Effect of FK-506 (tacrolimus) therapy on bone healing of titanium implants: a histometric and biomechanical study in mice

2016 ◽  
Vol 125 (1) ◽  
pp. 28-33 ◽  
Author(s):  
Xiaofei Zheng ◽  
Anchun Mo ◽  
Yuan Wang ◽  
Yuchen Guo ◽  
Yunshu Wu ◽  
...  
Keyword(s):  
Bone Healing ◽  
Biomechanical Study ◽  
Titanium Implants ◽  
Fk 506 ◽  
Tacrolimus Therapy

scholarly journals Influence of the Thermal Treatment to Address a Better Osseointegration of Ti6Al4V Dental Implants: Histological and Histomorphometrical Study in a Rabbit Model

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Antonio Scarano ◽  
Ezio Crocetta ◽  
Alessandro Quaranta ◽  
Felice Lorusso
Keyword(s):  
Thermal Treatment ◽  
Dental Implants ◽  
Bone Healing ◽  
Rabbit Model ◽  
Titanium Implants ◽  
Control Group ◽  
Left Femur ◽  
Bone Response ◽  
First Choice ◽  
Significant Difference

Background. Pure titanium continues to be the first choice for dental implants and represents the gold standard for their biocompatibility and physical and mechanical characteristics, while the titanium alloy (Ti6Al4V) has good mechanical properties. The surface structure of the titanium oxide layer formation on the surface influences and improves the bone response around dental implants. Purpose. The purpose of this study is to evaluate the influence of a thermal treatment of Ti6Al4V implant surfaces and the bone healing response in a rabbit model. Methods. Altogether sixteen implants with same design were inserted into the distal femoral metaphysis. A screw (13 mm long, 4 mm in diameter) was inserted in an implant bed. Each rabbit received two implants, one in the left femur and one in the right femur. The samples were histologically and histomorphometrically evaluated at 8 weeks. Results. A statistically significant difference (p = 0.000034) was present histologically in the percentages of bone-implant contact (BIC) between the test group (BIC = 69.25±4.49%.) and control group (BIC = 56.25 ± 4.8%) by one-way analysis of variance (ANOVA). Significance was set at p ≤ 0.05. Conclusions. The outcome of the present study indicates a novel approach to improving bone healing around titanium implants.

Thyroid Hormones May Influence Cortical Bone Healing Around Titanium Implants: A Histometric Study in Rats

2008 ◽  
Vol 79 (5) ◽  
pp. 881-887 ◽  
Author(s):  
Daniela da Silva Feitosa ◽  
Beatriz de Brito Bezerra ◽  
Gláucia Maria Bovi Ambrosano ◽  
Francisco Humberto Nociti ◽  
Márcio Zaffalon Casati ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Cortical Bone ◽  
Bone Healing ◽  
Titanium Implants

Porous Titanium Implants with and without Hydroxyapatite Coating: A Biomechanical Study

Bioceramics ◽  
1991 ◽  
pp. 335-342
Author(s):  
A. Moroni ◽  
V. Pezzuto ◽  
G. Rollo ◽  
F. Gottsauner-Wolf ◽  
V. Caja ◽  
...  
Keyword(s):  
Porous Titanium ◽  
Biomechanical Study ◽  
Titanium Implants ◽  
Hydroxyapatite Coating

scholarly journals Proteomics of regenerated tissue in response to a titanium implant with a bioactive surface in a rat tibial defect model

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Raluca M. Boteanu ◽  
Viorel I. Suica ◽  
Luminita Ivan ◽  
Florentina Safciuc ◽  
Elena Uyy ◽  
...  
Keyword(s):  
Bone Healing ◽  
Cultured Cells ◽  
Traumatic Event ◽  
Healing Process ◽  
Dip Coating ◽  
Polymer Coatings ◽  
Titanium Implants ◽  
Mass Spectrometry Analysis ◽  
Defect Model ◽  
Tibial Defect

Abstract Due to their excellent mechanical and biocompatibility properties, titanium-based implants are successfully used as biomedical devices. However, when new bone formation fails for different reasons, impaired fracture healing becomes a clinical problem and affects the patient's quality of life. We aimed to design a new bioactive surface of titanium implants with a synergetic PEG biopolymer-based composition for gradual delivery of growth factors (FGF2, VEGF, and BMP4) during bone healing. The optimal architecture of non-cytotoxic polymeric coatings deposited by dip coating under controlled parameters was assessed both in cultured cells and in a rat tibial defect model (100% viability). Notably, the titanium adsorbed polymer matrix induced an improved healing process when compared with the individual action of each biomolecules. High-performance mass spectrometry analysis demonstrated that recovery after a traumatic event is governed by specific differentially regulated proteins, acting in a coordinated response to the external stimulus. Predicted protein interactions shown by STRING analysis were well organized in hub-based networks related with response to chemical, wound healing and response to stress pathways. The proposed functional polymer coatings of the titanium implants demonstrated the significant improvement of bone healing process after injury.

