Evaluation of Blood Lactate Concentration in Dogs Receiving Whole Blood Transfusion

2020 ◽  
Author(s):  
B. Zakarevičiūtė ◽  
D. Juodžentė ◽  
B. Karvelienė ◽  
S. Čechovičienė ◽  
V. Riškevičienė
Keyword(s):  
Blood Transfusion ◽  
Blood Lactate ◽  
Whole Blood ◽  
Blood Cells ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Control Group ◽  
Patient Status ◽  
Group I ◽  
Life Saving

Background: A blood transfusion is a routine, life-saving procedure used to replace blood cells or blood products. The current study was aimed to assess whether the blood lactate concentration has a prognostic value of successful blood transfusion.Methods: During the period 2018-2019 group I dogs (n=19) received whole blood transfusion and twenty dogs were assigned to the control group (group II). Blood samples in group I were obtained from cephalic vein before blood transfusion (T0), then after it was finished (4hr±20 min) (T1) and 24hr±20 min after the T0 (T2).Result: The level of blood lactate reached the normal level after blood transfusion in T1 and T2. The clearance of lactate had a moderate negative correlation with packed cell volume (PCV) and red blood cells (RBC). There was no significant correlation between survival rate and blood lactate level. The survivals 24hr after transfusion (T2) had five times higher count of reticulocytes (RETIC) then non-survivals. Serial blood lactate measurement can improve the prediction of successful blood transfusion and it is useful in monitoring the patient status 24hr post blood transfusion, but it doesn’t have the predictive value of survival.

Optimal Adrenergic Support in Septic Shock Due to Peritonitis

2003 ◽  
Vol 98 (4) ◽  
pp. 888-896 ◽  
Author(s):  
Qinghua Sun ◽  
Zizhi Tu ◽  
Suzana Lobo ◽  
George Dimopoulos ◽  
Nathalie Nagy ◽  
...  
Keyword(s):  
Septic Shock ◽  
Cardiac Output ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Blood Lactate ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
The Other ◽  
Control Group ◽  
Lower Blood

Background The authors evaluated optimal adrenergic support using norepinephrine, dopamine, and dobutamine in a clinically relevant model of septic shock. Methods Twenty-eight mature, female, anesthetized sheep (weight, 30.5 +/- 3.6 kg) underwent cecal ligation and perforation and were randomized into four groups of seven animals to be treated with norepinephrine, dopamine-norepinephrine, dobutamine-norepinephrine, or no adrenergic agent. In all groups, lactated Ringer's solution was administered to restore cardiac filling pressures to baseline. In the norepinephrine group, norepinephrine (0.5-5 microg. kg(-1). min(-1)) was titrated to maintain mean arterial pressure between 75-85 mmHg. In the dopamine-norepinephrine group, dopamine was given first, and norepinephrine was added only when mean arterial pressure remained below 75 mmHg despite the infusion of 20 microg. kg(-1). min(-1) dopamine. In the dobutamine-norepinephrine group, dobutamine was started at the same time as norepinephrine and titrated up to 20 microg. kg(-1). min(-1) to get a 15% increase in cardiac output. Results The dobutamine-norepinephrine group had greater cardiac output; superior mesenteric blood flow, oxygen delivery (Do(2)), and oxygen consumption ([OV0312]o(2)); and lower blood lactate concentration and partial pressure of carbon dioxide (Pco(2)) gap than the controls did. Cumulative urine output was significantly higher in the dobutamine-norepinephrine group than in the other groups. Survival time was significantly longer in the dobutamine-norepinephrine (24 +/- 4 h), dopamine- norepinephrine (24 +/- 6 h), and norepinephrine (20 +/- 1 h) groups than the control group (17 +/- 2 h; P < 0.05 vs. other groups), and significantly longer in the combined dopamine-norepinephrine and dobutamine-norepinephrine groups (24 +/- 5 h) than in the norepinephrine alone group (P < 0.05). Histologic examination of lung biopsies revealed less severe lesions in the dobutamine-norepinephrine group than in the control and norepinephrine alone groups. Anatomic alterations in the lung, liver, and small intestine were less severe in the dobutamine-norepinephrine group than in the other groups. Conclusions In this prolonged septic shock model, association of norepinephrine with either dopamine or dobutamine resulted in the longest survival and the least severe pulmonary lesions. The combination of dobutamine with norepinephrine was associated with a better myocardial performance, greater Do(2) and [OV0312]o(2), lower blood lactate concentration and Pco(2) gap, and less anatomic injury.

