scholarly journals Optimization of therapy in patients with lichen ruber planus by means of cranial electrotherapy stimulation

2021 ◽  
Vol 49 ◽  
Author(s):  
M. M. Tlish ◽  
P. S. Osmolovskaya
Keyword(s):  
Combination Therapy ◽  
Lichen Planus ◽  
Depression Scale ◽  
Anxiety Scale ◽  
Hamilton Depression Scale ◽  
Lichen Ruber ◽  
Cranial Electrotherapy Stimulation ◽  
Lichen Ruber Planus ◽  
Hamilton Anxiety Scale ◽  
Hamilton Anxiety

Rationale: Taking into account the significance of psychogenic factor in the onset of lichen planus, its correction is advisable. Transcranial electric stimulation is promising, given its autonomous regulating, analgesic, antipruritic, reparative and regenerative, and immunomodulatory effects, in addition to the anti-stress one.Aim: To assess the effectiveness of the combination therapy including cranial electrotherapy stimulation (CES) with lichen ruber planus.Materials and methods: This was an open label, prospective, comparative study in 61 patients with common typical form of lichen ruber planus (39 (63%) women and 22 (37%) men) aged 18 to 74 years (mean age 41 ± 14.29 years). The duration of the disease was 11.88 ± 10.15 months (range, 1 to 42 months). The patients were adaptively randomized into two groups of similar gender distribution, age, and disease duration. The patients in the comparison group (n = 30) were treated conventionally in accordance with the Federal Clinical Guidelines (chloroquine, hydroxyzine, topical corticosteroids). The main group (n = 31) was administered similar therapy; however, instead of hydroxyzine, CES was performed. The duration of in-patient treatment in both groups was 14 days, with the follow-up lasting for up to 3 months. The results of treatment were assessed by dynamics of pathological changes of the skin (Index of Lichen Planus, ILP), impact of dermatosis on various domains of the patient’s life (Dermatology Life Quality Index, DLQI), changes in psychological status (Hamilton Anxiety Scale and Hamilton Depression Scale). In addition, the impact of pruritus on the patients' daily activities was assessed by Behavioral Rating Scores questionnaire (BRS).Results: At baseline, there were no significant differences between the groups in ILP (p = 0.801), DLQI (p = 0.501), BRS (p = 0.521), Hamilton Anxiety Scale (p = 0.301), and Hamilton Depression Scale (p = 0.493). At the end of treatment, ILP in the CES group decreased 3.25-fold (p < 0.001), whereas in the group treated with conventional therapy the decrease was 2.1-fold (p < 0.001); DLQI decreased 2.5-fold (p < 0.001) and 1.8-fold (p < 0.001), respectively. The corresponding decreases of Hamilton Anxiety Scale in the treatment groups were 2.3-fold and 1.3-fold, respectively, and those in Hamilton Depression Scale – 2-fold and 1.6-fold, respectively (all p < 0.001). In addition, statistically significant intergroup differences were found for ILP (p = 0.04), DQLI (p < 0.001), Hamilton Anxiety and Depression scale scores (p = 0.021 and p = 0.006, respectively). As for the BRS changes, in both groups there was an equally significant (p < 0.001) decrease, but the intergroup differences were not statistically significant (p = 0.485).Conclusion: The proposed combination therapy of patients with lichen ruber planus including CES has led to a decrease in the indicators of the skin process activity within a shorter time period than in the patients under conventional treatment. In addition, the patients of both groups showed normalization of psychological parameters and improvement in dermatological quality of life; however, only in the CES group, these changes were significant.

The validity of the Melancholia Scale (MES) in predicting outcome of antidepressants in chronic idiopathic pain disorders

1991 ◽  
Vol 6 (3) ◽  
pp. 119-125 ◽  
Author(s):  
D Loldrup ◽  
M Langemark ◽  
HJ Hansen ◽  
M Kastrup ◽  
K Jeppesen ◽  
...  
Keyword(s):  
Construct Validity ◽  
Scale Score ◽  
Anxiety Scale ◽  
Full Recovery ◽  
Hamilton Depression Scale ◽  
Depressed Patients ◽  
Idiopathic Pain ◽  
Hamilton Anxiety Scale ◽  
Structure Evaluation ◽  
Hamilton Anxiety

