scholarly journals Association of Maternal Iodine Intake with Congenital Hypothyroidism

2020 ◽  
Author(s):  
P. Gopika ◽  
M. Sreelakshmi ◽  
Sajal Nalwaya ◽  
Sarita Jangra Bhyan
Keyword(s):  
Quality Of Life ◽  
Congenital Hypothyroidism ◽  
Iodine Intake ◽  
Spontaneous Abortions ◽  
High Iodine ◽  
Dosage Range ◽  
Iodine Supplementation ◽  
Transient Congenital Hypothyroidism ◽  
Excess Load

The iodine intake in a pregnant woman has been closely correlated with development of transient congenital hypothyroidism which leads to decline in neurocognitive abilities of the child later in life as the effects are very subtle at birth. Both low and excess ingestion of iodine has been found to contribute to this cause, although iodine deficiency is more commonly observed in women of underdeveloped nations. It poses risks not only to the foetus but also to the mother leading to obstetric complications such as still birth and spontaneous abortions. It can be prevented using WHO recommended daily iodine supplementation in deficient regions or decreasing the excess load in groups exposed to high iodine. Programmes designed to screen the new-born at birth can also help in improving the quality of life of the child. The deficient iodine condition is managed by administration of levothyroxine in dosage range of 10-15 mcg/kg/day. Generally, the prognosis of infants starting treatment early in life have a better neurocognitive outcome as compared to the treated infants late age at a later age. Avoidance of agents causing iodine exposure has resulted in decrease in the abnormal thyroid function levels.

scholarly journals Effect of delayed diagnosis and treatment of congenital hypothyroidism on intelligence and quality of life: an observational study

2019 ◽  
Vol 28 (4) ◽  
pp. 396-401 ◽  
Author(s):  
Aman Bhakti Pulungan ◽  
Myrte Everarda Oldenkamp ◽  
Adrianus Sarinus Paulus Van Trotsenburg ◽  
Wiwik Windarti ◽  
Hartono Gunardi
Keyword(s):  
Quality Of Life ◽  
Thyroid Hormone ◽  
Congenital Hypothyroidism ◽  
Delayed Diagnosis ◽  
Hormone Treatment ◽  
Hormone Substitution ◽  
Late Initiation ◽  
Related Quality ◽  
Health Related

BACKGROUND Congenital hypothyroidism is one of the most prevalent, albeit preventable causes of intellectual disability. This study determined the intellectual outcome and health-related quality of life (QoL) in children and adolescents clinically diagnosed with congenital hypothyroidism and the associations among age of starting thyroid hormone treatment, current free thyroxine (FT4) level, intelligence quotient (IQ), and QoL.METHODS Intelligence (Wechsler scales) and QoL (PedsQLTM 4.0 parent proxy-report) tests were administered to 25 patients with congenital hypothyroidism in the pediatric clinic of Cipto Mangunkusumo Hospital, Jakarta. Nineteen patients underwent thyroid ultrasonography or scintigraphy to determine the etiology of congenital hypothyroidism.RESULTS A total of 25 patients with the median age of 9 (5.5–12.5) years were recruited. Eighteen patients had a total IQ of <70. The age of treatment initiation did not correlate with full scale IQ (FSIQ) (r = −0.261, p = 0.071) and verbal IQ (VIQ) (r = −0.232, p = 0.265). The late initiation of treatment was correlated with lower performance IQ (PIQ) (r = −0.325, p = 0.025). The higher current FT4 levels was correlated with higher scores ofFSIQ (r = 0.314, p = 0.046) and PIQ (r = 0.320, p = 0.043). The late initiation of treatment (r = 0.006, p = 0.980) and higher current FT4 levels (r = 0.246, p = 0.310) were not correlated with QoL. Hemiagenesis of thyroid gland was the most common etiology.CONCLUSIONS The late initiation of thyroid hormone substitution in patients with congenital hypothyroidism negatively affects intellectual abilities.

scholarly journals Pediatric Quality of Life in Congenital Hypothyroidism: an Indonesian Study

2020 ◽  
Vol 13 (2) ◽  
pp. 150-154
Author(s):  
Nur Rochmah ◽  
Muhammad Faizi ◽  
Carrina Dewanti ◽  
Ahmad Suryawan
Keyword(s):  
Quality Of Life ◽  
Congenital Hypothyroidism

scholarly journals Effect of High Iodine Intake on Selected Parameters of Immunity in Sheep

2012 ◽  
Vol 56 (4) ◽  
pp. 659-662
Author(s):  
Hana Dušová ◽  
Jan Trávníček ◽  
Vlasta Kroupová ◽  
Martina Staňková ◽  
Zdeněk Peksa
Keyword(s):  
Immunoglobulin G ◽  
Dry Matter ◽  
Iodine Intake ◽  
Average Concentration ◽  
Control Group ◽  
High Iodine ◽  
Immunological Parameters ◽  
Average Percentage ◽  
Iodine Supplementation ◽  
Γ Globulins

