Maternal serum levels of C-reactive protein at early pregnancy to predict fetal growth restriction and preterm delivery: A prospective cohort study

Background: A considerable evidence suggests that maternal inflammation dysregulation may play as a risk factor for both maternal and neonatal outcomes. Objective: The study’s objectives were designed to evaluate the correlation between serum C-reactive protein (CRP) levels, as an inflammation factor, preterm delivery, and small for gestational age (SGA) births. Materials and Methods: This prospective cohort study was conducted on 120 singleton pregnant women with gestational age less than 20 wk. Maternal CRP serum concentration was measured before 20 wk gestation. Patients were followed-up until the delivery and final outcomes of pregnancy were recorded in terms of preterm delivery and SGA births. Results: Serum CRP levels in participants with normal fetuses and SGA births were 4.09 ± 1.35 mg/l and 6.04 ± 3.29 mg/l, respectively (p = 0.19), while in cases of preterm delivery, it was 9.63 ± 5.78 mg/l (p < 0.001). By using receiver operating characteristic (ROC) curve, serum CRP levels (cut-off point 5.27 mg/l, area 0.836) had acceptable diagnostic accuracy value in distinguishing preterm delivery (sensitivity (75%), specificity (86.1%), positive predictive value (37.5%), negative predictive value (96.87%), accuracy (85%)) and serum CRP levels (cut-off point 6.67 mg/l, area 0.673) in distinguishing SGA births (sensitivity (50%), specificity (91.2%), positive predictive value (23.07%), and negative predictive value (97.19%), and accuracy (89.16 %)). Conclusion: Higher maternal serum CRP levels measured early in pregnancy may associate with higher risk of preterm delivery and SGA. Key words: C-reactive protein, Small for gestational age, Preterm birth.

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Measurement of serum C-reactive protein levels in early second trimester as a predictor of preterm delivery

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20195349 ◽

2019 ◽

Vol 8 (12) ◽

pp. 4946

Author(s):

Sujatha Senthil ◽

S. Dhamayanthi

Keyword(s):

Preterm Delivery ◽

Preterm Labour ◽

Maternal Serum ◽

Second Trimester ◽

C Reactive Protein ◽

Spontaneous Preterm Birth ◽

Singleton Pregnancy ◽

Inflammatory Biomarker ◽

Reactive Protein ◽

Serum Crp

Background: Preterm labour is the leading cause of perinatal morbidity and mortality. Infection plays a major role in preterm labour. Elevation of CRP, an inflammatory biomarker has been associated with spontaneous preterm birth. This study was aimed at evaluating the relation of C-reactive protein in early second trimester with preterm labour and neonatal morbidity.Methods: It is a prospective cohort study, 200 pregnant women of singleton pregnancy between the gestational age of 14 to 20 weeks were enrolled. After detailed history taking, maternal serum CRP levels were estimated by ELISA method. These women were divided into two groups according to CRP levels. Incidence of preterm delivery and incidence of neonatal morbidity was compared in both groups to ascertain if measured maternal CRP levels has any association with preterm labour and neonatal morbidity.Results: In this study 42 patients (21%) had preterm delivery. Of these 30 patients had CRP > 1.5mg/dl; 12 had CRP < 1.5 mg/dl. In CRP increased group, 30 patients (57.7%) delivered preterm, 22 patients (42.3%) had term. It was found that increased levels of maternal serum CRP in early pregnancy were associated with increased incidence of preterm delivery. According to this study if the CRP value 1.5 the sensitivity will be 71.4% and specificity will be 86% to predict the preterm. Of the total 42 preterm babies, 1 from Group A (8.3%) and 12 from Group B (40%) developed sepsis. So increased CRP has association with neonatal sepsis.Conclusions: Elevated maternal serum CRP concentration in early second trimester was associated with increased incidence of preterm delivery and showed a positive correlation with neonatal sepsis.

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Association between Serum C-reactive Protein and Pre-eclampsia

Faridpur Medical College Journal ◽

10.3329/fmcj.v15i2.53888 ◽

2021 ◽

Vol 15 (2) ◽

pp. 58-61

Author(s):

Sanjoy Kumar Das ◽

Shafeya Khanam ◽

Rajib Kumar Roy ◽

Samiya Alam ◽

Tapan Kumar Roy ◽

...

