scholarly journals Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms

Oncotarget ◽  
2015 ◽  
Vol 6 (34) ◽  
pp. 36319-36337 ◽  
Author(s):  
Pei-Li Yao ◽  
Li Ping Chen ◽  
Tomasz P. Dobrzański ◽  
Dylan A. Phillips ◽  
Bokai Zhu ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Embryonal Carcinoma ◽  
Carcinoma Cell ◽  
Retinoic Acid Receptor ◽  
Peroxisome Proliferator ◽  
Embryonal Carcinoma Cell ◽  
Peroxisome Proliferator Activated Receptor ◽  
Acid Receptor

Evidence that Shh cooperates with a retinoic acid inducible co-factor to establish ZPA-like activity

Development ◽  
1996 ◽  
Vol 122 (2) ◽  
pp. 537-542 ◽  
Author(s):  
T. Ogura ◽  
I.S. Alvarez ◽  
A. Vogel ◽  
C. Rodriguez ◽  
R.M. Evans ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Sonic Hedgehog ◽  
Embryonal Carcinoma ◽  
Carcinoma Cell ◽  
Retinoic Acid Receptor ◽  
Mirror Image ◽  
Limb Bud ◽  
Embryonal Carcinoma Cell ◽  
Embryonal Carcinoma Cell Line ◽  
Vertebrate Limb

Patterning across the anteroposterior axis of the vertebrate limb bud involves a signal from the polarizing region, a small group of cells at the posterior margin of the bud. Retinoic acid (RA; Tickle, C., Alberts, B., Wolpert, L. and Lee, J. (1982) Nature 296, 554–566) and Sonic hedgehog (Shh; Riddle, R. D. Johnson, R. L., Laufer, E. and Tabin, C. J. (1993) Cell 25, 1401–1416; Chang, D. T., Lopez, A., von Kessler, D. P., Chiang, C., Simandl, B. K., Zhao, R., Seldin, M. F., Fallon, J. F. and Beachy, P. A. (1994 Development 120, 3339–3353) have been independently postulated as such signals because they can mimic the mirror image digit duplication obtained after grafting polarizing cells to the anterior of limb buds. Here we show that a embryonal carcinoma cell line, P19, transfected with a Shh expression vector shows low polarizing activity, but when cultured with retinoic acid, duplications like those induced by the polarizing region (ZPA) arise. Complete duplications are also obtained by cotransfecting P19 Shh cells with a constitutively active human retinoic acid receptor (VP16-hRARalpha). These data suggest that Shh and RA cooperate in generating ZPA activity and that Shh, while essential, may not act alone in this process.

scholarly journals Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Ana Carolina Proença da Fonseca ◽  
Alan Cleveland Ochioni ◽  
Raisa da Silva Martins ◽  
Verônica Marques Zembrzuski ◽  
Mario Campos Junior ◽  
...  
Keyword(s):  
Body Weight ◽  
Retinoic Acid ◽  
Waist Circumference ◽  
Retinoic Acid Receptor ◽  
Case Group ◽  
Peroxisome Proliferator ◽  
Nutritional Disorder ◽  
Peroxisome Proliferator Activated Receptor ◽  
Acid Receptor ◽  
Genotype Frequencies

Obesity is the most common nutritional disorder. This disease is a multifactorial disease influenced by environmental and genetic factors. This study investigated the relationship between common variants of adiponectin (ADIPOQ), retinoic acid receptor responder 2 (RARRES2), and peroxisome proliferator-activated receptor-γ coativator-1 (PPARGC1) and obesity-related traits and susceptibility. A total of 167 individuals with obesity and 165 normal-weight subjects were recruited. Genotype frequencies of rs182052 in ADIPOQ differed significantly between the groups. Genotype AA was observed at a higher frequency in case than in control subjects. Association analysis showed that the A allele was a risk factor for obesity. This polymorphism was associated with body weight, body mass index (BMI), and waist circumference. After stratification by BMI, eutrophic individuals with AA or AG genotypes had higher body weights and waist circumferences than those with GG genotypes. In the case group, no associations were observed, except for stratified subjects with morbid obesity that exhibited a progressive increase of body weight, BMI, and waist circumference when rs182052 A was present. No associations were observed between SNPs in RARRES2 and PPARGC1 and obesity or any other studied variables. The rs182052 polymorphism in ADIPOQ is associated with a higher risk for obesity and obesity-related parameters.

A Widely Used Retinoic Acid Receptor Antagonist Induces Peroxisome Proliferator-Activated Receptor-γ Activity

2007 ◽  
Vol 71 (5) ◽  
pp. 1251-1257 ◽  
Author(s):  
Michael Schupp ◽  
Joshua C. Curtin ◽  
Roy J. Kim ◽  
Andrew N. Billin ◽  
Mitchell A. Lazar
Keyword(s):  
Retinoic Acid ◽  
Receptor Antagonist ◽  
Retinoic Acid Receptor ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Acid Receptor

Variations in parametrial white adipose tissue mass during the mouse estrous cycle: relationship with the expression of peroxisome proliferator-activated receptor-γ and retinoic acid receptor-α

2006 ◽  
Vol 84 (8-9) ◽  
pp. 887-892 ◽  
Author(s):  
Yaoting Gui ◽  
Zhiming Cai ◽  
Josef V. Silha ◽  
Liam J. Murphy
Keyword(s):  
Adipose Tissue ◽  
Retinoic Acid ◽  
Estrous Cycle ◽  
Retinoic Acid Receptor ◽  
Peroxisome Proliferator ◽  
Adipose Tissues ◽  
Peroxisome Proliferator Activated Receptor ◽  
Acid Receptor ◽  
Brown Adipose ◽  
Significant Difference

Estrogen and progestin participate in the regulation of adipose tissue metabolism, and peroxisome proliferator-activated receptor-gamma (PPARγ) and retinoic acid receptor-alpha (RXRα) are absolutely required for adipose tissue development. The present study is to investigate the changes in parametrial fat mass and expression of PPARγ and RXRα during estrous cycle in mice. Parametrial white adipose tissues (WAT), inter-scapula brown adipose tissues, and uteri from female mice were weighed. Blood samples were collected for the measurement of 17 β-estradiol and progesterone levels. An RNase protection assay and Western blot analysis were used to compare the expression of PPARγ and RXRα in adipose tissue. The mass of parametrial WAT in diestrus was significantly higher compared with estrus. However, there is no significant difference on the mass of brown adipose tissues during estrous cycle. The expression of PPARγ in WAT in diestrus was significantly higher than that in estrus. The expression of RXRα during estrous cycle was unchanged in both white and brown adipose tissues. In conclusion, the variation in parametrial WAT mass during the mouse estrous cycle correlates with changes in the expression of PPARγ in WAT.

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