Cytokine response to killed Staphylococcus pseudintermedius antigen in dogs with skin diseases

2019 ◽  
Author(s):  
M. Ananda Chitra ◽  
Hridya Susan Varughese ◽  
Ranjani Rajasekaran ◽  
S. Rajalakshmi ◽  
G. Dhinakar Raj
Keyword(s):  
Quantitative Pcr ◽  
Skin Infection ◽  
Skin Diseases ◽  
Housekeeping Gene ◽  
The Other ◽  
Measurable Quantity ◽  
Th2 Response ◽  
Healthy Control ◽  
Underlying Causes ◽  
High Level

The attempt was made to study the response of the dog having skin infection with various underlying causes to killed S.pseudintermedius antigen. PBMC were separated and sensitized with killed S. pseudintermedius for 24 hours. cDNA was made from extracted RNA and quantitative PCR were carried out for 8 cytokines with GAPDH as housekeeping gene. IL-6 was the cytokine which was expressed in a statistically significant high level in PBMC of healthy animals to killed antigen than PBMC of infected animals. Except for the IL-6, all other cytokines were expressed at high level in pyoderma animals than healthy control, demodicosis and allergy cases. In the present study, IL-1â, IL-8 and TNF-á were the cytokines that were up-regulated and, IL-6 and IFN-ã were down-regulated in demodicosis dogs with pyoderma at apparently significant level than the other tested cytokines. IL-4 was the only cytokine that was expressed in measurable quantity in allergic cases when compared to other cytokines. Thus, it was concluded that dogs with staphylococcal pyoderma infections developed a Th1/Th2 response to fight the infection.

scholarly journals 217 PROFIL PIODERMA PADA ANAK DI POLIKLINIK KULIT DAN KELAMINRSUP PROF. DR. R. D. KANDOU MANADO PERIODE JANUARI-DESEMBER 2012

e-CliniC ◽  
2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Caren C.a Pangow ◽  
Herry E. J. Pandaleke ◽  
Renate T. Kandou
Keyword(s):  
Nutritional Status ◽  
Skin Infection ◽  
Skin Diseases ◽  
Topical Therapy ◽  
Secondary Data ◽  
Infected Group ◽  
Number Of Patients ◽  
High Level ◽  
Infectious Skin Diseases ◽  
Systemic Antibiotics

Abstract: Pyoderma is a skin infection caused byeither or both of staphylococcus and streptococcus bacteria. This infectious skin diseases are still the main problem of high level morbidity cases in children, especially indeveloping countries with topical climate including Indonesia. This study’s goal to gain pyoderma patients profile in children at the dermatovenereology clinic of Prof. Dr R. D. Kandou General Hospital Manado during the period from January - December 2012. This is a retrospectivedescriptive study from the secondary data of pyoderma’spatient in children, based on the number of patients, sex, age, diagnose, nutritional status, and therapy. The results showed that of pyoderma’s cases in children during January - Decemberwas fifty three cases (16,51%). The distribution based on sex mostly on female (56,6%), based on age infected group mostly on 1-4 years old (43,4%). The majortypes of pyoderma isimpetigo (58,5%). The distributionbased on nutritional status mostly on well-nourished (64,7%). There were thirty fivepatients (66%) givensystemic antibiotic with topical therapy.The most systemic antibiotics therapy used was erythromycin (62,2%), and the most topical therapy used was fusidic acid (34 %).Keywords: pyoderma, childrenAbstrak: Pioderma adalah infeksi kulit yang disebabkan oleh kuman staphylococcus, streptococcus atau keduanya.Penyakit infeksi kulit masih merupakan masalah utama penyebab tingginya angka morbiditas pada anak-anak terutama di negara-negara berkembang dan wilayah beriklim tropis, termasuk di Indonesia.Tujuan penelitian ini untuk mengetahui profil pasien pioderma pada anak di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2012 – Desember 2012. Penelitian ini merupakan penelitian deskriptif retrospektif dari data sekunder pasien pioderma anak (umur 0-14 tahun) berdasarkan jumlah pasien, umur, jenis kelamin, diagnosis, status gizi, dan terapi. Hasil penelitian menunjukkan bahwa pioderma pada anak periode januari – desember 2012 sebanyak 53 kasus (16,51%). Distribusi menurut jenis kelamin terbanyak pada perempuan (35,6 %) dan menurut umur terbanyak adalah kelompok umur 1-4 tahun (43,4%). Jenis pioderma terbanyak adalah impetigo (58,5%). Distribusi menurut status gizi terbanyak adalah bergizi baik (64,7%). Sebanyak 35 pasien (66%) diberikan terapi antibiotik sistemik dengan topikal. Terapi antibiotik sistemik terbanyak yang digunakan adalah eritromisin (62,2%), dan topikal yang paling sering digunakan adalah asam fusidat (34%).Kata kunci: pioderma, anak

