scholarly journals The senescence-associated secretory phenotype (SASP) from mesenchymal stromal cells impairs growth of immortalized prostate cells but has no effect on metastatic prostatic cancer cells

Aging ◽  
2019 ◽  
Vol 11 (15) ◽  
pp. 5817-5828 ◽  
Author(s):  
Nicola Alessio ◽  
Domenico Aprile ◽  
Tiziana Squillaro ◽  
Giovanni Di Bernardo ◽  
Mauro Finicelli ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Prostatic Cancer ◽  
Prostate Cells ◽  
Secretory Phenotype ◽  
Metastatic Prostatic Cancer

Bone Marrow/Bone Pre-Metastatic Niche For Breast Cancer Cells Colonization: The Role Of Mesenchymal Stromal Cells

2021 ◽  
pp. 103416
Author(s):  
M.C. Sanmartin ◽  
F.R. Borzone ◽  
M.B. Giorello ◽  
N. Pacienza ◽  
G. Yannarelli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Cancer Cells ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Breast Cancer Cells ◽  
Metastatic Niche

scholarly journals Altered features and increased chemosensitivity of human breast cancer cells mediated by adipose tissue-derived mesenchymal stromal cells

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Lucia Kucerova ◽  
Svetlana Skolekova ◽  
Miroslava Matuskova ◽  
Martin Bohac ◽  
Zuzana Kozovska
Keyword(s):  
Breast Cancer ◽  
Adipose Tissue ◽  
Cancer Cells ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast

scholarly journals P11.41 Comparison of fibroblast activation protein expression and localization in glioblastomas and brain metastases

2019 ◽  
Vol 21 (Supplement_3) ◽  
pp. iii52-iii52
Author(s):  
P Busek ◽  
M Zubal ◽  
B Chmielova ◽  
Z Vanickova ◽  
P Hrabal ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Brain Metastases ◽  
Cancer Cells ◽  
Brain Tissue ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Glioma Cells ◽  
Fibroblast Activation Protein ◽  
Epithelial Cancer ◽  
Fibroblast Activation

Abstract BACKGROUND Fibroblast activation protein (FAP) is a transmembrane serine protease that is frequently upregulated in the tumor microenvironment. In several cases, FAP protein itself and/or FAP expressing stromal cells have been shown to contribute to cancer progression and to be associated with more aggressive cancer behaviour and shorter patient survival. The aim of this study was to determine FAP expression in glioblastomas and brain metastases and to identify the cell types that express FAP in the microenvironment of these malignancies. MATERIAL AND METHODS FAP enzymatic activity and protein concentration were determined in samples from patients with brain metastases, glioblastomas and pharmacoresistant epilepsy (control non-tumorous brain tissue) by an enzymatic assay using a specific fluorogenic substrate and ELISA, respectively. Immunohistochemical labelling with antibodies against FAP and markers of astroglia, epithelial cancer cells and mesenchymal stromal cells was performed to characterize FAP expressing cells. RESULTS FAP was significantly upregulated in the majority of glioblastomas and brain metastases in comparison to non-tumorous brain tissue. In glioblastomas, FAP was localized perivascularly and in mesenchymal cells, and in part of the tumors also in the glioma cells. In brain metastases, FAP positivity was abundantly present in the stroma and predominantly co-localised with markers of mesenchymal stromal cells (TE-7, SMA, PDGFRbeta, NG2), but there was no overlap between FAP and markers of epithelial cancer cells (EpCAM, pancytokeratin). CONCLUSION FAP is upregulated in the microenvironment of human glioblastomas and brain metastases compared to non-tumorous brain tissue. In glioblastomas, FAP is expressed in part of the glioma cells, in pericytes and mesenchymal stromal cells, whereas no positivity in cancer cells and more abundant FAP+ stroma was detected in brain metastases. The selective expression of FAP in these brain tumors may be useful for the visualization and possibly therapeutic targeting of their tumor microenvironment. GRANT SUPPORT Ministry of Health of the Czech Republic, grant No. 15-31379A, Progres Q28/LF1, 2015064 LM EATRIS and the project,Center for Tumor Ecology - Research of the Cancer Microenvironment Supporting Cancer Growth and Spread” (reg. n. CZ.02.1.01/0.0/0.0/16_019/0000785) supported by the Operational Programme Research, Development and Education.