SummaryIn patients with chronic idiopathic pain disorders we have analysed the construct validity of the Melancholia Scale as compared to the results with the scale in primary depression. The patients (n= 253) were treated in a placebo controlled trial with either clomipramine or mianserin independently of the Melancholia score. The construct validity of the Melancholia Scale was further analysed by the testing of the intensity model of depression versus anxiety using the Beck Depression Inventory, the Hamilton Anxiety Scale, the Spielberger State-Trait Anxiety Scale, and the Melancholia Scale. The construct validity in terms of scale homogeneity was analysed by Loevinger coefficients which can be considered as a latent structure evaluation. The Melancholia Scale showed acceptable homogeneity, while the Hamilton Anxiety Scale lacked sufficient homogeneity. In total, 33% of the patients had a score of 10 or more on the Melancholia Scale (corresponding to 13 or more on the Hamilton Depression Scale). The predictive validity of the Melancholia Scale was evaluated using active treatment versus placebo response after 6 weeks of therapy. It was shown that in patients with a Melancholia Scale score of 10 or more (corresponding to “less than major depression”) 72% had full recovery when treated with clomipramine, while 36% of the placebo treated patients obtained a full recovery (P≤0.05). The patients treated with mianserin obtained a full recovery in 52%. The group of patients with a Melancholia Scale score of 10 or more scored higher also on the anxiety scales indicating that the relation between depression and anxiety is a matter of severity. The depressed patients had significantly lower imipramine binding sites than the non-depressed patients.

Cognitive behavioral therapy for chronic migraine

2017 ◽  
Vol 41 (S1) ◽  
pp. s500-s500 ◽  
Author(s):  
O. Onur ◽  
D.H. Ertem ◽  
D. Uludüz ◽  
Ç. Karşıdağ
Keyword(s):  
Chronic Migraine ◽  
Psychological Treatment ◽  
Treatment Options ◽  
Depression Scale ◽  
Migraine Treatment ◽  
Hamilton Depression Scale ◽  
Post Traumatic Stress ◽  
Current Standard ◽  
Significant Difference ◽  
Hamilton Anxiety

AimAlthough current standard treatment for migraine headache is medication, high levels of psychological comorbidity has led to migraine influencing by cognitive, emotional and environmental factors, as well as biological. Viewing migraine in a biopsychosocial framework introduces the possible utilisation of psychological treatment options, such as cognitive behavioural therapy (CBT). The aim of this study was to evaluate the efficacy of CBT for chronic migraine.MethodologyThirty-five participants diagnosed as chronic migraine were recruited from Headache Clinic. According to inclusion criteria 14 participants, underwent bi-weekly lasting 30 minutes CBT sessions for 6 months, were administered Hamilton Anxiety Scale, Hamilton Depression Scale, Visual Analog Scale (VAS) and the Migraine Disability Assessment Scale (MİDAS) before and after CBT.FindingsNine of the participants were female and 5 male. Mean age of group was 34.35 ± 8.17. Duration of illness was 13.07 ± 7.18 and 12 of participants had the history of a psychiatry illness whose diagnoses were depression (7), anxiety disorder (4) and post-traumatic stress disorder (1). Nine of the patients had prophylactic migraine treatment. There were statistically significant difference in Hamilton Depression scores between before CBT (29.07 ± 7.74) and after CBT (14.21 ± 7.7); in Hamilton Anxiety scores before CBT (26.8 ± 11.7) and after CBT (11.7 ± 2.6); in VAS scores before CBT (8.07± 0.91) and after CBT (3.71 ± 1.32); in frequency of migraine attacks between before CBT (10.85 ± 3.50 day) and after CBT (4.92 ± 2.70 day) and in MİDAS before CBT (55.5 ± 20.4) and after CBT (20.12 ± 16.6) (P < 0.05).ConclusionCBT might reduce the severity of symptoms in migraine patients especially with the comorbidity of psychiatric illness.Disclosure of interestThe authors have not supplied their declaration of competing interest.

A Three-Month Double-Blind Study of Clobazam versus Diazepam in Out-Patients Suffering from Neurotic Disturbances

1979 ◽  
Vol 7 (5) ◽  
pp. 404-410 ◽  
Author(s):  
H P Schjønsby ◽  
A E Gordon ◽  
D Koeppen
Keyword(s):  
Global Assessment ◽  
Anxiety Scale ◽  
Double Blind Study ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Significant Difference ◽  
Hamilton Anxiety Scale ◽  
Period Data ◽  
The Individual ◽  
Hamilton Anxiety

