scholarly journals Calcinosis Cutis: Symptomatic Cutaneous Calcium Deposits After Failed Medical Management

2017 ◽  
Vol 4 (1) ◽  
Author(s):  
Brano Djenic
Keyword(s):  
Medical Management ◽  
Calcinosis Cutis ◽  
Calcium Deposits

Congenital Bilateral Calcinosis Cutis of the Hands

2006 ◽  
Vol 31 (5) ◽  
pp. 522-523
Author(s):  
N. WHITE ◽  
D. L. CHESTER ◽  
A. KHANNA
Keyword(s):  
Calcium Phosphate ◽  
Calcinosis Cutis ◽  
Calcium Deposits

Calcinosis cutis is the cutaneous deposition of calcium phosphate. We present the first reported case of symmetrical calcium deposits being present in both hands at birth.

scholarly journals Idiopathic calcinosis cutis of the right iliac region: Common lesion at uncommon

2022 ◽  
pp. 541-543
Author(s):  
Nidha Gaffoor ◽  
Hima Sree Edupuganti ◽  
Jessica Minal ◽  
Archana Shetty ◽  
Supriya T R ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Subcutaneous Tissue ◽  
Final Diagnosis ◽  
Healthy Patient ◽  
Soft Tissue Lesion ◽  
Calcinosis Cutis ◽  
Iliac Region ◽  
Clinical Background ◽  
Calcium Deposits ◽  
The Right

Calcinosis cutis is an uncommon soft tissue lesion characterized by the deposition of calcium salts in the skin or subcutaneous tissue attributed to a wide variety of causes. We present a case of idiopathic calcinosis cutis in an adult male, who presented with a swelling in the right iliac region. Chalky white aspirate and amorphous basophilic granular material on microscopy suggestive of calcium deposits were noted. Histopathological examination of the excised mass coupled with appropriate clinical background led to the final diagnosis of idiopathic calcinosis cutis. We present this case with a complete diagnostic workup to undermine the importance of considering this lesion in the differential diagnoses of a subcutaneous hard lump in an otherwise healthy patient.

scholarly journals Calcinosis cutis associated with systemic sclerosis: a rare case report

2020 ◽  
Vol 7 (8) ◽  
pp. 2803
Author(s):  
Surya Rao Rao Venkata Mahipathy ◽  
Alagar Raja Durairaj ◽  
Narayanamurthy Sundaramurthy ◽  
Anand Prasath Jayachandiran
Keyword(s):  
Systemic Sclerosis ◽  
The Body ◽  
Calcium Deposition ◽  
Pressure Sores ◽  
Connective Tissue Disorders ◽  
Calcinosis Cutis ◽  
Rare Case Report ◽  
The Face ◽  
Subcutaneous Tissues ◽  
Calcium Deposits

Calcinosis cutis is abnormal calcium deposition in the skin and subcutaneous tissues of the body. It is generally associated with autoimmune connective tissue disorders and in our case, it is systemic sclerosis. It most commonly occurs in the fingers presenting with pain and functional impairment. Here, we present a case of calcinosis cutis with systemic sclerosis in a teenage girl presented with bilateral gluteal pressure sores and multiple sites of calcium deposition like sacrum, upper limbs, knees and the face. We treated here with reconstructive surgery with Limberg flaps for the pressure ulcers with excision and primary closure of the other sites with calcium deposits. 

scholarly journals Metastatic Calcinosis Cutis: A Case in a Child with Acute Pre-B Cell Lymphoblastic Leukemia

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Juan Pablo Castanedo-Cázares ◽  
Amalia Reyes-Herrera ◽  
Diana Hernández-Blanco ◽  
Cuauhtémoc Oros-Ovalle ◽  
Bertha Torres-Álvarez
Keyword(s):  
B Cell ◽  
Lymphoblastic Leukemia ◽  
Gastrointestinal Symptoms ◽  
Cutaneous Lesions ◽  
Calcinosis Cutis ◽  
Initial Manifestation ◽  
Hematopoietic Malignancies ◽  
Clinical Diagnoses ◽  
Calcium Deposits ◽  
Uncommon Condition

Hypercalcemia in children with malignancy is an uncommon condition. It has been described in leukemia patients with impaired renal excretion of calcium or osteolytic lesions. Metastatic calcinosis cutis (MCC) may develop if hypercalcemia persists. We report the case of a 5-year-old girl with an atypical dermatosis and unspecific gastrointestinal symptoms. Considered clinical diagnoses were xanthomas, histiocytosis, molluscum contagiosum, and nongenital warts. Cutaneous histological analysis showed amorphous basophilic deposits in the dermis suggestive of calcium deposits. Laboratory tests confirmed serum hypercalcemia. Extensive investigations such as bone marrow biopsy established the diagnosis of an acute pre-B cell lymphoblastic leukemia. Hypercalcemia in hematopoietic malignancies is unusual, especially as initial manifestation of the disease. Careful review of the literature fails to reveal previous reports of these peculiar cutaneous lesions of MCC in children with leukemia.

