scholarly journals Syrup Hedera helix Extract Poisoning in Dog: a Clinical Report

2021 ◽  
Vol 1 (42) ◽  
pp. 21-22
Author(s):  
Erdem Gülersoy ◽  
Murat Kaan Durgut ◽  
Süleyman Serhat İyigün ◽  
Mutlu Sevinç
Keyword(s):  
Laboratory Tests ◽  
Clinical Findings ◽  
Clinical Report ◽  
Supportive Treatment ◽  
Triterpene Saponins ◽  
Successful Management ◽  
Hedera Helix ◽  
Severe Gastroenteritis ◽  
Human Use ◽  
High Doses

This clinical report describes a 1-year-old Golden Retriever dog weighing 24 kg that developed gastroenteritis as a result of the unprescribed and random use of a syrup Hedera helix extract, which is for human use only. Diagnosis was made after ruling out other factors that could cause gastroenteritis. An improvement in clinical findings was observed as a result of supportive treatment. It is already widely recognized that triterpene saponins, biological active compounds of Hedera helix, cause gastroenteritis in dogs and it is considered that unprescribed and random use of syrup Hedera helix at high doses, may cause severe gastroenteritis symptoms that will endanger life. It is concluded that successful management of Hedera helix extract poisoning depends on a good anamnesis, physical exams, and laboratory tests, rapidly ruling out other causes of gastroenteritis, quitting the use of syrup immediately and a supportive treatment

CAT SCRATCH SYNDROME

PEDIATRICS ◽  
1952 ◽  
Vol 10 (3) ◽  
pp. 311-318
Author(s):  
WILLIAM J. WATERS ◽  
SEYMOUR S. KALTER ◽  
JOHN T. PRIOR
Keyword(s):  
Skin Test ◽  
Laboratory Tests ◽  
Complement Fixation Test ◽  
Complement Fixation ◽  
Clinical Laboratory ◽  
Clinical Course ◽  
Diagnostic Value ◽  
Clinical Findings ◽  
Pathologic Findings ◽  
History Of

The clinical, laboratory and pathologic findings of a series of cases of cat scratch syndrome have been reviewed. In spite of a variable clinical course, certain features associated with a selected group of laboratory tests appear to be constant enough to be of diagnostic value. A history of contact with a cat and/or scratch which is usually associated with a peripheral skin lesion, lack of lymphangitis, presence of regional lymphadenopathy with tenderness to palpation are the most constant clinical findings. Fever, so frequently emphasized as a characteristic clinical sign, may be extremely variable in type and duration or entirely absent. A skin test with cat scratch antigen has been positive in all cases. Lacking this antigen, a negative Frei skin test in conjunction with a positive complement fixation test (Lygranum C. F.) is suggestive evidence for the diagnosis. With positive evidence from the above data, biopsy of an affected gland with its relatively nonspecific pathologic picture is not considered essential for the establishment of the diagnosis of cat scratch syndrome.

scholarly journals Atypical Bilateral Fuchs Uveitis: Diagnostic Challenges

2015 ◽  
Vol 6 (3) ◽  
pp. 284-288 ◽  
Author(s):  
Cristóbal Couto ◽  
Erika Hurtado ◽  
Dana Faingold ◽  
Carmen Demetrio ◽  
Ariel Schlaen ◽  
...  
Keyword(s):  
Case Report ◽  
Laboratory Tests ◽  
Clinical Findings ◽  
Posterior Segment ◽  
In Vivo Confocal Microscopy ◽  
Keratic Precipitates ◽  
Vitreous Opacities ◽  
High Index Of Suspicion ◽  
Rule Out

Bilateral Fuchs uveitis associated with vitreous infiltration and posterior segment involvement requires a thorough diagnostic evaluation. The lack of well-defined diagnostic criteria makes identification of this entity difficult. The aim of this case report was to present the characteristics of a patient with atypical Fuchs uveitis and the procedures needed to rule out the differential diagnosis with specific attention to the utility of in vivo confocal microscopy (IVCM). Case Report: One case of chronic bilateral uveitis with severe vitreous opacities is presented. After extensive systemic workup, including vitrectomy, the case had no identifiable systemic etiology. IVCM of the cornea revealed the presence of dendritiform keratic precipitates. Conclusion: The diagnosis of Fuchs uveitis is based on clinical findings as no confirmatory laboratory tests are available. A high index of suspicion is key to an early diagnosis, especially in the cases with vitreous opacities and posterior segment manifestations. Auxiliary tests such as IVCM may aid the clinician in the diagnosis of Fuchs uveitis.

