Endotypes of allergic rhinitis and asthma accompanying food allergy

61 people suffering from persistent allergic rhinitis and asthma accompanying food allergies were studied using case histories, the NHANES questionnaire, polyspecific serum levels, allergen-specific IgE, IL4, IFNg and IL10 assays, and allergy skin tests. Four different endotypes have been identified, including entopic, which can be the basis for new approaches to the diagnosis and treatment of allergic rhinitis and asthma.

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Addressing Common Misconceptions in Food Allergy: A Review

Children ◽

10.3390/children8060497 ◽

2021 ◽

Vol 8 (6) ◽

pp. 497

Author(s):

Aikaterini Anagnostou

Keyword(s):

Food Allergy ◽

The United States ◽

Specific Ige ◽

Oral Immunotherapy ◽

Food Allergies ◽

Allergy Prevention ◽

Diagnosis And Management ◽

Skin Prick Tests ◽

Food Specific Ige ◽

Common Misconceptions

Background: Food allergies are common, affecting 1 in 13 school children in the United States and their prevalence is increasing. Many misconceptions exist with regards to food allergy prevention, diagnosis and management. Objective: The main objective of this review is to address misconceptions with regards to food allergies and discuss the optimal, evidence-based approach for patients who carry this diagnosis. Observations: Common misconceptions in terms of food allergy prevention include beliefs that breastfeeding and delayed introduction of allergenic foods prevent the development of food allergies. In terms of diagnosis, statements such as ‘larger skin prick tests or/and higher levels of food-specific IgE can predict the severity of food-induced allergic reactions’, or ‘Tryptase is always elevated in food-induced anaphylaxis’ are inaccurate. Additionally, egg allergy is not a contraindication for receiving the influenza vaccine, food-allergy related fatalities are rare and peanut oral immunotherapy, despite reported benefits, is not a cure for food allergies. Finally, not all infants with eczema will develop food allergies and epinephrine auto-injectors may unfortunately be both unavailable and underused in food-triggered anaphylaxis. Conclusions and relevance: Healthcare professionals must be familiar with recent evidence in the food allergy field and avoid common misunderstandings that may negatively affect prevention, diagnosis and management of this chronic disease.

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Evaluation of Dermatophagoides pteronyssinus (Trouessart) and D. farinae Hughes (Acari: Pyroglyphidae) sensitivity in patients with allergic rhinitis: a comparative study

Systematic and Applied Acarology ◽

10.11158/saa.23.2.2 ◽

2018 ◽

Vol 23 (2) ◽

pp. 206

Author(s):

Erhan ZEYTUN ◽

Salih DOĞAN ◽

Edhem Ünver ◽

Fatih ÖZÇÜÇEK

Keyword(s):

Allergic Rhinitis ◽

Comparative Study ◽

Clinical Assessment ◽

Serum Levels ◽

Specific Ige ◽

Dermatophagoides Pteronyssinus ◽

Total Ige ◽

Serologic Tests ◽

Stereo Microscope ◽

Skin Prick Tests

This study was conducted to determine the sensitivity to Dermatophagoides pteronyssinus (Trouessart) and D. farinae Hughes with skin prick tests (SPT) and serologic tests in patients with allergic rhinitis (AR), and to specifically search for those mites in homes of patients. A total of 51 participants, (23 patients and 28 controls) were utilized. Skin-prick tests with D. pteronyssinus and D. farinae allergens were performed on all participants, and serum levels of allergen-specific lgE and total IgE were also measured. Dust samples were collected from homes of all participants and examined under a stereo microscope. 977 D. pteronyssinus (mean 44.4/g) and 24 D. farinae (mean 4.0/g) were isolated from the homes of patients, whereas 35 D. pteronyssinus (mean 4.4/g), and four D. farinae (mean 2.0/g) were isolated from the homes of the controls. Patients with D. pteronyssinus in their homes had 95.5% sensitivity to the species according to SPT and 27.3 according to IgE. Patients with D. farinae in their homes had 83.3% sensitivity to the species according to SPT, and 50% according to IgE. Dermatophagoides pteronyssinus sensitivity in the controls was detected as 12.5% according to SPT; however, D. farinae sensitivity was not detected according to both SPT and mite-specific IgE. Differences between patients and controls utilizing SPT results was statistically significant, but not when using mite-specific IgE results. As a result, it was determined that patients with AR in Erzincan province were sensitized to D. pteronyssinus and D. farinae, and that their homes contained those species. It may be helpful to consider these findings in clinical assessment of patients with AR, and also in treatment utilizing immunotherapy techniques.

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Flow cytometric analysis of in vitro activated basophils, specific IgE and skin tests in the diagnosis of pollen-associated food allergy

Cytometry Part B Clinical Cytometry ◽

10.1002/cyto.b.20042 ◽

2005 ◽

Vol 64B (1) ◽

pp. 28-33 ◽

Cited By ~ 60

Author(s):

Didier G. Ebo ◽

Margo M. Hagendorens ◽

Chris H. Bridts ◽

Annemie J. Schuerwegh ◽

Luc S. De Clerck ◽

...

