The oncogenic role of LncRNA FAM83C-AS1 in colorectal cancer development by epigenetically inhibits SEMA3F via stabilizing EZH2

The intestinal microbiota consists of a dynamic organization of bacteria, viruses, archaea, and fungal species essential for maintaining gut homeostasis and protecting the host against pathogenic invasion. When dysregulated, the intestinal microbiota can contribute to colorectal cancer development. Though the microbiota is multifaceted in its ability to induce colorectal cancer, this review will focus on the capability of the microbiota to induce colorectal cancer through the modulation of immune function and the production of microbial-derived metabolites. We will also explore an experimental technique that is revolutionizing intestinal research. By elucidating the interactions of microbial species with epithelial tissue, and allowing for drug screening of patients with colorectal cancers, organoid development is a novel culturing technique that is innovating intestinal research. As a cancer that remains one of the leading causes of cancer-related deaths worldwide, it is imperative that scientific findings are translated into the creation of effective therapeutics to treat colorectal cancer.

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Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.00026.2016 ◽

2016 ◽

Vol 310 (11) ◽

pp. G1081-G1090 ◽

Cited By ~ 29

Author(s):

Yvette J. Merga ◽

Adrian O'Hara ◽

Michael D. Burkitt ◽

Carrie A. Duckworth ◽

Christopher S. Probert ◽

...

Keyword(s):

Colorectal Cancer ◽

Gastrointestinal Tract ◽

Signaling Pathway ◽

Current Knowledge ◽

Common Factor ◽

Cancer Development ◽

Gastrointestinal Malignancies ◽

Activation Pathway ◽

Inflammatory Bowel

Chronic inflammation is a common factor in the development of many gastrointestinal malignancies. Examples include inflammatory bowel disease predisposing to colorectal cancer, Barrett's esophagus as a precursor of esophageal adenocarcinoma, and Helicobacter pylori-induced gastric cancer. The classical activation pathway of NF-κB signaling has been identified as regulating several sporadic and inflammation-associated gastrointestinal tract malignancies. Emerging evidence suggests that the alternative NF-κB signaling pathway also exerts a distinct influence on these processes. This review brings together current knowledge of the role of the alternative NF-κB signaling pathway in the gastrointestinal tract, with a particular emphasis on inflammation-associated cancer development.

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0908 The role of red and processed meat in colorectal cancer development: A perspective

Journal of Animal Science ◽

10.2527/jam2016-0908 ◽

2016 ◽

Vol 94 (suppl_5) ◽

pp. 437-438

Author(s):

S. De Smet

Keyword(s):

Colorectal Cancer ◽

Cancer Development ◽

Processed Meat ◽

Red And Processed Meat

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The role of red and processed meat in colorectal cancer development: a perspective

Meat Science ◽

10.1016/j.meatsci.2014.02.011 ◽

2014 ◽

Vol 97 (4) ◽

pp. 583-596 ◽

Cited By ~ 97

Author(s):

Marije Oostindjer ◽

Jan Alexander ◽

Gro V. Amdam ◽

Grethe Andersen ◽

Nathan S. Bryan ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Development ◽

Processed Meat ◽

Red And Processed Meat

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Mo1662 The Role of SNPs of Genes Encoding Psca, MUC1 and PLCE1 in Gastritis, Gastric Cancer and Colorectal Cancer Development

Gastroenterology ◽

10.1016/s0016-5085(14)62279-4 ◽

2014 ◽

Vol 146 (5) ◽

pp. S-630

Author(s):

Limas Kupcinskas ◽

Alexander Link ◽

Thomas Wex ◽

Gediminas Kiudelis ◽

Laimas Jonaitis ◽

...

Keyword(s):

Colorectal Cancer ◽

Gastric Cancer ◽

Cancer Development ◽

Genes Encoding

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The Role of the Immune System in IBD-Associated Colorectal Cancer: From Pro to Anti-Tumorigenic Mechanisms

International Journal of Molecular Sciences ◽

10.3390/ijms222312739 ◽

2021 ◽

Vol 22 (23) ◽

pp. 12739

Author(s):

Sofía Frigerio ◽

Dalia A. Lartey ◽

Geert R. D’Haens ◽

Joep Grootjans

Keyword(s):

Colorectal Cancer ◽

Immune System ◽

Chronic Inflammation ◽

Immune Cells ◽

Checkpoint Inhibitors ◽

Inflammatory Diseases ◽

Cancer Development ◽

Anti Inflammatory ◽

Immunosuppressive Microenvironment

Patients with inflammatory bowel disease (IBD) have increased incidence of colorectal cancer (CRC). IBD-associated cancer follows a well-characterized sequence of intestinal epithelial changes, in which genetic mutations and molecular aberrations play a key role. IBD-associated cancer develops against a background of chronic inflammation and pro-inflammatory immune cells, and their products contribute to cancer development and progression. In recent years, the effect of the immunosuppressive microenvironment in cancer development and progression has gained more attention, mainly because of the unprecedented anti-tumor effects of immune checkpoint inhibitors in selected groups of patients. Even though IBD-associated cancer develops in the background of chronic inflammation which is associated with activation of endogenous anti-inflammatory or suppressive mechanisms, the potential role of an immunosuppressive microenvironment in these cancers is largely unknown. In this review, we outline the role of the immune system in promoting cancer development in chronic inflammatory diseases such as IBD, with a specific focus on the anti-inflammatory mechanisms and suppressive immune cells that may play a role in IBD-associated tumorigenesis.

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