scholarly journals Anthelmintic drugs

WormBook ◽  
2007 ◽  
pp. 1-13 ◽  
Author(s):  
Lindy Holden-Dye
Keyword(s):  
Anthelmintic Drugs

Liver ultrastructure in sheep fasciolosis

2021 ◽  
Vol 1 (1) ◽  
pp. 6-12
Author(s):  
V. N. Baymatov ◽  
◽  
G. R. Shakirova ◽  
Keyword(s):  
Experimental Infection ◽  
Ultrastructural Level ◽  
Dense Matrix ◽  
Membrane Structures ◽  
Liver Ultrastructure ◽  
Perinuclear Space ◽  
Liver Membrane ◽  
Electron Dense Matrix ◽  
Anthelmintic Drugs

This experiment has studied the changes in the liver in sheep during experimental infection with fascioliasis. Sheep were infested with 300 adoliskaria and observed changes up to 142 days. At the ultrastructural level in animals with fascioliasis, destructive changes were found in the liver. In the nucleus, the number of nucleoli decreases or they disappear completely, fragmentation of heterochromatin occurs and the content of euchromatin increases. The karyolemma exfoliates from the nucleus, as a result of which the perinuclear space expands. Mitochondria swell, they are polymorphic, and have an electron-dense matrix. At the beginning of the invasion, their number increases, and then their vacuolization, destruction occurs, while under the action of anthelmintic drugs and fasciolus toxins, the structure of the endolasmic network first of all changes: its cavities expand, then fragmentation occurs. Ribosomes are sprayed into the cytoplasm of the hepatocyte. It should be noted that under the influence of hexichol, acemidophene and thiopagol in the liver, membrane structures change most significantly and undergo necrobiosis.

Supramolecular encapsulation of benzimidazole-derived drugs by cucurbit[7]uril

2011 ◽  
Vol 89 (2) ◽  
pp. 139-147 ◽  
Author(s):  
Apurba L. Koner ◽  
Indrajit Ghosh ◽  
Na'il Saleh ◽  
Werner M. Nau
Keyword(s):  
Photophysical Properties ◽  
Solubility Enhancement ◽  
Spectroscopic Techniques ◽  
Protonated Forms ◽  
The Absolute ◽  
Anthelmintic Drugs

UV–vis and NMR spectroscopic techniques were employed to demonstrate the ability of the synthetic macrocyclic host cucurbit[7]uril (CB7) to solubilize and stabilize widely used fungicides and anthelmintic drugs of the benzimidazole family in water, namely, albendazole (ABZ), carbendazim (CBZ), thiabendazole (TBZ), fuberidazole (FBZ), and the parent benzimidazole (BZ). CB7 binds the protonated forms of these guests very strongly (e.g., K = 2.6 × 107 L/mol for ABZ) but their neutral forms significantly more weakly (e.g., K = 6.5 × 104 L/mol for ABZ), which reflects a complexation-induced increase of their pKa values by 2.6 units for ABZ, 2.5 units for CBZ, 4.0 units for TBZ, 3.8 units for FBZ, and 3.5 units for BZ. The absolute drug solubilities increased upon complexation from 0.003 to 0.300 mmol/L for ABZ, from 0.160 to 1.12 mmol/L for CBZ, from 0.110 to 1.11 mmol/L for TBZ, and from 0.25 to 0.75 mmol/L for FBZ (for BZ, the solubility enhancement was found to be insignificant). Complexation by CB7 further improves the photostability of the drugs and alters their photophysical properties.

Removal of anthelmintic drugs and their photodegradation products from water with RO/NF membranes

2012 ◽  
Vol 90 (2) ◽  
pp. 147-152 ◽  
Author(s):  
Davor Dolar ◽  
Sanja Pelko ◽  
Krešimir Košutić ◽  
Alka J.M. Horvat
Keyword(s):  
Photodegradation Products ◽  
Anthelmintic Drugs

scholarly journals Infection With The Pinworm Blatticola Blattae And Survival of Starving German Cockroaches, Blattella Germanica

2021 ◽  
Author(s):  
Masuko Kobayashi ◽  
Kensuke Taira
Keyword(s):  
Survival Rates ◽  
Blattella Germanica ◽  
German Cockroach ◽  
Infection Status ◽  
Anthelmintic Drugs

Abstract The German cockroach, Blattella germanica, is often infected with the pinworm, Blatticola blattae. To investigate the effect of pinworm infection on cockroach survival, we artificially manipulated the pinworm infection status of two lines of German cockroaches kept in the laboratory and compared survival rates in starvation. Of the two lines of German cockroaches WATn and NIIDp bred in the laboratory, the WATn line was not infected with pinworm, and the NIIDp line was naturally infected with pinworm B. blattae. The WATp line was created by artificially infecting the pinworm B. blattae with this WATn line. The NIIDn line was created by treating the NIIDp line with anthelmintic drugs. The 50% survival days of uninfected WATn line of starving cockroaches was 8 days, and infected WATp line of starving cockroaches was 13 days. The 50% survival days of naturally infected NIIDp line of starving cockroaches was 6 days, and that of anthelmintic-treated NIIDn line of cockroaches was 4 days. The survival days were significantly longer in pinworm-infected cockroaches than uninfected or anthelmintic-treated cockroaches. These results suggest that pinworm infection enhances the survival of cockroaches under starving conditions.

scholarly journals Botanicals: a natural approach to control ascaridiosis in poultry

