ANALGESIC ACTIVITY OF CRUDE HYDRO-ALCOHOLIC EXTRACT OF SALVADORA PERSICA ROOT

2017 ◽  
pp. 895-902
Author(s):  
Mangal Sain Hooda
Keyword(s):  
Analgesic Activity ◽  
Alcoholic Extract ◽  
Salvadora Persica

Effect of Arak, gall of Quercus infectoriaand Syzgiumaromaticum extracts on the growth and viability ofEntamoeba gingivalis in vitro.

2018 ◽  
Vol 9 (SPL1) ◽  
Author(s):  
Sajida S. Hussein Al-Zako ◽  
Ban N. Mohammadali Al-Neamy
Keyword(s):  
Medical Treatment ◽  
Aqueous Extract ◽  
Inhibitory Effect ◽  
Alcoholic Extract ◽  
Aqueous Extracts ◽  
Salvadora Persica ◽  
Oak Trees ◽  
Oak Tree

After the succession of E.gingivalis cultivation on the DMEMmedium. This study was performedin order to identify the effect ofincreasing concentrations from aqueous and alcoholic extracts of a threeplants,known with their usage for medical treatment to dental and oraldiseases,those are Arak sticks (Salvadora persica), gall of oak tree (Quercusinfectoria) and flowering bud of clove (Syzgium aromaticum)on the viabilityof E. gingivalis.Aqueous and alcoholic extracts of Arak sticks showed a clear effectwith the superiority of the aqueous extract in its impact inhibitory effect onE.gingivalis.The results alsoshowed the existence of a negative and inhibitory impact increasingly on the growth ofE. gingivalis with the increasingconcentrations used of aqueous and alcoholic extracts fromgall of oak andflowering buds of clove, with simple superiority of aqueous extracts onalcoholic one for galls of oak trees and alcoholic extract of the of floweringbuds on aqueous one of buds clove.A clear increasing LT50 and LT90 where gained when using aqueousand alcoholic extracts of three plants with an Arak superiority in theelimination of the parasite, specially the aqueous one with the lower time.

scholarly journals EVALUATION OF THE ANALGESIC ACTIVITY OF AQUEOUS AND ALCOHOLIC EXTRACT OF FLOWERS OF PLUMERIA ALBA LINN IN EXPERIMENTAL ANIMALS

2021 ◽  
pp. 172-174
Author(s):  
SATHIYA VINOTHA AT ◽  
UMAMAGESWARI MS ◽  
UMAMAHESWARI A ◽  
VELARUL S
Keyword(s):  
Acetic Acid ◽  
Analgesic Activity ◽  
Diclofenac Sodium ◽  
Local Area ◽  
Alcoholic Extract ◽  
Hot Plate ◽  
Standard Drug ◽  
Soxhlet Apparatus ◽  
Pain Reaction ◽  
Important Medicinal Plant

Objective: Plumeria alba (Apocynaceae), commonly known as “Frangipani” is an important medicinal plant, widely distributed throughout Southern India. In the traditional medicinal system, different parts of this plant have been mentioned to be useful in a wide variety of diseases. In this study, analgesic activity of aqueous and alcoholic extract of flowers of P. alba Linn was evaluated by hot-plate and acetic acid-induced writhing methods to substantiate and expand its clinical applications. Methods: The flowers of P. alba were collected from the local area in and around Coimbatore (India). The flowers were dried, powdered, and were extracted using soxhlet apparatus for 12 h using water and 95% of ethanol as a solvent. The test extracts were administered orally at a dose of 100 & 200 mg/kg while diclofenac sodium (10 mg/kg) served as standard. Results: The ethanolic flower extract of 200 mg/kg had significant analgesic activity in acetic acid-induced abdominal writhing response (***p<0.001) when compared to control and standard drug diclofenac. It also exhibited significant analgesic activity (***p<0.001) by increasing the pain reaction time of the rats in comparison to control and standard in hot plate method. Conclusion: The results suggest that ethanolic flower extracts of P. alba possess potent analgesic properties, which support its use in traditional medicine and suggesting that the plant should be further investigated for its pharmacological active natural products.

scholarly journals Anti-Inflammatory Activity of Salvadora persica L. against Carrageenan Induced Paw Oedema in Rat Relevant to Inflammatory Cytokines

2011 ◽  
Vol 3 (4) ◽  
pp. 22-28 ◽  
Author(s):  
Abeer Y. IBRAHIM ◽  
Souad E. El-GENGAIHI ◽  
Hemaia M. MOTAWEA ◽  
Amany A. SLEEM
Keyword(s):  
Ethyl Acetate ◽  
Inflammatory Cytokines ◽  
Crude Extract ◽  
Ethyl Acetate Extract ◽  
Inflammatory Activity ◽  
Alcoholic Extract ◽  
Salvadora Persica ◽  
Group I ◽  
Paw Oedema ◽  
Anti Inflammatory

