal women at a tertiary care hospital

2017 ◽  
Vol 6 (4) ◽  
pp. 851
Author(s):  
Satyanarayana V. ◽  
Shabeer D. ◽  
Suma Jayaram ◽  
Basavaraj Bhandare
Keyword(s):  
Pregnant Women ◽  
Ferrous Sulphate ◽  
Tertiary Care ◽  
Healthcare Providers ◽  
Oral Iron ◽  
High Morbidity ◽  
Care Hospital ◽  
Acid Therapy ◽  
Detailed Medical History ◽  
Iron Preparation

Background: Iron deficiency is the most common cause of anemia in pregnancy worldwide. It can be mild, moderate or severe. Severe anemia can have very serious consequences for mothers and babies. Pregnant women requiring medication represent a challenge to healthcare providers to avoid any teratogenic risk to foetus. The purpose of this study was to provide information about the most effective iron preparations prescribed to pregnant women and to evaluate the haemoglobin status before and after oral iron therapy.Methods: This was a Prospective observational study conducted in the Department of Obstetrics and Gynaecology, Rajarajeswari Medical College and Hospital, between October 2013 and March 2014.This study was conducted by reviewing the antenatal care Outpatient department case papers of 200 pregnant women who were anaemic.Results: Demographic profile, detailed medical history and drug intake in current pregnancy was noted. The prescription pattern was assessed. Of the three common iron preparations prescribed, Ferrous sulphate was the most common preparation. Findings of our study showed that all pregnant anaemic women included in the study were provided with iron and folic acid therapy and the most effective oral iron preparation was Ferrous sulphate.Conclusions: Present study shows that ferrous sulphate is the most common iron preparation prescribed. Ferrous sulphate and ferrous fumarate preparations showed better improvement in Hb levels. Anaemia is common among all pregnant women and therefore it raises the concern about high morbidity and mortality associated with pregnancy outcome. This can be minimized by educating pregnant women about importance of balanced diet and utilization of antenatal facilities even during early pregnancy. 

scholarly journals Association of Iron Deficiency Anemia with Febrile Seizure in Children in a Tertiary Care Hospital

2021 ◽  
Vol 19 (1) ◽  
pp. 66-70
Author(s):  
Brajesh Raj Chaudhary ◽  
Kalpana Karmacharya Malla ◽  
Binod Gaire
Keyword(s):  
Risk Factors ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Febrile Seizure ◽  
Binding Capacity ◽  
Tertiary Care ◽  
Transferrin Saturation ◽  
Deficiency Anemia ◽  
Seizure Threshold ◽  
Care Hospital

Background: Febrile seizure is the most common cause of seizure in children. Iron deficiency, by lowering seizure threshold, is proposed to be one of the risk factors for febrile seizure. Many studies have been done to determine the association of iron deficiency anemia with febrile seizure but the results are controversial. Hence, the present study was conducted to evaluate the association of iron deficiency anemia with febrile seizure in Nepalese children. Methods: A prospective age and sex matched case control study was performed in 68 cases of febrile seizures and 68 controls of febrile illness without seizure after calculating the sample size. The study was conducted from October 21, 2019 to October 20, 2020 in Pediatric ward and intensive care unit of College of Medical Sciences, Bharatpur, Nepal after obtaining ethical clearance from institutional review committee. Data entry was done in statistical packages for the social science version 20.Results: Mean of haematological parameters (haemoglobin and mean corpuscular volume) as well as mean of serum iron, ferritin and transferrin saturation were significantly less and total iron binding capacity was significantly high in cases as compared to controls (P <0.05). Iron deficiency anemia was significantly associated with cases (59.7%), with odds ratio of 2.5 (95% confidence interval =1.24 – 5.01) as compared to control (40.3%) (P <0.05).Conclusions: Iron deficiency anemia may be considered one of the risk factors for febrile seizure in children. Hence, Children with febrile seizure should be investigated and treated for Iron deficiency anemia.Keywords: Children; febrile seizure; iron deficiency anemia

scholarly journals Prevalence of iron deficiency and thalassemia in patients presenting Tertiary Care Hospital.

2020 ◽  
Vol 27 (12) ◽  
pp. 2618-2621
Author(s):  
Nadia Taj ◽  
Saba Javed ◽  
Munazza Munir ◽  
Anam Naz ◽  
Asma Sajid ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Gestational Age ◽  
Tertiary Care ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Contributing Factors ◽  
Cross Sectional ◽  
Iron Deficient ◽  
Tertiary Care Hospitals

Objectives: To find the frequency of iron deficient anemia and thalassemia in anemic patient reporting in tertiary hospital in Multan. Study Design: Cross Sectional study. Setting: Department of Obstetrics and Gynecology in Nishtar Hospital, Multan. Period: 20th October 2018 to 20th April 2019. Material & Method: In this study total 260 females with anemia HB<10.5g/dl were incorporated. Blood of all the patients were collected following the septic measures in CBC vial for counting of hemoglobin and blood investigation serum ferritin [<11ng/ml] and HB electrophoresis HBA [>6]. Gestational age was predicted depending upon last period of menstruation. Results: Age of patients in this study was between 24 to 34 year with the average age of 29.9±2.3 year, average gestational age 33.2±2.11 week, average parity 1.46±1.3. Iron deficient anemia was observed in 88.4 percent patient. Thalassemia was observed in 5.7 percent patient. Conclusion: The results of our study revealed that iron deficiency and thalassemia are significant contributing factors of anemia in patients reporting tertiary care hospitals Multan. General screening for carriers of thalassemia should be provided to all pregnant females attending prenatal care.

scholarly journals Role of iron in breath holding spells and effect of iron therapy in children

2021 ◽  
Vol 8 (11) ◽  
pp. 1861
Author(s):  
Mohmad Saleem Chesti ◽  
Shilakha Chaman ◽  
Mudasir Nazir
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Significant Rise ◽  
Hemoglobin Level ◽  
Iron Therapy ◽  
Deficiency Anemia ◽  
Breath Holding ◽  
Iron Supplement

Background: Breath holding spells (BHS) are paroxysmal events resulting from painful stimulus or emotional event resulting in forceful crying, occur in children’s aged between 6 months to 6 years. To assess the role of iron in breath holding spells (BHS) and to assess the efficiency of iron therapy in reducing frequency of BHS.Methods: This was a prospective, interventional study conducted at GMC baramulla. A total of 70 patients between the ages of 6 months and 5 years with breath holding spells with iron deficiency and iron deficiency anemia were studied. After giving them iron therapy for 6 and 12 weeks, they were assessed for the improvement in their anemia and its impact on the frequency of breath holding spells.Results: Seventy children with breath holding spells were studied prospectively. Forty (57.15%) cases were males and 30 (42.85%) females. There was a statistically significant rise in the hemoglobin level, serum ferritin, serum iron with 6 and12 weeks of iron therapy (p<0.001). This rise in the hemoglobin level serum ferritin and serum iron was associated with a statistically significant fall in the frequency of breath holding spells with 6 and 12 weeks of iron therapy (p<0.001).Conclusions: iron supplement is effective in reducing the frequency of breath holding spells and thus iron has role in BHS.

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