Congenital Bilateral Calcinosis Cutis of the Hands

2006 ◽  
Vol 31 (5) ◽  
pp. 522-523
Author(s):  
N. WHITE ◽  
D. L. CHESTER ◽  
A. KHANNA
Keyword(s):  
Calcium Phosphate ◽  
Calcinosis Cutis ◽  
Calcium Deposits

Calcinosis cutis is the cutaneous deposition of calcium phosphate. We present the first reported case of symmetrical calcium deposits being present in both hands at birth.

scholarly journals Idiopathic calcinosis cutis of the right iliac region: Common lesion at uncommon

2022 ◽  
pp. 541-543
Author(s):  
Nidha Gaffoor ◽  
Hima Sree Edupuganti ◽  
Jessica Minal ◽  
Archana Shetty ◽  
Supriya T R ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Subcutaneous Tissue ◽  
Final Diagnosis ◽  
Healthy Patient ◽  
Soft Tissue Lesion ◽  
Calcinosis Cutis ◽  
Iliac Region ◽  
Clinical Background ◽  
Calcium Deposits ◽  
The Right

Calcinosis cutis is an uncommon soft tissue lesion characterized by the deposition of calcium salts in the skin or subcutaneous tissue attributed to a wide variety of causes. We present a case of idiopathic calcinosis cutis in an adult male, who presented with a swelling in the right iliac region. Chalky white aspirate and amorphous basophilic granular material on microscopy suggestive of calcium deposits were noted. Histopathological examination of the excised mass coupled with appropriate clinical background led to the final diagnosis of idiopathic calcinosis cutis. We present this case with a complete diagnostic workup to undermine the importance of considering this lesion in the differential diagnoses of a subcutaneous hard lump in an otherwise healthy patient.

scholarly journals Calcinosis cutis associated with systemic sclerosis: a rare case report

2020 ◽  
Vol 7 (8) ◽  
pp. 2803
Author(s):  
Surya Rao Rao Venkata Mahipathy ◽  
Alagar Raja Durairaj ◽  
Narayanamurthy Sundaramurthy ◽  
Anand Prasath Jayachandiran
Keyword(s):  
Systemic Sclerosis ◽  
The Body ◽  
Calcium Deposition ◽  
Pressure Sores ◽  
Connective Tissue Disorders ◽  
Calcinosis Cutis ◽  
Rare Case Report ◽  
The Face ◽  
Subcutaneous Tissues ◽  
Calcium Deposits

Calcinosis cutis is abnormal calcium deposition in the skin and subcutaneous tissues of the body. It is generally associated with autoimmune connective tissue disorders and in our case, it is systemic sclerosis. It most commonly occurs in the fingers presenting with pain and functional impairment. Here, we present a case of calcinosis cutis with systemic sclerosis in a teenage girl presented with bilateral gluteal pressure sores and multiple sites of calcium deposition like sacrum, upper limbs, knees and the face. We treated here with reconstructive surgery with Limberg flaps for the pressure ulcers with excision and primary closure of the other sites with calcium deposits. 

IDIOPATHIC CALCINOSIS CUTIS IN FINGERTIP TREATED WITH OCCLUSIVE DRESSING USING ALUMINUM FOIL: A CASE REPORT

Hand Surgery ◽  
2007 ◽  
Vol 12 (03) ◽  
pp. 149-154 ◽  
Author(s):  
Kazuki Sato ◽  
Toshiyasu Nakamura ◽  
Yoshiaki Toyama ◽  
Hiroyasu Ikegami ◽  
Kaori Kameyama ◽  
...  
Keyword(s):  
Case Report ◽  
Calcium Phosphate ◽  
Pain Relief ◽  
Aluminum Foil ◽  
Surgical Excision ◽  
Calcium Deposition ◽  
Calcinosis Cutis ◽  
Occlusive Dressing ◽  
Significant Pain

Calcium deposition in the skin, known as calcinosis cutis, is an uncommon disorder caused by an abnormal deposit of calcium phosphate in the skin. We report a case of idiopathic calcinosis cutis in fingertip treated with surgical excision followed by the occlusive dressing using aluminum foil, and obtained significant pain relief and round-shaped fingertip which looked normal.

