Revisiting pathogenesis of protracted forms of serous otitis media

2021 ◽  
Vol 20 (5) ◽  
pp. 40-47
Author(s):  
S. Yu. Krotov ◽  
◽  
I. N. Putalova ◽  
Yu. A. Krotov ◽  
A. V. Pavlov ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Otitis Media ◽  
Middle Ear ◽  
Point Of View ◽  
Laboratory Animals ◽  
Mastoid Process ◽  
Regional Lymph Nodes ◽  
Male Wistar Rats ◽  
Primary Focus ◽  
Serous Otitis Media

The article is devoted to the role of the regional lymphatic system of the middle ear, from the point of view of the pathogenesis of the prolonged presence of fluid in the air cavities of the temporal bone with a prolonged course of serous otitis media. The study was carried out in an experiment on a model of exudative otitis media in laboratory animals (20 sexually mature male Wistar rats). Studied the state of regional (superficial, facial, and deep) lymph nodes collecting lymph from the mastoid process, tympanic cavity; external auditory canal, auditory tube. Comparative morphological and morphometric studies of lymph nodes were carried out on the 12th day of experimental otitis media and were assessed according to 19 criteria: total area of the node section, area of the capsule, marginal sinus, cortex, paracortex, medullary sinuses, medullary cords, number and area of primary and secondary lymphoid nodules, area of germinal centers, specific areas of cortical and medullary substance, sinus system, cortical/medullary ratio (C/M index), T- and B-dependent areas. Disorders of lymph outflow in the middle ear area, different nature, and degree of response of regional lymph nodes of different groups to the exudative process were revealed. It is assumed that the restructuring of the structural organization of the nodes, reflecting the inhibition of their protective and drainage functions, can prolong the phenomena of lymphostasis in the area of the primary focus and lead to the protracted course of exudative otitis media in clinical practice.

Serous Otitis Media

1973 ◽  
Vol 82 (3) ◽  
pp. 297-301 ◽  
Author(s):  
Robert W. Veltri ◽  
Philip M. Sprinkle
Keyword(s):  
Otitis Media ◽  
Eustachian Tube ◽  
Middle Ear ◽  
Secretory Iga ◽  
Secretory Cells ◽  
Sterile Condition ◽  
Local Synthesis ◽  
Serous Otitis Media ◽  
Inflammatory Insult ◽  
Partial Vacuum

The middle ear fluids of seven patients with bilateral, and five patients with unilateral serous otitis media (SOM), were demonstrated to be microbiologically sterile when assessed for the presence of bacteria, mycoplasma, viruses, and fungi. The concentrations of immunoglobulins G, M, A, D, and lysozyme (muramidase) were determined in the serum and middle ear fluids. Lysozyme levels of middle ear aspirates were found to be elevated in SOM patients. The elevated levels of lysozyme in combination with the antibody-containing classes of immunoglobulins may explain the microbiologically sterile condition of the middle ear fluids of SOM patients. Also, the elevated lysozyme concentrations in middle ear fluids may indicate the previous presence of neutrophils and hence a previous inflammatory insult. The increased levels of IgA demonstrated in middle ear fluids may indicate local synthesis of secretory IgA by secretory cells of Eustachian tube and middle ear. The closed Eustachian tube, partial vacuum conditions and absence of a portal of exit for accumulated serous fluids are offered as a possible explanation for SOM.

Impedance audiometry: Is it a wise investment?

PEDIATRICS ◽  
1976 ◽  
Vol 58 (2) ◽  
pp. 151-153
Author(s):  
Edward A. Mortimer
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Impedance Audiometry ◽  
Diagnosis And Management ◽  
Middle Ear Pressure ◽  
External Pressures ◽  
Serous Otitis Media

In this issue of Pediatrics there is a report1 of a method by which abnormalities of the middle ear that affect mobility of the drum, and therefore hearing, may be assessed quantitatively. In brief, the technique, called tympanometry, measures the compliance of the ear drum and, by ascertaining compliance at different external pressures, estimates pressures in the middle ear. The value to pediatricians and their patients of a means by which ear drum compliance and middle ear pressure can be measured lies primarily in the diagnosis and management of serous otitis media. Clearly, the data presented in this report indicate that this technique will usually discriminate between ears with middle ear effusions and normal ears.

scholarly journals Primary Inverted Papilloma of the Middle Ear

2021 ◽  
pp. 014556132110533
Author(s):  
Sarantis Blioskas ◽  
Iordanis Konstantinidis ◽  
Ioannis Antoniadis ◽  
Anastasia Kypriotou ◽  
Prodromos Hytiroglou ◽  
...  
Keyword(s):  
Otitis Media ◽  
Malignant Transformation ◽  
Middle Ear ◽  
Inverted Papilloma ◽  
Radiological Findings ◽  
Diagnostic Challenge ◽  
Recurrence Rates ◽  
Rare Finding ◽  
Local Destruction ◽  
Serous Otitis Media

Significance Statement: Primary middle ear inverted papilloma is an exceedingly rare finding posing a diagnostic challenge, as symptomatology often mimics common clinical entities like serous otitis media. Clinical and radiological findings are not specific, whilst high recurrence rates, local destruction, and potential malignant transformation constitute an overall demanding surgical challenge, requiring aggressive procedures. We report the case of a primary inverted papilloma of the middle ear, discussing diagnostic and therapeutic issues.

