Influence of Cyclosporin A Therapy on Bone Healing Around Titanium Implants: A Histometric and Biomechanic Study in Rabbits

Background. Pure titanium continues to be the first choice for dental implants and represents the gold standard for their biocompatibility and physical and mechanical characteristics, while the titanium alloy (Ti6Al4V) has good mechanical properties. The surface structure of the titanium oxide layer formation on the surface influences and improves the bone response around dental implants. Purpose. The purpose of this study is to evaluate the influence of a thermal treatment of Ti6Al4V implant surfaces and the bone healing response in a rabbit model. Methods. Altogether sixteen implants with same design were inserted into the distal femoral metaphysis. A screw (13 mm long, 4 mm in diameter) was inserted in an implant bed. Each rabbit received two implants, one in the left femur and one in the right femur. The samples were histologically and histomorphometrically evaluated at 8 weeks. Results. A statistically significant difference (p = 0.000034) was present histologically in the percentages of bone-implant contact (BIC) between the test group (BIC = 69.25±4.49%.) and control group (BIC = 56.25 ± 4.8%) by one-way analysis of variance (ANOVA). Significance was set at p ≤ 0.05. Conclusions. The outcome of the present study indicates a novel approach to improving bone healing around titanium implants.

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Thyroid Hormones May Influence Cortical Bone Healing Around Titanium Implants: A Histometric Study in Rats

Journal of Periodontology ◽

10.1902/jop.2008.070466 ◽

2008 ◽

Vol 79 (5) ◽

pp. 881-887 ◽

Cited By ~ 14

Author(s):

Daniela da Silva Feitosa ◽

Beatriz de Brito Bezerra ◽

Gláucia Maria Bovi Ambrosano ◽

Francisco Humberto Nociti ◽

Márcio Zaffalon Casati ◽

...

Keyword(s):

Thyroid Hormones ◽

Cortical Bone ◽

Bone Healing ◽

Titanium Implants

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Proteomics of regenerated tissue in response to a titanium implant with a bioactive surface in a rat tibial defect model

Scientific Reports ◽

10.1038/s41598-020-75527-2 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Raluca M. Boteanu ◽

Viorel I. Suica ◽

Luminita Ivan ◽

Florentina Safciuc ◽

Elena Uyy ◽

...

Keyword(s):

Bone Healing ◽

Cultured Cells ◽

Traumatic Event ◽

Healing Process ◽

Dip Coating ◽

Polymer Coatings ◽

Titanium Implants ◽

Mass Spectrometry Analysis ◽

Defect Model ◽

Tibial Defect

Abstract Due to their excellent mechanical and biocompatibility properties, titanium-based implants are successfully used as biomedical devices. However, when new bone formation fails for different reasons, impaired fracture healing becomes a clinical problem and affects the patient's quality of life. We aimed to design a new bioactive surface of titanium implants with a synergetic PEG biopolymer-based composition for gradual delivery of growth factors (FGF2, VEGF, and BMP4) during bone healing. The optimal architecture of non-cytotoxic polymeric coatings deposited by dip coating under controlled parameters was assessed both in cultured cells and in a rat tibial defect model (100% viability). Notably, the titanium adsorbed polymer matrix induced an improved healing process when compared with the individual action of each biomolecules. High-performance mass spectrometry analysis demonstrated that recovery after a traumatic event is governed by specific differentially regulated proteins, acting in a coordinated response to the external stimulus. Predicted protein interactions shown by STRING analysis were well organized in hub-based networks related with response to chemical, wound healing and response to stress pathways. The proposed functional polymer coatings of the titanium implants demonstrated the significant improvement of bone healing process after injury.

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