scholarly journals Assessment of Distortion Product Otoacoustic Emissions Input-Output Function in Individuals with and without Musical Abilities

2021 ◽  
Author(s):  
Kavitha Gurunathgowda Sannamani ◽  
Madhumanti Chakraborty ◽  
Neelamegarajan Devi ◽  
Prashanth Prabhu
Keyword(s):  
Otoacoustic Emissions ◽  
Musical Training ◽  
Superior Performance ◽  
Distortion Product Otoacoustic Emissions ◽  
Output Function ◽  
Input Output ◽  
Distortion Product ◽  
Significant Difference ◽  
Auditory Tasks ◽  
Age Range

Background and Aim: Musical  training  has shown to bring about superior  performance  in several auditory and non-auditory tasks compared to those without musical exposure. Distortion product otoacoustic emissions (DPOAE) input-output function can be an indicator of the non-linear functioning of the cochlea. The objective of this study was to evaluate and compare the differences in the slope of DPOAE input-output function in individuals with and without musical abilities. Methods: Twenty normal-hearing individuals were considered in the age range of 18–25 years. They were divided based on the scores obtained on the questionnaire of musical abilities, as individuals with and without musical abilities. DPOAE input-output function was done   for each of the two groups. The slope of the DPOAE input-output function was compared at different frequencies between the groups. Results: The results of the Mann Whitney test revealed that the slope was significantly steeper at 2000, 3000, 4000 and 6000 Hz in individuals with musical abilities. There was no significant difference in slope at 1000 and 1500 Hz. Conclusion: The increased steepness of the slope indicates a relatively better functioning     of the cochlea in individuals with musical abilities. The enhanced perception of music may induce changes in the cochlea resulting in a better appreciation of music.

scholarly journals Otoacoustic emissions in young adults exposed to drums noise of a college band

Revista CEFAC ◽  
2017 ◽  
Vol 19 (5) ◽  
pp. 645-653 ◽  
Author(s):  
Paula Botelho da Silva ◽  
Ana Cláudia Fiorini ◽  
Marisa Frasson de Azevedo
Keyword(s):  
Young Adults ◽  
Otoacoustic Emissions ◽  
Distortion Product Otoacoustic Emissions ◽  
Control Group ◽  
Study Group ◽  
Output Function ◽  
Input Output ◽  
Transient Evoked Otoacoustic Emissions ◽  
Distortion Product ◽  
College Band

ABSTRACT Purpose: to identify cochlear dysfunction and occurrence of tinnitus in young adults exposed to drums noise of a college band. Methods: the sample included 50 subjects: 25 musicians (study group) and 25 non-musicians (control group). The procedures included anamnesis, pure tone audiometry, acoustic impedance and Transient Evoked Otoacoustic Emissions, Distortion Product Otoacoustic Emissions and Distortion Product Otoacoustic Emissions Input-Output function. Results: positive correlation between the occurrence of tinnitus and the variables exposure time and use of personal stereos was found. Overall, the study group showed significantly lower Transient Evoked Otoacoustic Emissions, when compared to the control group. In the study group, there was a tendency toward worse response in 6 kHz(f2) in Distortion Product Otoacoustic Emissions in both ears. The Distortion Product Otoacoustic Emissions Input-Output function did not differ between groups nor did its slope. Conclusion: in general, otoacoustic emissions were worse in noise-exposed young people (study group) when compared to the unexposed (control group), indicating that the test may be important in early identification of cochlear changes.

scholarly journals Hubungan ototoksisitas dan kemoterapi neoadjuvan pada karsinoma nasofaring berdasarkan ASHA, CTCAE, dan DPOAE

2018 ◽  
Vol 47 (2) ◽  
pp. 102
Author(s):  
Meyrna Heryaning Putri ◽  
Pudji Rahaju ◽  
Dyah Indrasworo
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Early Detection ◽  
Adverse Events ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Distortion Product Otoacoustic Emissions ◽  
Hearing Level ◽  
Type Iii ◽  
Distortion Product ◽  
Significant Difference