scholarly journals La privación de sueño no afecta la resistencia aeróbica ni la concentración de lactato en sangre de jóvenes deportistas (Sleep deprivation does not affect aerobic resistance or blood lactate concentration of young athletes)

Retos ◽  
2018 ◽  
pp. 221-223
Author(s):  
Jorge Alberto Aburto Corona ◽  
Tatiana Miranda Núñez ◽  
Alicia Bárcenas Ugalde ◽  
Roberto Espinoza Gutiérrez ◽  
Emilio Manuel Arrayales Millán
Keyword(s):  
Sleep Deprivation ◽  
Blood Lactate ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Aerobic Performance ◽  
Control Group ◽  
Experimental Conditions ◽  
Male Athletes ◽  
Physical Test ◽  
Significant Difference

El objetivo de este estudio fue determinar si la resistencia aeróbica y la concentración de lactato en sangre, pueden ser influenciados por la privación parcial o total del sueño en un grupo de deportistas. Se reclutaron 13 deportistas masculinos (21.8 ± 2.9 años de edad) los cuales fueron sometidos a tres condiciones experimentales: dormir cuatro horas (D4H), no dormir (0H) y una condición contol de dormir ocho horas (D8H). No se encontraron diferencias estadísticamente significativas en la resistencia aeróbica (p=.845). De la misma manera, no se halló diferencia significativa en la concentración de lactato en sangre (p>.05). Estos resultados señalan que la privación parcial (dormir cuatro horas) o total (no dormir) del sueño, previo a una prueba física, no es un factor que influya en el rendimiento aeróbico ni en la concentración de lactato en sangre en comparación a la cantidad de horas de sueño recomendadas (dormir ocho horas).Abstract. The purpose of this study was to determinate if aerobic performance and blood lactate concentration are influenced by partial or total sleep deprivation. Thirteen male athletes (age: 21.8 ± 2.9 y.o) were randomly assigned to three experimental conditions: sleep four hours (D4H), no sleep (0H), and sleep eigth hours (D8H, control group). No significant difference was found in the aerobic performance (p=.845). Similarly, there was no sifnificant difference in blood lactate concentration (p>.05). This results suggest that partial (sleep four hours) or total (no sleep) sleep deprivation before a physical test are not a factor influencing aerobic performance or blood lactate concentration compared to the amount of recommended hours of sleep (sleep eight hours).

Beta-adrenergic blockade does not prevent the lactate response to exercise after acclimatization to high altitude

1994 ◽  
Vol 76 (2) ◽  
pp. 610-615 ◽  
Author(s):  
R. S. Mazzeo ◽  
G. A. Brooks ◽  
G. E. Butterfield ◽  
A. Cymerman ◽  
A. C. Roberts ◽  
...  
Keyword(s):  
High Altitude ◽  
Sea Level ◽  
Blood Lactate ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Control Group ◽  
Adrenergic Blockade ◽  
Arterial O2 Saturation ◽  
Response To Exercise ◽  
Peak Blood

We examined the extent to which epinephrine influences blood lactate adjustments to exercise during both acute (AC) and chronic (CH) high-altitude exposure. Eleven male sea level residents were divided into a control group (n = 5) receiving a placebo or a drug group (n = 6) receiving 240 mg/day of propranolol. All subjects were studied at rest and during 45 min of submaximal exercise (approximately 50% of sea level maximal O2 uptake) at sea level (SL) and within 4 h of exposure to and after 3 wk residence at 4,300 m (summit of Pikes Peak). Blood samples were collected from the femoral artery for epinephrine and lactate concentration. Exercising blood lactate concentration was significantly different across all altitude conditions such that AC > CH > SL (P < 0.05). For a given arterial O2 saturation, mean exercising blood lactates were lower for the beta-blocked group compared with controls; however, both groups demonstrated similar patterns across all conditions. Epinephrine levels during exercise followed a similar pattern to that of lactate, averaging 0.67, 0.43, and 0.29 ng/ml for AC, CH, and SL, respectively. The correlation between lactate and epinephrine was 0.93 and 0.84 for control and beta-blocked subjects, respectively. Whereas during exercise epinephrine was consistently higher for the beta-blocked group than controls, this difference was only significant during CH exposure. The epinephrine response was related to the extent of hypoxia in both groups.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Effects of Ball Drills and Repeated-Sprint-Ability Training in Basketball Players

