scholarly journals Assessment of Magnesium Levels in Ischemic Cerebral Stroke Patients and Its Correlation with Severity of Neurological Disability – A Longitudinal Observational Study from Sri Amritsar, Punjab

2021 ◽  
Vol 8 (35) ◽  
pp. 3224-3229
Author(s):  
Jasleen Kaur ◽  
Satya Bhushan Nayyar ◽  
Tejinder Sikri ◽  
Jasmine Kaur ◽  
Hardeep Singh Deep
Keyword(s):  
Ischemic Stroke ◽  
Serum Magnesium ◽  
Mean Value ◽  
Magnesium Level ◽  
Cerebral Stroke ◽  
Modified Rankin Scale ◽  
Serum Magnesium Level ◽  
Stroke Patients ◽  
Longitudinal Observational Study ◽  
The Mean

BACKGROUND World Health Organization (WHO) clinically defines a stroke as ‘the rapid development of clinical signs and symptoms of a focal neurological disturbance lasting more than 24 hours or leading to death with no apparent cause other than vascular origin’. Hypo magnesia (ionized form) leads to neuromuscular hyperirritability, tremors, increased vascular resistance, coronary vasospasm and hypertension. Magnesium deficiency triggers vasoconstriction enhancing vascular endothelial injury and hence leads to atherosclerosis. In the present study, we wanted to evaluate serum magnesium levels in ischemic cerebral stroke patients and correlate its severity with the neurological disability using modified Rankin scale (mRS) and Canadian neurological scale. METHODS It was a longitudinal observational study, undertaken in the Department of Medicine in Sri Guru Ram Das Institute of Medical Sciences and Research, Sri Amritsar from December 2018 to June 2020. 60 patients with acute ischemic cerebral stroke fulfilling the inclusion criteria were selected. 5 ml venous sample for serum magnesium level was taken within 24 hours and on day 5 of admission. Presence or absence of hypomagnesemia in patients after acute cerebral ischemic stroke was recorded during the hospital stay of patients, receiving standard management protocol of ischemic stroke. The correlation co-efficient of serum magnesium level with modified Rankin scale and Canadian neurological scale was calculated. RESULTS The mean age of patients was 61.6 ± 1.6 years, 42 (70 %) patients were male and 18 (30 %) were females and there was male preponderance. The mean serum magnesium level was measured as 1.78 ± 0.2 mg/dL, it was observed that the mean value for mRS was 3.93 ± 0.75 and Canadian neurological scale was 7.11 ± 2.01 within 24 hours and on the 5th day the mean value for mRS was 3.5 ± 1.09 and Canadian neurological scale was 8.02 ± 2.97. The present study observed a statistically significant correlation between mRS score and serum magnesium level as well as Canadian neurological scale and serum magnesium levels. CONCLUSIONS It was concluded through the results of this study that low levels of magnesium in the body can cause more severe stroke. KEYWORDS Stroke, Serum Magnesium, Hypomagnesemia, Modified Rankin Scale, Canadian Neurological Scale

scholarly journals Serum Magnesium Level among the Patients Admitted with Acute Stroke in a Tertiary care Hospital

2018 ◽  
Vol 27 (1) ◽  
pp. 50-56
Author(s):  
Md Firoj Hossain ◽  
MN Hasan ◽  
SM Uddin ◽  
AA Masum ◽  
PM Basak
Keyword(s):  
Ischemic Stroke ◽  
Acute Stroke ◽  
Hemorrhagic Stroke ◽  
Serum Magnesium ◽  
Normal Serum ◽  
Magnesium Level ◽  
P Value ◽  
Serum Magnesium Level ◽  
Stroke Patients ◽  
The Mean