Latar belakang: Kemoterapi neoadjuvan adalah induksi kemoterapi sebelum radioterapi dengan regimen cisplatin dan 5-Fluorouracil. Kemoterapi cisplatin bersifat ototoksik pada pendengaran sensorineural bilateral progresif dan bersifat irreversible. Kriteria dari American Speech-Language Hearing Association (ASHA) dan Common Terminology Criteria for Adverse Events (CTCAE) merupakan kriteria untuk mengidentifikasi ototoksisitas dengan menggunakan audiometri, selain pemeriksaan Distortion Product Otoacoustic Emissions (DPOAE). Tujuan: Mengidentifikasi hubungan ototoksisitas dengan kemoterapi neoadjuvan pada penderita karsinoma nasofaring (KNF) WHO tipe III menggunakan ASHA, CTCAE, serta DPOAE. Metode: Studi ini adalah penelitian observasional dengan desain cohort. Kriteria inklusi penelitian yaitu penderita baru KNF WHO tipe III, yang mendapatkan kemoterapi regimen standar dan berusia <60 tahun. Kriteria pemeriksaan DPOAE adalah penderita dengan ambang dengar ≤40 dB. Percontoh dilakukan pemeriksaan timpanometri, audiometri, dan DPOAE. Hasil: Terdapat 9 sampel percontoh penelitian. Uji repeated-ANOVA menunjukkan tidak ditemukan perbedaan bermakna pada tiga hasil pengukuran audiometri antara pascakemoterapi pertama, kedua, dan ketiga (p>0,05). Deteksi awal ototoksisitas menggunakan kriteria ASHA menunjukkan sensitivitas sebesar 67% dan dan CTCAE 44%, dibandingkan baku emas menggunakan DPOAE. Kesimpulan: Ototoksisitas cisplatin ditemukan sejak kemoterapi pertama dengan menggunakan pemeriksaan DPOAE walaupun tidak bermakna secara statistik. Kemampuan DPOAE untuk mendeteksi awal ototoksisitas lebih baik dibandingkan kriteria ASHA dan CTCAE yang menggunakan audiometri nada murni.Kata kunci: Karsinoma nasofaring, ototoksisitas sisplatin, DPOAE, CTCAE, ASHA ABSTRACT Introduction: Neoadjuvant chemotherapy is induction chemotherapy before radiotherapy with cisplatin and 5-Fluorouracyl regiment. Chemotherapy cisplatin is ototoxic, leads to frequently progresive and irreversible bilateral sensorineural hearing loss. American Speech-Language Hearing Association (ASHA) and Common Terminology Criteria for Adverse Events (CTCAE) are the criteria to determine ototoxicity with audiometry, beside Distortion Product Otoacoustic Emissions (DPOAE). Purpose: To identify the relationship between ototoxicity with neoadjuvant chemotherapy in patients NPC WHO type III using ASHA, CTCAE, and DPOAE. Method: This observational study approach with cohort design. Inclusion criteria: new patients NPC WHO type III who consented to undergo standard regiment chemotherapy, and age <60 year-old. For DPOAE examination: hearing level ≤40 dB. Exclucion criteria: NPC WHO type III patients who underwent chemotherapy with unconventional standard regiment. Examinations for hearing function conducted with tympanometry, pure tone audiometry, and Distortion Product Otoacoustic Emissions (DPOAE). Result: There were 9 sample in this study. The result of Repeated-ANOVA test showed no significant difference in three audiometry measurements among three series of chemotherapies. Early detection of ototoxicity using ASHA and CTCAE criterias showed sensitivity of 67% and 44% (compared with DPOAE as a gold standard). Conclusion: Cisplatin ototoxicity had occured since the first chemotherapy and detected with DPOAE, but statistically was not significantly related. Early detection of cisplatin ototoxicity with DPOAE was much better than with criteria American Speech-Language Hearing Association (ASHA) and Common Terminology Criteria for Adverse Events (CTCAE), which used pure tone audiometry.Keywords: Nasopharyngeal carcinoma, cisplatin ototoxicity, DPOAE, CTCAE, ASHA

