Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine

The Hedgehog (Hh) signaling pathway plays an essential role in embryonic and postnatal vasculature development and homeostasis of organs. Under physiological condition, Hh family’s member Sonic Hedgehog (SHh) regulates endothelial cell growth, promotes cell migration, and induces the construction of blood vessels. In this review, we highlight recent topics in EPC biology, regarding current advance in SHh canonical and non-canonical signaling pathway in EPCs and EC biology in terms of homeostasis, extracellular SHh signal transmission by parental cell-derived extracellular vesicle (exosomes containing single-strand non-codding miRNA), and SHh signal impairment in cardiovascular diseases. Also, we discuss SHh signaling pathway activation of EPCs as a promising therapeutic tool against cardiovascular disease patients.

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Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine

International Journal of Molecular Sciences ◽

10.3390/ijms19103040 ◽

2018 ◽

Vol 19 (10) ◽

pp. 3040 ◽

Cited By ~ 6

Author(s):

Amankeldi A. Salybekov ◽

Ainur K. Salybekova ◽

Roberto Pola ◽

Takayuki Asahara

Keyword(s):

Cardiovascular Diseases ◽

Signaling Pathway ◽

Sonic Hedgehog ◽

Cell Biology ◽

Hedgehog Signaling ◽

Signal Transmission ◽

Vascular Medicine ◽

Endothelial Progenitor ◽

Sonic Hedgehog Signaling ◽

Shh Signaling

The Hedgehog (HH) signaling pathway plays an important role in embryonic and postnatal vascular development and in maintaining the homeostasis of organs. Under physiological conditions, Sonic Hedgehog (SHH), a secreted protein belonging to the HH family, regulates endothelial cell growth, promotes cell migration and stimulates the formation of new blood vessels. The present review highlights recent advances made in the field of SHH signaling in endothelial progenitor cells (EPCs). The canonical and non-canonical SHH signaling pathways in EPCs and endothelial cells (ECs) related to homeostasis, SHH signal transmission by extracellular vesicles (EVs) or exosomes containing single-strand non-coding miRNAs and impaired SHH signaling in cardiovascular diseases are discussed. As a promising therapeutic tool, the possibility of using the SHH signaling pathway for the activation of EPCs in patients suffering from cardiovascular diseases is further explored.

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Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine

10.20944/preprints201808.0110.v2 ◽

2018 ◽

Author(s):

Amankeldi A. Salybekov ◽

Ainur K. Salybekova ◽

Roberto Pola ◽

Takayuki Asahara

Keyword(s):

Cardiovascular Diseases ◽

Signaling Pathway ◽

Sonic Hedgehog ◽

Cell Biology ◽

Hedgehog Signaling ◽

Signal Transmission ◽

Vascular Medicine ◽

Endothelial Progenitor ◽

Sonic Hedgehog Signaling ◽

Shh Signaling

The Hedgehog (Hh) signaling pathway plays an important role in embryonic and postnatal vascular development and in maintaining the homeostasis of organs. Under physiological conditions, Sonic Hedgehog (Shh), a secreted protein belonging to the Hh family, regulates endothelial cell growth, promotes cell migration, and stimulates the formation of new blood vessels. The present review highlights recent advances made in the field of Shh signaling in endothelial progenitor cells (EPCs). The canonical and non-canonical Shh signaling pathways in EPCs and endothelial cells (ECs) related to homeostasis, Shh signal transmission by extracellular vesicles (EVs) or exosomes containing single-strand non-coding miRNAs, and impaired Shh signaling in cardiovascular diseases are discussed. As a promising therapeutic tool, the possibility of using the Shh signaling pathway for the activation of EPCs in patients suffering from cardiovascular diseases is further explored.

Download Full-text