scholarly journals Anti-Inflammatory, Antioxidant and Wound Healing Properties of Cyanobacteria from Thermal Mud of Balaruc-les-Bains, France: A Multi-Approach Study

2020 ◽  
Author(s):  
Justine Demay ◽  
Sébastien Halary ◽  
Adeline Knittel-Obrecht ◽  
Pascal Villa ◽  
Charlotte Duval ◽  
...  
Keyword(s):  
Wound Healing ◽  
Natural Products ◽  
Ecological Niche ◽  
Microbial Biofilm ◽  
Specific Adaptation ◽  
Bioactive Natural Products ◽  
Anti Inflammatory

Background: The Balaruc-les-Bains’ thermal mud was found to be colonized predominantly by microorganisms, with cyanobacteria constituting the primary organism in the microbial biofilm observed on the mud surface. The success of cyanobacteria in colonizing this specific ecological niche can be explained in part by their taxa-specific adaptation capacities, and also the diversity of bioactive natural products that they synthesize. This array of components has physiological and ecological properties that may be exploited for various applications.

scholarly journals A Review of Anti-Inflammatory Compounds from Marine Fungi, 2000–2018

Marine Drugs ◽  
2019 ◽  
Vol 17 (11) ◽  
pp. 636 ◽  
Author(s):  
Jianzhou Xu ◽  
Mengqi Yi ◽  
Lijian Ding ◽  
Shan He
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Host Response ◽  
Marine Fungi ◽  
Tissue Injury ◽  
Fungal Metabolites ◽  
Bioactive Natural Products ◽  
Anti Inflammatory ◽  
Unique Mechanism ◽  
Inflammatory Action

Inflammation is a generalized, nonspecific, and beneficial host response of foreign challenge or tissue injury. However, prolonged inflammation is undesirable. It will cause loss function of involve organs, such as heat, pain redness, and swelling. Marine natural products have gained more and more attention due to their unique mechanism of anti-inflammatory action, and have considered a hotspot for anti-inflammatory drug development. Marine-derived fungi are promising sources of structurally unprecedented bioactive natural products. So far, a plethora of new secondary metabolites with anti-inflammatory activities from marine-derived fungi had been widely reported. This review covers 133 fungal metabolites described in the period of 2000 to 2018, including the structures and origins of these secondary metabolites.

Recent achievements in the synthesis of oxazoles

2021 ◽  
Vol 25 ◽  
Author(s):  
Dau Xuan Duc ◽  
Nguyen Thi Chung
Keyword(s):  
Natural Products ◽  
Biological Activities ◽  
Agricultural Fields ◽  
Disease Treatment ◽  
Bioactive Natural Products ◽  
Antiviral Activities ◽  
Novel Methods ◽  
Anti Inflammatory ◽  
Synthetic Approaches ◽  
Synthetic Transformations

: Oxazole-containing compounds have diverse biological activities, such as antimicrobial, anticancer, antitubercular, anti-inflammatory, antidiabetic, antiobesity, antimalarial, and antiviral activities, and some of them have been used as drugs for disease treatment. They also play important roles in the synthesis of bioactive natural products, pharmaceuticals, and synthetic transformations, as well as in materials, catalysts, and agricultural fields. Thus, the development of more efficient and facile synthetic approaches to access oxazole compounds has attracted the intensive interest of chemists, and diverse methods for their synthesis have been investigated. Various established methods have been improved and modified, while numerous novel methods have been discovered. This article summarizes considerable studies on the construction of the oxazole skeleton, which date back to 2014.

Anti-inflammatory efficacy of some potentially bioactive natural products against rheumatoid arthritis

2019 ◽  
pp. 61-100 ◽  
Author(s):  
Sushweta Mahalanobish ◽  
Sukanya Saha ◽  
Sayanta Dutta ◽  
Shatadal Ghosh ◽  
Parames C. Sil
Keyword(s):  
Rheumatoid Arthritis ◽  
Natural Products ◽  
Bioactive Natural Products ◽  
Anti Inflammatory

scholarly journals Coral and Coral-Associated Microorganisms: A Prolific Source of Potential Bioactive Natural Products

Marine Drugs ◽  
2019 ◽  
Vol 17 (8) ◽  
pp. 468 ◽  
Author(s):  
Sang ◽  
Dat ◽  
Vinh ◽  
Cuong ◽  
Oanh ◽  
...  
Keyword(s):  
Natural Products ◽  
Bioactive Compounds ◽  
Marine Invertebrates ◽  
Present Review ◽  
Bioactive Natural Products ◽  
Wide Range ◽  
Anti Inflammatory

Marine invertebrates and their associated microorganisms are rich sources of bioactive compounds. Among them, coral and its associated microorganisms are promising providers of marine bioactive compounds. The present review provides an overview of bioactive compounds that are produced by corals and coral-associated microorganisms, covering the literature from 2010 to March 2019. Accordingly, 245 natural products that possess a wide range of potent bioactivities, such as anti-inflammatory, cytotoxic, antimicrobial, antivirus, and antifouling activities, among others, are described in this review.