scholarly journals Classification and clinical features of chronic purulent otitis media

2019 ◽  
Vol 40 (1) ◽  
pp. 66-74
Author(s):  
A. D. Gusakov ◽  
A. A. Gusakova
Keyword(s):  
Hearing Loss ◽  
Otitis Media ◽  
Middle Ear ◽  
Personal Experience ◽  
Clinical Course ◽  
Point Of View ◽  
Control Data ◽  
Retraction Pocket ◽  
Radiological Control ◽  
Chronic Course

In this lecture information on the etiology, pathogenesis, and clinical course of chronic inflammation of the middle ear is systematized. The authors focus on the nature of the manifestations of otitis media, depending on the size and location of the perforation of the eardrum. Based on personal experience and accumulated knowledge, in detail reveal the issue of cholesteatoma, its precursors and possible complications. A lot of attention is paid to methods of examination and interpretation of audiometric and radiological control data. Speaking about the chronic course of the ear disease, the article describes frequently encountered situations such as tympanosclerosis, fistula, etc. In addition to their own point of view on the problem, the authors present literature data reflecting the views of other otorhinolaryngologists. Keywords: chronic otitis, hearing loss, cholesteatoma, retraction pocket, tympanosclerosis.

Middle Ear Cilia Activity as a Determinant of Tympanostomy Tube Placement

1986 ◽  
Vol 95 (4) ◽  
pp. 434-437 ◽  
Author(s):  
Douglas F. Wacker ◽  
Maridel L. Howe
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Tube Placement ◽  
Tympanostomy Tube ◽  
Future Health ◽  
The Future ◽  
Ventilating Tubes ◽  
Serous Otitis Media ◽  
Inferior Quadrant

Three hundred and twenty-six patients with diagnoses of serous otitis media—or mucold otitis medid—were reviewed for the presence or absence of middle ear cilia activity. This study strongly suggests that if active cilia can be observed, ventilating tubes are not needed. This easily observed activity in the anterior-inferior quadrant offers the otolaryngologist an accurate tool for determination of the future health of the middle ear.

Lactate Dehydrogenase Activity and Isoenzyme Patterns in Serous Middle Ear Effusions

1973 ◽  
Vol 82 (2) ◽  
pp. 192-195 ◽  
Author(s):  
S. K. Juhn ◽  
John S. Huff ◽  
Michael M. Paparella
Keyword(s):  
Lactate Dehydrogenase ◽  
Otitis Media ◽  
Middle Ear ◽  
Biochemical Characterization ◽  
Middle Ear Mucosa ◽  
Lactate Dehydrogenase Activity ◽  
Intracellular Enzyme ◽  
Ldh Activity ◽  
Serous Otitis Media ◽  
Isoenzyme Patterns

Biochemical characteristics of middle ear effusions (MEE) should provide a better understanding of the etiopathogenesis of serous otitis media. In order to develop another parameter for the biochemical characterization of the MEE, lactate dehydrogenase (LDH) and LDH isoenzyme patterns in the serous middle ear effusion and serum from 20 patients with serous otitis media were compared. The LDH activity was measured by the usual spectrophotometric method. The isoenzyme patterns were compared on electropherograms using cellulose polyacetate strips. The LDH activity in MEE was significantly higher (P < 0.001) than it was in serum. Fractions of isoenzymes 1 and 2 were each smaller in MEE than in serum. Isoenzymes 4 and 5 have a significantly higher (P < 0.001) fraction in MEE than in serum. Since LDH is an intracellular enzyme and middle ear mucosa is reported to have high content of isoenzymes 4 and 5, the inflammatory changes in the middle ear mucosa which may release intracellular LDH, are suggested as the cause of both higher activity of LDH and the higher fractions of isoenzymes 4 and 5 in MEE than those in the serum.

Atypical incus necrosis: a case report and literature review

2007 ◽  
Vol 122 (10) ◽  
pp. 1124-1126 ◽  
Author(s):  
N Choudhury ◽  
G Kumar ◽  
M Krishnan ◽  
D J Gatland
Keyword(s):  
Case Report ◽  
Otitis Media ◽  
Middle Ear ◽  
Chronic Otitis Media ◽  
Conductive Deafness ◽  
Ossicular Replacement ◽  
Stapes Footplate ◽  
History Of ◽  
Serous Otitis Media ◽  
Replacement Prosthesis

AbstractObjective:We report an atypical case of ossicular necrosis affecting the incus, in the absence of any history of chronic serous otitis media. We also discuss the current theories of incus necrosis.Case report:A male patient presented with a history of right unilateral hearing loss and tinnitus. Audiometry confirmed right conductive deafness; tympanometry was normal bilaterally. He underwent a right exploratory tympanotomy, which revealed atypical erosion of the proximal long process of the incus. Middle-ear examination was otherwise normal, with a mobile stapes footplate. The redundant long process of the incus was excised and a partial ossicular replacement prosthesis was inserted, resulting in improved hearing.Conclusion:Ossicular pathologies most commonly affect the incus. The commonest defect is an absent lenticular and distal long process of the incus, which is most commonly associated with chronic otitis media. This is the first reported case of ossicular necrosis, particularly of the proximal long process of the incus, in the absence of chronic middle-ear pathology.

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