Changes in Otoacoustic Emissions and Auditory Brain Stem Response after C/s-Platinum Exposure in Gerbils

1997 ◽  
Vol 116 (6) ◽  
pp. 585-592 ◽  
Author(s):  
Kathleen C. Y. Sie ◽  
Susan J. Norton
Keyword(s):  
Hearing Loss ◽  
Brain Stem ◽  
Otoacoustic Emissions ◽  
Outer Hair Cell ◽  
Outer Hair Cells ◽  
Distortion Product Otoacoustic Emissions ◽  
Auditory Brain Stem Response ◽  
Distortion Product ◽  
Auditory Brain Stem ◽  
Significant Difference

Ototoxicity associated with cis-platinum administration commonly presents as hearing loss and tinnitus. The hearing loss is usually an irreversible, high-frequency sensorineural loss. Histologic studies in humans and animals suggest that the outer hair cells (OHCs) are most susceptible to cis-platinum. Evoked otoacoustic emissions (EOAE), as a measure of outer hair cell function, are potentially useful in following ototoxic insults involving OHCs. Distortion-product otoacoustic emissions (DPOAE) test frequency-specific regions of the cochlea and therefore may be particularly well suited for monitoring ototoxic injuries. We measured distortion product otoacoustic emissions, at f2 = 2, 4, 6, 8, 10, and 12 kHz, in gerbils after a single large dose of cis-platinum. Animals treated with saline served as controls. The findings were compared to auditory brain stem evoked response (ABR) thresholds, using tone pips of the same frequencies. The DPOAE and ABR thresholds were measured before treatment and again 2, 5, and 14 days after drug administration. The changes in DPOAE were compared with the changes in ABR. No treatment effect was noted in the 2-day group. Animals treated with c/s-platinum demonstrated significant elevation of DPOAE and ABR thresholds compared with control animals at 5 and 14 days. There was no significant difference between the threshold changes in the 5-and 14-day groups.

scholarly journals Distortion Product Otoacoustic Emissions (DPOAEs) In Tinnitus Patients

2021 ◽  
Author(s):  
Hend F. Alshabory ◽  
Takwa A. Gabr ◽  
Mona A. Kotait
Keyword(s):  
Otoacoustic Emissions ◽  
Direct Consequence ◽  
Normal Hearing ◽  
Distortion Product Otoacoustic Emissions ◽  
Control Group ◽  
Study Group ◽  
Input Output ◽  
Sound Stimulation ◽  
Hearing Sensitivity ◽  
Distortion Product

Abstract Introduction Tinnitus is the perception of sound in the absence of external sound stimulation. There is a general agreement that it is a direct consequence of irreversible and permanent cochlear damage. Objectives The present work is designed to study the distortion product otoacoustic emissions (DPOAEs) in tinnitus patients with normal hearing in comparison with normal hearing control and to study any possible correlation between DPOAEs recording and patients' complaints. Methods The present study included 80 subjects divided into 2 groups: Control group: consisted of 30 normal-hearing adults not complaining of tinnitus and Study group: consisted of 50 normal-hearing adults complaining of tinnitus. The methodology includes full audiological history, otoscopic examination, basic audiological evaluation, DPOAEs including both DP-gram and DPOAEs input/output functions. Results Basic audiological evaluation showed within normal hearing sensitivity in both groups, however, with significant higher hearing thresholds in tinnitus patients at all frequency ranges. The Tinnitus Handicap Inventory Questionnaire showed mean scores of 35.2 ± 16.9 in the study group. The DP-gram showed higher amplitudes in the control group when compared with tinnitus patients. The DPOAEs input-output functions at different frequencies (1, 2, 4 and 6kHz) also showed higher amplitudes at all frequencies and different input levels. The slope of the I/O function tends to be steeper in tinnitus cases. Conclusion Patients with tinnitus might have neural dysfunction at either the level of the cochlea, as shown in reduced DPOAE levels, and changes in the normal DP-I/O function recorded in the present work.