Perioperative dilemma: Challenges of the management of a patient on mega doses of morphine and methadone

2014 ◽  
Vol 10 (1) ◽  
pp. 69 ◽  
Author(s):  
Alan David Kaye, MD, PhD, DABA, DABPM, DABIPP ◽  
Aymen A. Alian, MD ◽  
Nalini Vadivelu, MD ◽  
Keun Sam Chung, MD
Keyword(s):  
Back Pain ◽  
Case Report ◽  
High Dose ◽  
Successful Management ◽  
Present Case Report ◽  
Opioid Induced Hyperalgesia ◽  
History Of ◽  
High Doses

High doses of opioids are often needed in the management of cancer-related pain. A discussion of a patient’s perioperative opioid management and mechanisms contributing to opioid-induced hyperalgesia (OIH) are presented. In the present case report, a patient on high doses of opioids, including morphine and methadone, with severe worsening back pain and a history of increasing opioid requirements for the last 2 months due to metastatic leiomyosarcoma to the femur, spine, and neck is described. Use of high dose opioids is associated with numerous challenges, including tolerance. The successful management of this patient was multimodal and included the use of potent analgesics, N-methyl-D-aspartatereceptor antagonists, and the α-2 agonist clonidine.

Toward early diagnosis decision support for breast cancer: Ontology-based semantic interoperability.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e18072-e18072 ◽  
Author(s):  
Mengchun Gong ◽  
Zhi Wang ◽  
Yefu Liu ◽  
Hong Zhou ◽  
Fang Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Diagnosis ◽  
Cancer Diagnosis ◽  
Laboratory Tests ◽  
Treatment Guidelines ◽  
Breast Cancer Diagnosis ◽  
Clinical Findings ◽  
Semantic Interoperability ◽  
Snomed Ct ◽  
Imaging Results

e18072 Background: Breast cancer is ranked as the most common cancer among women in China, cases in China account for about 300,000 of all newly diagnosed breast cancers each year. Developing Clinical Decision Supporting System (CDSS) to assist early diagnosis breast cancer is valuable, however, lack of semantic interoperability in CDSS has been identified as the main obstacle for broad adoption of CDSS. Ontology is considered to be one of the effective approaches to bridge the terminology gap between various clinical systems and data sources. In this study, we describe our efforts in transforming breast cancer clinical knowledge into computable ontology to support breast cancer early diagnosis. Methods: We have built a breast cancer ontology (BCO) to support our CDSS pipeline. A number of NCCN clinical practice guidelines in Oncology for Breast Cancer and the breast cancer diagnosis and treatment guidelines of China are the main knowledge sources of the BCO. BCO is a manually curated resource that contains concepts and relations of breast cancer clinical findings, demographics, laboratory tests, imaging results, treatments, pathologies, cancer stages, body structure and follow-up information. These curated knowledges are annotated through interoperable standard vocabulary SNOMED CT. Two physicians reviewed and evaluated the BCO. Results: Concepts in BCO currently contains 79 clinical findings, 8 demographics, 42 laboratory tests, 105 imaging results, 332 treatments, 141 pathology and cancer stages, 30 body structures and 3 follow-ups. Relations are defined such as finding site, associated with, etc. The concepts hierarchies and relationships were built by using Protégé to support OWL representation. As an initial evaluation results, most of concepts could be mapped to SNOMED CT, but there are some concepts could not be exactly mapped to SNOMED CT. We created local Chinese Vocabularies for these local terms. Conclusions: Based on interoperable BCO, a group of computable rules are developed by adding statements according to early diagnosis criteria of breast cancer. Diagnosis assistance around complex patients is supported though connecting the Electronic Health Record (EHR). This is an ongoing development that the BCO is continuingly enriched with standard concepts, relations and integrate with individual instances to support broader adoptability.

