EFFECTS OF CALCIUM ANTAGONISTS OF THE THIRD GENERATION IN PATIENTS WITH ARTERIAL HYPERTENSION AND CONCOMITANT CHRONIC OBSTRUCTIVE PULMONARY DISEASE

AbstractLittle is known about the species and strain-level diversity of the airway microbiome, and its implication in chronic obstructive pulmonary disease (COPD).Here we report the first comprehensive analysis of the COPD airway microbiome at species and strain-levels. The full-length 16S rRNA gene was sequenced from sputum in 98 stable COPD patients and 27 age-matched healthy controls, using the ‘third-generation’ Pacific Biosciences sequencing platform.Individual species within the same genus exhibited reciprocal relationships with COPD and disease severity. Species dominant in health can be taken over by another species within the same genus in GOLD IV patients. Such turnover was also related to enhanced symptoms and exacerbation frequency. Ralstonia mannitolilytica, an opportunistic pathogen, was significantly increased in COPD frequent exacerbators. There were inflammatory phenotype-specific associations of microbiome at the species-level. One group of four pathogens including Haemophilus influenzae and Moraxella catarrhalis, were specifically associated with sputum mediators for neutrophilic inflammation. Another group of seven species, including Tropheryma whipplei, showed specific associations with mediators for eosinophilic inflammation. Strain-level detection uncovered three non-typeable H. influenzae strains PittEE, PittGG and 86-028NP in the airway microbiome, where PittGG and 86-028NP abundances may inversely predict eosinophilic inflammation. The full-length 16S data augmented the power of functional inference and led to the unique identification of butyrate-producing and nitrate reduction pathways as significantly depleted in COPD.Our analysis uncovered substantial intra-genus heterogeneity in the airway microbiome associated with inflammatory phenotypes and could be of clinical importance, thus enabled a refined view of the airway microbiome in COPD.“Take-home” messageThe species-level analysis using the ‘third-generation’ sequencing enabled a refined view of the airway microbiome and its relationship with clinical outcome and inflammatory phenotype in COPD.

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Arterial hypertension with comorbid chronic obstructive pulmonary disease: relationship between tolerance to physical exercise and structural and functional state of the heart.

Medicni perspektivi (Medical perspectives) ◽

10.26641/2307-0404.2019.4.189260 ◽

2019 ◽

Vol 24 (4) ◽

pp. 59-68

Author(s):

T. Z. Burtniak ◽

V. A. Potabasniy ◽

V. I. Fesenko

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Physical Exercise ◽

Arterial Hypertension ◽

Pulmonary Disease ◽

Functional State ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease

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ATRIAL FIBRILLATION IN COMORBID PATIENTS DEPENDING ON THE TREATMENT REGIMEN

Complex Issues of Cardiovascular Diseases ◽

10.17802/2306-1278-2019-8-2-21-29 ◽

2019 ◽

Vol 8 (2) ◽

pp. 21-29 ◽

Cited By ~ 2

Author(s):

L. D. Khidirova ◽

D. A. Yakhontov ◽

S. A. Zenin

Keyword(s):

