Correlation of Serum Levels of Interleukin‑1β and CCL 24 with Severity of Persistent Allergic Rhinitis in Children

Background. To study dynamics of cytokine status during early stages of allergen-specific immunotherapy (ASIT) in children suffering from persistent allergic rhinitis (PAR). Methods. 30 children suffering from PAR have received complete course of ASIT. Serum levels ofILL-4, -5, -6, -8, -12, -13, sIL-2R were studied in 0, 7, 30 and 90 days and have been analyzed differentially in groups with good/excellent and incomplete effectiveness of treatment. Results. Good/excellent effectiveness of completed course of ASIT has been demonstrated in 17/30 (56,7%) children, partial effectiveness has been demonstrated for 13/30 (43,3%) ones.The decreased IL-12 and IL-6 levels and the increase of sIL-2R production were described for good/excellent results of treatment, but insufficient effectiveness was characterized by delayed dynamics of these cytokines. IL-8 level was increased in both groups but decreased effectiveness was associated with early start and long duration of it. IL-4 production was decreased in the good/ excellent group while on the second one changes of cytokine level were absent. IL-13 and IL-5 synthesis were increased in both groups. Conclusion. The effectiveness of ASIT in PAR patients depends on synthesis dynamics of ILL-4, -6, -8, -12, sIL-2R at the early treatment stages.

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Endotypes of allergic rhinitis and asthma accompanying food allergy

Bulletin of Siberian Medicine ◽

10.20538/1682-0363-2019-2-287-289 ◽

2019 ◽

Vol 18 (2) ◽

pp. 287-289 ◽

Cited By ~ 1

Author(s):

A. V. Klimov ◽

P. Yu. Isaev ◽

V. V. Klimov ◽

V. S. Sviridova

Keyword(s):

Allergic Rhinitis ◽

Food Allergy ◽

Serum Levels ◽

Specific Ige ◽

Diagnosis And Treatment ◽

Skin Tests ◽

Food Allergies ◽

Case Histories ◽

New Approaches ◽

Persistent Allergic Rhinitis

61 people suffering from persistent allergic rhinitis and asthma accompanying food allergies were studied using case histories, the NHANES questionnaire, polyspecific serum levels, allergen-specific IgE, IL4, IFNg and IL10 assays, and allergy skin tests. Four different endotypes have been identified, including entopic, which can be the basis for new approaches to the diagnosis and treatment of allergic rhinitis and asthma.

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Topical nasal steroids for intermittent and persistent allergic rhinitis in children

10.1002/14651858.cd003163.pub3 ◽

2005 ◽

Author(s):

JJ Al Sayyad ◽

D Alhashimi ◽

Z Fedorowicz ◽

A Jamal

Keyword(s):

Allergic Rhinitis ◽

Persistent Allergic Rhinitis ◽

Nasal Steroids

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Effect of adjunctive sodium hyaluronate versus surfactant nasal irrigation on mucociliary clearance in allergic rhinitis: a single-blind, randomised, controlled study

The Journal of Laryngology & Otology ◽

10.1017/s0022215121000967 ◽

2021 ◽

pp. 1-4

Author(s):

E Ocak ◽

S Mulazimoglu ◽

D Kocaoz ◽

E Mirici ◽

E Dagli ◽

...

Keyword(s):

Allergic Rhinitis ◽

Mucociliary Clearance ◽

Isotonic Saline ◽

Sodium Hyaluronate ◽

Controlled Study ◽

Control Group ◽

Clearance Time ◽

Nasal Irrigation ◽

Persistent Allergic Rhinitis ◽

Randomised Controlled

Abstract Objective To investigate the effects of nasal irrigation with sodium hyaluronate and surfactant solutions on mucociliary clearance time in patients with mild persistent allergic rhinitis. Methods A total of 120 patients diagnosed with mild persistent allergic rhinitis were enrolled in this prospective study. The patients were allocated randomly to the surfactant, sodium hyaluronate or isotonic saline (as a control) nasal irrigation group. The mucociliary clearance times and improvements in mucociliary clearance times were compared. Results Improvements in mean mucociliary clearance time were significantly greater in the surfactant and sodium hyaluronate groups than in the control group (p < 0.01). The mean post-treatment mucociliary clearance time of the surfactant group was significantly lower than that of the control (p < 0.001) and sodium hyaluronate groups (p = 0.03). Conclusion Surfactant and sodium hyaluronate nasal irrigation solutions may both be used as adjunctive treatments for allergic rhinitis. Surfactant nasal irrigation resulted in better mucociliary clearance times.

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Correlation of specific and total IgE serum levels with symptoms and effects of anti-IgE treatment in children with seasonal allergic rhinitis (SAR)

Journal of Allergy and Clinical Immunology ◽

10.1016/s0091-6749(03)81275-7 ◽

2003 ◽

Vol 111 (2) ◽

pp. S347

Author(s):

E.H. Hamelmann ◽

C. Rolick-Werninghaus ◽

M. Kopp ◽

J. Kuehr ◽

U. Wahn

Keyword(s):

Allergic Rhinitis ◽

Seasonal Allergic Rhinitis ◽

Serum Levels ◽

Total Ige

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Correlation of Nasal Fluid Biomarkers and Symptoms in Patients with Persistent Allergic Rhinitis

Annals of Otology Rhinology & Laryngology ◽

10.1177/0003489419898717 ◽

2020 ◽

Vol 129 (6) ◽

pp. 542-547

Author(s):

Su Il Kim ◽

Oh Eun Kwon ◽

Jung Min Park ◽

Jeon Gang Doo ◽

Seok Hyun Kim ◽

...

Keyword(s):

Allergic Rhinitis ◽

Inverse Correlation ◽

Lavage Fluid ◽

Nasal Symptom ◽

Clara Cell ◽

Cell Protein ◽

Enzyme Linked Immunosorbent Assay ◽

Prick Test ◽

Persistent Allergic Rhinitis ◽

Nasal Fluid

Objectives: This study investigated whether the biomarkers present in nasal fluid reflect the severity of symptoms in patients with persistent allergic rhinitis (PAR). Methods: We enrolled 29 PAR patients complaining of nasal symptoms and testing positive to skin prick test. Patients’ total nasal symptom score (TNSS) was measured and their nasal lavage fluid (NALF) was collected. The levels of biomarkers including Clara cell protein 16 (CC16), tryptase, and interleukin 5 (IL-5) in NALF were determined via enzyme-linked immunosorbent assay (ELISA). Results: PAR patients were classified into persistent mild and persistent moderate-to-severe groups according to the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. The CC16 alone was significantly negatively correlated with TNSS ( P < .05). Further, the CC16 level was significantly lower in persistent moderate-to-severe group than persistent mild group of patients ( P < .05). Conclusions: The levels of CC16 alone among several NALF biomarkers showed an inverse correlation with symptoms of PAR patients.

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