Effect of Hippophae rhamnoides extract on Cisplatin-induced ototoxicity in Guinea Pigs

2017 ◽  
Author(s):  
Ertugrul Erhan ◽  
Renad Mammadov ◽  
Durdu Altuner ◽  
Ferda Cimen ◽  
Nezahat Kurt ◽  
...  
Keyword(s):  
Gene Expression ◽  
Guinea Pigs ◽  
Cost Effective ◽  
Hippophae Rhamnoides ◽  
Fruit Extract ◽  
Hippophaë Rhamnoides ◽  
Anti Oxidant ◽  
Histopathological Results ◽  
Fat Soluble Vitamins ◽  
Gene Expression Levels

No previous studies have examined the effect of Hippophae rhamnoides fruit extract (HRE), which contains both water and fat soluble vitamins, on cisplatin-induced ototoxicity. Therefore, the aim of the study was to investigate the effects of HRE on cisplatin-induced ototoxicity in Guinea pigs and to evaluate the biochemical, gene expression and histopathological changes associated with cisplatin use. Experimental animals were divided into three groups: healthy (HG), HRE+cisplatin (HRC) and cisplatin control (CCG) groups. Biochemical, gene expression and histopathological examinations were carried on the removed inner ear tissues. In the HRC group, the oxidant parameter was lower and the anti-oxidant parameter was higher than in the CCG. These results are supported by gene expression levels and histopathological results. The use of HRE against cisplatin-induced oxidative ototoxicity may be easier, more cost effective and more beneficial than the use of vitamins alone or in combination with each other.

Supplementation of Fruit Extract of Hippophae rhamnoides Speeds Adaptation to Simulated High Altitude Stressors in Rats

2010 ◽  
Vol 7 (1) ◽  
Author(s):  
Rajkumar Tulsawani ◽  
Priyanka Sharma ◽  
Harish Madan Divekar ◽  
Ram Niwas Meena ◽  
Mrinalini Singh ◽  
...  
Keyword(s):  
High Altitude ◽  
Hippophae Rhamnoides ◽  
Fruit Extract ◽  
Hippophaë Rhamnoides ◽  
Simulated High Altitude

Protective effects of fruit extracts of Hippophae rhamnoides L. against arsenic toxicity in Swiss albino mice

2006 ◽  
Vol 25 (6) ◽  
pp. 285-295 ◽  
Author(s):  
R Gupta ◽  
S JS Flora
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Room Temperature ◽  
Arsenic Concentration ◽  
Hippophae Rhamnoides ◽  
Herbal Extract ◽  
Fruit Extract ◽  
Fruit Extracts ◽  
Hippophaë Rhamnoides ◽  
Hippophae Rhamnoïdes L

Seabuckthorn (Hippophae rhamnoides L.) berry has a long history of applications as a food and medicinal ingredient in eastern countries. The present study was carried out to investigate the effect of different fruit extracts of H. rhamnoides on altered biochemical parameters indicative of haematological alterations, tissue oxidative stress, and arsenic concentration in arsenicexposed mice (2.5 mg/kg body weight, intraperitoneally). Two aqueous extracts (at room temperature and under reflux condition) and an ethanolic extract of H. rhamnoides at a dose of 500 mg/kg body weight were coadministered daily during arsenic exposure in mice for 3 weeks. Exposure to arsenic led to a significant inhibition of blood @aminolevulinic acid dehydratase (ALAD) activity, suggesting disturbed haem synthesis pathway. Arsenic also caused significant depletion of reduced hepatic glutathione (GSH) level, glutathione S-transferase (GST) and glutathione peroxidase and catalase activities, while it increased the level of thiobarbituric acid reactive substance (TBARS), suggesting liver oxidative stress. Most of the altered biochemical variables responded favorably to the co-supplementation of H. rhamnoides, particularly the aqueous fruit extract, extracted at room temperature (HF-WRT). However, arsenic concentration in blood and tissues remained unchanged, suggesting the lack of chelating property of fruit extract of H. rhamnoides. The present study, thus, led us to conclude that the fruit extract of H. rhamnoides has a significant protective role against arsenic-induced oxidative injury. However, it lacks the ability to remove arsenic from the binding sites, suggesting that the herbal extract could be co-administered with a chelating agent of known efficacy during treatment of arsenic to achieve the optimum effect of chelation treatment.

scholarly journals Chemical composition of sea buckthorn (Hippophae rhamnoides L.) berry grown in the Chelyabinsk region

Vestnik MGTU ◽  
2021 ◽  
Vol 24 (3) ◽  
pp. 306-312
Author(s):  
N. L. Naumova
Keyword(s):  
Chemical Composition ◽  
Mineral Elements ◽  
Sea Buckthorn ◽  
Biologically Active ◽  
Hippophae Rhamnoides ◽  
Customs Union ◽  
Hippophaë Rhamnoides ◽  
Hippophae Rhamnoïdes L ◽  
Chelyabinsk Region ◽  
Fat Soluble Vitamins