Ethics in the Judiciary System of Bangladesh

1970 ◽  
Vol 1 (2) ◽  
pp. 34-36
Author(s):  
Mehedi Imam
Keyword(s):  
Rule Of Law ◽  
Judicial Independence ◽  
Moral Values ◽  
The Other ◽  
Considerable Time ◽  
Ethical Knowledge ◽  
Judicial Practice ◽  
Independent Judiciary ◽  
Role Players ◽  
High Level

In Bangladesh, demand for judicial independence in practice has been a much debated issue and the demand is fulfilled but expectation of people is not only limited to have an independent judiciary but to have an impartial system and cadre of people, which will administer justice rationally being free from fear or force. The independence of judiciary and the impartial judicial practice are related concepts, one cannot sustain without the other and here existence as well as the need of practicing impartiality is well recognized. But the art of practicing impartiality does not develop overnight as it’s related to development of one’s attitude. It takes a considerable time resulting from understanding, appreciating and acknowledging the moral values, ethics and professional responsibility. The judiciary includes Judges, Advocates mostly who are expected to demonstrate a high level of moral values and impartiality towards people seeking justice and ‘rule of law’. This is true that bench officers and clerks are also part of the process to ensure rule of law with same level of participation by the law enforcing agencies such as police. However the paper includes only those who either join judiciary as Judge/Magistrate or Advocate to explore level and extent of ethical knowledge they receive being key role players of the system. DOI: http://dx.doi.org/10.3329/bioethics.v1i2.9628 Bangladesh Journal of Bioethics 2010; 1(2): 34-36

scholarly journals AI-based localization and classification of skin disease with erythema

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ha Min Son ◽  
Wooho Jeon ◽  
Jinhyun Kim ◽  
Chan Yeong Heo ◽  
Hye Jin Yoon ◽  
...  
Keyword(s):  
Neural Network ◽  
Skin Diseases ◽  
Classification Model ◽  
Screening Tests ◽  
Sensitivity Score ◽  
Common Skin ◽  
Novel Method ◽  
Improved Performance ◽  
High Level

AbstractAlthough computer-aided diagnosis (CAD) is used to improve the quality of diagnosis in various medical fields such as mammography and colonography, it is not used in dermatology, where noninvasive screening tests are performed only with the naked eye, and avoidable inaccuracies may exist. This study shows that CAD may also be a viable option in dermatology by presenting a novel method to sequentially combine accurate segmentation and classification models. Given an image of the skin, we decompose the image to normalize and extract high-level features. Using a neural network-based segmentation model to create a segmented map of the image, we then cluster sections of abnormal skin and pass this information to a classification model. We classify each cluster into different common skin diseases using another neural network model. Our segmentation model achieves better performance compared to previous studies, and also achieves a near-perfect sensitivity score in unfavorable conditions. Our classification model is more accurate than a baseline model trained without segmentation, while also being able to classify multiple diseases within a single image. This improved performance may be sufficient to use CAD in the field of dermatology.