2018 ◽  
Vol 69 (1) ◽  
pp. 711 ◽  
Author(s):  
I. SYMEONIDOU ◽  
E. BONOS ◽  
K. MOUSTAKIDIS ◽  
P. FLOROU-PANERI ◽  
E. CHRISTAKI ◽  
...  
Keyword(s):  
Economic Losses ◽  
Meat Production ◽  
Ascaridia Galli ◽  
Natural Approach ◽  
The Past ◽  
Poultry Products ◽  
Anthelmintic Efficacy ◽  
Anthelmintic Drugs

Parasites (protozoa, helminthes, arthropods) represent a main threat for poultry worldwide. Among helminthes, nematodes constitute the most important group of parasites of poultry. The nematode Ascaridia galli, the cause of ascaridiosis in poultry, is one of the most important and prevalent parasites, resulting in serious economic losses, associated with the treatment cost, the decreased feed efficiency, and the poor egg and meat production. During the past few decades the indiscriminate use of anthelmintic drugs has generated several cases of resistance in helminthes in poultry, situation which is coupled with the severity of residues in poultry products. For this reason, nowadays attention has been drawn to the use of botanicals in poultry diet, due to their anthelmintic properties. Furthermore, the dietary use eco-friend ly of these plant derived substances compared to conventional synthetic anthelmintic drugs is considered as a natural and ecofriendly approach by the consumers. The focus of the present review is to recapitulate the studies, both in vivo and in vitro, that have demonstrated the anthelmintic efficacy of various dietary botanicals in controlling poultry ascaridiosis.

The current state of the pharmaceutical market for anthelmintic drugs for veterinary use

2021 ◽  
Vol 1 (9) ◽  
pp. 37-44
Author(s):  
A. K. Klyueva ◽  
◽  
A. A. Deltsov ◽  
K. O. Belova ◽  
◽  
...  
Keyword(s):  
Russian Federation ◽  
Wide Spectrum ◽  
Pharmaceutical Market ◽  
The Past ◽  
Veterinary Medicines ◽  
Current State ◽  
Prevention And Treatment ◽  
The Russian Federation ◽  
State Registration ◽  
Anthelmintic Drugs

This paper presents an analysis of the range of veterinary medicines registered in the territory of the Russian Federation and used for the prevention and treatment of helminthiasis. The Russian Federation is a leader in the development and production of anthelmintic medicines registered on its territory. Antiparasitic medicines used for the prevention and treatment of helminthiasis are divided according to the spectrum of action depending on the class of helminths. It was revealed that the majority of medicines (89 medicines – 58,17%) have a wide spectrum of action. Of these, 62 medicines (40,52% of the total amount of anthelmintic medicines) are intended for the treatment of nematodes and cestodoses. When distributing anthelmintic medicines among target animals, it was found that 75 medicines (49.02%) are intended for the treatment of productive animals, and 78 medicines (50,98%) are intended for the treatment of unproductive animals. When assessing the dynamics of state registration of anthelmintic medicines for veterinary use, it can be noted that over the past 4 years there has been a tendency towards an increase in the average annual registration.

Anthelmintic Drugs Resistance of Gastrointestinal Nematodes of Naturally Infected Goats in Haramaya, Ethiopia

2019 ◽  
Author(s):  
Anteneh Wondimu ◽  
Yehualashet Bayu
Keyword(s):  
Management Practices ◽  
Narrow Range ◽  
Anthelmintic Resistance ◽  
Control Strategies ◽  
Nematode Resistance ◽  
Treated Group ◽  
Gastrointestinal Nematodes ◽  
Drug Resistant ◽  
Global Threat ◽  
Anthelmintic Drugs

Abstract Background: The occurrence of anthelmintic resistance to commonly used drugs is becoming worldwide constrain in livestock production. Considering the narrow range of available drugs and slow rate of new drug development, anthelmintic resistance presents an alarming global threat demanding vigilant monitoring and management. It is likely that anthelmintic resistance of gastrointestinal goats present in Ethiopia, but little information regarding the prevalence and species of nematode resistance to drugs is available. Current study done with objective to assess anthelmintic resistance of gastrointestinal nematodes of goats to commonly used anthelmintic drugs. Results: The result of the FECRT % and lower 95% confidence limit reported the presence of anthelmintic resistance for tested drugs; albendazole (41.5%, 36.9), tetraclozan (69.5%, 66.1), tetramisole (91.1%, 87.4) and ivermectin (43%, 38.2) respectively. Trichostrongylus spp, Teladorsagia spp and Haemonchus spp showed anthelmintic resistance for all tested drugs. Coproculture from different treated group revealed of Trichostrongylus spp (69.2% in ivermectin and 59.6% in albendazole) was the predominant nematode followed by Teladorsagia spp (21.9% in albendazole and 14.7% in ivermectin). In tetraclozan treatment group, Trichostrongylus spp (42%) and Teladorsagia spp (41.3%) were comparable, followed by Haemonchus spp (13%). In group treated with tetramisole, Teladorsagia spp (54.3%) was the major nematode detected followed by Trichostrongylus spp (25.7%) and Haemonchus spp (11.4%). Conclusions: The study demonstrated the presence of multi-drug resistant nematodes mainly Trichostrongylus spp, Teladorsagia spp and Haemonchus spp. Control strategies including management practices of pasture rotation, supplementary feeding and encouraging traditional nematode control methods. Further studies covering wider areas of Ethiopia and mechanism of nematode resistance need to be studied in future.

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