The most important phytonutrients of sea buckthorn ( Hippophae rhamnoides L.) berry are carotenoids, flavonoids, anthocyanins, sugars, organic and amino acids, water and fat-soluble vitamins, tannins and pectin substances, phospholipids, macro- and microelements. In the Chelyabinsk region it is almost impossible to find well-groomed industrial plantings of sea buckthorn, since its main areas (600 hectares) are concentrated in amateur and home gardens. To form a healthy diet, it is important not only to ensure the safety of horticultural products, but also to raise the priority of signs that determine consumer demand, namely the quality and chemical composition of fruits, their saturation with the necessary micronutrients. While studying food and biologically active substances of sea buckthorn berries of the "Velikan" variety growing in different garden agrocenoses of the Chelyabinsk region it has been determined that sea buckthorn berries cultivated in the garden "Lokomotiv-1" (Chelyabinsk) contain more flavonoids (by 21.4 %), proteins (by 17.4 %), mineral elements - Al (in 5.3 times), V (3.4 times), Cu (3 times), Ti (2.4 times), Ca and Fe (1.9 times), Mn (1.5 times), in berries obtained in the garden "Dizelist-1" (Chelyabinsk region, Troitsk) contains more sugars (by 15.1 %), as well as Mo and Sr (2-2.3 times), Se (1.4 times), Cr (by 76.2 %), etc. In terms of Se content, the studied fruits exceed the clarke values by 4-6 times; in terms of Pb content, they turned out to be as close as possible to the upper limit of MPC according to the requirements of the Technical Regulations of the Customs Union. The study of the mineral composition of sea buckthorn is especially important in the context of the ecological disadvantage of the Chelyabinsk region due to the pollution of the environment with heavy metals.

scholarly journals Sex-Biased Temporal Gene Expression in Male and Female Floral Buds of Seabuckthorn (Hippophae rhamnoides)

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0124890 ◽  
Author(s):  
Aseem Chawla ◽  
Tsering Stobdan ◽  
Ravi B. Srivastava ◽  
Varun Jaiswal ◽  
Rajinder S. Chauhan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hippophae Rhamnoides ◽  
Male And Female ◽  
Temporal Gene Expression ◽  
Floral Buds ◽  
Hippophaë Rhamnoides

scholarly journals Effects of Sea Buckthorn (Hippophae rhamnoides L.) Fruit Extract on Ultraviolet-induced Apoptosis of Skin Fibroblasts

2014 ◽  
Vol 24 (5) ◽  
pp. 467-475
Author(s):  
In Sik Hwang ◽  
Eun Kyoung Koh ◽  
Ji Eun Kim ◽  
Young Ju Lee ◽  
Moon Hwa Kwak ◽  
...  
Keyword(s):  
Skin Fibroblasts ◽  
Sea Buckthorn ◽  
Hippophae Rhamnoides ◽  
Fruit Extract ◽  
Hippophaë Rhamnoides ◽  
Hippophae Rhamnoïdes L ◽  
Induced Apoptosis

scholarly journals Analysis of Chemical Composition and in vitro Anti-oxidant Properties of Extracts from Sea Buckthorn (Hippophae rhamnoides)

2009 ◽  
Vol 52 (2) ◽  
pp. 58-64 ◽  
Author(s):  
Kyung-Min Kim ◽  
Min-Hee Park ◽  
Kyung-Hee Kim ◽  
Sang-Hyun Im ◽  
Yoo-Hwa Park ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Sea Buckthorn ◽  
Hippophae Rhamnoides ◽  
Hippophaë Rhamnoides ◽  
Anti Oxidant

scholarly journals Anti-Oxidant and Anti-Enzymatic Activities of Sea Buckthorn (Hippophaë rhamnoides L.) Fruits Modulated by Chemical Components

Antioxidants ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 618 ◽  
Author(s):  
Karolina Tkacz ◽  
Aneta Wojdyło ◽  
Igor Piotr Turkiewicz ◽  
Łukasz Bobak ◽  
Paulina Nowicka
Keyword(s):  
Biological Activities ◽  
Dry Mass ◽  
Sea Buckthorn ◽  
Hippophae Rhamnoides ◽  
Raw Material ◽  
Chemical Components ◽  
High Biological Activity ◽  
Hippophaë Rhamnoides ◽  
Anti Oxidant

The aim of this study was to analyze in vitro biological activities as anti-oxidant, anti-α-amylase, anti-α-glucosidase, anti-lipase, and anti-lipoxygenase activity, relative to bioactive components (phenolic acids, flavonols, xanthophylls, carotenes, esterified carotenoids, tocopherols, tocotrienols, and fatty acids) and the basic chemical composition (sugars, organic acid, dry matter, soluble solid, pH, titratable acidity, ash, pectins, and vitamin C) of Hippophaë rhamnoides berries. Six sea buckthorn cultivars commonly grown in Poland were analyzed including Aromatnaja, Botaniczeskaja-Lubitelskaja, Józef, Luczistaja, Moskwiczka, and Podarok Sadu. Berries contained 1.34–2.87 g of sugars and 0.96–4.22 g of organic acids in 100 g fresh weight, 468.60–901.11 mg of phenolic compounds, and 46.61–508.57 mg of carotenoids in 100 g dry mass. The fatty acid profile was established: palmitic > palmitoleic > oleic and linoleic > stearic and linolenic acids. The highest anti-oxidant (34.68 mmol Trolox/100 g dry mass) and anti-α-amylase potential (IC50 = 26.83 mg/mL) was determined in Aromatnaja, anti-α-glucosidase in Botaniczeskaja-Lubitelskaja (IC50 = 41.78 mg/mL), anti-lipase in Moskwiczka and Aromatnaja (average IC50 = 4.37 mg/mL), and anti-lipoxygenase in Aromatnaja and Podarok Sadu fruits (100% inhibition). The studied sea buckthorn berries may be a raw material for the development of functional foods and nutraceutical products rich in compounds with high biological activity.

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