scholarly journals Tumoral Calcinosis: Case Report and Review

2020 ◽  
Vol 10 (02) ◽  
pp. 90-96
Author(s):  
Piyush Vaghasiya ◽  
Lathika Shetty ◽  
Molahalli Shantharam Shetty ◽  
Muthur Ajith Kumar
Keyword(s):  
Case Report ◽  
Calcium Phosphate ◽  
Elbow Joint ◽  
Daily Living ◽  
Clinical Presentation ◽  
Tumoral Calcinosis ◽  
Radiological Imaging ◽  
Left Elbow ◽  
Calcium Deposits ◽  
Reduced Mobility

AbstractTumoral calcinosis (TC) is an uncommon disorder characterized by the deposition of calcium phosphate in periarticular tissues. TC has been a controversial clinico-pathological entity first described in 1943. The calcium deposits are usually present in the large joints such as the hips and shoulders. Patients often present with localized swelling and reduced mobility around the involved joints which interfere with activities of daily living. A 12-year-old boy presented at our clinic with a painful swelling around his left elbow joint with 6-month duration over which the swellings progressively increased. Radiological imaging identified a soft tissue calcified mass present around both elbow joints. Excision and biopsy of the left elbow demonstrated a tumor consisting of myxoid material with multiple areas of calcification with a well-defined capsule. Microscopy confirmed typical features of TC. We present our case report due to unusual clinical presentation noted in this case.

scholarly journals Metastatic Calcinosis Cutis: A Case in a Child with Acute Pre-B Cell Lymphoblastic Leukemia

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Juan Pablo Castanedo-Cázares ◽  
Amalia Reyes-Herrera ◽  
Diana Hernández-Blanco ◽  
Cuauhtémoc Oros-Ovalle ◽  
Bertha Torres-Álvarez
Keyword(s):  
B Cell ◽  
Lymphoblastic Leukemia ◽  
Gastrointestinal Symptoms ◽  
Cutaneous Lesions ◽  
Calcinosis Cutis ◽  
Initial Manifestation ◽  
Hematopoietic Malignancies ◽  
Clinical Diagnoses ◽  
Calcium Deposits ◽  
Uncommon Condition

Hypercalcemia in children with malignancy is an uncommon condition. It has been described in leukemia patients with impaired renal excretion of calcium or osteolytic lesions. Metastatic calcinosis cutis (MCC) may develop if hypercalcemia persists. We report the case of a 5-year-old girl with an atypical dermatosis and unspecific gastrointestinal symptoms. Considered clinical diagnoses were xanthomas, histiocytosis, molluscum contagiosum, and nongenital warts. Cutaneous histological analysis showed amorphous basophilic deposits in the dermis suggestive of calcium deposits. Laboratory tests confirmed serum hypercalcemia. Extensive investigations such as bone marrow biopsy established the diagnosis of an acute pre-B cell lymphoblastic leukemia. Hypercalcemia in hematopoietic malignancies is unusual, especially as initial manifestation of the disease. Careful review of the literature fails to reveal previous reports of these peculiar cutaneous lesions of MCC in children with leukemia.

scholarly journals Calcium Phosphate Bions Cause Intimal Hyperplasia in Intact Aortas of Normolipidemic Rats through Endothelial Injury

2019 ◽  
Vol 20 (22) ◽  
pp. 5728 ◽  
Author(s):  
Daria Shishkova ◽  
Elena Velikanova ◽  
Maxim Sinitsky ◽  
Anna Tsepokina ◽  
Olga Gruzdeva ◽  
...  
Keyword(s):  
Blood Flow ◽  
Calcium Phosphate ◽  
Intimal Hyperplasia ◽  
Serum Proteins ◽  
Physiological Saline ◽  
Endothelial Injury ◽  
Reactive Protein ◽  
Calcium Deposits ◽  
Organic Particles ◽  
Injection Regimen

Calcium phosphate bions (CPBs) are formed under blood supersaturation with calcium and phosphate owing to the mineral chaperone fetuin-A and representing mineralo-organic particles consisting of bioapatite and multiple serum proteins. While protecting the arteries from a rapid medial calcification, CPBs cause endothelial injury and aggravate intimal hyperplasia in balloon-injured rat aortas. Here, we asked whether CPBs induce intimal hyperplasia in intact rat arteries in the absence of cardiovascular risk factors. Normolipidemic Wistar rats were subjected to regular (once/thrice per week over 5 weeks) tail vein injections of either spherical (CPB-S) or needle-shaped CPBs (CPB-N), magnesium phosphate bions (MPBs), or physiological saline (n = 5 per group). Neointima was revealed in 3/10 and 4/10 rats which received CPB-S or CPB-N, respectively, regardless of the injection regimen or blood flow pattern in the aortic segments. In contrast, none of the rats treated with MPBs or physiological saline had intimal hyperplasia. The animals also did not display signs of liver or spleen injury as well as extraskeletal calcium deposits. Serum alanine/aspartate transaminases, interleukin-1β, MCP-1/CCL2, C-reactive protein, and ceruloplasmin levels did not differ among the groups. Hence, CPBs may provoke intimal hyperplasia via direct endothelial injury regardless of their shape or type of blood flow.