Magnesium deficiency was shown to trigger vasoconstriction and enhance vascular endothelial injury, thus promoting the development and progression of atherosclerosis. We hereby intended to investigate serum magnesium in the early stage of acute stroke and to evaluate the relationship between serum magnesium concentration and the development of neurological deficits. This is a descriptive type of cross sectional study was carried out in department of medicine, Comilla Medical College Hospital from June 2013 to December 2013. Fifty admitted acute stroke patients were randomly chosen for this study who fulfills inclusion criteria. The serum magnesium concentrations were measured by photometric colorimetric end point method on admission. Out of 50 acute stroke patients 30 (60%) were male and 20 (40%) were female. The mean age is 66.44 (SD ±14.8) years with male predominance. Most of the patients 30 (60%) belongs to above 60 years and 36 (72%) patients had hypomagnesaemia and 14 (28%) had normal serum magnesium level. Serum magnesium level more low in ischemic stroke (56%) . The mean serum magnesium level was 1.59 (SD ±0.37) mg/dl in all stroke patient and 1.47 (SD ±0.32) mg/dl in ischemic stroke patient was and was 1.83 (SD ±0.34) mg/dl in hemorrhagic stroke patients. Among 33 ischemic stroke patients mostly 17 (34%) patients had serum magnesium level between 1.0-1.4 mg/dl and in hemorrhagic stroke patients maximum 05 (10%) serum magnessium level was in between 1.5-1.8 mg/dl (P-value 0.0017 HS). In our study most of the patients with acute stroke were improved with marked residual disability were [19 (38.0%)], improved with minimal residual disability were [08 (16%)], improved without residual disability [04 (08%)] and death [03 (6%)] having hypomagnesaemia compared to the patients who have normal serum magnesium level with maximum improvement with minimal residual disability were [10 (20.0%)], improved without residual disability were [06 (12%)], improved with marked residual disability and death were [0 (0%)]. Gross clinical outcome disability of acute stroke patients was worse who had hypomagnesaemia (P-value 0.001 significant). Magnesium levels are significantly decreased in acute stroke; both in ischemic stroke patients as well as in patients of hemorrhagic. Patients with low serum magnesium level in acute stroke associated with worse clinical outcome.TAJ 2014; 27(1): 50-56

scholarly journals Evaluation of Serum Magnesium Level in Preeclampsia

2018 ◽  
Vol 10 (1) ◽  
pp. 10-15
Author(s):  
HL Roy ◽  
S Nargis ◽  
SH Mahmud ◽  
NWB Jahan ◽  
MS Hossain ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Serum Magnesium ◽  
Colorimetric Method ◽  
Magnesium Level ◽  
Medical Complication ◽  
Serum Magnesium Level ◽  
Cross Sectional ◽  
The Mean ◽  
Age Range

Preeclampsia is the most common medical complication of pregnancy associated with increased maternal and infant mortality and morbidity. Reduced serum magnesium level is found to be associated with elevated blood pressure in preeclampsia. The purpose of this cross-sectional study is to evaluate the serum magnesium level in preeclamptic women. For this study 50 preeclamptic patients, with age range 20 to 40 years having gestational age range from 20 to 40 weeks and 50 age and gestational age matched normotensive pregnant women having no proteinuria were enrolled. Serum magnesium was measured by colorimetric method. The mean(±SD) age and mean(±SD) gestational age of preeclampsia was not significantly different from those of normotensive pregnant women (p=0.203 and p=0.251 respectively). The mean(±SD) body mass index of the preeclamptic patients was significantly higher compared to that of normotensive pregnant women (p<0.001). The mean(±SD) serum magnesium level was 3.37±2.05 mg/dl in preeclamptic group and 2.87±1.38 mg/dl in normal pregnant women; the level did not differ significantly between the subject of preeclampsia and normal pregnant women (p=0.153). Findings of this study suggest that serum magnesium has no association with preeclampsia.Bangladesh J Med Biochem 2017; 10(1): 10-15

scholarly journals MEAN PLATELET VOLUME DI STROK

2016 ◽  
Vol 19 (1) ◽  
pp. 37
Author(s):  
Besse Rosmiati ◽  
Sulina Y Wibawa ◽  
Darmawaty ER
Keyword(s):  
Cohort Study ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Mean Platelet Volume ◽  
Modified Rankin Scale ◽  
Platelet Activity ◽  
Stroke Patients ◽  
Platelet Volume ◽  
P Values ◽  
The Mean

Ischemic stroke is the cause of most cases which occur due to obstruction, this pathogenesis can be caused by the formation of thrombus in the cerebrum blood vessels. Platelet aggregation plays a role in the pathogenesis of thromboembolic cerebrovascular disease. Platelets size, measured as Mean Platelet Volume (MPV) is a marker of platelet function and is associated with the indicator of platelet activity. Several studies have found that there was an increased of MPV in acute ischemic stroke while the correlation with the severity and outcome of stroke was still controversial. The aim of study is to determine the MPV and their association with outcomes in acute ischemic stroke patients. A cohort study during May up to July 2010 was carried out, the researchers measured MPV and analyze their correlation with its outcome using modified Rankin scale score 10 days after the onset in 33 acute ischemic stroke patients. The mean of MPV for the first three days of the onset was 8.9 fl, on the 5th day was increased up to 9.4 but at the 10th day of onset the MPV remains the same value as the 5th day. The MPV of first three days and 5th day have a positive correlation, but insignificant with their outcome, with p values 0.158 and 0.06, respectively. From this study can be concluded that the increased of MPV on the fifth day onset did not have any significant correlation with the outcome of acute ischemic stroke illness.