2019 ◽  
Vol 14 (6) ◽  
pp. 757-764 ◽  
Author(s):  
Martina A. Maggioni ◽  
Matteo Bonato ◽  
Alexander Stahn ◽  
Antonio La Torre ◽  
Luca Agnello ◽  
...  
Keyword(s):  
Blood Lactate ◽  
Physical Performance ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Technical Skills ◽  
Control Group ◽  
Basketball Players ◽  
Repeated Sprint Ability ◽  
Repeated Sprint ◽  
Sprint Ability

Purpose: To investigate the effects of ball drills and repeated-sprint-ability training during the regular season in basketball players. Methods: A total of 30 players were randomized into 3 groups: ball-drills training (BDT, n = 12, 4 × 4 min, 3 vs 3 with 3-min passive recovery), repeated-sprint-ability training (RSAT, n = 9, 3 × 6 × 20-m shuttle running with 20-s and 4-min recovery), and general basketball training (n = 9, basketball technical/tactical exercises), as control group. Players were tested before and after 8 wk of training using the following tests: , squat jump, countermovement jump, Yo-Yo Intermittent Recovery Test Level 1 (YIRT1), agility T test, line-drill test, 5-/10-/20-m sprints, and blood lactate concentration. A custom-developed survey was used to analyze players’ technical skills. Results: After training, significant improvements were seen in YIRT1 (BDT P = .014, effect size [ES] ± 90% CI = 0.8 ± 0.3; RSAT P = .022, ES ± 90% CI = 0.7 ± 0.3), the agility T test (BDT P = .018, ES ± 90% CI = 0.7 ± 0.5; RSAT P = .037, ES ± 90% CI = 0.7 ± 0.5), and the line-drill test (BDT P = .010, ES ± 90% CI = 0.3 ± 0.1; RSAT P < .0001, ES ± 90% CI = 0.4 ± 0.1). In the RSAT group, only 10-m sprint speeds (P = .039, ES ± 90% CI = 0.3 ± 0.2) and blood lactate concentration (P = .004, ES ± 90% CI = 0.8 ± 1.1) were improved. Finally, technical skills were increased in BDT regarding dribbling (P = .038, ES ± 90% CI = 0.8 ± 0.6), shooting (P = .036, ES ± 90% CI = 0.8 ± 0.8), passing (P = .034, ES ± 90% CI = 0.9 ± 0.3), rebounding (P = .023, ES ± 90% CI = 1.1 ± 0.3), defense (P = .042, ES ± 90% CI = 0.5 ± 0.5), and offense (P = .044, ES ± 90% CI = 0.4 ± 0.4) skills. Conclusions: BDT and RSAT are both effective in improving the physical performance of basketball players. BDT had also a positive impact on technical skills. Basketball strength and conditioning professionals should include BDT as a routine tool to improve technical skills and physical performance simultaneously throughout the regular training season.

Effects of 2 Intersection Strategies for Physical Recovery in Jiu-Jitsu Athletes

2020 ◽  
pp. 1-6
Author(s):  
Eurico P. César ◽  
Cleito S.R. Júnior ◽  
Raphael N. Francisco
Keyword(s):  
Grip Strength ◽  
Blood Lactate ◽  
Handgrip Strength ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Strength Test ◽  
Time Effect ◽  
Control Group ◽  
Lactate Levels ◽  
Blood Lactate Levels

Purpose: To compare the effect of static stretching (SS) and cold-water immersion (CWI) on strength performance and blood lactate levels of jiu-jitsu athletes. Methods: A total of 21 male Brazilian jiu-jitsu fighters were randomly assigned to SS (9 × 30-s carpal extension), CWI (3 × 3 min at 10°C), or a control group (CG); their maximal handgrip strength, handgrip muscle endurance, dynamic kimono grip strength test, and blood lactate concentration were assessed before and after a simulated Brazilian jiu-jitsu fight and after one of the recovery interventions. Results: There was an interaction (F = 9.075; P = .002) and a time effect (F = 11.792; P = .003) for dynamic kimono grip strength test, showing a decrease in performance for the CG (P = .0001; effect size [ES] = 0.52, moderate) and after SS (P = .006; ES = 0.43, small). There was an interaction (F = 3.592; P = .015) and a time effect (F = 122.631; P = .0001) for blood lactate concentration, showing lower levels after CWI versus CG (P = .028; ES = 0.93, moderate) and after CWI versus SS (P = .042; ES = 0.82, moderate). There was an interaction (F = 9.617; P = .001) for handgrip strength, showing an impairment in performance after SS (P = .001; ES = 0.67, moderate). Conclusion: CWI promoted restoration of muscle strength and endurance and reduction in blood lactate levels after the simulated fight and can thus be used by jiu-jitsu athletes as a recovery strategy between fights.