Amitraz: an unusual aetiology of Ogilvie's syndrome

2005 ◽  
Vol 24 (9) ◽  
pp. 481-483 ◽  
Author(s):  
Sahin Aslan ◽  
Fatih Bilge ◽  
Bulent Aydinli ◽  
Tarik Ocak ◽  
Mustafa Uzkeser ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Gastric Lavage ◽  
Vital Signs ◽  
Abdominal Distension ◽  
Clinical Findings ◽  
Fluid Replacement ◽  
Supportive Treatment ◽  
Ogilvie's Syndrome ◽  
Ogilvie’S Syndrome ◽  
The Third

Amitraz is an insecticide/acaricide of formamidine pesticides used worldwide for ectoparasites in animals. Because of its widespread use, amitraz poisoning is frequently encountered in Turkey. Case report: A 36-year-old, comatose female was admitted to the hospital. Although it was stated that she had taken a glass of water containing amitraz, the exact volume of the substance was unknown. On admission, her Glasgow Coma Scale score was 10/15. Clinical findings were vomiting, miosis, bradycardia and hypotension. The patient's vital signs were body temperature 37.28C, pulse 54 bpm, blood pressure 80/50 mmHg and pulse-oximetry 84%. Supportive treatment consisting of oxygen, fluid replacement and gastric lavage, activated charcoal and atropine was administered. On the second day, signs of Ogilvie's syndrome characterized by severe tenderness, distension and pain in the abdomen were seen. On the third day, the patient's condition improved except for abdominal distension and pain, inability to pass faeces or flatus through the anus. Although continuous nasogastric tube decompression was performed, her complaints were not resolved completely. Neostigmine was administered on the fourth day. On the fifth day, abdominal pain and distension were decreased, and stool passage began. She had a complete clinical and laboratory improvement, which warranted her discharge on the seventh day of admission.

scholarly journals Peripartum cardiomyopathy: a rare complication in a teenage pregnancy

2021 ◽  
Vol 10 (7) ◽  
pp. 2854
Author(s):  
Uma Chourasia ◽  
Jyoti Nath Modi
Keyword(s):  
Multidisciplinary Team ◽  
Teenage Pregnancy ◽  
Rare Complication ◽  
Clinical Findings ◽  
Peripartum Cardiomyopathy ◽  
Team Approach ◽  
Successful Management ◽  
Emergency Cesarean ◽  
Life Threatening ◽  
High Index Of Suspicion

The aim of this case report was to present a rare case of peripartum cardiomyopathy (PPCM) in an adolescent primigravida, and discuss its presentation and successful management. PPCM is a relatively rare yet life threatening cardiac complication of pregnancy. It often remains undiagnosed as its symptoms may simulate the physiological symptoms of pregnancy and peripartum period. An early diagnosis is crucial for improving survival. We herein report an unusual case of PPCM in an young and otherwise healthy primigravida. A 19-year-old primigravida presented at 33 weeks of gestation with, severe pre-eclampsia with dyspnea, cough and discomfort in the chest. Based on clinical findings and ECG, the echocardiography was done, and a definitive diagnosis of PPCM was made. The patient was managed for heart failure and preeclampsia by a multidisciplinary team. Emergency cesarean was done for obstetric indication and patient was managed conservatively in intensive care unit. Patient improved clinically and was discharged at day 10. Peripartum cardiomyopathy though typically associates with advanced maternal age can occur in very young women as well. A high index of suspicion for PPCM is recommended on a background of `severe preeclampsia with breathlessness. Timely echocardiography for diagnosis, and a multidisciplinary team approach are a key to successful management. Clinical significance of the study was to shed new light on the unusual presentation of PPCM and to contribute to the existing knowledge of PPCM.

scholarly journals Inborn Errors of Metabolism-Clinical Findings and Laboratory Tests at the Children’s Medical Center, Tehran, Iran

2016 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Farzaneh Abbasi ◽  
Aria Setoodeh ◽  
Fatemeh Sayarifard ◽  
Parastoo Rostami ◽  
Ali Rabbani
Keyword(s):  
Laboratory Tests ◽  
Inborn Errors Of Metabolism ◽  
Medical Center ◽  
Clinical Findings ◽  
Inborn Errors

scholarly journals 1585. Isavuconazonium Sulfate plus Micafungin Improves Survival in an Immunocompromised Murine Model of Disseminated Fusariosis

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S578-S579
Author(s):  
Eleftheria Mavridou ◽  
Nura Al-Saddah ◽  
Konstantinos Mouskas ◽  
Ethan Naing ◽  
Rinat Abzalimov ◽  
...  
Keyword(s):  
Murine Model ◽  
Hematological Malignancies ◽  
Fusarium Spp ◽  
Successful Management ◽  
Antifungal Effect ◽  
Fungal Burden ◽  
Kaplan Meier ◽  
Invasive Mycosis ◽  
Excellent Safety Profile ◽  
High Doses

