scholarly journals Epigenetics in the Transgenerational Transmission of Chronic Diseases in the Context of Poverty with a Perinatal Approach

2021 ◽  
Author(s):  
Iván Enrique Naranjo Logroño ◽  
Leslie Gricel Cuzco Macías ◽  
Carla Victoria Sandoval Flores ◽  
Anthony Alfonso Naranjo Coronel
Keyword(s):  
Chronic Disease ◽  
Chronic Diseases ◽  
Search Engines ◽  
Neonatal Period ◽  
Potential Effect ◽  
Fetal Life ◽  
Factors Affecting ◽  
Transgenerational Transmission ◽  
Epigenetic Information ◽  
Palabras Clave

Introduction: Epigenetics is relevant in obstetrics for its action during pregnancy, in embryo-fetal life and even for the events that exist at birth. Objective: To investigate and analyze information about the role that epigeomics plays in the transgenerational transmission of chronic diseases in the context of poverty with a perinatal approach. Methods: Through a non-systematic bibliographic review through the search engines: LILACS, CINAHL, COCHRANE, EBSCO, MEDLINE, SCIELO, SCOPUS and PUBMED. Results: 32 bibliographic publications were found, of which 30 articles containing information related to the topic were included. Discussion: The genome has been compared to the hardware of a computer, while the epigenetic information is compared to the software that controls the operation of the hardware. Furthermore, the factors affecting epigenetic information can be analog as parameters to operate the software. Conclusion: The epigenomics studies the process by which the expression of certain genes occurs, in order to reduce the probability of the appearance of chronic diseases, having a potential effect during pregnancy and neonatal period. Keywords: epigenomics, transcription, genetic, poverty, chronic disease. RESUMEN Introducción: La epigenética tiene relevancia en la obstetricia por su acción durante el embarazo, en la vida embrio-fetal e inclusive, por los sucesos que existen al nacimiento. Objetivo: Investigar y analizar de información acerca del rol que juega la epigenómica en la transmisión transgeneracional de las enfermedades crónicas en el contexto de la pobreza con enfoque perinatal. Métodos: Por medio de una revisión bibliográfica no sistemática a través de los buscadores: LILACS, CINAHL, COCHRANE, EBSCO, MEDLINE, SCIELO, SCOPUS y PUBMED. Resultados: Se encontraron 32 publicaciones bibliográficas, de las cuales se incluyeron 30 artículos que contenían la información relacionada al tema. Discusión: El genoma se lo ha comparado con el hardware de una computadora, mientras que la información epigenética se lo compara con el software que controla el funcionamiento del hardware. Además, los factores que afectan la información epigenética pueden ser analógicos como parámetros para operar el software. Conclusiones: La epigenómica estudia proceso por el cual se da la expresión de determinados genes, con la finalidad de disminuir la probabilidad de la aparición de enfermedades crónicas, teniendo un efecto potencial durante el embarazo y periodo neonatal. Palabras clave: epigenómica, transcripción genética, pobreza, enfermedad crónica.

scholarly journals Factors Affecting Healthcare Utilization among Patients with Single and Multiple Chronic Diseases

2020 ◽  
Author(s):  
Ka Young KIM ◽  
Eunmi LEE ◽  
Jeonghyun CHO
Keyword(s):  
Chronic Disease ◽  
Health Status ◽  
Chronic Diseases ◽  
Healthcare Utilization ◽  
Private Insurance ◽  
Subjective Health ◽  
Subjective Health Status ◽  
Factors Affecting ◽  
Andersen Model ◽  
Multiple Chronic Diseases

Background: We aimed to investigate the factors affecting healthcare utilization among patients with single and multiple chronic diseases using the Andersen healthcare utilization model. Methods: We used a combination of the data from the sixth and seventh Korea National Health and Nutrition Survey (2014–2016). The study population was 3,901 patients with single chronic disease and 1,829 patients with multiple chronic diseases as defined by the WHO. Participants were aged 19 yr or older. Multiple regression analysis was employed using the Andersen model to identify factors affecting healthcare utilization (inpatient and outpatient). Results: According to the Andersen model (comprising predisposing, enabling, and need factors and health behaviors), the factors that increased outpatients with single chronic disease were female, being aged 65 yr or older, having basic livelihood security benefit, immobility, and poor subjective health status. Factors that increased inpatients with single chronic disease were being aged under 65, having private insurance, immobility, poor subjective health status, and nondrinking. Moreover, factors that increased outpatients and inpatients with multiple chronic diseases were female, being aged under 65, immobility, and poor subjective health status and immobility, poor subjective health status, nondrinking, and not engaging in physical activity, respectively Conclusion: We identified factors affecting outpatient and inpatient care utilization among patients with single and multiple chronic diseases, using the Andersen healthcare utilization model. The findings can be used as foundational data to develop preventive and management strategies in healthcare utilization among patients with single and multiple chronic diseases.