Keyword(s):

Food Allergy ◽

Flow Cytometric Analysis ◽

Specific Ige ◽

Skin Tests ◽

Flow Cytometric

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Effect of acupuncture on house dust mite specific IgE, substance P, and symptoms in persistent allergic rhinitis

Annals of Allergy Asthma & Immunology ◽

10.1016/j.anai.2016.04.002 ◽

2016 ◽

Vol 116 (6) ◽

pp. 497-505 ◽

Cited By ~ 10

Author(s):

John Leslie McDonald ◽

Peter K. Smith ◽

Caroline A. Smith ◽

Charlie Changli Xue ◽

Brenda Golianu ◽

...

Keyword(s):

Allergic Rhinitis ◽

Substance P ◽

House Dust ◽

House Dust Mite ◽

Specific Ige ◽

Persistent Allergic Rhinitis ◽

Dust Mite

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Clinical manifestations of atopy in children up to two years of age

Vojnosanitetski pregled ◽

10.2298/vsp1108690i ◽

2011 ◽

Vol 68 (8) ◽

pp. 690-695 ◽

Cited By ~ 1

Author(s):

Nevenka Ilic ◽

Vesna Velickovic ◽

Dragoljub Djokic ◽

Nebojsa Rankovic ◽

Gordana Kostic ◽

...

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Clinical Manifestations ◽

Allergic Diseases ◽

Developed Countries ◽

Specific Ige ◽

Food Allergies ◽

Atopic Diseases ◽

Ige Antibodies ◽

Total Ige

Background/Aim. Atopic diseases such as atopic dermatitis, allergic rhinitis and asthma have had increased prevalence during the past decade and nowadays occur in every third child in developed countries. The aim of the study was to determine frequency and type of atopic diseases at the age of two, as well as the importance the total IgE antibodies concentrations have in diagnosis and prognosis of the disease. Methods. The study involved 175 children up to two years of age. Allergy-like symptoms were found after surveying their parents and pediatric medical records. Using the fluorescence immunossay (FIA) method, total IgE antibodies concentrations and specific IgE antibodies (Phadiatop infant) were determined on an Immunocap 100 Dyagnostic System. Results. One or more allergy-like symptoms accounted for 57.7% of findings in children under the age of two, whilst in 19.4% the existence of IgE-related allergic diseases was found. Atopic diseases usually have clinical manifestations of atopic dermatitis (11.4%), IgE-bound wheezing/asthma (10.8%) and food allergies (7.4%), and to much lesser extent those of allergic rhinitis (3.4%) and urticaria (1.7%). The significantly higher total IgE antibodies concentrations were found in children with allergy-like symptoms (p < 0.0005) (cut-off 15.15 kU/L, sensitivity 76.5% specificity 71.6%). Conclusion. Almost 20% of two-year-old children have any of clinically manifested allergic diseases, with atopic dermatitis and IgE wheeze/asthma being predominant. The higher total IgE antibodies concentration is a good marker for sensitization in children with allergy-like symptoms.

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Lipid Transfer Protein Sensitization: Risk of Anaphylaxis and Molecular Sensitization Profile in Pru p 3-Sensitized Patients

International Archives of Allergy and Immunology ◽

10.1159/000511977 ◽

2020 ◽

pp. 1-8

Author(s):

Maria Ruano-Zaragoza ◽

Maria Luisa Somoza ◽

Teodorikez Wilfox Jiménez-Rodriguez ◽

Victor Soriano-Gomis ◽

Purificación González-Delgado ◽

...

Keyword(s):

Lipid Transfer Protein ◽

Allergic Diseases ◽

Specific Ige ◽

Oral Allergy Syndrome ◽

Skin Tests ◽

Food Allergies ◽

Lipid Transfer ◽

Cross Sectional ◽

Positive Skin ◽

Pru P 3

Background: Component-resolved diagnosis reveals the IgE response to many inhaled, food, and other allergens, improving the understanding and diagnosis of allergic diseases. Objective: The aims of the study are to study the recognition of different lipid transfer proteins (LTPs) and other allergen families in a large group of people sensitized to Pru p 3 and to analyze the relationship between the clinical entities and the allergens. Methods: This cross-sectional study included a large cohort of patients with positive skin tests to peach fruit and Pru p 3 specific IgE antibodies. Respiratory and food allergy symptoms were collected, and we performed prick tests with pollen, plant food, and other allergens plus the ImmunoCAP ISAC assay. Results: Our sample consisted of 421 people with a mean age of 33.25 years (range 16–68); 54.6% were women. Clinical entities included anaphylaxis (37.1%), urticaria (67.9%), and oral allergy syndrome (59.1%). Rhinitis, rhinoconjunctivitis, and/or asthma were diagnosed in 71.8% of the participants. The most pronounced correlation existed between sensitization to Pru p 3 and to Jug r 3, Pla a 3, Ara h 9, and Cor a 8. We found a higher incidence of anaphylaxis in people with 5 or more recognized LTPs. No association was observed between inhaled and food allergies. Conclusion: Most Pru p 3-sensitized participants were sensitized to additional allergens from the same family and, to a lesser extent, to other allergens, mainly in the profilin and PR-10 protein families. Anaphylaxis occurred in more than a third of the cases evaluated, and almost three-quarters of them had respiratory symptoms. Respiratory and food allergies involving LTPs do not seem to be associated.

