scholarly journals BRCA Role Changes with Association: Tissue-specific impact on the prognosis

Oncotarget ◽  
2021 ◽  
Vol 12 (26) ◽  
pp. 2541-2542
Author(s):  
Bhavana Gupta ◽  
Kumaravel Somasundaram
Keyword(s):  
Tissue Specific ◽  
Role Changes ◽  
Specific Impact

scholarly journals RegVar: Tissue-specific Prioritization of Noncoding Regulatory Variants

2021 ◽  
Author(s):  
Hao Lu ◽  
Luyu Ma ◽  
Lei Li ◽  
Cheng Quan ◽  
Yiming Lu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Target Genes ◽  
Human Genetics ◽  
Computational Framework ◽  
Tissue Specific ◽  
Regulatory Variants ◽  
Regulatory Impact ◽  
Genome Variations ◽  
The Impact ◽  
Specific Impact

Noncoding genomic variants constitute the majority of trait-associated genome variations; however, identification of functional noncoding variants is still a challenge in human genetics, and a method systematically assessing the impact of regulatory variants on gene expression and linking them to potential target genes is still lacking. Here we introduce a deep neural network (DNN)-based computational framework, RegVar, that can accurately predict the tissue-specific impact of noncoding regulatory variants on target genes. We show that, by robustly learning the genomic characteristics of massive variant-gene expression associations in a variety of human tissues, RegVar vastly surpasses all current noncoding variants prioritization methods in predicting regulatory variants under different circumstances. The unique features of RegVar make it an excellent framework for assessing the regulatory impact of any variant on its putative target genes in a variety of tissues. RegVar is available as a webserver at http://regvar.cbportal.org/.

scholarly journals Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation inDrosophila melanogaster

RNA ◽  
2017 ◽  
Vol 23 (12) ◽  
pp. 1807-1816 ◽  
Author(s):  
Xiaochuan Liu ◽  
Jaime Freitas ◽  
Dinghai Zheng ◽  
Marta S. Oliveira ◽  
Mainul Hoque ◽  
...  
Keyword(s):  
Transcription Elongation ◽  
Elongation Rate ◽  
Tissue Specific ◽  
Cleavage And Polyadenylation ◽  
Specific Impact

scholarly journals Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0194610 ◽  
Author(s):  
Lindsay M. Reynolds ◽  
Timothy D. Howard ◽  
Ingo Ruczinski ◽  
Kanika Kanchan ◽  
Michael C. Seeds ◽  
...  
Keyword(s):  
Gene Expression ◽  
Tissue Specific ◽  
Specific Impact

scholarly journals Mitochondrial Bioenergetic and Proteomic Phenotyping Reveals Organ-Specific Consequences of Chronic Kidney Disease in Mice

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3282
Author(s):  
Trace Thome ◽  
Madeline D. Coleman ◽  
Terence E. Ryan
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Protein Complexes ◽  
Mitochondrial Protein ◽  
Renal Tissue ◽  
Tissue Specific ◽  
Organ Specific ◽  
Proteomic Analyses ◽  
Reduced Kidney Function ◽  
Specific Impact

Chronic kidney disease (CKD) results in reduced kidney function, uremia, and accumulation of uremic metabolites. Mitochondrial alterations have been suggested to play a role in the disease pathology within various tissues. The purpose of this study was to perform a comprehensive bioenergetic and proteomic phenotyping of mitochondria from skeletal muscle (SkM), cardiac muscle (CM), and renal tissue from mice with CKD. The 5-month-old C57BL/6J male mice were fed a casein control or adenine-supplemented diet for 6 months. CKD was confirmed by blood urea nitrogen. A mitochondrial diagnostic workflow was employed to examine respiratory function, membrane and redox potential, reactive oxygen species production, and maximal activities of matrix dehydrogenases and electron transport system (ETS) protein complexes. Additionally, tandem-mass-tag-assisted proteomic analyses were performed to uncover possible differences in mitochondrial protein abundance. CKD negatively impacted mitochondrial energy transduction (all p < 0.05) in SkM, CM, and renal mitochondria, when assessed at physiologically relevant cellular energy demands (ΔGATP) and revealed the tissue-specific impact of CKD on mitochondrial health. Proteomic analyses indicated significant abundance changes in CM and renal mitochondria (115 and 164 proteins, p < 0.05), but no differences in SkM. Taken together, these findings reveal the tissue-specific impact of chronic renal insufficiency on mitochondrial health.

scholarly journals Tissue-specific impact of stem-loops and quadruplexes on cancer breakpoints formation

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Kseniia Cheloshkina ◽  
Maria Poptsova
Keyword(s):  
Tissue Specific ◽  
Specific Impact

Expression of sunflower cytochrome c mRNA is tissue-specific and controlled by nitrate and light

1997 ◽  
Vol 99 (2) ◽  
pp. 342-347 ◽  
Author(s):  
Silvina A. Felitti ◽  
Raquel L. Chan ◽  
Gabriela Gago ◽  
Estela M. Valle ◽  
Daniel H. Gonzalez
Keyword(s):  
Cytochrome C ◽  
Tissue Specific

Spatial expression profiling reveals tissue-specific sexual dimorphism of the natriuretic peptide system in mice

2014 ◽  
Author(s):  
Samantha Mirczuk ◽  
Camille Robson ◽  
Benjamin Robinson ◽  
Andrew Lessey ◽  
Victoria Lipscomb ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Natriuretic Peptide ◽  
Expression Profiling ◽  
Tissue Specific ◽  
Spatial Expression ◽  
Peptide System ◽  
Natriuretic Peptide System
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