scholarly journals Ghrelin and orexin levels in infertile male: evaluation of effects on varicocele pathophysiology, relationship seminal and hormonal parameter

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Üçler Kısa ◽  
M. Murad Başar ◽  
Timuçin Şipal ◽  
Özlem Doğan Ceylan
Keyword(s):  
The Other ◽  
Control Group ◽  
Infertile Male ◽  
Seminal Parameters ◽  
Other Hand ◽  
Healthy Control ◽  
Regulatory Effects ◽  
Serum Ghrelin ◽  
Infertile Patients ◽  
Group 1

AbstractObjectiveThe aim of the present study was to investigate serum ghrelin and orexin levels in patients with varicocele and compare these levels with idiopathic infertile male and healthy control cases.MethodsThis study enrolled 24 men with varicocele, 24 males having idiopathic infertility, and 21 fertile men as the control group. Hormonal analyses, ghrelin and orexin levels were measured samples. Semen was analyzed after 3 and 5 days of sexual abstinence.ResultsSerum ghrelin levels were statistically different among the three groups (p=0.015), and it was due to a statistically lower level in group-1 than the level in the control cases (p=0.012). On the other hand, serum orexin levels were lower than healthy subjects in infertile groups with/without varicocele, but there was no difference (p=0.685) among three groups. Serum ghrelin level showed a negative and significant correlation only with sperm motility (r=−0.646, p=0.022), there was no correlation with other parameters. On the other hand, serum orexin levels did not show a significant correlation with seminal parameters.ConclusionBoth new investigated peptides ghrelin and orexin have regulatory effects on testicular function. However, ghrelin has a more obvious and complex effect on spermatogenesis. Impaired seminal parameters, especially motility was associated with increased serum ghrelin levels in infertile patients, especially with varicocele.

scholarly journals Current Insights into Immunology and Novel Therapeutics of Atopic Dermatitis

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1392
Author(s):  
Hidaya A. Kader ◽  
Muhammad Azeem ◽  
Suhib A. Jwayed ◽  
Aaesha Al-Shehhi ◽  
Attia Tabassum ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Current Knowledge ◽  
Treatment Strategies ◽  
Developed Countries ◽  
Food Allergies ◽  
Th2 Response ◽  
Therapeutic Outcomes ◽  
Environmental Agents ◽  
Novel Treatment Strategies

Atopic dermatitis (AD) is one of the most prevalent inflammatory disease among non-fatal skin diseases, affecting up to one fifth of the population in developed countries. AD is characterized by recurrent pruritic and localized eczema with seasonal fluctuations. AD initializes the phenomenon of atopic march, during which infant AD patients are predisposed to progressive secondary allergies such as allergic rhinitis, asthma, and food allergies. The pathophysiology of AD is complex; onset of the disease is caused by several factors, including strong genetic predisposition, disrupted epidermal barrier, and immune dysregulation. AD was initially characterized by defects in the innate immune system and a vigorous skewed adaptive Th2 response to environmental agents; there are compelling evidences that the disorder involves multiple immune pathways. Symptomatic palliative treatment is the only strategy to manage the disease and restore skin integrity. Researchers are trying to more precisely define the contribution of different AD genotypes and elucidate the role of various immune axes. In this review, we have summarized the current knowledge about the roles of innate and adaptive immune responsive cells in AD. In addition, current and novel treatment strategies for the management of AD are comprehensively described, including some ongoing clinical trials and promising therapeutic agents. This information will provide an asset towards identifying personalized targets for better therapeutic outcomes.

scholarly journals Smart sensing metasurface with self-defined functions in dual polarizations

Nanophotonics ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 3271-3278 ◽  
Author(s):  
Qian Ma ◽  
Qiao Ru Hong ◽  
Xin Xin Gao ◽  
Hong Bo Jing ◽  
Che Liu ◽  
...  
Keyword(s):  
Field Programmable Gate Array ◽  
The Other ◽  
Rf Power ◽  
Pin Diodes ◽  
Self Recognition ◽  
Field Programmable ◽  
Power Detector ◽  
Smart Sensing ◽  
High Level ◽  
Rf Power Detector