In this study, the anti-inflammatory effect of aqueous alcoholic crude extract and ethyl acetate extract of miswak sticks (Salvadora persica L.) was investigated in carrageenan induced rat paw oedema in respect to immunological parameters. Adult male sapargue dawely rats were classified into four groups, group I received the vehicle (0.25% gum acacia solution), group II received crude aqueous alcoholic extract orally at 100 mg/kg, group III received ethyl acetate extract (100 mg/kg) orally and group IV received indomethacin (20 mg/kg) orally, and served as standard reference. The oedema was quantified by measuring the hind paw thickness immediately before subplantar injection, and at 1, 2, 3 and 4 h. Blood samples were withdrawn after the 4th hour of carrageenan induction, centrifuged and sera were used for analysis of pro-inflammatory cytokines. Administration of aqueous alcoholic extract and ethyl acetate extract (100 mg/ml) significantly reduced the oedema thickness in a time dependent manner, the inhibition percentage of inflammation was 17% for crude extract and 27% for ethyl acetate extract. Also the two extracts reduced secretion of inflammatory mediators, interleukin-1β (IL-1β), IL-6, tumor nercrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) in serum. The ethyl acetate extract shows potent activity to be nearly the same of indomethacin activity on all determined parameters at the last hour of following up. These results may be due to the presence of flavonoids in ethyl acetate extract. Three major flavonoids were isolated from ethyl acetate extract and identified as apigenin rhamnoglucoside, luteolin glucoside and rutin. The experimental study revealed that Salvadora persica extracts display remarkable anti-inflammatory activity.

Anti-inflammatory and analgesic activity in alcoholic extract of Tamus communis L.

1983 ◽  
Vol 8 (3) ◽  
pp. 321-325 ◽  
Author(s):  
F. Capasso ◽  
N. Mascolo ◽  
G. Autore ◽  
F. de Simone ◽  
F. Senatore
Keyword(s):  
Analgesic Activity ◽  
Alcoholic Extract ◽  
Anti Inflammatory

scholarly journals Analgesic activity of aqueous extract of Amorphophallus paeoniifolius in Swiss albino mice

2019 ◽  
Vol 8 (6) ◽  
pp. 1327
Author(s):  
Hemalatha A. ◽  
Sathiya Vinotha A. T.
Keyword(s):  
Aqueous Extract ◽  
Analgesic Activity ◽  
Group Iv ◽  
Alcoholic Extract ◽  
Swiss Albino Mice ◽  
Group I ◽  
Cox Inhibitor ◽  
Albino Mice ◽  
Group Ii ◽  
Animal House

Background: Pain is defined as an unpleasant feeling caused by intense or damaging stimuli. Amorphophallus paeoniifolius known as “Elephant foot yam” is a highly potential tropical tuber crop of Araceae family. The tubers are used as antihaemorrhoidal, haemostatic, expectorant, appetizer, anthelmintic, aphrodisiac and rejuvenating agent. Diclofenac, a COX inhibitor is used as analgesic widely. Analgesic activity of alcoholic extract of Amorphophallus paeoniifolius has been proved in previous animal studies.Methods: Swiss Albino mice of either sex (20-30g) were procured from the central animal house of KFMS&R, Coimbatore. Animals were maintained under controlled temperature and light conditions with food and water ad libitum. Mice were kept in the department to get acclimatized. 24 mice were divided into 4 groups (n=6). Drugs were given orally after 12 hours of fasting. Group I was the control received normal saline, Group II received standard-diclofenac (25mg/kg). Group III and Group IV received aqueous extract of Amorphophallus paeoniifolius 200mg/kg and 400mg/kg respectively.Results: The latency period of Group IV (aqueous extract of Amorphophallus paeoniifolius 400mg/kg) was significant (p<0.01) compared to Group I (controls) and Group II (standard) was significant (p<0.001) when compared to Group IV (aqueous extract of Amorphophallus paeoniifolius 400mg/kg) by hot plate method. In acetic acid induced writhing when compared to control, the percentage inhibition of aqueous extract of Amorphophallus paeoniifolius was 43.65% at 200mg/kg, 46.09% at 400mg/kg and that of the standard was 54.39%.Conclusions: It was concluded that aqueous extract of Amorphophallus paeoniifolius has analgesic activity due to peripheral and central inhibition of prostaglandins synthesis. The extract may have phytoconstituents which inhibit COX enzyme peripherally or act on central opioid receptors(µreceptors) for producing analgesia. It can be used as an add-on drug there by reducing side effects by conventional analgesics.