A Common Polymorphism of the MCT1 Gene and Athletic Performance

2014 ◽  
Vol 9 (1) ◽  
pp. 173-180 ◽  
Author(s):  
Olga N. Fedotovskaya ◽  
Leysan J. Mustafina ◽  
Daniil V. Popov ◽  
Olga L. Vinogradova ◽  
Ildus I. Ahmetov
Keyword(s):  
Blood Lactate ◽  
Maximal Oxygen Consumption ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Monocarboxylate Transporter ◽  
Control Group ◽  
Monocarboxylate Transporter 1 ◽  
Rowing Ergometer ◽  
Pcr Rflp ◽  
Genotype And Allele Frequencies

Purpose:In red skeletal muscle, monocarboxylate transporter 1 (MCT1) is required for lactate to enter the myocytes for oxidation. The A1470T polymorphism (rs1049434) in the MCT1 gene was shown to be associated with lactate transport rates in human skeletal muscles. The aim of the study was to compare genotype and allele frequencies of the MCT1 gene polymorphism in 323 Russian athletes and 467 nonathletic controls and to investigate the association of the MCT1 gene A1470T polymorphism with maximal oxygen consumption and maximal lactate concentration in rowers (n = 79).Methods:Genotyping for the A1470T MCT1 polymorphism was performed by PCR-RFLP method. Physiological measurements of 79 Russian rowers of national competitive standard were determined during an incremental test to exhaustion on a rowing ergometer.Results:Frequencies of the A allele (71.8% vs 62.5%, P < .0001) and AA genotype (59.8% vs 39.4%, P < .0001) were significantly higher in endurance-oriented athletes (n = 142) than in the control group. Mean blood lactate concentration was higher in male rowers with the T allele (AT+TT 10.26 ± 1.89 mmol/L, AA 8.75 ± 1.69 mmol/L, P = .005).Conclusions:MCT1 gene A1470T polymorphism is associated with endurance athlete status and blood lactate level after intensive exercise.

The influence of execution speed on blood lactate concentration in strength training protocol in bench press exercise

2020 ◽  
Vol 19 (1) ◽  
pp. 32
Author(s):  
Gustavo Taques Marczynski ◽  
Luís Carlos Zattar Coelho ◽  
Leonardo Emmanuel De Medeiros Lima ◽  
Rodrigo Pereira Da Silva ◽  
Dilmar Pinto Guedes Jr ◽  
...  
Keyword(s):  
Strength Training ◽  
Blood Lactate ◽  
Bench Press ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
The Third ◽  
Fast Speed ◽  
Work Volume ◽  
Execution Speed ◽  
Training Protocol

The aim of this study was to analyze the influence of two velocities of execution relative to blood lactate concentration in strength training exercise until the momentary concentric failure. Fifteen men (29.1 ± 5.9 years), trained, participated in the experiment. The volunteers performed three bench press sessions, with an interval of 48 hours between them. At the first session, individuals determined loads through the 10-12 RMs test. In the following two sessions, three series with 90 seconds of interval were performed, in the second session slow execution speed (cadence 3030) and later in the third session fast speed (cadence 1010). For statistical analysis, the Student-T test was used for an independent sample study and considered the value of probability (p) ≤ 0.05 statistically significant. By comparing the number of repetitions and time under tension of the two runs, all series compared to the first presented significant reductions (p < 0.05). The total work volume was higher with the fast speed (p < 0.05). The study revealed that rapid velocities (cadence 1010) present a higher concentration of blood lactate when compared to slow runs (cadence 3030). The blood lactate concentration, in maximum repetitions, is affected by the speed of execution.Keywords: resistance training, cadence, blood lactate.