High-throughput gene expression analysis in bone healing around titanium implants by DNA microarray

2008 ◽  
Vol 19 (2) ◽  
pp. 173-181 ◽  
Author(s):  
Norinaga Kojima ◽  
Shogo Ozawa ◽  
Yasuhiro Miyata ◽  
Hideki Hasegawa ◽  
Yoshinobu Tanaka ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Microarray ◽  
Expression Analysis ◽  
High Throughput ◽  
Bone Healing ◽  
Gene Expression Analysis ◽  
Titanium Implants ◽  
High Throughput Gene Expression

Influence of Cyclosporin A Therapy on Bone Healing Around Titanium Implants: A Histometric and Biomechanic Study in Rabbits

2003 ◽  
Vol 74 (7) ◽  
pp. 976-981 ◽  
Author(s):  
Celso E. Sakakura ◽  
Rogério Margonar ◽  
Marinella Holzhausen ◽  
Francisco H. Nociti ◽  
Rodolfo Candia Alba ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Bone Healing ◽  
Titanium Implants

Effects of metformin on bone healing around titanium implants inserted in non-diabetic rats

2016 ◽  
Vol 28 (10) ◽  
pp. e146-e150 ◽  
Author(s):  
Marta Ferreira Bastos ◽  
Caroline Ribeiro Serrão ◽  
Tamires Szeremeske Miranda ◽  
Daniele Ferreira Cruz ◽  
Fernando de Souza Malta ◽  
...  
Keyword(s):  
Bone Healing ◽  
Diabetic Rats ◽  
Titanium Implants

Early Cellular Responses in Cortical Bone Healing Around Unloaded Titanium Implants: An Animal Study

2006 ◽  
Vol 77 (6) ◽  
pp. 1015-1024 ◽  
Author(s):  
Elke Slaets ◽  
Geert Carmeliet ◽  
Ignace Naert ◽  
Joke Duyck
Keyword(s):  
Cortical Bone ◽  
Animal Study ◽  
Bone Healing ◽  
Cellular Responses ◽  
Titanium Implants

A Comparative Study on the Effect of Nicotine Administration and Cigarette Smoke Inhalation on Bone Healing Around Titanium Implants

2003 ◽  
Vol 74 (10) ◽  
pp. 1454-1459 ◽  
Author(s):  
João B. César-Neto ◽  
Poliana M. Duarte ◽  
Enilson A. Sallum ◽  
Deise Barbieri ◽  
Heitor Moreno ◽  
...  
Keyword(s):  
Comparative Study ◽  
Cigarette Smoke ◽  
Bone Healing ◽  
Titanium Implants ◽  
Smoke Inhalation ◽  
Nicotine Administration

Biomechanical Study on the Influence of Shaping Amplitude on Material Strenght of Titanium Implant

2013 ◽  
Vol 275-277 ◽  
pp. 23-27 ◽  
Author(s):  
Ya Lan Li ◽  
Wei Peng Guo ◽  
Wen Tao Jiang ◽  
Qing Yuan Wang ◽  
Yu Bo Fan
Keyword(s):  
Titanium Implant ◽  
Biomechanical Study ◽  
Titanium Implants ◽  
Uniaxial Tensile ◽  
Material Strength ◽  
Element Analysis ◽  
Three Point Bending ◽  
Uniaxial Tensile Testing ◽  
Residual Material ◽  
Different Levels

The effect of shaping amplitude on the residual material strength of titanium implants was studied. A purposely built to and fro three point bending apparatus was developed for different amplitudes on the implant material. The strength of the material after different levels of amplitude was investigated thorough uniaxial tensile testing. The effect of stress concentration due to amplitude was investigated by finite element analysis. It was concluded that plastic deformation due to shaping amplitude produced different effect on the residual strength of the material.

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