Is Ototopical Nystatin Ototoxic? A Chinchilla Model

2011 ◽  
Vol 145 (6) ◽  
pp. 1022-1024 ◽  
Author(s):  
Sam J. Daniel ◽  
Sofia Sahmkow ◽  
Olubunmi V. Akinpelu
Keyword(s):  
Otoacoustic Emissions ◽  
Distortion Product Otoacoustic Emissions ◽  
Tympanostomy Tube ◽  
Distortion Product ◽  
Significant Difference ◽  
Ventilation Tubes ◽  
And Control ◽  
To Receive ◽  
Scanning Electron

In this prospective controlled animal study, the authors investigated the potential ototoxic effects of ototopical application of nystatin through a tympanostomy tube, using their established chinchilla animal model. Each of the 10 animals used had ventilation tubes inserted in both ears; 1 ear was randomly assigned to receive nystatin suspension, whereas the other ear did not receive any medication, serving as control. Distortion product otoacoustic emissions (DPOAEs) were measured in each animal before application of nystatin and at 45 and 60 days after application. Each cochlea was also processed for scanning electron microscopy (SEM) at the end of the experiment. There was no significant difference in the DPOAEs and SEM appearances of the experimental and control ears over the 60-day period of the experiment. The authors conclude that transtympanic nystatin did not produce any long-term ototoxic effects detectable by DPOAEs or SEM.

Effects of Cigarette Smoking on Distortion Product Otoacoustic Emissions

2007 ◽  
Vol 18 (08) ◽  
pp. 665-674 ◽  
Author(s):  
Candice Negley ◽  
Bharti Katbamna ◽  
Teresa Crumpton ◽  
Gary D. Lawson
Keyword(s):  
Otoacoustic Emissions ◽  
Distortion Product Otoacoustic Emissions ◽  
Cochlear Function ◽  
Detection Thresholds ◽  
High Frequencies ◽  
Distortion Product ◽  
Age Appropriate ◽  
Cochlear Damage ◽  
Age Range ◽  
Rule Out

This study measured distortion product otoacoustic emissions (DPOAEs) and DPOAE input/output (I/O) curves to assess the effects of smoking on cochlear function. Twenty-four healthy adults, 12 smokers and 12 nonsmokers in the 20–30 years age range were selected based on self-reported histories of five to eight years of smoking or no smoking, respectively. All subjects received tympanometric screening to rule out middle ear pathology. Conventional (0.25–8 kHz) and ultra high frequency (UHF; 10–20 kHz) audiometry showed normal or age-appropriate thresholds across both groups. DPOAE results showed small, but significant, decline in DPOAE levels without concomitant changes in noise floors in smokers as compared to nonsmokers. I/O detection thresholds were also significantly elevated at high frequencies in smokers as compared to their nonsmoking counterparts. These findings indicate that smokers are at greater risk for cochlear damage than nonsmokers, and that DPOAE amplitudes and I/O detection thresholds may identify early changes in cochlear function in smokers. Este estudio midió las emisiones otoacústicas por productos de distorsión (DPOAES) y las curvas de ingreso/salida (I/O) de las DPOAE para evaluar los efectos del fumado sobre la función coclear. Veinticuatro adultos, 12 fumadores y 12 no fumadores, en el rango de edad de 20 a 30 años, fueron seleccionados con base en sus historia auto-reportadas de fumado o no fumado en los últimos 5–8 años, respectivamente. Todos los sujetos se sometieron a un tamizaje timpanométrico para descartar patología del oído medio. La audiometría convencional (0.25–8 kHz) y la de ultra-alta frecuencia (UHF, 10–20 kHz) mostraron umbrales normales o apropiados para la edad en ambos grupos. Los resultados de las DPOAE mostraron una caída pequeña pero significativa en los niveles de las DPOAE en los fumadores comparado con los no fumadores, sin cambios concomitantes en el piso de ruido. Los umbrales I/O de detección también estuvieron significativamente elevados en las altas frecuencias en los fumadores, comparado con sus contrapartes no fumadores. Estos hallazgos indican que los fumadores tienen un mayor riesgo de daño coclear que los no fumadores, y que las amplitudes de las DPOAE y los umbrales I/O de detección pueden identificar cambios tempranos en la función coclear de los fumadores.

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