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Serum Levels of Specific IgE, Soluble Interleukin-2 Receptor, and Soluble Intercellular Adhesion Molecule-1 in Seasonal Allergic Rhinitis

Annals of Allergy Asthma & Immunology ◽

10.1016/s1081-1206(10)63004-9 ◽

1997 ◽

Vol 79 (3) ◽

pp. 213-220 ◽

Cited By ~ 10

Author(s):

Yoshihiro Ohashi ◽

Yoshiaki Nakai ◽

Ayaki Tanaka ◽

Yasushi Kakinoki ◽

Yoshiharu Ohno ◽

...

Keyword(s):

Allergic Rhinitis ◽

Adhesion Molecule ◽

Seasonal Allergic Rhinitis ◽

Interleukin 2 ◽

Serum Levels ◽

Specific Ige ◽

Intercellular Adhesion Molecule ◽

Intercellular Adhesion Molecule 1 ◽

Soluble Interleukin 2 Receptor ◽

Soluble Intercellular Adhesion Molecule

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The significance of cow’s milk proteins in the development of IgE-mediated food allergy among children

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja1196 ◽

2019 ◽

Vol 16 (2) ◽

pp. 38-44

Author(s):

S Yu Petrova ◽

S V Khlgatian ◽

V M Berzhets ◽

L A Pishchulina ◽

A V Vasilyeva

Keyword(s):

Food Allergy ◽

Whey Proteins ◽

Milk Proteins ◽

Specific Ige ◽

Moscow Region ◽

Food Allergies ◽

Cow’S Milk ◽

Food Allergens ◽

Cow's Milk ◽

Cow’S Milk Proteins

Identification of offending allergens in patients with food allergy is a very important part of an allergist’s activity. Objective. To study the structure оf sensitization to food allergens among children in Moscow and Moscow region and to determine the significance of sensitization to milk proteins . Methods. The level and class of specific IgE in blood serum of children with IgEmediated allergic diseases were examined with RIDA AllergyScreen method. Serum of children with high level of specific IgE to milk allergenic proteins was studied. The level and ratio of specific IgE to individual milk allergens were revealed. Results. The structure of sensitization to food allergens was determined. It was revealed that cow’s milk allergens are the leading triggers of food allergy, especially in early childhood in Moscow and the Moscow region. The features of sensitization to cow’s milk proteins among children were analyzed. Conclusions. According to the study, about half of children with IgEmediated food allergies in Moscow and the Moscow region have sensitization to cow’s milk proteins. The leading role in the frequency of sensitization belongs to whey proteins of milk. Among them sensitization to а-lactalbumin was detected more often. The questions about the selection of hypoallergenic milk formulas for feeding of children with allergy to cow’s milk proteins were discussed.

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The availability of vitamin D in children of the first year of life with food allergies residing in conditions of military conflict in Donbass

Pediatrician (St Petersburg) ◽

10.17816/ped11251-56 ◽

2020 ◽

Vol 11 (2) ◽

pp. 51-56

Author(s):

Andrew V. Nalyotov ◽

Tatyana I. Shapchenko ◽

Natalia A. Svistunova ◽

Maxim V. Vakulenko

Keyword(s):

Vitamin D ◽

Food Allergy ◽

Clinical Symptoms ◽

Serum Levels ◽

Food Allergies ◽

Healthy Children ◽

Military Conflict ◽

Vitamin D Levels ◽

First Year Of Life

The problem of vitamin D deficiency is one of the most actual today. According to numerous clinical studies, its insufficiency of this micronutrient is registered in half of the worlds population. Aim of the study. To study the provision of vitamin D in infants, suffering from food allergy and living in the Donbass in a military conflict. Materials and methods. 105 infants living in the Donetsk Peoples Republic suffering from food allergy were examined. The level of vitamin D in serum in these patients was studied by determining serum levels of 25(OH)D. Results and discussion. Insufficient vitamin D levels were found in 57.1 4.8% infants with food allergy, which was significantly higher (р 0.05) compared to healthy children (12.5 5.2%). At the same time, children with food allergies, long-term living near the region of active hostilities, statistically significant (р 0.001) often had a reduced level of vitamin D. It was found that in the group of patients with low level of vitamin D polyvalent food allergy was determined statistically significantly more common compared to the group of patients with normal level of vitamin D. Conclusion. Infants, suffering from food allergy and living in the Donetsk Peoples Republic in a long-term military conflict are characterized by a decrease in vitamin D level, which may play a role in the formation of the immune response, the development of clinical symptoms of pathology and disrupt the development of tolerance to the food allergens.

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