scholarly journals Idiopathic Calcinosis Cutis over Elbow in a 12-Year Old Child

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
S. K. Venkatesh Gupta ◽  
Ramana Rao Balaga ◽  
Suman Kumar Banik
Keyword(s):  
Tissue Injury ◽  
Female Child ◽  
Giant Cells ◽  
The Body ◽  
Dystrophic Calcification ◽  
Calcinosis Cutis ◽  
Metastatic Calcification ◽  
Pediatric Age Group ◽  
Tissue Changes ◽  
Calcium Deposits

Calcinosis cutis is an uncommon disorder caused by an abnormal deposit of calcium phosphate in the skin in various parts of the body. Four main types of calcinosis cutis have been recognized according to etiology: associated with localized or widespread tissue changes or damage (dystrophic calcification), that associated with an abnormal calcium and phosphorus metabolism (metastatic calcification), not associated with any tissue damage or demonstrable metabolic disorder (idiopathic calcification), andIatrogenic.Very few cases of idiopathic calcinosis cutis are reported in early childhood in the literature. We report one such case of idiopathic calcinosis cutis over elbow in a 12-year-old female child. Histological examinations of the lesions resected in this case reveal calcium deposits in the dermis, surrounded by foreign body giant cells. Idiopathic calcinosis cutis is a rare phenomenon and occurs in the absence of known tissue injury or systemic metabolic defect. It is important to delineate it from other calcification disorders for further plan of management. Medical therapy in calcinosis cutis is of limited benefit in pediatric age group and poses a challenging problem of postsurgical management.

Calcinosis cutis in a renal transplant patient

2021 ◽  
Vol 14 (5) ◽  
pp. e242610
Author(s):  
Nguyen T Nguyen ◽  
Mohamed K M Shakir ◽  
Thanh Duc Hoang
Keyword(s):  
Calcium Phosphate ◽  
Renal Transplant Patient ◽  
Transplant Patient ◽  
Phosphate Metabolism ◽  
Calcinosis Cutis ◽  
History Of ◽  
Subcutaneous Tissues ◽  
Stage Renal Disease ◽  
End Stage ◽  
Calcium Phosphate Metabolism

Calcinosis cutis is an unusual disorder characterised by calcium–phosphate deposition into cutaneous and subcutaneous tissues. There are five subtypes: dystrophic, metastatic, idiopathic, iatrogenic and calciphylaxis. Our objective was to report a patient with a history of haemodialysis-dependent end-stage renal disease (ESRD) who developed metastatic calcinosis cutis, which is usually associated with abnormalities of calcium–phosphate metabolism in renal failure. In our patient, the serum calcium and phosphate levels were normal. Additionally, we describe the diagnostic approach and the difficulties involved in the management of calcinosis cutis in patients with haemodialysis-dependent ESRD.

scholarly journals Dystrophic calcinosis cutis in autosomal recessive dystrophic epidermolysis bullosa

2019 ◽  
Vol 12 (9) ◽  
pp. e231287 ◽  
Author(s):  
Neetu Bhari ◽  
Prashant Bharti
Keyword(s):  
Epidermolysis Bullosa ◽  
Autosomal Recessive ◽  
Sodium Thiosulfate ◽  
Dystrophic Calcification ◽  
Clinical Genetic ◽  
Calcinosis Cutis ◽  
Dystrophic Epidermolysis Bullosa ◽  
History Of ◽  
Calcium Deposits ◽  
Recessive Dystrophic Epidermolysis Bullosa

A 6-year-old girl presented with a history of blistering and scarring in trauma-prone areas. On examination, calcium deposits were seen on bilateral palms and soles within her non-healing wounds. Clinical, genetic and radiological evaluation confirmed the diagnosis of autosomal recessive dystrophic epidermolysis bullosa with dystrophic calcification. The patient was started on topical 10% sodium thiosulfate for her calcinosis cutis. Identification and management of dystrophic calcification are important as it impairs wound healing.

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