In-vivo Analgesic and In-vitro Cytoprotective Potential of Various Leaf Extracts of Bitter Apple

2020 ◽  
Author(s):  
Rashmi Sagar ◽  
V K Dumka ◽  
Dipak Deka
Keyword(s):  
Cell Lines ◽  
Analgesic Activity ◽  
Mdbk Cell ◽  
Tail Flick ◽  
Alcoholic Extract ◽  
Citrullus Colocynthis ◽  
Leaf Extracts ◽  
Cytoprotective Activity

The present study investigated the potential of different leaf extracts of Bitter Apple (Citrullus colocynthis) as an analgesic agent and In-vitro cytoprotective ameliorative effects of the various extracts in thiomethoxam-induced toxicity in MDBK cell lines. Different leaf extracts of Citrullus colocynthis i.e. alcoholic, acetone and chloroform were investigated for analgesic activity at the dose rate of 50 mg/kg and 100 mg/kg in Wistar rats. For the assessment of analgesic activity, tail flick method was used. In-vitro cytoprotective activity of various leaf extracts (at concentrations of 5% and 10%) was evaluated in ATCC acquired MDBK cell lines and for this study, cytotoxicity was induced by thiomethoxam. For cytoprotective study, oxidative stress parameters- catalase, LPO, SOD and GPx were determined. Study on analgesic activity revealed the presence of dose dependent effect in all extracts with highest effect in alcoholic extract of Bitter Apple. It is believe that triterpene alkaloids and steroidal principles present in the plant products might be responsible for the analgesic effect.

Hydro-alcoholic extract of Otostegia integrifolia Benth (Lamiacae) produces peripheral antinociception and central analgesia in mice models

2019 ◽  
Author(s):  
Abel Degu Woldesenbete ◽  
Rediet Tesfaye
Keyword(s):  
Analgesic Activity ◽  
Alcoholic Extract ◽  
Analgesic Effects ◽  
Inflammatory Conditions ◽  
Potential Source ◽  
Significant Difference ◽  
Analgesic Activities ◽  
Pharmacologic Agents ◽  
Oral Doses ◽  
Higher Doses

Abstract Objective Pain and inflammatory conditions are the commonest health problems reported to this date. The advent of numerous pharmacologic agents cannot still abated the demand due to the associated side effects, the search for satisfactory new molecule particularly from herbal sources is the main endeavor as experience shows. Thus, this study evaluated the analgesic activity of the 80% methanol leaf extract of Otostegia integrifolia in mice models of pain.Results Analgesic effect of various oral doses of the hydro-alcoholic extract (100, 200 and 400 mg/kg) was determined in hot plate and acetic acid induced writhing methods. In all models, the higher doses of the extract (400mg/kg) exhibited significant central and peripheral analgesic activities without significant difference compared to the standard drugs morphine and aspirin respectively. However, the lowest dose of the extract lacks central analgesic activity. The experimental finding from this study corroborates perhaps the presence of similar constituents within the genus Otostegia that might be responsible for the analgesic effects observed on other species. Thus, Otostegia integrifolia could be potential source for development of new analgesics.

Anti-inflammatory and analgesic activity of Jateorhiza macrantha (Menispermaceae)

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
GO Ajayi ◽  
O Salako ◽  
IM Mosebolatan
Keyword(s):  
Analgesic Activity ◽  
Anti Inflammatory

Antiplasmin Deficiency in Polycythaemia: a Form of Thrombopathy

1961 ◽  
Vol 06 (03) ◽  
pp. 445-461 ◽  
Author(s):  
S. I de Vries ◽  
M. A. J Braat-van Straaten ◽  
E Müller ◽  
M Wettermark
Keyword(s):  
Fibrinolytic Activity ◽  
Alcoholic Extract ◽  
Surgical Interventions ◽  
Fallot's Tetralogy ◽  
Naturally Occurring ◽  
Fallot’S Tetralogy

SummaryA marked fibrinolytic activity could be demonstrated in the blood of 10 patients with polycythaemia. In these cases fibrinolysis was considered the result of a deficiency an antiplasmin. It could be demonstrated that this naturally occurring inhibitor of fibrinolysis is present in normal platelets but is lacking in the patient’s own thrombocytes. This factor is probably attached to the surface of the thrombocytes. It could be removed by repeatedly washing. Lack of antiplasmin is a dysfunction of platelets and a form of thrombopathy. It does not respond on treatment with ACA or prednisone. In primary polycythaemia busulfan (Myleran) was considered to be the treatment of choice, whereas in 1 case of secundary erythrocytosis (Fallot’s tetralogy) the reaction on unroasted peanuts was unmistakable. In 4 more patients an alcoholic extract of peanuts was given, and promising results were obtained in 3 of them. The importance of this “thrombopathic type’ of fibrinolysis has been pointed out especially in view of surgical interventions.

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