The development of nanotechnology is making the interest of researchers towards thesynthesis of nanoparticles for the bioapplication. Metal oxides such as ZnO have received increasing attentionas antibacterial materials in recent years because of their stability under harsh processing conditions, and also because they are generally regarded as safe materials for human beingsand animals. Zinc activates 300 enzymes, and it plays a role in many another phenomenon like growth, membrane stability, bone mineralization, tissue growth, and repair, wound healing and cell signaling.Many studies have shown that ZnO nanoparticles have enhanced antibacterial activity. Use of plant and plant materials for the synthesis of Zinc nanoparticles is relatively new and exciting research field. Various plants were used for the synthesis of nanoparticles using green synthesis method. Nanoparticles were synthesized from all the parts of the plant separately like stem, flower, leaf, latex, root, peel, stem bark and fruits. The prepared nanoparticles of Zinc oxide were characterized by using XRD, FTIR, UV-VIS Spectroscopy, EDAX, Particle size analyzer, TGA, and SEM. The objective of this review was to report on thesynthesis of Zinc oxide nanoparticles by using different plant extracts and their significance in different fields.