Interaction of human adipose tissue-derived mesenchymal stromal cells with breast cancer cells

Neoplasma ◽  
2011 ◽  
Vol 58 (5) ◽  
pp. 361-370 ◽  
Author(s):  
L. KUCEROVA ◽  
M. KOVACOVICOVA ◽  
S. POLAK ◽  
M. BOHAC ◽  
J. FEDELES ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adipose Tissue ◽  
Cancer Cells ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Breast Cancer Cells ◽  
Human Adipose Tissue

Mortalin antibody-conjugated quantum dot transfer from human mesenchymal stromal cells to breast cancer cells requires cell–cell interaction

2013 ◽  
Vol 319 (18) ◽  
pp. 2770-2780 ◽  
Author(s):  
Mika Pietilä ◽  
Petri Lehenkari ◽  
Paula Kuvaja ◽  
Mika Kaakinen ◽  
Sunil C. Kaul ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quantum Dot ◽  
Cancer Cells ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Breast Cancer Cells ◽  
Cell Interaction ◽  
Human Mesenchymal Stromal Cells ◽  
Cell Cell

scholarly journals Pre-clinical Models for Studying the Interaction Between Mesenchymal Stromal Cells and Cancer Cells and the Induction of Stemness

2019 ◽  
Vol 9 ◽  
Author(s):  
Sofia Avnet ◽  
Silvia Lemma ◽  
Margherita Cortini ◽  
Gemma Di Pompo ◽  
Francesca Perut ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Clinical Models

scholarly journals Mesenchymal stromal cells as carriers of IL-12 reduce primary and metastatic tumors of murine melanoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Natalia Kułach ◽  
Ewelina Pilny ◽  
Tomasz Cichoń ◽  
Justyna Czapla ◽  
Magdalena Jarosz-Biej ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Vascular Density ◽  
Strong Immune Response ◽  
M1 Macrophages ◽  
Murine Melanoma ◽  
Anti Cancer ◽  
Inhibition Of Tumor Growth ◽  
Therapeutic Properties

AbstractDue to immunosuppressive properties and confirmed tropism towards cancer cells mesenchymal stromal cells (MSC) have been used in many trials. In our study we used these cells as carriers of IL-12 in the treatment of mice with primary and metastatic B16-F10 melanomas. IL-12 has confirmed anti-cancer activity, induces a strong immune response against cancer cells and acts as an anti-angiogenic agent. A major limitation of the use of IL-12 in therapy is its systemic toxicity. The aim of the work was to develop a system in which cytokine may be administered intravenously without toxic side effects. In this study MSC were used as carriers of the IL-12. We confirmed antitumor effectiveness of the cells secreting IL-12 (MSC/IL-12) in primary and metastatic murine melanoma models. We observed inhibition of tumor growth and a significant reduction in the number of metastases in mice after MSC/IL-12 administration. MSC/IL-12 decreased vascular density and increased the number of anticancer M1 macrophages and CD8+ cytotoxic T lymphocytes in tumors of treated mice. To summarize, we showed that MSC are an effective, safe carrier of IL-12 cytokine. Administered systemically they exert therapeutic properties of IL-12 cytokine without toxicity. Therapeutic effect may be a result of pleiotropic (proinflammatory and anti-angiogenic) properties of IL-12 released by modified MSC.

scholarly journals Self-assembling nanoparticles encapsulating zoledronic acid inhibit mesenchymal stromal cells differentiation, migration and secretion of proangiogenic factors and their interactions with prostate cancer cells

Oncotarget ◽  
2017 ◽  
Vol 8 (26) ◽  
pp. 42926-42938 ◽  
Author(s):  
Cinzia Borghese ◽  
Naike Casagrande ◽  
Eliana Pivetta ◽  
Alfonso Colombatti ◽  
Mariarosaria Boccellino ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Zoledronic Acid ◽  
Cancer Cells ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Prostate Cancer Cells ◽  
Self Assembling
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