scholarly journals Lower Confidence Limit for Mean Time between Failures in a System Featuring Repairable Components

2018 ◽  
Author(s):  
И.В. Павлов ◽  
◽  
С.В. Разгуляев ◽  
Keyword(s):  
Confidence Limit ◽  
Lower Confidence Limit ◽  
Mean Time Between Failures ◽  
Time Between Failures ◽  
Lower Confidence ◽  
Mean Time ◽  
Repairable Components

scholarly journals Lower Confidence Limit of Mean Time to Critical Failure of an Anthropogenic-Dangerous Object

2012 ◽  
Author(s):  
Г.С. Садыхов ◽  
◽  
И.А. Бабаев ◽  
О.В. Елисеева ◽  
◽  
...  
Keyword(s):  
Confidence Limit ◽  
Dangerous Object ◽  
Lower Confidence Limit ◽  
Lower Confidence ◽  
Mean Time

Review of Technological Advancements and HSE-Based Safety Model for Deep-Water Human Occupied Vehicles

2014 ◽  
Vol 48 (3) ◽  
pp. 25-42 ◽  
Author(s):  
Narayanaswamy Vedachalam ◽  
Gidugu Ananada Ramadass ◽  
Malayath Aravindakshan Atmanand
Keyword(s):  
Deep Water ◽  
Capital Expenditure ◽  
Mean Time Between Failures ◽  
Safety Integrity Level ◽  
Geological Surveys ◽  
Time Between Failures ◽  
High Resolution Bathymetry ◽  
Safety Systems ◽  
Mean Time ◽  
Safety And Environment

AbstractThis paper reviews the latest advancements in subsea technologies associated with the safety of deep-water human occupied vehicles. Human occupied submersible operations are required for deep-water activities, such as high-resolution bathymetry, biological and geological surveys, search activities, salvage operations, and engineering support for underwater operations. As this involves direct human presence, the system has to be extremely safe and reliable. Based on applicable IEC 61508 Standards for health, safety, and environment (HSE), the safety integrity level requirements for the submersible safety systems are estimated. Safety analyses are done on 10 critical submersible safety systems with the assumption that the submersible is utilized for 10 deep-water missions per year. The results of the analyses are compared with the estimated target HSE requirements, and it is found that, with the present technological maturity and safety-centered design, it is possible to meet the required safety integrity levels. By proper maintenance, it is possible to keep the mean time between failures to more than 9 years. The results presented shall serve as a model for designers to arrive at the required trade-off between the capital expenditure, operating expenditure, and required safety levels.

scholarly journals A Statistical State Analysis of a Marine Gas Turbine

Actuators ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 54 ◽  
Author(s):  
Suzana Lampreia ◽  
Valter Vairinhos ◽  
Victor Lobo ◽  
José Requeijo
Keyword(s):  
Gas Turbine ◽  
Point Of View ◽  
Operating Conditions ◽  
Environmental Data ◽  
Statistical Point ◽  
Mean Time Between Failures ◽  
Time Between Failures ◽  
Intervention Plan ◽  
Mean Time

This paper describes the analysis, from a statistical point of view, of a maritime gas turbine, under various operating conditions, so as to determine its state. The data used concerns several functioning parameters of the turbines, such as temperatures and vibrations, environmental data, such as surrounding temperature, and past failures or quasi-failures of the equipment. The determination of the Mean Time Between Failures (MTBF) gives a rough estimate of the state of the turbine, but in this paper we show that it can be greatly improved with graphical and statistical analysis of data measured during operation. We apply the Laplace Test and calculate the gas turbine reliability using that data, to define the gas turbine failure tendency. Using these techniques, we can have a better estimate of the turbine’s state, and design a preventive observation, inspection and intervention plan.

Comparison of the Mean Time Between Failures for Two Systems Under Short Tests

2009 ◽  
Vol 58 (4) ◽  
pp. 589-596 ◽  
Author(s):  
Y.H. Michlin ◽  
G.Y. Grabarnik ◽  
E. Leshchenko
Keyword(s):  
Mean Time Between Failures ◽  
Time Between Failures ◽  
Two Systems ◽  
The Mean ◽  
Mean Time

scholarly journals Phase 2 study of subcutaneous omacetaxine mepesuccinate after TKI failure in patients with chronic-phase CML with T315I mutation

Blood ◽  
2012 ◽  
Vol 120 (13) ◽  
pp. 2573-2580 ◽  
Author(s):  
Jorge Cortes ◽  
Jeff H. Lipton ◽  
Delphine Rea ◽  
Raghunadharao Digumarti ◽  
Charles Chuah ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Confidence Limit ◽  
Chronic Phase ◽  
Cytogenetic Response ◽  
Phase 2 ◽  
Lower Confidence Limit ◽  
Hematologic Response ◽  
Lower Confidence ◽  
Omacetaxine Mepesuccinate ◽  
T315i Mutation

Abstract Chronic myeloid leukemia (CML) patients with the BCR-ABL T315I mutation do not benefit from therapy with currently approved tyrosine kinase inhibitors. Omacetaxine mepesuccinate is a protein synthesis inhibitor that has demonstrated activity in cells harboring the T315I mutation. This phase 2 trial assessed the efficacy of omacetaxine in CML patients with T315I and tyrosine kinase inhibitor failure. Patients received subcutaneous omacetaxine 1.25 mg/m2 twice daily, days 1-14, every 28 days until hematologic response or a maximum of 6 cycles, and then days 1-7 every 28 days as maintenance. Results for patients treated in chronic phase are reported here. Patients (n = 62) received a median of 7 (range, 1-41) cycles. Complete hematologic response was achieved in 48 patients (77%; 95% lower confidence limit, 65%); median response duration was 9.1 months. Fourteen patients (23%; 95% lower confidence limit, 13%) achieved major cytogenetic response, including complete cytogenetic response in 10 (16%). Median progression free-survival was 7.7 months. Grade 3/4 hematologic toxicity included thrombocytopenia (76%), neutropenia (44%), and anemia (39%) and was typically manageable by dose reduction. Nonhematologic adverse events were mostly grade 1/2 and included infection (42%), diarrhea (40%), and nausea (34%). Omacetaxine may provide a safe and effective treatment for CML patients with T315I mutation. This study is registered at www.clinicaltrials.gov as NCT00375219.

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