Role of hypoxia-inducible factor-1 alpha and transforming growth factor-beta 1 in the development of oxidative stress and immune dysbalance in endometriosis

2019 ◽  
Vol 6_2019 ◽  
pp. 14-22
Author(s):  
Vanko L.V. Vanko ◽  
Korotkova T.D. Korotkova ◽  
Krechetova L.V. Krechetova ◽  
Keyword(s):  
Oxidative Stress ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Hypoxia Inducible Factor ◽  
Hypoxia Inducible Factor 1 ◽  
Growth Factor Beta

N-acetylcysteine prevents carbon tetrachloride-induced liver cirrhosis: role of liver transforming growth factor-beta and oxidative stress

2009 ◽  
Vol 21 (8) ◽  
pp. 908-914 ◽  
Author(s):  
Marina Galicia-Moreno ◽  
Adriana Rodríguez-Rivera ◽  
Karina Reyes-Gordillo ◽  
José Segovia ◽  
Mineko Shibayama ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Growth Factor Beta ◽  
And Oxidative Stress

scholarly journals Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation

Oncogenesis ◽  
2021 ◽  
Vol 10 (10) ◽  
Author(s):  
Xiaoqing Fan ◽  
Junqi Fan ◽  
Haoran Yang ◽  
Chenggang Zhao ◽  
Wanxiang Niu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Transforming Growth Factor Beta ◽  
Cell Biology ◽  
Transforming Growth Factor ◽  
Hypoxia Inducible Factor ◽  
Stem Cell Biology ◽  
Isocitrate Dehydrogenase 1 ◽  
Hypoxia Inducible Factor 1 ◽  
Growth Factor Beta

AbstractGlioblastoma (GBM) is the most common and deadly of the primary intracranial tumors and is comprised of subsets that show plasticity and marked heterogeneity, contributing to the lack of success in genomic profiling to guide development of precision medicine for these tumors. In this study, a mutation in isocitrate dehydrogenase 1 was found to suppress the transforming growth factor-beta signaling pathway and E2F4 interacted with Smad3 to inhibit expression of mesenchymal markers. However, palmitoylation of Smad3 mediated by palmitoyltransferase ZDHHC19 promoted activation of the transforming growth factor-beta signaling pathway, and its interaction with EP300 promoted expression of mesenchymal markers in the mesenchymal subtype of GBM. Smad3 and hypoxia-inducible factor 1-alpha may be important molecular targets for treatment of glioma because they appear to coordinate the basic aspects of cancer stem cell biology.

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