Keyword(s):

Blood Pressure ◽

Pregnant Women ◽

Gestational Age ◽

Maternal Serum ◽

Control Group ◽

Case Group ◽

C Reactive Protein ◽

Reactive Protein ◽

Blood Pressures ◽

Serum Crp

Among the common disorders of pregnancy, Pre-eclampsia is important one which causes significant maternal and perinatal morbidity and mortality. Its incidence is still high in the developing countries. The triad of high blood pressure, edema and albuminuria is neither specific nor sensitive enough; therefore, a reliable biochemical marker is needed to solve the problem. C-reactive protein(CRP), a marker of tissue damage and inflammation, is elevated in serum in overt preeclampsia. The present study is aimed to explore the association of high maternal serum C-reactive protein (CRP) level with preeclampsia and correlation with the severity of pre-eclamptic process. A total of 60 pregnant women constituting 30 pre-eclamptic (case) and 30 normal (control) pregnant women in the third trimester were enrolled in this study. Both the groups were matched for their age, parity and other baseline characteristics. More than three quarters (76.70%) of the case group exhibited raised serum CRP, which was 20% in control group (p=0.001). CRP was elevated about 13 fold higher than that in the normal pregnant women. The mean systolic and diastolic blood pressure were significantly higher in case group (154±12 mm of Hg) vs (107±7 mm of Hg) in control group (p<_0.001) and serum level of CRP bears linear relationship with both systolic and diastolic blood pressures. Preeclamptic women with higher serum CRP level were at a significantly (p<0.001) lower gestational age than control. Twenty two (73.30%) cases had gestational age <37 weeks (p=0.302) and 66.70% control group had gestational age > 37 weeks. The hypothesis of the study was supported by the study findings that maternal CRP concentration was higher in women with preeclampsia and was correlated with disease progression as evidenced by the investigative analysis. Faridpur Med. Coll. J. Jan 2020;15(2): 58-61

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Usefulness of maternal serum C-reactive protein with vaginal Ureaplasma urealyticum as a marker for prediction of imminent preterm delivery and chorioamnionitis in patients with preterm labor or preterm premature rupture of membranes

Journal of Perinatal Medicine ◽

10.1515/jpm-2014-0142 ◽

2015 ◽

Vol 43 (4) ◽

Cited By ~ 5

Author(s):

Dong-Wook Kwak ◽

Hee-Young Cho ◽

Ja-Young Kwon ◽

Yong-Won Park ◽

Young-Han Kim

Keyword(s):

Preterm Delivery ◽

Preterm Labor ◽

Maternal Serum ◽

C Reactive Protein ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Reactive Protein ◽

Preterm Premature Rupture ◽

Serum Crp ◽

Genital Mycoplasmas

AbstractTo assess whether maternal serum C-reactive protein (CRP) and genital mycoplasmas measured can help predict imminent preterm delivery or chorioamnionitis in patients with preterm labor (PL) or preterm premature rupture of membranes (PPROM).The study group consisted of 165 women with PL or PPROM. Vaginal cultures for genital mycoplasmas and maternal blood for CRP were obtained when they were admitted for the management of PL or PPROM. An elevated level of serum CRP was defined as ≥0.8 mg/dL. Histologic evaluation of the placenta was performed after delivery.The prevalence of positive vaginal fluid cultures forAlthough vaginal UU in PL or PPROM cannot act as the sole predictor of imminent preterm delivery or chorioamnionitis, it can provide predictive information in patients with elevated maternal serum CRP levels.

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Maternal serum cadmium level during pregnancy and its association with small for gestational age infants: a population-based birth cohort study

Scientific Reports ◽

10.1038/srep22631 ◽

2016 ◽

Vol 6 (1) ◽

Cited By ~ 23

Author(s):

Hua Wang ◽

Lu Liu ◽

Yong-Fang Hu ◽

Jia-Hu Hao ◽

Yuan-Hua Chen ◽

...

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

Gestational Age ◽

Small For Gestational Age ◽

Population Based ◽

Maternal Serum ◽

Birth Cohort Study ◽

Cadmium Level

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Study of predictive value of serum C- reactive protein in diagnosis of acute appendicitis

Medpusle International Journal of Surgery ◽

10.26611/1061918 ◽

2021 ◽

Vol 19 (1) ◽

pp. 31-34

Author(s):

Pradeep Chandra Sharma ◽

Keyword(s):

