The synergistic effect of medial and lateral patellar retinaculum on the stability of patella in full extension

2017 ◽  
Vol 2 ◽  
pp. 80-80 ◽  
Author(s):  
Jiangfeng Lu ◽  
Yanru Wang ◽  
Yingzhen Niu ◽  
Weixia Bai ◽  
Shurong Liang ◽  
...  
2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Andery Lim ◽  
Noramaliyana Haji Manaf ◽  
Kushan Tennakoon ◽  
R. L. N. Chandrakanthi ◽  
Linda Biaw Leng Lim ◽  
...  

Chlorophyll and xanthophyll dyes extracted from a single source of filamentous freshwater green algae (Cladophora sp.) were used to sensitize dye sensitized solar cells and their performances were investigated. A more positive interaction is expected as the derived dyes come from a single natural source because they work mutually in nature. Cell sensitized with mixed chlorophyll and xanthophyll showed synergistic activity with improved cell performance of 1.5- to 2-fold higher than that sensitized with any individual dye. The effect of temperature and the stability of these dyes were also investigated. Xanthophyll dye was found to be more stable compared to chlorophyll that is attributed in the ability of xanthophyll to dissipate extra energy via reversible structural changes. Mixing the dyes resulted to an increase in effective electron life time and reduced the process of electron recombination during solar cell operation, hence exhibiting a synergistic effect.


Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 5054-5054
Author(s):  
Santiago Barrio ◽  
Miguel Gallardo ◽  
Alicia Arenas ◽  
Rosa M. Ayala ◽  
Inmaculada Rapado ◽  
...  

Abstract Abstract 5054 Objectives: In the present study we have determined the antitumor effects, molecular mechanisms of action and potential synergies between Ruxolitinib and the molecular targeted drugs Sorafenib, KNK437, Dasatinib and Perifosine, in Philadelphia negative chronic myeloproliferative neoplasms (MPN). Materials and methods: The cytotoxic and cytostatic effects of the different compounds were determined in the JAK2V617F positive cell lines HEL and Ba/F3 JAK2V617F EPOR, and in mononuclear and bone marrow CD34 positive cells from 19 MPN patients. The effects of different drugs at the molecular level were analyzed by flow cytometry and western blot. The IC50 and the synergy combination index (CI) were determined with GrafPath Prism software and Calcusyn software respectively. Results: Ruxolitinib (IC50PV=15nM), as well as Sorafenib (IC50PV=8uM), KNK437 (IC50PV=100uM) and Perifosine (IC50PV=15uM), was able to inhibit proliferation in cell line models and in cells from MPN patients. Dasatinib (IC50PV=12nM), however, was only effective in patient samples, with similar effects in both MPN patients and control donors. Moreover, Dasatinib, KNK437 and Sorafenib showed a strong synergistic effect in combination with Ruxolitinib (CIPV<0. 3, table 1). The Western blot analysis confirmed that Sorafenib inhibited the activation of ERK and P38, and, as a consequence, of STAT5. Ruxolitinib blocked the ERK and STAT5 activation, Dasatinib blocked SRC and STAT5, and KNK437 decreased the stability of the protein JAK2, reducing its expression. Conclusions: The blockage of JAK2 related proliferative pathways has the potential to inhibit cell proliferation in MPNs. Furthermore, the combination of Ruxolitinib with inhibitors targeted against these pathways has a strong synergistic effect. This may be related to a decrease in the activation of the final common effector STAT5. Disclosures: No relevant conflicts of interest to declare.


2013 ◽  
Vol 785-786 ◽  
pp. 359-364 ◽  
Author(s):  
Chen Chen ◽  
Zhi Rong Ren ◽  
Juan He ◽  
Yong Jun He

Foam is a thermodynamically unstable system, and the stability is the most important factor for the preparation and application of foams. In this paper, the effect of ZnO powders on the stability of the foams stabilized by sodium dodecyl benzene sulphonate (SDBS), hexadecyl trimethyl ammonium bromide (CTAB) and Polyethylene glycol tertoctyl phenyl ether (TritonX-100) was investigated. The results showed that ZnO powders have a synergistic effect with SDBS and CTAB. There is no synergy between ZnO powders and Triton X-100. The mechanism for the stabilizing effect of ZnO powders on the foams was discussed.


2019 ◽  
Author(s):  
Chen Qian ◽  
Ali Telmadarreie ◽  
Mingzhe Dong ◽  
Steven Bryant

Author(s):  
Camila P. Ferraz ◽  
Anouchka Kiméné ◽  
Karen Silva Vargas ◽  
Svetlana Heyte ◽  
Claire Durlin ◽  
...  

The synergistic effect Ni–Cu in the bimetallic catalyst Ni–Cu/C improved the stability and reduction temperature as well as enhanced the catalytic activity for the decarboxylation of palmitic acid.


2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Chih-Wei Chang ◽  
Chih-Hsien Chen ◽  
Chun-Ting Li ◽  
Yen-Nien Chen ◽  
Tai-Hua Yang ◽  
...  

Abstract Background Two parallel cannulated screws along with an anterior wire to construct a tension band is a popular approach in transverse patellar fractures. However, the optimal screw proximity, either deep or superficial screw placements, remains controversial. Hence, a new concept of the addition of a third screw to form a triangular configuration along with the original two parallel screws was proposed in this study. Therefore, the biomechanical effect of the additional third screw on the stability of the fractured patella was investigated with finite element (FE) simulation. Methods An FE knee model including the distal femur, proximal tibia, and fractured patella (type AT/OTA 34-C) was developed in this study. Four different screw configurations, including two parallel cannulated screws with superficial (5-mm proximity) and deep (10-mm proximity) placements and two parallel superficial screws plus a third deep screw, and two parallel deep screws plus a third superficial screw, with or without the anterior wire, were considered for the simulation. Results Results indicated that the addition of a third screw increased stability by reducing the dorsal gap opening when two parallel screws were deeply placed, particularly on the fractured patella without an anterior wire. However, the third screw was of little value when two parallel screws were superficially placed. In the existence of two deep parallel screws and the anterior wire, the third screw reduced the gap opening by 23.5% (from 1.15 mm to 0.88 mm) and 53.6% (from 1.21 mm to 0.61 mm) in knee flexion 45° and full extension, respectively. Furthermore, in the absence of the anterior wire, the third screw reduced the gap opening by 73.5% (from 2 mm to 0.53 mm) and 72.2% (from 1.33 mm to 0.37 mm) in knee flexion 45° and full extension, respectively. Conclusion Based on the results, a third cannulated screw superficially placed (5-mm proximity) is recommended to increase stability and maintain contact of the fractured patella, fixed with two parallel cannulated screws deeply placed (10-mm proximity), particularly when an anterior wire was not used. Furthermore, the third screw deeply placed is not recommended in a fractured patella with two parallel superficial screws.


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