A study of role of Insulin resistance in recently detected hypertensives in a rural population of Kishanganj, Bihar-A Cross sectional observational study

2021 ◽  
Vol 09 (10) ◽  
Author(s):  
Dr Sourav Chattopadhyay ◽  
Keyword(s):  
Insulin Resistance ◽  
Observational Study ◽  
Rural Population ◽  
Cross Sectional

scholarly journals The Role of Angiopoietin-like Protein 3 and Fibroblast Growth Factor 21 to Lipolysis, Inflammation and Insulin Resistance in Indonesian Non-Diabetic Obese Male

2010 ◽  
Vol 2 (2) ◽  
pp. 33
Author(s):  
Yani Lina ◽  
Gatot Susilo Lawrence ◽  
Andi Wijaya ◽  
Suryani As'ad
Keyword(s):  
Insulin Resistance ◽  
Fasting Blood Glucose ◽  
Feedback Mechanism ◽  
Fibroblast Growth Factor 21 ◽  
Low Grade ◽  
Cross Sectional ◽  
Negative Feedback Mechanism ◽  
Two Factors ◽  
Cross Sectional Design

BACKGROUND: Obesity is commonly associated with a systemic low grade inflammation and insulin resistance state. Although it is still being debated, increased lipolysis is known as one of the risk factors for inflammation and insulin resistance. Two factors already known to affect lipolysis are Angptl3, known as prolipolytic factor, and FGF21, known as antilipolytic factor. The aim of this study was to observe the role of Angptl3 and FGF21 to lipolysis, inflammation and insulin resistance in non diabetic obese male.METHODS: This was an observational study with cross sectional design. One hundred and thirty male subjects aged 30-60 years with non diabetic abdominal obesity characterized by waist circumference 97.32±5.63 cm and fasting blood glucose 90.19±8.78 mg/dL.RESULTS: The results of this study showed a correlation between Angptl3-FFA (r=0.203; p=0.021; R square=0.041; p=0.021), Angptl3-FABP4 (r=0.330; p=0.000; R square=0.109; p=0.000) and Angptl3-TNFα (r=0.288; p=0.001; R square=0.049; p=0.011). There was a correlation between FGF21-FABP4 (r=0.218, p=0.013; R square=0.047, p=0.013) and FGF21 HOMA-IR (r=0.308, p=0.000; R square=0.046, p=0.014).CONCLUSIONS: We conclude that Angptl3 may affect lipolysis and inflammation while FGF21 may affect lipolysis and insulin resistance. The increased FGF21 concentration might occur as a compensation (negative feedback mechanism) to reduce lipolysis and increase insulin sensitivity in non diabetic obese males. Further studies might be needed to observe Angptl3 and FGF21 profile in more severe obese population in Indonesia.KEYWORDS: obesity, lipolysis, inflammation, insulin resistance

scholarly journals Preoperative Gastric Residual Volumes in Fasted Patients Measured by Bedside Ultrasound: A Prospective Observational Study

2018 ◽  
Vol 46 (6) ◽  
pp. 608-613 ◽  
Author(s):  
Y. Ohashi ◽  
J. C. Walker ◽  
F. Zhang ◽  
F. E. Prindiville ◽  
J. P. Hanrahan ◽  
...  
Keyword(s):  
At Risk ◽  
Observational Study ◽  
Observational Studies ◽  
Prospective Observational Study ◽  
Opioid Use ◽  
Gastric Residual Volume ◽  
Patient Factors ◽  
Cross Sectional ◽  
Multivariable Analyses

The purpose of this prospective observational study was to measure gastric volumes in fasted patients using bedside gastric ultrasound. Patients presenting for non-emergency surgery underwent a gastric antrum assessment, using the two-diameter and free-trace methods to determine antral cross-sectional area. Gastric residual volume (GRV) was calculated using a validated formula. Univariate and multivariable analyses were performed to examine any potential relationships between ‘at risk’ GRVs (>100 ml) and patient factors. Two hundred and twenty-two successful scans were performed; of these 110 patients (49.5%) had an empty stomach, nine patients (4.1%) had a GRV >100 ml, and a further six patients (2.7%) had a GRV >1.5 ml/kg. There was no significant relationship between ‘at risk’ GRV and obesity, diabetes mellitus, gastro-oesophageal reflux disease or opioid use, although our study had insufficient power to exclude an influence of one or more of these factors. Our results indicate that despite compliance with fasting guidelines, a small percentage of patients still have GRVs that pose a pulmonary aspiration risk. Anaesthetists should consider this background incidence when choosing anaesthesia techniques for their patients. While future observational studies are required to determine the role of preoperative bedside gastric ultrasound, it is possible that this technique may assist anaesthetists in identifying patients with ‘at risk’ GRVs.

Relationship between Intraocular Pressure and Anterior Lamina Cribrosa Depth: A Cross-Sectional Observational Study in a Healthy Portuguese Population

2016 ◽  
Vol 27 (3) ◽  
pp. 295-300 ◽  
Author(s):  
David Cordeiro Sousa ◽  
Inês Leal ◽  
Carlos Marques-Neves ◽  
Filomena Pinto ◽  
Luís Abegão Pinto
Keyword(s):  
Intraocular Pressure ◽  
Observational Study ◽  
Lamina Cribrosa ◽  
Enhanced Depth Imaging ◽  
Multivariate Regression Model ◽  
Portuguese Population ◽  
Cross Sectional ◽  
Depth Imaging ◽  
Functional Dynamics

Purpose To investigate the association between anterior lamina cribrosa depth (ALCD), determined with enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT), and intraocular pressure (IOP) in a healthy Portuguese population. Methods In this cross-sectional observational study conducted between January and July 2015, 2 optic nerve head (ONH)–centered EDI-OCT cross-scans were performed and ALCD was defined as the perpendicular distance between the line connecting both edges of Bruch's membrane opening and the anterior border of the lamina cribrosa at the maximum depth point. A multivariate regression model was performed to assess the association of IOP and ALCD. Results The studied population included 59 subjects (35 women) with a mean age of 61.7 ± 15.1 years. Mean vertical and horizontal maximum ALCD was 444.5 ± 92.2 μm and 427.6 ± 82.7 μm, respectively. When controlling for age and spherical equivalent, maximum vertical and horizontal ALCD were positively correlated with intraocular pressure (R2>0.20) by 8.58 μm (95% confidence interval [CI] 2.80-14.36 μm; p<0.01) and 8.25 μm (95% CI 2.71-13.78 μm; p<0.01) per mm Hg of IOP, respectively. Conclusions Our sample of healthy subjects presented a statistically significant positive correlation between IOP and ALCD when controlling for possible confounding factors. These results may trigger further studies to better elucidate the role of IOP in the morphologic and functional dynamics of the ONH.

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