AbstractFor the intelligence of metamaterials, the -sensing mechanism and programmable reaction units are two important components for self-recognition and -determination. However, their realization still face great challenges. Here, we propose a smart sensing metasurface to achieve self-defined functions in the framework of digital coding metamaterials. A sensing unit that can simultaneously process the sensing channel and realize phase-programmable capability is designed by integrating radio frequency (RF) power detector and PIN diodes. Four sensing units distributed on the metasurface aperture can detect the microwave incidences in the x- and y-polarizations, while the other elements can modulate the reflected phase patterns under the control of a field programmable gate array (FPGA). To validate the performance, three schemes containing six coding patterns are presented and simulated, after which two of them are measured, showing good agreements with designs. We envision that this work may motivate studies on smart metamaterials with high-level recognition and manipulation.

scholarly journals Voluntary Withdrawals, Forced Resignations, Collective Retirements or Just Bad Fortune? A Competing Risks Analysis of Ministerial Turnover in the German Länder (1990-2010)

2016 ◽  
Vol 34 (1) ◽  
pp. 54-76
Author(s):  
Sebastian Jäckle
Keyword(s):  
Competing Risks ◽  
Prime Minister ◽  
The Other ◽  
Cox Models ◽  
Coalition Governments ◽  
German Länder ◽  
Competing Risks Analysis ◽  
Terminal Events ◽  
Hiring And Firing ◽  
High Level

This paper explores the determinants of ministerial duration within the German Länder between 1990 and 2010. In arguing that different terminal events ceasing ministerial tenures should be analyzed separately, it distinguishes four exit types: voluntary, forced, collective (ministers leaving office because their whole party does so) and exits that are neither volitional acts of the minister nor politically induced. Depending on the exit type, competing-risks Cox-models show different effects for one and the same variable on the hazard for ministerial turnover. Seniority in high-level politics for example helps not to be forced out of office while it has no effect on voluntary or collective exits. Heading an important ministry on the other hand increases the chances to rise to other positions in high politics or private business, but does not impact the other two hazards. The analysis furthermore shows that the principal-agent-logic known from Westminster systems with the prime minister being largely sovereign in hiring and firing cabinet members must be adapted to the German context of frequent coalition governments. In coalition governments, only ministers from the same party as the prime minister exhibit higher hazards for forced exits, while ministers from other coalition partners are much safer in that regard.

Measurement of Noise inside the Compartment and Vibration on both Sides of Elastomeric Powertrain Mounts of Passenger Car

2013 ◽  
Vol 471 ◽  
pp. 59-63
Author(s):  
Mohd Noor Arib Rejab ◽  
Roslan Abd Rahman ◽  
Raja Ishak Raja Hamzah ◽  
Jawaid Iqbal Inayat Hussain ◽  
Nazirah Ahmad ◽  
...  
Keyword(s):  
Fast Response ◽  
Sound Level ◽  
Measurement Noise ◽  
The Other ◽  
Vibration Level ◽  
Test Conditions ◽  
Exhaust Noise ◽  
Run Up ◽  
Level Meter ◽  
High Level