Abstract The study aimed at defining the immunity risks connected with high iodine supplementation in ewes and their lambs. The feed ration for control group (C) of ewes (n=6) contained 3.1 mg of iodine per kilogram of dietary dry matter and for experimental group (E) of ewes (n=6) 5.1 mg of iodine per kilogram of dietary dry matter. The animals were fed the diets for 8 months. Parallelly with different iodine supplementation, some immunological parameters (percentage of γ-globulins, concentration of immunoglobulin G, and white blood cell count) were examined in ewes and their lambs. The difference in the average concentration of immunoglobulin G between the ewes of group C and E was not significant during the experiment. A significant decrease (P<0.01) in the concentration of immunoglobulin G from 19.6 mg/mL before the experiment to 9.8 mg/mL on day 60 of the experiment was demonstrated in the ewes of group E. The average percentage of γ-globulins in the whole period after parturition was lower in the ewes of group E than in group C. The concentration of immunoglobulin G and the percentage of γ-globulins in lambs from dams in group E was continually lower (P<0.01) for the entire period of 1-30 d and demonstrated immunological risks of the excessive intake of iodine. The obtained results document a dangerous influence of high iodine intake on immunity in the prenatal period in ewes and mainly in the postnatal period in their lambs.

scholarly journals Health-related quality of life in patients with early-detected central congenital hypothyroidism

2021 ◽  
Author(s):  
Jolanda Christine Naafs ◽  
Jan Pieter Marchal ◽  
Paul Hendrikus Verkerk ◽  
Eric Fliers ◽  
Adrianus Sarinus Paulus van Trotsenburg ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Congenital Hypothyroidism ◽  
Linear Mixed Model ◽  
Pituitary Hormone ◽  
Health Related Quality ◽  
Parent Reports ◽  
Self Reports ◽  
Related Quality ◽  
Health Related

Abstract Context Central congenital hypothyroidism (CH) requires lifelong medical treatment. The majority of children with central CH have multiple pituitary hormone deficiencies (MPHD), but in some cases central CH is isolated. Most pituitary hormone deficiencies are associated with impaired health-related quality of life (HRQoL). However, studies on HRQoL in central CH are lacking. Objective to evaluate HRQoL and fatigue in children and young adults with central CH, as well as parent perspectives. Design nationwide cross-sectional study comparing HRQoL between early-detected central CH patients and unaffected siblings with the Pediatric Quality of Life inventory (PedsQL™) and PedsQL Multidimensional Fatigue Scale. Participants ≥8 years old filled in self-reports; parents of participants aged 3-18 years filled in parent-reports. Isolated central CH patients, MPHD patients and siblings were compared using a linear mixed model and Tukey’s post hoc test. Results Eighty-eight patients and 52 siblings participated, yielding 98 self-reports and 115 parent-reports. Isolated central CH patients (n=35) and siblings showed similar scores on all subscales, both in the self-reports and parent-reports. For MPHD patients (n=53), self-reported scores were similar to those of siblings. Parent-reported total HRQoL and fatigue scores were significantly poorer in MPHD patients compared with siblings (mean differences -10.2 and -9.4 points; p&lt;0.01), as were scores for physical functioning, social functioning and general fatigue. Conclusion Self-reported HRQoL scores in isolated central CH and MPHD patients were similar to siblings. However, parents reported significantly lower HRQoL and fatigue scores for MPHD patients, suggesting a difference in perceived limitations between MPHD patients and their parents.

Quality of life of young adults with congenital hypothyroidism

2009 ◽  
Vol 51 (1) ◽  
pp. 126-131 ◽  
Author(s):  
Hirokazu Sato ◽  
Nobue Nakamura ◽  
Shohei Harada ◽  
Naoko Kakee ◽  
Nozomu Sasaki
Keyword(s):  
Quality Of Life ◽  
Young Adults ◽  
Congenital Hypothyroidism

scholarly journals Health- related quality of life and self-worth in 10-year old children with congenital hypothyroidism diagnosed by neonatal screening

2012 ◽  
Vol 6 (1) ◽  
pp. 32 ◽  
Author(s):  
Liesbeth van der Sluijs Veer ◽  
Marlies JE Kempers ◽  
Heleen Maurice-Stam ◽  
Bob F Last ◽  
Tom Vulsma ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Congenital Hypothyroidism ◽  
Neonatal Screening ◽  
Health Related Quality ◽  
Self Worth ◽  
Related Quality ◽  
Health Related

scholarly journals Effects of increased iodine supply on the selenium status of kids

2012 ◽  
Vol 50 (No. 5) ◽  
pp. 186-194 ◽  
Author(s):  
L. Pavlata ◽  
S. Slosarkova ◽  
P. Fleischer ◽  
A. Pechova
Keyword(s):  
Potassium Iodide ◽  
Selenium Concentration ◽  
Experimental Period ◽  
Iodine Intake ◽  
Selenium Status ◽  
Glutathione Peroxidase Activity ◽  
High Iodine ◽  
Selenium Metabolism ◽  
Iodine Supplementation ◽  
Negative Effect