More Eggs, Less Sugar: A Sneak Peek into the Latest Dietary Guidelines for Americans

2018 ◽  
Vol 7 (1) ◽  
pp. 22-24
Author(s):  
Darlene Zimmerman
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Disease ◽  
Chronic Diseases ◽  
Dietary Guidelines ◽  
Healthy Diet ◽  
Dietary Guidelines For Americans

ABSTRACT The 2015 – 2020 Dietary Guidelines for Americans provides guidance for choosing a healthy diet. There is a focus on preventing and alleviating the effects of diet-related chronic diseases. These include obesity, diabetes, cardiovascular disease, and stroke, among others. This article briefly reviews the primary guideline items that can be used to teach patients with respect to improving their diet. Clinical exercise physiologists who work with patients with chronic disease can use these guidelines for general discussions regarding a heart-healthy diet.

scholarly journals The impact of chronic disease and disability on the elderly

1999 ◽  
Vol 55 (3) ◽  
pp. 9-14
Author(s):  
C. J. Eales
Keyword(s):  
Health Care ◽  
Chronic Disease ◽  
Chronic Diseases ◽  
Health Care Systems ◽  
The Elderly ◽  
Therapeutic Interventions ◽  
Elderly Persons ◽  
Care Systems ◽  
And Function ◽  
The Impact

Health care systems for elderly people should aim to delay the onset of illness, reducing the final period of infirmity and illness to the shortest possible time. The most effective way to achieve this is by health education and preventative medicine to maintain mobility and function. Changes in life style even in late life may result in improved health, effectively decreasing the incidence of chronic diseases associated with advancing age. This paper presents the problems experienced by elderly persons with chronic diseases and disabilities with indications for meaningful therapeutic interventions.

scholarly journals Smoking, drinking, diet and physical activity—modifiable lifestyle risk factors and their associations with age to first chronic disease

2019 ◽  
Vol 49 (1) ◽  
pp. 113-130 ◽  
Author(s):  
Ryan Ng ◽  
Rinku Sutradhar ◽  
Zhan Yao ◽  
Walter P Wodchis ◽  
Laura C Rosella
Keyword(s):  
Risk Factors ◽  
Chronic Disease ◽  
Chronic Diseases ◽  
Lifestyle Factors ◽  
Competing Risk ◽  
Chronic Obstructive ◽  
Common Disease ◽  
Heavy Smoking ◽  
Lifestyle Risk Factors ◽  
Lifestyle Risk

AbstractBackgroundThis study examined the incidence of a person’s first diagnosis of a selected chronic disease, and the relationships between modifiable lifestyle risk factors and age to first of six chronic diseases.MethodsOntario respondents from 2001 to 2010 of the Canadian Community Health Survey were followed up with administrative data until 2014 for congestive heart failure, chronic obstructive respiratory disease, diabetes, lung cancer, myocardial infarction and stroke. By sex, the cumulative incidence function of age to first chronic disease was calculated for the six chronic diseases individually and compositely. The associations between modifiable lifestyle risk factors (alcohol, body mass index, smoking, diet, physical inactivity) and age to first chronic disease were estimated using cause-specific Cox proportional hazards models and Fine-Gray competing risk models.ResultsDiabetes was the most common disease. By age 70.5 years (2015 world life expectancy), 50.9% of females and 58.1% of males had at least one disease and few had a death free of the selected diseases (3.4% females; 5.4% males). Of the lifestyle factors, heavy smoking had the strongest association with the risk of experiencing at least one chronic disease (cause-specific hazard ratio = 3.86; 95% confidence interval = 3.46, 4.31). The lifestyle factors were modelled for each disease separately, and the associations varied by chronic disease and sex.ConclusionsWe found that most individuals will have at least one of the six chronic diseases before dying. This study provides a novel approach using competing risk methods to examine the incidence of chronic diseases relative to the life course and how their incidences are associated with lifestyle behaviours.

A New Path to Address Multimorbidity? Longitudinal Analyses of Retirement Sequences and Chronic Diseases in Old Age

2021 ◽  
pp. 073346482110310
Author(s):  
Esteban Calvo ◽  
Ariel Azar ◽  
Robin Shura ◽  
Ursula M. Staudinger
Keyword(s):  
Chronic Disease ◽  
Labor Force ◽  
Chronic Diseases ◽  
Old Age ◽  
Full Time ◽  
Longitudinal Analyses ◽  
Employment Opportunities ◽  
Time Work ◽  
Aging Populations ◽  
Retirement Study

Chronic disease and multimorbidity are growing health challenges for aging populations, often coinciding with retirement. We examine late-life predictors of multimorbidity, focusing on the association between retirement sequences and number of chronic diseases. We modeled the number of chronic diseases as a function of six types of previously identified 10-year retirement sequences using Health and Retirement Study (HRS) data for 7,880 Americans observed between ages 60 to 61 and 70 to 71. Our results show that at baseline, the adjusted prevalence of multimorbidity was lowest in sequences characterized by late retirement from full-time work and highest in sequences characterized by early labor-force disengagement. Age increases in multimorbidity varied across retirement sequences, though overall differences in prevalence persisted at age 70 to 71. Earlier life disadvantages did not moderate these associations. Findings suggest further investigation of policies that target health limitations affecting work, promote continued beneficial employment opportunities, and ultimately leverage retirement sequences as a novel path to influence multimorbidity in old age.