scholarly journals Intra-arterial Thrombectomy with Stent Retriever for Acute Ischemic Stroke – a Retrospective, Single-centered Study from Brazil

2017 ◽  
Vol 36 (04) ◽  
pp. 213-216
Author(s):  
Luana Gatto ◽  
Viviane Zétola ◽  
Zeferino Demartini Junior ◽  
Fábio Nascimento ◽  
Gelson Koppe
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Mean Value ◽  
Posterior Circulation ◽  
Stent Retriever ◽  
National Institutes Of Health ◽  
Initial Experience ◽  
Modified Rankin Scale ◽  
Anterior Circulation ◽  
The Mean

Objective To report our initial experience with intra-arterial thrombectomy (IAT) with stent retriever for acute ischemic stroke. Methods We conducted a retrospective review of patients with acute ischemic stroke who underwent IAT from September 2010 to August 2016. Results Forty-one patients were included; mean age was 57 years (range: 29–85), and 54% were women. There were 32 anterior circulation occlusions, and 11 posterior circulation occlusions. The mean value of the National Institutes of Health Stroke Scale (NIHSS) upon admission (available in 9/41 patients) was 14 (range: 6–20). Nineteen patients had favorable outcomes (modified Rankin Scale [mRS]: 0–2 at 6 months), and 22 had unfavorable outcomes (mRS: 3–6 at 6 months). The mortality rate was 37% (15/41). Favorable outcomes were associated with revascularization within the first 360 minutes of the onset of symptoms (p = 0.000001), and satisfactory revascularization (thrombolysis in cerebral infarction [TICI] scale: 2b or 3) (p = 0.0018). Conclusion It is of paramount importance to educate stroke teams on the benefits of IAT for acute ischemic stroke and the population on identifying stroke and seeking immediate care following symptom onset.

scholarly journals A Comparative Study on Serum Magnesium in Pre-eclampsia and Non Pregnant Women

2021 ◽  
Vol 33 (1) ◽  
pp. 58-60
Author(s):  
Heera Lal Roy ◽  
Susmita Nargis ◽  
Farhana Ferdaus
Keyword(s):  
Pregnant Women ◽  
Serum Magnesium ◽  
Colorimetric Method ◽  
Magnesium Level ◽  
Medical Complication ◽  
Serum Magnesium Level ◽  
Medical College ◽  
Significant Difference ◽  
The Mean ◽  
Normal Women

Introduction: There are many Hypertensive disorders in pregnancy like preeclampsia, eclampsia etc. Pre-eclampsia is the most common medical complication of pregnancy associated with increased maternal and infant mortality and morbidity. Some studies have implicated that low serum calcium levels may have a role in pre-eclampsia but other studies failed to find relation between low levels of these trace elements and pre-eclampsia. Materials and Methods: This cross sectional study was carried out in the Department of Biochemistry, Sylhet MAG Osmani Medical College in collaboration with the Department of Obstetrics and Gynaecology, Sylhet MAG Osmani Medical College Hospital during the period from January 2016 to December 2016. This Study was occured in among 31 pre-eclampsia patients, aged 20 to 40 years, and gestational age ranges from 20 to 40 weeks and 31 age matched normotensive non-pregnant women having no proteinuria. Serum magnesium was measured by Colorimetric method. Results: The mean serum magnesium level was 3.24 (±1.42) mg/dl in pre–eclampsia and was 3.30 (±1.5) mg/dl in normal women. The mean serum magnesium level did not differ significantly between the subjects of pre–eclampsia and normal women (t=0; p<.05). Conclusion: The means of both data sets are equal. So we can conclude that there is no significant difference between them. Medicine Today 2021 Vol.33(1): 58-60

Correlation of Serum Albumin Level with Short Term Outcome of Acute Ischemic Stroke Patients

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mohammed Saad El-Din Mahmud ◽  
Hala Mahmoud EL-Khawas ◽  
Hossam El Din Mahmoud Afify ◽  
Mohamed Mohamed Tawfik
Keyword(s):  
Ischemic Stroke ◽  
Serum Albumin ◽  
Acute Ischemic Stroke ◽  
Serum Albumin Level ◽  
Albumin Level ◽  
Modified Rankin Scale ◽  
Stroke Patients ◽  
Short Term ◽  
The Mean ◽  
Discharge From Hospital