scholarly journals Idiopathic Calcinosis Cutis over Elbow in a 12-Year Old Child

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
S. K. Venkatesh Gupta ◽  
Ramana Rao Balaga ◽  
Suman Kumar Banik
Keyword(s):  
Tissue Injury ◽  
Female Child ◽  
Giant Cells ◽  
The Body ◽  
Dystrophic Calcification ◽  
Calcinosis Cutis ◽  
Metastatic Calcification ◽  
Pediatric Age Group ◽  
Tissue Changes ◽  
Calcium Deposits

Calcinosis cutis is an uncommon disorder caused by an abnormal deposit of calcium phosphate in the skin in various parts of the body. Four main types of calcinosis cutis have been recognized according to etiology: associated with localized or widespread tissue changes or damage (dystrophic calcification), that associated with an abnormal calcium and phosphorus metabolism (metastatic calcification), not associated with any tissue damage or demonstrable metabolic disorder (idiopathic calcification), andIatrogenic.Very few cases of idiopathic calcinosis cutis are reported in early childhood in the literature. We report one such case of idiopathic calcinosis cutis over elbow in a 12-year-old female child. Histological examinations of the lesions resected in this case reveal calcium deposits in the dermis, surrounded by foreign body giant cells. Idiopathic calcinosis cutis is a rare phenomenon and occurs in the absence of known tissue injury or systemic metabolic defect. It is important to delineate it from other calcification disorders for further plan of management. Medical therapy in calcinosis cutis is of limited benefit in pediatric age group and poses a challenging problem of postsurgical management.

scholarly journals Dystrophic calcinosis cutis in autosomal recessive dystrophic epidermolysis bullosa

2019 ◽  
Vol 12 (9) ◽  
pp. e231287 ◽  
Author(s):  
Neetu Bhari ◽  
Prashant Bharti
Keyword(s):  
Epidermolysis Bullosa ◽  
Autosomal Recessive ◽  
Sodium Thiosulfate ◽  
Dystrophic Calcification ◽  
Clinical Genetic ◽  
Calcinosis Cutis ◽  
Dystrophic Epidermolysis Bullosa ◽  
History Of ◽  
Calcium Deposits ◽  
Recessive Dystrophic Epidermolysis Bullosa

A 6-year-old girl presented with a history of blistering and scarring in trauma-prone areas. On examination, calcium deposits were seen on bilateral palms and soles within her non-healing wounds. Clinical, genetic and radiological evaluation confirmed the diagnosis of autosomal recessive dystrophic epidermolysis bullosa with dystrophic calcification. The patient was started on topical 10% sodium thiosulfate for her calcinosis cutis. Identification and management of dystrophic calcification are important as it impairs wound healing.

The effect of ionophore A23178 on the α-actinin crosslinks in the z-band of frog skeletal muscle: An EM study

1986 ◽  
Vol 44 ◽  
pp. 154-155
Author(s):  
F.T. Llados ◽  
V. Krlho ◽  
G.D. Pappas
Keyword(s):  
Muscle Damage ◽  
Transmitter Release ◽  
Skeletal Muscles ◽  
Calcium Uptake ◽  
Muscle Membrane ◽  
Frog Skeletal Muscle ◽  
Ach Release ◽  
Sustained Action ◽  
Calcium Deposits ◽  
Intense Stimulation

It Is known that Ca++ enters the muscle fiber at the junctional area during the action of the neurotransmitter, acetylcholine (ACh). Pappas and Rose demonstrated that following Intense stimulation, calcium deposits are found In the postsynaptic muscle membrane, Indicating the existence of calcium uptake In the postsynaptic area following ACh release. In addition to this calcium uptake, when mammal Ian skeletal muscles are exposed to a sustained action of the neurotransmitter, muscle damage develops. These same effects, l.e., Increased transmitter release, calcium uptake and finally muscle damage, can be obtained by Incubating the muscle with lonophore A23178.

Drug-Induced Movement Disorders

2015 ◽  
Vol 25 (2) ◽  
pp. 70-77
Author(s):  
Amy Lustig ◽  
Cesar Ruiz
Keyword(s):  
Movement Disorders ◽  
Medical Management ◽  
Disease Process ◽  
Underlying Disease ◽  
Extrapyramidal Symptoms ◽  
Drug Induced ◽  
General Overview ◽  
Management Approaches ◽  
Broad Understanding ◽  
Underlying Disease Process

The purpose of this article is to present a general overview of the features of drug-induced movement disorders (DIMDs) comprised by Parkinsonism and extrapyramidal symptoms. Speech-language pathologists (SLPs) who work with patients presenting with these issues must have a broad understanding of the underlying disease process. This article will provide a brief introduction to the neuropathophysiology of DIMDs, a discussion of the associated symptomatology, the pharmacology implicated in causing DIMDs, and the medical management approaches currently in use.

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