Acute Appendicitis ◽

Predictive Value ◽

Signs And Symptoms ◽

Final Diagnosis ◽

Common Finding ◽

C Reactive Protein ◽

Diagnostic Efficacy ◽

Female Ratio ◽

Reactive Protein ◽

Serum Crp

Background: Acute appendicitis is a common surgical condition and the most common cause of acute surgical abdomen. Commonly used tests for diagnosis of acute appendicitis were WBC, CRP ESR and procalcitonin (PCT) levels. In present study we correlated the serum levels of CRP with the histopathology of the removed appendix, to study predictive value of serum C- reactive protein in diagnosis of acute appendicitis. Material and Methods:Present study was conducted in patients with possibility of acute appendicitis, underwent appendicectomy. The histopathology report was considered as the final diagnosis. CRP more than 6 mg/dl was considered to be positive. Results: In present study total 88 patients were included. Male to female ratio was 1.4:1, most common age group was 21-30 years (35.23%) followed by 31-40 years (27.27%). Abdominal pain (92.05%), McBurney tenderness (80.68%), vomiting (76.14%), rebound tenderness (67.05%) and fever (55.68%) were common signs and symptoms noted in present study. On histopathology examination, inflammed appendix (51.14%) was most common finding, others were gangrenous appendix (23.86%), perforated appendix (5.68%) and normal appendix (19.32%). In present study diagnostic efficacy of serum CRP was sensitivity (80%), specificity (84.62%), positive predictive value (96.77%), negative predictive value (42.31%), diagnostic accuracy (80.68%). Conclusion. Serum CRP estimation is useful adjunct in diagnosis of acute appendicitis along with clinical diagnosis. Serum CRP value should be interpreted in combination with clinical findings.

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Previous Preeclampsia, Preterm Delivery, and Delivery of a Small for Gestational Age Infant and the Risk of Unexplained Stillbirth in the Second Pregnancy: A Retrospective Cohort Study, Scotland, 1992-2001

American Journal of Epidemiology ◽

10.1093/aje/kwj354 ◽

2006 ◽

Vol 165 (2) ◽

pp. 194-202 ◽

Cited By ~ 43

Author(s):

G. C. S. Smith ◽

I. Shah ◽

I. R. White ◽

J. P. Pell ◽

R. Dobbie

Keyword(s):

Cohort Study ◽

Preterm Delivery ◽

Gestational Age ◽

Small For Gestational Age ◽

Retrospective Cohort Study ◽

Retrospective Cohort

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Maternal serum C-reactive protein concentrations in early pregnancy and subsequent risk of preterm delivery

Clinical Biochemistry ◽

10.1016/j.clinbiochem.2006.11.017 ◽

2007 ◽

Vol 40 (5-6) ◽

pp. 330-335 ◽

Cited By ~ 50

Author(s):

Vitool Lohsoonthorn ◽

Chunfang Qiu ◽

Michelle A. Williams

Keyword(s):

Preterm Delivery ◽

Early Pregnancy ◽

Maternal Serum ◽

C Reactive Protein ◽

Reactive Protein ◽

Subsequent Risk

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PREDICTIVE VALUE OF MATERNAL SERUM C- REACTIVE PROTEIN LEVELS WITH SEVERITY OF PREECLAMPSIA

Zagazig University Medical Journal ◽

10.21608/zumj.2016.4638 ◽

2016 ◽

Vol 22 (2) ◽

pp. 1-12

Author(s):

Mahmoud Gharib ◽

Mostafa Mostafa ◽

Mervat Harira ◽

Amany Attia

Keyword(s):

Predictive Value ◽

Maternal Serum ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein

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A study on validity of C-reactive protein in deciding the duration of antibiotic therapy in suspected neonatal bacterial infection

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20173796 ◽

2017 ◽

Vol 4 (5) ◽

pp. 1838 ◽

Cited By ~ 1

Author(s):

Prashanth Siddaiah ◽

Pradeep Nanjappa Shetty ◽

Krishna N. W. ◽

Sowmya Jagadeeshwara

Keyword(s):

Antibiotic Therapy ◽

Bacterial Infection ◽

Negative Predictive Value ◽

Antibiotic Treatment ◽

Predictive Value ◽

Decision Criterion ◽

C Reactive Protein ◽

Neonatal Septicemia ◽

Reactive Protein ◽

Serum Crp

Background: Neonatal septicemia is defined as generalized bacterial infection of newborns documented by positive blood culture in first four weeks of life. Objective of present study was to determine whether C-Reactive protein can be used as a parameter to identify the time point when antibiotic treatment can safely be discontinued in a defined major subgroup of neonates treated for suspected bacterial infection.Methods: A total of 50 neonates with birth weight more than 1500gms with suspected septicemia were enrolled in the prospective study. Serum CRP were determined 24-48 hours after the first dose of antibiotics. If CRP was less than 6mg/l, infants were considered unlikely to be infected and the antibiotic treatment was stopped. If CRP was more than 6mg/l, antibiotics were continued and CRP measured on alternative days in one subgroup (2a) and on seventh day in another subgroup (2b). CRP was the single decision criterion to stop the antibiotic therapy. Negative predictive value with respect to further treatment was determined.Results: Duration of antibiotic therapy could be reduced to less than seven days in 54% cases and < 72 hours in 48% cases.Conclusions: Negative predictive value of serial CRP is 100% in deciding the duration of antibiotic therapy in suspected neonatal septicemia.

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