The aim of the study was to monitor the effect of increased iodine supplementation of the clinically healthy kid organism on the selenium status. The study included 7 clinically healthy 14-day-old kids from mothers with high iodine supplementation (group E) and 7 clinically healthy kids from mothers with hypoiodaemia (group C). Kids in group E were administered potassium iodide orally from 14 to 90 days of age. During the experimental period, the group E kids had a total daily iodine intake (from the feeding ration and from the per os potassium iodide administration) of 440&ndash;590 &micro;g per head and day in comparison with 140&ndash;190 &micro;g per head and day in the group C kids (only from the feeding ration; no potassium iodide administration). In kids of both groups, selenium concentration (Se), glutathione peroxidase activity (GSH-Px), concentration of the thyroid gland hormones (T<sub>3</sub> and T<sub>4</sub>) and animal weights were monitored. In the group E kids, lower Se concentration (88.1 &plusmn; 10.9 &micro;g/l; p &lt; 0.01) and lower activity of GSH-Px (484.0 &plusmn; 125.4 &micro;kat/l; p &lt; 0.05) were proved at the end of the experiment (at 105 days of age of the kids) in comparison with the group C kids (131.8 &plusmn; 23.2 &micro;g/l and 713.3&nbsp;&plusmn; 153.3 &micro;kat/l, respectively). No significant differences were found out in the T<sub>3</sub> or T<sub>4</sub> concentrations or in the weights of animals of both groups. The results indicate that increased iodine supplementation may have a negative effect on selenium metabolism and/or selenium status in kids.

Self-Compassion and Quality of Life in Adults Who Stutter

2020 ◽  
Vol 29 (4) ◽  
pp. 2097-2108
Author(s):  
Robyn L. Croft ◽  
Courtney T. Byrd
Keyword(s):  
Quality Of Life ◽  
Social Connectedness ◽  
The Self ◽  
Future Research ◽  
Self Compassion ◽  
Adults Who Stutter ◽  
And Gender ◽  
Relationship Of ◽  
The Impact

Purpose The purpose of this study was to identify levels of self-compassion in adults who do and do not stutter and to determine whether self-compassion predicts the impact of stuttering on quality of life in adults who stutter. Method Participants included 140 adults who do and do not stutter matched for age and gender. All participants completed the Self-Compassion Scale. Adults who stutter also completed the Overall Assessment of the Speaker's Experience of Stuttering. Data were analyzed for self-compassion differences between and within adults who do and do not stutter and to predict self-compassion on quality of life in adults who stutter. Results Adults who do and do not stutter exhibited no significant differences in total self-compassion, regardless of participant gender. A simple linear regression of the total self-compassion score and total Overall Assessment of the Speaker's Experience of Stuttering score showed a significant, negative linear relationship of self-compassion predicting the impact of stuttering on quality of life. Conclusions Data suggest that higher levels of self-kindness, mindfulness, and social connectedness (i.e., self-compassion) are related to reduced negative reactions to stuttering, an increased participation in daily communication situations, and an improved overall quality of life. Future research should replicate current findings and identify moderators of the self-compassion–quality of life relationship.

Misophonia: An Evidence-Based Case Report

2020 ◽  
Vol 29 (4) ◽  
pp. 685-690
Author(s):  
C. S. Vanaja ◽  
Miriam Soni Abigail
Keyword(s):  
Quality Of Life ◽  
Case Report ◽  
Case History ◽  
Pure Tone ◽  
Physiological Responses ◽  
Evidence Based ◽  
Management Option ◽  
Pure Tone Audiogram

Purpose Misophonia is a sound tolerance disorder condition in certain sounds that trigger intense emotional or physiological responses. While some persons may experience misophonia, a few patients suffer from misophonia. However, there is a dearth of literature on audiological assessment and management of persons with misophonia. The purpose of this report is to discuss the assessment of misophonia and highlight the management option that helped a patient with misophonia. Method A case study of a 26-year-old woman with the complaint of decreased tolerance to specific sounds affecting quality of life is reported. Audiological assessment differentiated misophonia from hyperacusis. Management included retraining counseling as well as desensitization and habituation therapy based on the principles described by P. J. Jastreboff and Jastreboff (2014). A misophonia questionnaire was administered at regular intervals to monitor the effectiveness of therapy. Results A detailed case history and audiological evaluations including pure-tone audiogram and Johnson Hyperacusis Index revealed the presence of misophonia. The patient benefitted from intervention, and the scores of the misophonia questionnaire indicated a decrease in the severity of the problem. Conclusions It is important to differentially diagnose misophonia and hyperacusis in persons with sound tolerance disorders. Retraining counseling as well as desensitization and habituation therapy can help patients who suffer from misophonia.

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