scholarly journals Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

Oncotarget ◽  
2011 ◽  
Vol 2 (7) ◽  
pp. 551-556 ◽  
Author(s):  
Weibo Luo ◽  
Gregg L. Semenza
Keyword(s):  
Glucose Metabolism ◽  
Cancer Cells ◽  
Pyruvate Kinase ◽  
Hypoxia Inducible Factor ◽  
Pyruvate Kinase M2 ◽  
Hypoxia Inducible Factor 1

scholarly journals Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

Cell ◽  
2011 ◽  
Vol 145 (5) ◽  
pp. 732-744 ◽  
Author(s):  
Weibo Luo ◽  
Hongxia Hu ◽  
Ryan Chang ◽  
Jun Zhong ◽  
Matthew Knabel ◽  
...  
Keyword(s):  
Pyruvate Kinase ◽  
Hypoxia Inducible Factor ◽  
Pyruvate Kinase M2 ◽  
Hypoxia Inducible Factor 1

Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/β-catenin pathway in colon cancer cells

2015 ◽  
Vol 459 (2) ◽  
pp. 327-332 ◽  
Author(s):  
Peng Yang ◽  
Zongwei Li ◽  
Yingying Wang ◽  
Lichao Zhang ◽  
Haili Wu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Migration ◽  
Cancer Cells ◽  
Pyruvate Kinase ◽  
Colon Cancer Cells ◽  
Pyruvate Kinase M2

scholarly journals Berberine Inhibited the Proliferation of Cancer Cells by Suppressing the Activity of Tumor Pyruvate Kinase M2

2017 ◽  
Vol 12 (9) ◽  
pp. 1934578X1701200
Author(s):  
Zhichao Li ◽  
Hanqing Li ◽  
Yangxu Lu ◽  
Peng Yang ◽  
Zhuoyu Li
Keyword(s):  
Cancer Cells ◽  
Pyruvate Kinase ◽  
Aerobic Glycolysis ◽  
Isoquinoline Alkaloid ◽  
Therapeutic Drug ◽  
Pyruvate Kinase M2 ◽  
Anticancer Properties ◽  
Key Enzyme ◽  
Hct 116 ◽  
Dynamic Fluorescence

Berberine, an isoquinoline alkaloid extracted from coptis, exerts anti-proliferation and anticancer properties. Pyruvate kinase M2 (PKM2) is a key enzyme of aerobic glycolysis and considered as the potential anticancer target. However, the inhibition effects and interaction action between Berberine and PKM2 is not well known. In this study, berberine showed antitumor activity of HCT-116 and HeLa cells with the suppression of cell proliferation. Moreover, berberine inhibited the enzyme activity of PKM2 in cancer cells, but had no impact on PKM2 expression. Further research showed that the interaction between berberine and PKM2 was dynamic fluorescence quenching and the main intermolecular force was hydrogen bonding. These findings revealed that berberine may serve as a therapeutic drug for cancer chemotherapy.

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