Effects of cocaine on incremental treadmill exercise in horses

1993 ◽  
Vol 75 (6) ◽  
pp. 2727-2733 ◽  
Author(s):  
K. H. McKeever ◽  
K. W. Hinchcliff ◽  
D. F. Gerken ◽  
R. A. Sams
Keyword(s):  
Right Ventricular ◽  
Blood Lactate ◽  
Venous Blood ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Ventricular Pressure ◽  
Mixed Venous Blood ◽  
Work Intensity ◽  
Venous Blood Lactate ◽  
Mixed Venous

Four mature horses were used to test the effects of two doses (50 and 200 mg) of intravenously administered cocaine on hemodynamics and selected indexes of performance [maximal heart rate (HRmax), treadmill velocity at HRmax, treadmill velocity needed to produce a blood lactate concentration of 4 mmol/l, maximal mixed venous blood lactate concentration, maximal treadmill work intensity, and test duration] measured during an incremental treadmill test. Both doses of cocaine increased HRmax approximately 7% (P < 0.05). Mean arterial pressure was 30 mmHg greater (P < 0.05) during the 4- to 7-m/s steps of the exercise test in the 200-mg trial. Neither dose of cocaine had an effect on the responses to exertion of right atrial pressure, right ventricular pressure, or maximal change in right ventricular pressure over time. Maximal mixed venous blood lactate concentration increased 41% (P < 0.05) with the 50-mg dose and 75% (P < 0.05) with the 200-mg dose during exercise. Administration of cocaine resulted in decreases (P < 0.05) in the treadmill velocity needed to produce a blood lactate concentration of 4 mmol/l from 6.9 +/- 0.5 and 6.8 +/- 0.9 m/s during the control trials to 4.4 +/- 0.1 m/s during the 200-mg cocaine trial. Cocaine did not alter maximal treadmill work intensity (P > 0.05); however, time to exhaustion increased by approximately 92 s (15%; P < 0.05) during the 200-mg trial.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Peripheral Modulators of the Central Fatigue Development and Their Relationship with Athletic Performance in Jumper Horses

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 743
Author(s):  
Francesca Arfuso ◽  
Claudia Giannetto ◽  
Elisabetta Giudice ◽  
Francesco Fazio ◽  
Michele Panzera ◽  
...  
Keyword(s):  
Blood Lactate ◽  
Athletic Performance ◽  
Lactate Concentration ◽  
Indirect Evidence ◽  
Blood Lactate Concentration ◽  
Central Fatigue ◽  
Serotoninergic System ◽  
Stressful Situation ◽  
Passive Behavior ◽  
Fatigue Development

The current study aimed to investigate whether peripheral modulators of serotoninergic function and neurohumoral factors’ changes in athletic horses during an official jumping competition, and to evaluate their relationship with the physical performance of competing horses. From 7 Italian Saddle mares (6–9 years; mean body weight 440 ± 15 kg), performing the same standardized warm-up and jumping course during an official class, heart rate (HR) was monitored throughout the competition. Rectal temperature (RT) measurement, blood lactate and glucose concentration, serum tryptophan, leucine, valine, the tryptophan/branched-chain amino-acids ratio (Try/BCAAs), dopamine, prolactin, and non-esterified fatty acids (NEFAs) were assessed before the exercise event (T0), at the end of the competition stage (5 min ± 10 s following the cessation of the exercise, TPOST5), and 30 min after the end of competition (TPOST30). Highest HR values were recorded during the course and at the outbound (p < 0.0001); blood lactate concentration and RT increased after exercise with respect to the rest condition (p < 0.0001). Lower leucine and valine levels (p < 0.01), and higher tryptophan, Try/BCAAs ratio, and NEFAs values were found at TPOST5 and TPOST30 with respect to T0 (p < 0.0001). A higher prolactin concentration was found at TPOST5 and TPOST30 compared to T0 (p < 0.0001), whereas dopamine showed decreased values after exercise compared to rest (p < 0.0001). Statistically significant correlations among the peripheral indices of serotoninergic function, neurohumoral factors, and athletic performance parameters were found throughout the monitoring period. The findings provide indirect evidence that the serotoninergic system may be involved in fatigue during jumper exercise under a stressful situation, such as competition, in which, in addition to physical effort, athletic horses exhibit more passive behavior.

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