scholarly journals A study on the prevalence of non-alcoholic fatty liver disease in hypothyroid patients in a tertiary care hospital in north India

2019 ◽  
Vol 7 (12) ◽  
Author(s):  
Dr Rajendra Kumar ◽  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
North India ◽  
Care Hospital ◽  
Alcoholic Fatty Liver ◽  
Hypothyroid Patients ◽  
Alcoholic Fatty Liver Disease

scholarly journals PREVALENCE OF NON-ALCOHOLIC FATTY LIVER DISEASE IN HYPOTHYROIDISM IN A TERTIARY CARE HOSPITAL IN EASTERN INDIA

2017 ◽  
Vol 6 (79) ◽  
pp. 5589-5593 ◽  
Author(s):  
Rina Mohanty ◽  
Samarendra Nath Das ◽  
Aujjwalya Kumar Jena ◽  
Sarita Behera ◽  
Nirmal Chandra Sahu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Eastern India ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease in patients with hypothyroidism presenting at a rural tertiary care centre in north India

2020 ◽  
pp. 004947552094505
Author(s):  
Harpreet Grewal ◽  
Sandeep Joshi ◽  
Ruby Sharma ◽  
Puneet Mittal ◽  
Ankur Goel
Keyword(s):  
Risk Factor ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Tertiary Care ◽  
North India ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Apart from its association with metabolic syndrome and diabetes mellitus, non-alcoholic fatty liver disease (NAFLD) has been thought to be linked with other endocrine and metabolic disorders. Recent data suggest that hypothyroidism may be a significant risk factor for development and progression of NAFLD. The present study was conducted to evaluate the presence of NAFLD in patients with hypothyroidism presenting to a rural tertiary care centre in north India. The diagnosis of NAFLD was made on the basis of radiological findings and derangement of liver enzymes. Our findings showed that ultrasonographic evidence of fatty liver as well as increase in the serum transaminase level above normal range were significantly higher in hypothyroidism patients as compared with controls. On multivariate regression analysis of the patients’ data, the presence of hypothyroidism was independently associated with risk of NAFLD. We therefore conclude that hypothyroidism is a significant independent risk factor.

scholarly journals A cross sectional study: to determine the prevalence and risk factors of non-fatty alcoholic liver diseases among diabetics-I and II

2020 ◽  
Vol 7 (2) ◽  
pp. 283
Author(s):  
Geetha Navuduri ◽  
Asma .
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Waist Hip Ratio ◽  
Alcoholic Fatty Liver Disease

Background: Non Alcoholic Fatty Liver Disease (NAFLD) is an important health problem globally as well as in India. The present was taken to determine the prevalence of NAFLD among diabetics attending a tertiary care hospital in Telangana.Methods: A total of 75 subjects who were all diabetics were taken. The diagnosis of NAFLD was done using Ultra sonogram. Preliminary information along with duration of diabetes, Waist Hip Ratio, Body Mass Index, Triglycerides and Cholesterol was collected and analyzed.Results: The prevalence of NAFLD among diabetics was 41.3%. Majority of the subjects belonged to age group of 41-60 years. The prevalence of NAFLD among females was 35.99%. Among patients who had Non-alcoholic fatty liver disease 74.19% had Waist Hip ratio >1. Almost 90.3% had higher levels of triglycerides (>180 mg/dl).Conclusions: The prevalence of NAFLD among diabetics was comparatively high. Early diagnosis, treatment, awareness and education is needed to reduce the burden of NAFLD.

scholarly journals A 12-week multi-component dietary intervention improves markers of non-alcoholic fatty liver disease in Irish patients in tertiary care

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Deirdre Ní Fhloinn ◽  
Ciara Wright ◽  
Sara Naimimohasses ◽  
Stephen Finn ◽  
Suzanne Norris ◽  
...  
Keyword(s):  
Weight Loss ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Dietary Intervention ◽  
Tertiary Care ◽  
Intervention Group ◽  
Post Intervention ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

AbstractNon-alcoholic fatty liver disease (NAFLD) is a significant public health concern closely linked to obesity, affecting an estimated 25% of adults in Europe. Understudied in Ireland, the aim of this research was to examine the effects of a 12-week multi-component dietary intervention on weight loss and markers of liver injury in Irish NAFLD patients in tertiary care. Biopsy confirmed NAFLD patients (n = 27) were recruited from St James’ Hospital in Dublin, Ireland. Consenting participants underwent a 12-week moderate-intensity intervention incorporating weekly group nutritional education, behavioural change and group support, as well as individualised advice and weigh-ins from a trained nutritionist. Control group participants were given routine clinical care. All participants were clinically reviewed before, immediately after, and 3 months post intervention. Individuals (n = 12) with histological evidence of steatohepatitis underwent a repeat liver biopsy on completion of the intervention. Detailed dietary assessment was performed using both a 4-day diet diary (4DDD) and a novel, recently validated, short food frequency questionnaire (SFFQ) designed specifically to assess habitual intakes of food items related to NAFLD. Nutrient intakes were analysed using myFood24TM dietary analysis software, and the Mediterranean diet quality score (MDQS) was used to assess the overall change in dietary patterns. Of the 15 participants who completed the intervention, 80% (n = 12) achieved a weight loss exceeding 5%, with 47% (n = 7) achieving > 7%. There were significant improvements from baseline to week 12 in the intervention group for the majority of clinical parameters including HbA1c (p = 0.0054), liver enzymes (ALT, p = 0.0108; GGT, p = 0.0001) and transient elastography (kPA, p = 0.0308; CAP, p = 0.0081). However, these results failed to maintain significance when analysed compared to controls. The overall dietary pattern was significantly improved after 12 weeks as assessed by the MDQS (p = 0.03), with no apparent compromise in micronutrient intake despite the energy reduction. Reductions in energy, saturated fat, carbohydrate and sugar intakes at 12 weeks, were maintained at three months follow up. Analysis of pre- and post-intervention liver biopsies in the intervention group demonstrated a clinically significant improvement in NAS score (p = 0.0273), attributable to reductions in hepatic steatosis (p = 0.0078). A significant correlation was observed between improvement in liver histology and change in sugar intake (r = 0.7534, p = 0.0093). Although results were somewhat limited by small sample size, nutritional education achieved beneficial dietary changes that persisted after the intervention ceased. Notably, achieving reductions in sugar intakes may be particularly beneficial in reducing the severity of hepatic steatosis in Irish adults with NAFLD.

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