Abstract Objectives We aimed to Detect if there is association between serum albumin level in acute ischemic stroke patients and its short term neurological and functional outcome in a tertiary care hospital in Cairo. Methods The study was carried out as descriptive (cross-sectional) study conducted on 50 cases first-ever acute ischemic stroke patients were enrolled between June 2018 to December 2018 with follow up after 30 days of discharge from hospital. Inclusion and exclusion criteria were strictly exercised. National Institute of Health Stroke Scale (NIHSS) and modified Rankin scale (mRS) score was noted. Serum albumin (SA) was estimated from blood Clinical, functional, and radiological evaluation was done for the patients. Statistical SPSS 20.0 software and Microsoft excel were used for statistical analysis (P ≤ 0.05).Relationship between serum albumin and stroke outcome was determined. Results A total of 50 stroke cases were thus included in the study comprising 34 males and 16 females. The mean age of patients was 40-65 [59.26±6.25] years, we found the most prevalent risk factors in the present study results were hypertension 36 (72.0%). The mean serum level of albumin were (3.73±0.63) on day o of onset and (3.72±0.63) after 30 days of discharge from hospital. Bivariate analysis shows serum albumin was inversely associated with NIHS score and mRS on day o of onset and after 30 days of discharge from hospital which were NIHSS(r= -0.264, P = 0.044) (r= -0.645, P = &lt;0.001) and mrs (r= -0.321, P = 0.031) (r= -0.587, P = &lt;0.001) respectively. Conclusion Hypoalbuminemia had influence to degree of stroke severity, degree of disability and functional outcome. Serum albumin levels had a negatively correlation with NIHSS score and modified Rankin scale. Low serum albumin levels associated with poor prognosis in acute ischemic stroke patients.

scholarly journals P1400ASSOCIATION BETWEEN MEAN SERUM MAGNESIUM LEVEL DURING THE FIRST 3 YEARS OF HEMODIALYSIS AND THE RISK OF SUBSEQUENT BONE FRACTURES

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Takayuki Fujii ◽  
JUNYA KOSHIZAKA ◽  
NOBUAKI YAMAUCHI ◽  
MAYU MORIMOTO ◽  
NORIKO TERASAKI ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Phosphate Binder ◽  
Bone Fractures ◽  
Serum Magnesium ◽  
Univariate Analysis ◽  
Albumin Level ◽  
Magnesium Level ◽  
Serum Magnesium Level ◽  
History Of ◽  
The Mean

Abstract Background and Aims Serum magnesium levels are an important factor associated with vital prognosis, cardiovascular disease, and vascular calcification in hemodialysis patients. Moreover, low serum magnesium levels are reportedly associated with an increased risk of hip fractures. Previously we reported that mean magnesium level during the first 3 years of hemodialysis was associated with all-cause mortality in ERA-EDTA 2018. Here, we investigated whether mean magnesium level during the first 3 years of hemodialysis can predict fracture risk. Method A retrospective cohort study was conducted in 283 patients who started hemodialysis at our hospital between March 2004 and the present and who could be followed for at least 3 years or had a fracture within 3 years. To assess the association between mean serum magnesium level during 3 years after the start of hemodialysis or until fracture and fracture risk, a multivariate analysis was performed using the Cox proportional hazard model with factors related to fractures as covariates, with all fractures such as hip fracture and spinal compression fracture as the outcome. Results The mean follow-up period was 6.1 years, and the mean age of patients was 64 years, with women accounting for 31%. Of all 283 patients, 62 developed fractures. A univariate analysis of factors associated with fractures revealed that high serum magnesium level was a significant fracture suppressor (hazard ratio [HR]: 0.31 [0.12–0.73]). Multivariate analysis conducted with significant factors in univariate analysis (mean serum albumin level, serum phosphorus level, hemoglobin level, C-reactive protein level, age, history of heart disease, history of bone fractures, and use or nonuse of phosphate binder during the 3 years) as the covariates revealed that the serum magnesium level was not significantly associated with bone fractures (HR: 0.95 [0.33–2.78]), whereas, old age, history of fractures, low albumin level, high CRP level, and nonuse of phosphate binder were significantly associated with fractures. Conclusion Serum magnesium levels during 3 years after the initiation of hemodialysis did not predict the risk of subsequent fractures, whereas a high level of inflammatory response, malnutrition, and nonuse of phosphate binder did.

scholarly journals Acute Decrease in Serum Magnesium Level after Ischemic Stroke May Not Predict Decrease in Neurologic Function