This paper presents an evaluation on elastomeric mount used to isolate vibration from powertrain to chassis or structure vehicle. The assessments started with measurement of noise inside compartment, and exhaust noise. This is followed by the measurement of vibration on both sides of elastomeric mounts. The noise in the compartment and exhaust noise is measured according to BS 6086: 1981 and BS ISO 5130: 2007. The noise in the compartment and vibration is tested in three conditions. Firstly, engine is run-up with load (driving at second gear); secondly, without load; and thirdly, without load but hanging. A microphone is fixed at the ear of the mannequin. The fast response and A weighting sound level meter were used for measurement noise in the compartment and exhaust noise. The vibration is measured in terms of acceleration on both sides of each elastomeric powertrain mounts. Two accelerometer transducers are fixed on both sides of powertrain elastomeric mounts. One side was identified as a source of vibration and the other as receiver of vibrations. The results showed that the pattern of overall vibration level on source and receiver increased from 1050 RPM (idling) to 4000 RPM on all test conditions. Vibration transmitted to chassis or receiver structure was analyzed using transmissibility concept. By evaluating test condition of engine run-up without load, informed that the front and rear mounts showed a high level transmissibility contributing to structure-borne noise.

scholarly journals The S66 Non-Covalent Interactions Benchmark Reconsidered Using Explicitly Correlated Methods Near the Basis Set Limit

2018 ◽  
Vol 71 (4) ◽  
pp. 238 ◽  
Author(s):  
Manoj K. Kesharwani ◽  
Amir Karton ◽  
Nitai Sylvetsky ◽  
Jan M. L. Martin
Keyword(s):  
Computational Cost ◽  
The Other ◽  
Basis Set ◽  
Basis Sets ◽  
Explicitly Correlated ◽  
Non Covalent Interactions ◽  
Explicitly Correlated Methods ◽  
The One ◽  
High Level ◽  
Covalent Interactions

The S66 benchmark for non-covalent interactions has been re-evaluated using explicitly correlated methods with basis sets near the one-particle basis set limit. It is found that post-MP2 ‘high-level corrections’ are treated adequately well using a combination of CCSD(F12*) with (aug-)cc-pVTZ-F12 basis sets on the one hand, and (T) extrapolated from conventional CCSD(T)/heavy-aug-cc-pV{D,T}Z on the other hand. Implications for earlier benchmarks on the larger S66×8 problem set in particular, and for accurate calculations on non-covalent interactions in general, are discussed. At a slight cost in accuracy, (T) can be considerably accelerated by using sano-V{D,T}Z+ basis sets, whereas half-counterpoise CCSD(F12*)(T)/cc-pVDZ-F12 offers the best compromise between accuracy and computational cost.

scholarly journals The influence of athletic performance on the highest positions of the final ranking during 2017/2018 Serie A season

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Umile Giuseppe Longo ◽  
Francesco Sofi ◽  
Vincenzo Candela ◽  
Laura Risi Ambrogioni ◽  
Giuditta Pagliai ◽  
...  
Keyword(s):  
Athletic Performance ◽  
The Other ◽  
Lower Percentage ◽  
Average Speed ◽  
Total Distance ◽  
High Level

Abstract Background Our previous study on the 2016/2017 Serie A season showed that a greater likelihood of reaching the top positions in the Italian league “Serie A” seemed to be mainly related to sprint activity, goal attempts, total throws, target shots and assists. Therefore, we aim to evaluate the following season data in the same league to compare, confirm, and improve these results. Methods The data of all the matches played during the “Serie A” 2017–2018 season were obtained from the Italian soccer league. The teams’ analysis was performed in terms of total distance covered in km, jogging, running and sprint activities, average speed, and match statistics (total shots, shots on target, goal attempts, assists, turnovers, and steals). Results Teams that reached the first four positions revealed a lower percentage of running (65.98 ± 1.51 vs. 66.84 ± 2.18; p < 0.001), a higher percentage of jogging (25.61 ± 1.71 vs. 25.30 ± 1.97; p = 0.037) and sprint activities (8.41 ± 1.04 vs. 7.86 ± 0.82; p < 0.001). Match statistics seem to be statistically different between the first four teams the other teams. The total goals are strongly associated both with the total score at the end of the championship (R = 0.906; p < 0.001) and with the position in the final ranking (R = 0.850; p < 0.001). Conclusions Our results suggest that high-level teams have a lower running rate and a higher percentage of jogging and sprinting than other teams.

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