Abstract Background Disseminated fusariosis in patients with hematological malignancies is a frequently fatal and emerging invasive mycosis. Fusarium spp. are often resistant to safely achievable concentrations of mould active triazoles and amphotericin B. We aimed to determine the efficacy of isavuconazonium sulfate (ISA) alone or in combination with micafungin (MICA) in a murine model of disseminated fusariosis caused by Fusarium solani. Methods Groups of five 5-week-old Swiss Webster female mice, 20–22 g, were rendered neutropenic by intraperitoneal (IP) injection of cyclophosphamide at 200 mg/kg on day −2 and 150 mg/kg on day +3. Mice were infected with 5 × 10E5 CFU F. solani intravenously (IV) via the lateral tail vein on day 0. To prevent bacterial infection, ceftazidime was administered 50 mg/kg/day IP. Therapy began 18 h post-challenge for 6 days. MICA was given at dosages of 10, 5, 2.5 and 1.25 mg/kg IP Q12h combined with ISA 14 mg/kg/day IP. Six groups of mice received ISA orogastrically (OG) Q8h, Q12h and Q24h at 224 mg/kg alone or combined with MICA at 10 mg/kg Q12h IP. Kaplan–Meier survival analysis was performed. Results ISA at 14 mg/kg Q12h combined with 10 mg/kg MICA doses resulted in improved survival but with no significant reduction of residual fungal burden compared with monotherapy or other ISA/MICA dose combinations. Improved survival with dose-escalated oral monotherapy was observed at ISA 224 mg/kg Q12h (50% survival) and Q8h OG (60%) compared with other monotherapy or combination, or untreated groups (18–20%). The residual fungal burden in kidney between monotherapy and combination therapy groups was 5.81 10Log (untreated), 4.03 10Log (ISA 224 mg/kg, OG Q12h), 5.19 10Log (ISA 224 mg/kg Q12h + MICA 10 mg/kg, Q12h), 4.67 10Log (ISA 224 mg/kg, Q24h), and 4.82 10Log (ISA 224 mg/kg Q24h + MICA 10 mg/kg, Q12h). Conclusion High doses of isavuconazole (exceeding currently approved human dosages) in combination with micafungin improved survival in experimental murine disseminated fusariosis. Given the excellent safety profile of ISA, exploration of higher dosages that are necessary to achieve this antifungal effect is warranted for successful management of disseminated fusariosis. Disclosures All authors: No reported disclosures.

scholarly journals Development of an improved Streptococcus uberis experimental mastitis challenge model using different doses and strains in lactating dairy cows

2015 ◽  
Vol 82 (4) ◽  
pp. 470-477 ◽  
Author(s):  
Manouchehr Khazandi ◽  
Patricia Eats ◽  
Darren Trott ◽  
Esmaeil Ebrahimie ◽  
Jeanette Perry ◽  
...  
Keyword(s):  
Success Rate ◽  
Bovine Mastitis ◽  
Clinical Signs ◽  
Clinical Mastitis ◽  
Clinical Findings ◽  
Infection Model ◽  
Treatment Groups ◽  
Streptococcus Uberis ◽  
Reliable Model ◽  
High Doses

Developing a reliable mastitis challenge infection model is required to test new intramammary antimicrobial preparations, other novel bovine mastitis treatments, and study mastitis pathogenesis. Three treatment groups of Holstein Friesian cows in active lactation were administered two doses (104 and 106 cfu/quarter) on a single occasion with one of the three Streptococcus uberis strains (BFR6019, MFF1283 and SA002) suspended in 5 ml of sterile PBS, administered via intramammary inoculation immediately after milking. All quarters that were challenged with S. uberis strains MLF1283 and BFR6019 showed clinical signs of mastitis on day 1 and 2 after the challenge. Strain SA002 had a lower rate of inducing clinical mastitis which was detected later than day 3 after the challenge. We successfully developed a rapid and reliable model for inducing experimental S. uberis mastitis with 100% success rate in cows in active lactation. On the basis of the correlation results between strains, RAPD fingerprinting results, clinical findings, and a 100% success rate of mastitis induction for low and high doses S. uberis strains MLF1283 and BFR6019, strain virulence seems to be a more important effect than challenge dose in induction of clinical mastitis following experimental challenge.

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