scholarly journals Macrocyclic Tetramers – Structural Investigation of Peptide-Peptoid Hybrids

2021 ◽  
Author(s):  
Claudine Herlan ◽  
Anna Sonnefeld ◽  
Thomas Gloge ◽  
Julian Brückel ◽  
Luisa Schlee ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Bioactive Compounds ◽  
Rational Design ◽  
Structural Investigation ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
X Ray ◽  
Three Dimensional Structure ◽  
X Ray Scattering

The determination of the three-dimensional structure is a key step for the identification of new targets as well as the rational design of bioactive compounds. Herein, we report the synthesis and the structural elucidation of novel tetrameric macrocycles. Measurements were taken in solid and solution states with the help of X-ray scattering and NMR spectroscopy. The investigations made will help to find diverse applications for this new, promising compound class.

scholarly journals Macrocyclic Tetramers—Structural Investigation of Peptide-Peptoid Hybrids

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4548
Author(s):  
Claudine Nicole Herlan ◽  
Anna Sonnefeld ◽  
Thomas Gloge ◽  
Julian Brückel ◽  
Luisa Chiara Schlee ◽  
...  
Keyword(s):  
Amino Acids ◽  
Nmr Spectroscopy ◽  
Rational Design ◽  
Structural Investigation ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Proteolytic Degradation ◽  
X Ray ◽  
X Ray Scattering

Outstanding affinity and specificity are the main characteristics of peptides, rendering them interesting compounds for basic and medicinal research. However, their biological applicability is limited due to fast proteolytic degradation. The use of mimetic peptoids overcomes this disadvantage, though they lack stereochemical information at the α-carbon. Hybrids composed of amino acids and peptoid monomers combine the unique properties of both parent classes. Rigidification of the backbone increases the affinity towards various targets. However, only little is known about the spatial structure of such constrained hybrids. The determination of the three-dimensional structure is a key step for the identification of new targets as well as the rational design of bioactive compounds. Herein, we report the synthesis and the structural elucidation of novel tetrameric macrocycles. Measurements were taken in solid and solution states with the help of X-ray scattering and NMR spectroscopy. The investigations made will help to find diverse applications for this new, promising compound class.

scholarly journals Determination of the Three-dimensional Structure of Dislocations by Synchrotron White X-ray Topography Combined with a Topo-tomographic Technique

Materia Japan ◽  
2007 ◽  
Vol 46 (12) ◽  
pp. 823-823
Author(s):  
Seiji Kawado ◽  
Toshinori Taishi ◽  
Satoshi Iida ◽  
Yoshifumi Suzuki ◽  
Yoshinori Chikaura ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Dimensional Structure ◽  
X Ray ◽  
Three Dimensional Structure ◽  
Tomographic Technique

Three-dimensional structure of the calcite–water interface by surface X-ray scattering

2004 ◽  
Vol 573 (2) ◽  
pp. 191-203 ◽  
Author(s):  
P. Geissbühler ◽  
P. Fenter ◽  
E. DiMasi ◽  
G. Srajer ◽  
L.B. Sorensen ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Dimensional Structure ◽  
Water Interface ◽  
X Ray ◽  
Three Dimensional Structure ◽  
X Ray Scattering ◽  
Ray Scattering
Sign in / Sign up

Export Citation Format

Share Document