scholarly journals Anti-Inflammatory, Antioxidant, and Wound-Healing Properties of Cyanobacteria from Thermal Mud of Balaruc-Les-Bains, France: A Multi-Approach Study

Biomolecules ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 28
Author(s):  
Justine Demay ◽  
Sébastien Halary ◽  
Adeline Knittel-Obrecht ◽  
Pascal Villa ◽  
Charlotte Duval ◽  
...  
Keyword(s):  
Wound Healing ◽  
Therapeutic Potential ◽  
Gene Clusters ◽  
Cell Types ◽  
Bioactive Metabolites ◽  
Antioxidant Compounds ◽  
Full Genome Sequencing ◽  
Bioactive Natural Products ◽  
Tnf Α ◽  
Anti Inflammatory

Background: The Balaruc-les-Bains’ thermal mud was found to be colonized predominantly by microorganisms, with cyanobacteria constituting the primary organism in the microbial biofilm observed on the mud surface. The success of cyanobacteria in colonizing this specific ecological niche can be explained in part by their taxa-specific adaptation capacities, and also the diversity of bioactive natural products that they synthesize. This array of components has physiological and ecological properties that may be exploited for various applications. Methods: Nine cyanobacterial strains were isolated from Balaruc thermal mud and maintained in the Paris Museum Collection (PMC). Full genome sequencing was performed coupled with targeted and untargeted metabolomic analyses (HPLC-DAD and LC-MS/MS). Bioassays were performed to determine antioxidant, anti-inflammatory, and wound-healing properties. Results: Biosynthetic pathways for phycobiliproteins, scytonemin, and carotenoid pigments and 124 metabolite biosynthetic gene clusters (BGCs) were characterized. Several compounds with known antioxidant or anti-inflammatory properties, such as carotenoids, phycobilins, mycosporine-like amino acids, and aeruginosins, and other bioactive metabolites like microginins, microviridins, and anabaenolysins were identified. Secretion of the proinflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 appeared to be inhibited by crude extracts of Planktothricoides raciborskii PMC 877.14, Nostoc sp. PMC 881.14, and Pseudo-chroococcus couteii PMC 885.14. The extract of the Aliinostoc sp. PMC 882.14 strain was able to slightly enhance migration of HaCat cells that may be helpful in wound healing. Several antioxidant compounds were detected, but no significant effects on nitric oxide secretion were observed. There was no cytotoxicity on the three cell types tested, indicating that cyanobacterial extracts may have anti-inflammatory therapeutic potential without harming body cells. These data open up promising uses for these extracts and their respective molecules in drugs or thermal therapies.

An in vitro model for investigation of vitamin A effects on wound healing

2021 ◽  
pp. 1-6
Author(s):  
Hoda Keshmiri Neghab ◽  
Mohammad Hasan Soheilifar ◽  
Gholamreza Esmaeeli Djavid
Keyword(s):  
Wound Healing ◽  
Endothelial Cell ◽  
Vitamin A ◽  
In Vitro Model ◽  
Cellular Proliferation ◽  
Endothelial Cell Migration ◽  
Normal Fibroblast ◽  
Anti Inflammatory ◽  
Vitro Model

Abstract. Wound healing consists of a series of highly orderly overlapping processes characterized by hemostasis, inflammation, proliferation, and remodeling. Prolongation or interruption in each phase can lead to delayed wound healing or a non-healing chronic wound. Vitamin A is a crucial nutrient that is most beneficial for the health of the skin. The present study was undertaken to determine the effect of vitamin A on regeneration, angiogenesis, and inflammation characteristics in an in vitro model system during wound healing. For this purpose, mouse skin normal fibroblast (L929), human umbilical vein endothelial cell (HUVEC), and monocyte/macrophage-like cell line (RAW 264.7) were considered to evaluate proliferation, angiogenesis, and anti-inflammatory responses, respectively. Vitamin A (0.1–5 μM) increased cellular proliferation of L929 and HUVEC (p < 0.05). Similarly, it stimulated angiogenesis by promoting endothelial cell migration up to approximately 4 fold and interestingly tube formation up to 8.5 fold (p < 0.01). Furthermore, vitamin A treatment was shown to decrease the level of nitric oxide production in a dose-dependent effect (p < 0.05), exhibiting the anti-inflammatory property of vitamin A in accelerating wound healing. These results may reveal the therapeutic potential of vitamin A in diabetic wound healing by stimulating regeneration, angiogenesis, and anti-inflammation responses.

Biotransformations of Bioactive Natural Products with Complicated Structures

Planta Medica ◽  
2012 ◽  
Vol 78 (05) ◽  
Author(s):  
JG Dai ◽  
RD Chen ◽  
D Xie ◽  
JH Li ◽  
K Wang ◽  
...  
Keyword(s):  
Natural Products ◽  
Bioactive Natural Products

In vitro anti-inflammatory and wound healing activities of Citrus auraptene

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
F Epifano ◽  
S Genovese ◽  
L Zhao ◽  
V Dang La ◽  
D Grenier
Keyword(s):  
Wound Healing ◽  
Anti Inflammatory
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