scholarly journals Biofield Energy Healing Based Vitamin D3: An Improved Overall Bone Health Activity in MG-63 Cell Line

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Mahendra Kumar Trivedi
Keyword(s):  
Cell Line ◽  
Vitamin D3 ◽  
Bone Health ◽  
Energy Healing

A monoclonal antibody to a novel surface antigen, MKW, blocks the antiproliferative and differentiation effects of granulocyte- macrophagecolony-stimulating factor and vitamin D3

Blood ◽  
1992 ◽  
Vol 80 (2) ◽  
pp. 367-373
Author(s):  
M Koehler ◽  
R Goorha ◽  
GR Kitchingman ◽  
GD Ayers ◽  
J Jr Mirro
Keyword(s):  
Monoclonal Antibody ◽  
Cell Line ◽  
Vitamin D3 ◽  
U937 Cell ◽  
Cell Protein ◽  
U937 Cells ◽  
Differentiation Antigen ◽  
Inducing Factors ◽  
Macrophage Colony ◽  
Stimulating Factor

A monoclonal antibody (MoAb) recognizes a novel 52-Kd cell protein (MKW) that is expressed on cells of the normal myelocytic and monocytic lineage, a subset of B cells, and the U937 cell line. Using the U937 cell line as a model, the MoAb (anti-MKW) was examined for its ability to inhibit the effects of differentiation-inducing factors. In the U937 cell line, recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) inhibits cell proliferation, 12-O- tetradecanoylphorbol-13-acetate (TPA) inhibits proliferation and induces the early differentiation antigen CD11b, and vitamin D3 inhibits proliferation and induces both CD11b and the late differentiation antigen CD14. The antiproliferative and differentiation effects of rhGM-CSF and vitamin D3 on U937 cells were inhibited by the anti-MKW MoAb. Similar effects were seen when anti-MKW antibody was added 30 minutes before or 2 hours after rhGM-CSF or vitamin D3, suggesting that its effects are not mediated by blocking or binding to the receptors for these growth factors. The anti-MKW MoAb had no effect on TPA-induced differentiation in U937 cells, indicating that TPA exerts its effects through a pathway different from rhGM-CSF and vitamin D3. These results suggest that the MKW antigen is important in controlling the proliferation and differentiation of monocytic cells.

scholarly journals Two-Year Randomized Controlled Trial of Vitamin K1 (Phylloquinone) and Vitamin D3 Plus Calcium on the Bone Health of Older Women

2007 ◽  
Vol 22 (4) ◽  
pp. 509-519 ◽  
Author(s):  
Caroline Bolton-Smith ◽  
Marion ET McMurdo ◽  
Colin R Paterson ◽  
Patricia A Mole ◽  
Julia M Harvey ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Older Women ◽  
Vitamin D3 ◽  
Bone Health ◽  
Controlled Trial ◽  
Vitamin K1 ◽  
Randomized Controlled
Sign in / Sign up

Export Citation Format

Share Document