Diabetes Mellitus ◽

Atrial Fibrillation ◽

Chronic Obstructive Pulmonary Disease ◽

Arterial Hypertension ◽

Pulmonary Disease ◽

Abdominal Obesity ◽

Blood Pressure Monitoring ◽

Clinical Status ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease

Aim. To study the clinical course of atrial fibrillation in patients with arterial hypertension and extracardiac comorbid pathology depending on the administered therapy.Methods. 207 men aged 45–65 years with atrial fibrillation (paroxysmal and persistent) and arterial hypertension in combination with diabetes mellitus (n = 40), abdominal obesity (n = 64) and chronic obstructive pulmonary disease (n = 47) were recruited to a observational cohort study. 56 patients with atrial fibrillation and arterial hypertension but without any extracardiac diseases were included in the comparison group. Clinical and anthropometric parameters were assessed in all patients. Adherence to therapy was estimated with the Morisky-Green test. All patients underwent ECG; electrocardiographic holter monitoring, 24-hour blood pressure monitoring with the Daily Monitoring Systems SCHILLER (Schiller, Switzerland), 2D and M-mode echocardiography using a Vivid 7 device (General Electric, USA). The statistical analysis was performed in the Rstudio software (version 0.99.879, RStudio, Inc., MA, USA).Results. 66% of patients with atrial fibrillation and arterial hypertension had concomitant extracardiac comorbid pathology, of them 20% of had diabetes mellitus, 22% with chronic obstructive pulmonary disease, and 24% with abdominal obesity. The clinical groups were comparable in electro impulse and drug therapy. Patients who received medical treatment were frequently admitted to hospitals for atrial fibrillation recurrence (p<0.001), compared with those who underwent electro impulse therapy. Adherence to antiarrhythmic therapy was low in the entire cohort of patients. There were no significant differences found between the clinical groups.Conclusion. Early diagnosis of the factors contributing to the progression of AF, the prescription of additional therapy for the secondary prevention of arrhythmia and the choice of its optimal treatment strategy may slow the progression of arrhythmia and the development of CHF, which will improve not only the clinical status of patients, but also their prognosis.

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PECULIARITIES OF APOPTOTIC MARKER EXPRESSION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ARTERIAL HYPERTENSION

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії ◽

10.31718/2077-1096.18.4.65 ◽

2018 ◽

Vol 18 (4) ◽

pp. 65-71

Author(s):

O.S. Tyaglaya

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Essential Hypertension ◽

Arterial Hypertension ◽

Pulmonary Disease ◽

Cysteine Proteases ◽

Chronic Obstructive ◽

Significant Elevation ◽

Caspase 9 ◽

Obstructive Pulmonary Disease ◽

Caspase 7

It is known that both chronic obstructive pulmonary disease and arterial hypertension are multifactorial diseases, and develop as a result of a complex interaction of genetic and environmental factors. The purpose of this work was to study the metabolism of caspase-7 and caspase-9 in patients with chronic obstructive pulmonary disease (COPD) in combination with arterial hypertension (AH). Materials and methods. We examined 23 patients with a diagnosis of essential hypertension stage II and COPD stage II without a clinically significant concomitant pathology. The plasma level of caspase-7 and caspase-9 was determined using the appropriate ELISA test systems (manufacturer – Bender Medsystems, Austria) at the Medical and Laboratory Training Centre of Zaporizhzhia State Medical University in accordance with the instructions attached to the kit. The analysis of the dynamics of the studied cysteine proteases indicates a statistically significant elevation of these apoptosis markers in the conditions of hypertension and COPD. The value of caspase-7 in the cohort of patients with COPD + AH significantly exceeded similar figures for the groups of patients with a single pathology presented by AH or COPD, and averaged 0.41 ± 0.09 ng / ml. A statistically significant elevation of the caspase-9 level in patients with COPD + AH up to 2.16 ± 0.29 ng / ml compared with other groups also indicates a more significant induction of apoptotic processes in comorbid pathology than in isolated AH or COPD. Conclusion. The obtained results require further clarification of the nature of the relationship between changes in the metabolism of cysteine proteases and the primacy of pathogenetic processes in the mechanisms of risk formation for complications and progression of ventilation disorders in patients with COPD and comorbid essential hypertension.

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Point-of-Care COPD Diagnostics: Biomarkers, Sampling, Paper-based Analytical Devices, and Perspectives

The Analyst ◽

10.1039/d1an01702k ◽

2022 ◽

Author(s):

Guozhen He ◽

Tao Dong ◽

Zhaochu Yang ◽

Are Branstad ◽

Lan Huang ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Early Diagnosis ◽

Pulmonary Disease ◽

Economic Burden ◽

Point Of Care ◽

Diagnosis And Treatment ◽

Chronic Obstructive ◽

Copd Exacerbation ◽

Obstructive Pulmonary Disease ◽

The Third

Chronic Obstructive pulmonary disease (COPD) has become the third leading causes of global death. Insufficiency in early-diagnosis and treatment of COPD, especially COPD exacerbation, leads to tremendous economic burden and...

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