Efficacy and safety of the 1,5 benzodiazepine, clobazam, in comparison to the 1,4 benzodiazepine, diazepam, were controlled in sixty psychiatric out-patients over a period of three months. In the course of this long treatment period data were obtained confirming findings of shorter-lasting studies. Global assessment of the therapeutic efficacy and the total scores of the Hamilton Anxiety Scale revealed no significant difference between the compounds. Both groups showed a significant (p < 0.01) improvement in the total scores of the Hamilton Anxiety Scale after two weeks of treatment. Scores of the individual items indicated distinct spectra of action: Clobazam was more effective in diminishing anxious mood, whereas diazepam was better able to influence muscular symptoms of anxiety. The relevance of the findings for a more individualized therapy is pointed out.

scholarly journals Treatment of mixed anxiety and depressive disorder: results from a observational study of the efficacy and tolerability of agomelatine

2021 ◽  
Vol 13 (6) ◽  
pp. 48-54
Author(s):  
D. S. Petelin ◽  
I. V. Niinoya ◽  
O. V. Sorokina ◽  
D. V. Troshina ◽  
O. N. Voskresenskaya ◽  
...  
Keyword(s):  
Depressive Disorder ◽  
Short Form ◽  
Depression Scale ◽  
Life Questionnaire ◽  
Hamilton Depression Scale ◽  
Depression And Anxiety ◽  
Workplace Performance ◽  
Symptoms Of Depression ◽  
Hamilton Anxiety Scale

Objective: to study the efficacy, safety and tolerability of agomelatine in mixed anxiety and depressive disorder.Patients and methods. Agomelatine was administered to 30 patients diagnosed with mixed anxiety and depressive disorder for 3 months. The patients' condition was assessed using a battery of psychometric methods – the Hamilton Depression Scale, the Hamilton Anxiety Scale, and a short form of the SF-12v2 quality of life questionnaire.Results and discussion. It was shown that agomelatine effectively reduces both symptoms of depression and anxiety, begins to have a therapeutic effect a week after the start of administration, however, the drug shows the best clinical effect when administered for a period of three months or more. The predictors of complete remission on agomelatine therapy in this sample were: the presence of sleep disorders (early and medium, but not late insomnia), a greater severity of somatized anxiety, the presence of complaints of decreased workplace performance and activity.Conclusion. Our study has shown that agomelatine is an effective, safe and well-tolerated drug in the treatment of mixed anxiety and depressive disorder.

scholarly journals Lichenoid vulvar dermatoses: clinical presentation, morphology, and dermatoscopic signs

2020 ◽  
Vol 4 (10) ◽  
pp. 617-624
Author(s):  
O.V. Parygina ◽  
◽  
I.O. Smirnova ◽  
M.V. Oganesyan ◽  
Y.G. Petunova ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Plasma Cell ◽  
Clinical Presentation ◽  
Diagnostic Errors ◽  
Lichen Sclerosus ◽  
Disease Evolution ◽  
Histological Pattern ◽  
Lichen Ruber ◽  
Lichen Simplex Chronicus ◽  
Lichen Ruber Planus

Lichenoid vulvar dermatoses are a heterogeneous group of diseases characterized by a number of overlapping signs and/or morphological features. Clinical similarity is accounted for by the appearance of small discrete papules with closely adjacent superficial squamae. The prototype of lichenoid dermatoses is lichen ruber planus. Histologically, lichenoid pattern is characterized by basal epithelial cell damage and a band-like infiltrate in the upper dermis. The International Society on Vulvovaginal Diseases categorizes lichen ruber planus and early lichen sclerosus as dermatoses with this histological pattern. Some authors also classify plasma cell (Zoon) vulvitis as lichenoid vulvar dermatoses. The cause of diagnostic errors lies in the similarity of the clinical and histological presentations of lichenoid vulvar dermatoses. Dermatoscopy should be considered as an additional diagnostic test. Only few studies address the key dermatoscopic signs of vulvar dermatoses. Histological study is important for the differential diagnosis. However, at some stages of disease evolution, vulvar dermatoses can have an overlapping histological pattern. This paper summarizes the data on the clinical, histological, and dermatoscopic presentation of the most common lichenoid vulvar dermatoses, i.e., lichen planus, lichen sclerosus, lichen simplex chronicus, and plasma cell vulvitis. KEYWORDS: lichenoid dermatoses, vulvar dermatoses, lichen sclerosus, lichen planus, lichen simplex chronicus, plasma cell vulvitis, Zoon vulvitis, dermoscopy. FOR CITATION: Parygina O.V., Smirnova I.O., Oganesyan M.V. et al. Lichenoid vulvar dermatoses: clinical presentation, morphology, and dermatoscopic signs. Russian Medical Inquiry. 2020;4(10):617–624. DOI: 10.32364/2587-6821-2020-4-10-617-624.