scholarly journals Epigenetics and DOHaD: from basics to birth and beyond

2017 ◽  
Vol 8 (5) ◽  
pp. 513-519 ◽  
Author(s):  
T. Bianco-Miotto ◽  
J. M. Craig ◽  
Y. P. Gasser ◽  
S. J. van Dijk ◽  
S. E. Ozanne
Keyword(s):  
Dna Methylation ◽  
Chronic Disease ◽  
Chronic Diseases ◽  
Early Life ◽  
Later Life ◽  
Metabolic Health ◽  
Number Of Children ◽  
Early Life Environment ◽  
Increased Risk ◽  
Early Life Exposures

Developmental origins of health and disease (DOHaD) is the study of how the early life environment can impact the risk of chronic diseases from childhood to adulthood and the mechanisms involved. Epigenetic modifications such as DNA methylation, histone modifications and non-coding RNAs are involved in mediating how early life environment impacts later health. This review is a summary of the Epigenetics and DOHaD workshop held at the 2016 DOHaD Society of Australia and New Zealand Conference. Our extensive knowledge of how the early life environment impacts later risk for chronic disease would not have been possible without animal models. In this review we highlight some animal model examples that demonstrate how an adverse early life exposure results in epigenetic and gene expression changes that may contribute to increased risk of chronic disease later in life. Type 2 diabetes and cardiovascular disease are chronic diseases with an increasing incidence due to the increased number of children and adults that are obese. Epigenetic changes such as DNA methylation have been shown to be associated with metabolic health measures and potentially predict future metabolic health status. Although more difficult to elucidate in humans, recent studies suggest that DNA methylation may be one of the epigenetic mechanisms that mediates the effects of early life exposures on later life risk of obesity and obesity related diseases. Finally, we discuss the role of the microbiome and how it is a new player in developmental programming and mediating early life exposures on later risk of chronic disease.

Does Learners’ Proficiency Level Affect Oral Corrective Feedback Preferences?

2016 ◽  
Vol 8 (4) ◽  
pp. 150 ◽  
Author(s):  
Nesa Bandarchian Rashti ◽  
Maryam Danaye Tous
Keyword(s):  
Error Correction ◽  
Corrective Feedback ◽  
Good Deal ◽  
Potential Effect ◽  
Factors Affecting ◽  
Proficiency Level ◽  
Oral Corrective Feedback ◽  
One Step ◽  
Feedback Preferences ◽  
The Impact

<p>For decades now, there has been a good deal of research on factors affecting students’ oral corrective feedback preferences. Although it has been proven that learners’ characteristics such as their verbal intelligence and attitude toward error correction are highly effective in students’ preferred type of oral corrective feedback, the claims regarding the impact of learners’ proficiency level on their choice of oral corrective feedback have yet to be fully substantiated. In order to take this line of research one step forward, it is important to examine the potential effect of students’ level of proficiency in error correction literature. To this end, this paper aims to shed light on lower and higher level learners’ opinion about corrective feedback issues in an EFL context.</p>

scholarly journals CHRONIC CONGENITAL AREGENERATIVE ANEMIA (PURE RED-CELL ANEMIA) ASSOCIATED WITH ISO-IMMUNIZATION BY THE BLOOD GROUP FACTOR "A"

Blood ◽  
1949 ◽  
Vol 4 (6) ◽  
pp. 697-705 ◽  
Author(s):  
CARL H. SMITH
Keyword(s):  
Bone Marrow ◽  
Blood Group ◽  
Neonatal Period ◽  
Blood Levels ◽  
Fetal Life ◽  
Red Cell ◽  
Serum Titer ◽  
Persistent Depression ◽  
Blood Group Factor ◽  
Hypoplastic Anemia

Abstract Chronic congenital aregenerative anemia describes a "pure red-cell" anemia in which the failure of hematopoiesis is restricted entirely to the erythrocytes without simultaneous impairment of leukocyte or platelet production. The separation of this entity from the category of the increasing number of cases designated as hypoplastic anemia will facilitate a more direct examination of the factors involved in its pathogenesis. In the case described in this paper illustrating this condition, the onset of the anemia dated to the newborn period with the clinical and hematologic features of a mild type of erythroblastosis fetalis. The mother’s blood group was O, Rh positive and that of the infant and father A, Rh positive. The anti-A serum titer in the mother reached a maximum of 1:128,000. The infant was shown to be a non-secretor. The patient, now 17 months of age, requires repeated transfusions to maintain normal blood levels. The bone marrow reveals a persistent depression of erythropoiesis but the platelet and granulocyte levels are entirely unaffected. It is postulated that prolonged depression in red blood cell production may result from an antibody directed solely against the red cells in fetal life or from the early neonatal period. This concept finds substantiation in other cases of erythroblastosis in which temporary failure of erythropoiesis as confirmed by bone marrow studies is reflected in a state of protracted anemia.

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