2013 ◽  
Vol 22 (8) ◽  
pp. e516-e521 ◽  
Author(s):  
James E. Siegler ◽  
Amelia K. Boehme ◽  
Karen C. Albright ◽  
Sami Bdeir ◽  
Anoop K. Kar ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Serum Magnesium ◽  
Magnesium Level ◽  
Serum Magnesium Level ◽  
Neurologic Function

scholarly journals Association of serum magnesium level with microalbumin in urine of newly detected type-2 diabetes mellitus

2018 ◽  
Vol 9 (2) ◽  
pp. 291-294
Author(s):  
Tania Nasreen ◽  
Sheuly Ferdousi ◽  
Khorshed Alam ◽  
Tuhin Sultana ◽  
Tashmim Farhana Dipta ◽  
...  
Keyword(s):  
Negative Correlation ◽  
Serum Magnesium ◽  
Magnesium Level ◽  
P Value ◽  
Diabetic Patients ◽  
Serum Magnesium Level ◽  
Type 2 Diabetic Patients ◽  
The Mean ◽  
Type 2 Diabetic

Background : Magnesium (Mg++) deficiency is associated with poor glycemic control and Mg++ supplementation lowers blood sugar, improves insulin sensitivity and delays diabetic complications such as diabetic nephropathy, diabetic neuropathy, diabetic retinopathy. Objective : This study was designed to know the status of serum Mg++ in type 2 diabetic subjects with microalbuminuria and normoalbuminuria.Methodology : This study was conducted at the Department of Laboratory Medicine (Clinical Pathology) in collaboration with BIRDEM General Hospital, Dhaka. In this study, serum magnesium level and urine microalbumin level of 120 newly detected type 2 diabetic patients were measured. Both levels were measured by biochemical auto analyzer (Siemens Dimension RL Max).Result : The mean microalbumin level was found 22.9±3.1 mg/L with range from 2-105 mg/L and the mean magnesium level was found 1.9±0.3 mg/dl with range from 1.5-2.4 mg/dl. Pearson’s correlation coefficient was -0.353 between serum magnesium level and urine microalbumin which was statistically significant (p value < 0.05). Therefore, there was a linear negative correlation between serum magnesium level and urine microalbumin.Conclusion : The present study revealed negative correlation between serum magnesium level and urine microalbumin.Northern International Medical College Journal Vol.9(2) Jan 2018: 291-294

scholarly journals Magnesium levels in stable children with asthma: It’s relationship with asthma control

2020 ◽  
Vol 47 (2) ◽  
pp. 91-95
Author(s):  
F.N. Ogbuka ◽  
I.K. Ndu ◽  
T. Oguonu ◽  
A.N. Ikefuna ◽  
B.C. Ibe
Keyword(s):  
Asthma Control ◽  
Serum Magnesium ◽  
Cross Sectional Study ◽  
Magnesium Level ◽  
Asthma Prevalence ◽  
Serum Magnesium Level ◽  
Cross Sectional ◽  
Asthmatic Children ◽  
Children With Asthma ◽  
The Mean

Background: Asthma prevalence is rising worldwide. Amongst the various factors influencing asthma control, the magnesium level of the affected individuals seems to make a major contribution to achieving asthma control through i ts anti - inflammatory and bronchodilation effects.This study therefore was aimed at determining the magnesium level of stable asthmatic children and its relationship, if any, with their levels of asthma control.Methods: A cross-sectional study where the serum magnesium levels of 30 stable asthmatic children attending Asthma clinic and those of 30 children without asthma attending Children Out-patient clinic (CHOP) both at the University of Nigeria Teaching Hospital (UNTH), Enugu, were assessed using atomic absorption spectrophotometer. The levels of asthma control of children with asthma were assessed using asthma therapyassessment questionnaire (ATAQ). Mean serum magnesium levels of the different asthma control levels were compared using the analysis of variance (ANOVA).Results: The mean ages of children with asthma and those without asthma were 10.4 ± 2.98 years and 10.5 ±3.00 years respectively. The mean serum magnesium level of stable children with asthma (1.13 ±1.04 mmol/L) was found to be significantly lower than those of the non-asthmatic  controls (1.46 ±1.01 mmol/L), p= 0.004.A significant association was also found between the serum magnesium levels and the levels of asthma control (p = 0.015).Conclusion: This study shows that the serum magnesium level of stable asthmatic children is significantly lower than that of children without asthma and there is a significant association between the mean serum magnesium levels and their levels of asthma control. Keywords: Serum magnesium, asthma control, stable asthma

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