Treatment of Methadone Withdrawal with Cerebral Electrotherapy (Electrosleep)

1979 ◽  
Vol 134 (1) ◽  
pp. 111-113 ◽  
Author(s):  
Evaristo Gomez ◽  
Adib R. Mikhail
Keyword(s):  
Marked Reduction ◽  
Anxiety Scale ◽  
The Other ◽  
Control Group ◽  
Taylor Manifest Anxiety Scale ◽  
Before And After ◽  
Hamilton Anxiety Scale ◽  
Manifest Anxiety ◽  
Drug Free ◽  
Hamilton Anxiety

SummaryThe use of cerebral electrotherapy (CET) in methadone detoxification was studied in 28 patients. Fourteen patients received active CET; the other 14 acted as controls and received either simulated CET or only methadone detoxification therapy. One patient dropped out of the study. The Taylor Manifest Anxiety Scale and the Hamilton Anxiety Scale were administered before and after the study period. Nine of the patients receiving active CET were drug-free by the end of 8 to 10 days, and all experienced a marked reduction of their symptoms; the control group did not show significant changes. CET was clearly beneficial in the treatment of patients undergoing methadone withdrawal.

The Hamilton Anxiety Scale

1983 ◽  
Vol 5 (2) ◽  
pp. 163-170 ◽  
Author(s):  
A. Gjerris ◽  
P. Bech ◽  
S. Bøjholm ◽  
T.G. Bolwig ◽  
P. Kramp ◽  
...  
Keyword(s):  
Anxiety Scale ◽  
Hamilton Anxiety Scale ◽  
Hamilton Anxiety

scholarly journals Clinical Studies on Treatment of Earthquake-Caused Posttraumatic Stress Disorder Using Electroacupuncture

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Yu Wang ◽  
You-ping Hu ◽  
Wen-chun Wang ◽  
Ri-zhao Pang ◽  
An-ren Zhang
Keyword(s):  
Depression Scale ◽  
Treated Group ◽  
Acupuncture Group ◽  
Hamilton Depression Scale ◽  
Efficacy And Safety ◽  
Symptom Scale ◽  
Significant Efficacy ◽  
Hamilton Anxiety Scale ◽  
Ptsd Scale ◽  
Better Than

The objective of this study was to assess the efficacy and safety of electroacupuncture in 138 patients with earthquake-caused PTSD using Randomized Controlled Trials (RCTs). 138 cases enrolled were randomly assigned to an electro-acupuncture group and a paroxetine group. The electro-acupuncture group was treated by scalp electro-acupuncture on Baihui (GV 20), Sishencong (EX-HN 1), Shenting (GV 24), and Fengchi (GB 20), and the paroxetine group was treated with simple oral administration of paroxetine. The efficacy and safety of the electro-acupuncture on treatment of 69 PTSD patients were evaluated using Clinician-Administered PTSD Scale (CAPS), Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Treatment Emergent Symptom Scale (TESS) according to clinical data. The total scores of CAPS, HAMD, and HAMA in the two groups after treatment showed significant efficacy compared to those before treatment. The comparison of reduction in the scores of CAPS, HAMD, and HAMA between the two groups suggested that the efficacy in the treated group was better than that in the paroxetine group. The present study suggested that the electro-acupuncture and paroxetine groups have significant changes in test PTSD, but the electro-acupuncture 2 group was more significant.

The Effect of Mental State on EPI Scores

1977 ◽  
Vol 131 (3) ◽  
pp. 306-309 ◽  
Author(s):  
G. N. Bianchi ◽  
D. M. Fergusson
Keyword(s):  
Structural Equation Model ◽  
Mental State ◽  
Structural Equation ◽  
Equation Model ◽  
Anxiety Scale ◽  
Clinical Population ◽  
Hamilton Anxiety Scale ◽  
Hamilton Anxiety

SummaryThis paper develops a structural equation model to assess the effects of mental state on EPI scores. This model is applied to results obtained from a clinical population. The findings show that: (a) the E scale is not influenced by mental state as measured by the Hamilton Anxiety Scale (HAS); (b) the N scale is influenced by HAS. An attempt to revise the N scale to produce an un-contaminated score is discussed.

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