Reference values of respiratory impedance with impulse oscillometry in healthy Chinese adults

Background: Quantification of cardiac structure and function is essential for diagnostic interpretation and clinical decision making. We sought to establish cardiovascular magnetic resonance (CMR) reference values of left and right ventricular (LV and RV) morphology and function based on a large sample of healthy Chinese adults.Methods: Five hundred fifty validated healthy Chinese adults (aged 21–70 years; 323 men) free of hypertension, diabetes, and obesity were included in this study. All the subjects were stratified by gender (men and women) and age decades. On cine CMR, measurements of biventricular end-diastolic, end-systolic, and stroke volumes (EDV, ESV, and SV), ejection fraction (EF), and end-diastolic LV wall thickness (LVWT) and mass (LVM) were obtained.Results: Men had greater LVEDV (111.6 ± 19.8 vs. 94.6 ± 15.6 ml), LVESV (36.5 ± 9.8 vs. 28.2 ± 7.9 ml), LVM (121.1 ± 19.9 vs. 86.1 ± 14.5 g), global end-diastolic LVWT (8.1 ± 1.1 vs. 6.7 ± 1.0 mm), RVEDV (128.0 ± 23.6 vs. 101.7 ± 17.0 ml), and RVESV (53.5 ± 13.7 vs. 36.8 ± 8.9 ml), while women had greater LVEF (67.5 ± 5.4 vs. 70.4 ± 5.7%) and RVEF (58.5 ± 5.2 vs. 64.0 ± 5.3%) (all p < 0.001). For both men and women, age was negatively correlated with LVEDV (r = −0.31 and r = −0.32), LVESV (r = −0.37 and r = −0.47), RVEDV (r = −0.31 and r = −0.29), and RVESV (r = −0.33 and r = −0.44), while it was positively correlated with LVEF (r = 0.28 and r = 0.43) and RVEF (r = 0.28 and r = 0.41) (all p < 0.001). Aging was associated with increasing global end-diastolic LVWT and LVM/LVEDV in both sexes (all p < 0.001). Older age was associated with increasing LVM only in women (r = 0.36, p < 0.001), not in men (r = 0.05, p = 0.359).Conclusions: We systematically provide age-, sex-, and body size-specific CMR reference values for biventricular morphology and function based on a large sample of healthy Chinese adults. Biventricular structure and function are significantly associated with age and sex.

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Reference values of respiratory impedance with impulse oscillometry in healthy Chinese adults

10.21203/rs.3.rs-99501/v1 ◽

2020 ◽

Author(s):

Xiaolin Liang ◽

Yi Gao ◽

Weijie Guan ◽

Jing Du ◽

Li Chen ◽

...

Keyword(s):

Final Analysis ◽

Specific Reference ◽

Respiratory Impedance ◽

Impulse Oscillometry ◽

Chinese Adults ◽

European Respiratory Society ◽

Clinical Trial Registration ◽

Normal Ranges ◽

Normal Individuals ◽

Reference Equations

Abstract Background: Impulse oscillometry (IOS) is a non-invasive pulmonary function test for measuring respiratory impedance. Available reference equations of IOS indices for adults are limited. The aim of this study was to develop reference equations of IOS indices for Chinese adults.Methods: In a multicentral, cross-sessional study of impulse oscillometry in Chinese adults, IOS data from healthy subjects were collected from 19 general hospitals across China was between 2016 and 2018. IOS measurements were conducted in accordance with recommendations of the European Respiratory Society. Multiple linear regression was performed to develop sex-specific reference equations of IOS indices.Results: IOS measurements were performed in 1318 subjects, of which 567 subjects were defined as healthy normal individuals with acceptable IOS data and were included in the final analysis. Reference equations and limits of normal (LLN/ULN) of IOS indices were developed separately for males and females. Height but not age was shown to be the most influential contributor to IOS indices. The reference equations currently used in lung function laboratories predicted higher R5 and X5. Normal ranges of R5 and X5 recommended by the equipment manufacturer were clearly different from the ULN/LLN derived from the reference equations.Conclusions: Reference equations of IOS indices for Chinese adults from a wide region were provided in this study. It is necessary to update new IOS reference equations and adopt ULN/LLN as normal ranges of IOS indices.Clinical Trial Registration: This study was registered at www.clinicaltrials.gov as part of a larger study NCT03467880.

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Editorial for “Reference Values for Left Atrial Strain and Strain Rate Based on a Large Sample of Healthy Chinese Adults: An MR‐Feature Tracking Study”

Journal of Magnetic Resonance Imaging ◽

10.1002/jmri.27821 ◽

2021 ◽

Author(s):

Yeon Hyeon Choe

Keyword(s):

Strain Rate ◽

Reference Values ◽

Left Atrial ◽

Feature Tracking ◽

Chinese Adults ◽

Left Atrial Strain ◽

Large Sample ◽

Strain And Strain Rate ◽

Healthy Chinese ◽

Atrial Strain

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Reference Values of Left and Right Atrial Volumes and Phasic Function based on A Large Sample of Healthy Chinese Adults: A Cardiovascular Magnetic Resonance Study

10.21203/rs.3.rs-443718/v1 ◽

2021 ◽

Author(s):

Yiyuan Gao ◽

Zhen Zhang ◽

Shanshan Zhou ◽

Gengxiao Li ◽

Mingwu Lou ◽

...

Keyword(s):

Cardiovascular Magnetic Resonance ◽

Magnetic Resonance ◽

Reference Values ◽

Right Atrial ◽

Chinese Adults ◽

Large Sample ◽

Left And Right ◽

Healthy Chinese ◽

And Function ◽

Age And Sex

Abstract The left and right atrial (LA and RA) volumes and function are tightly linked to the morbidity and mortality of multiple cardiovascular diseases. We aimed to establish cardiovascular magnetic resonance (CMR) reference values for LA and RA volumes and phasic function based on a large sample of healthy Chinese adults. 408 validated healthy Chinese adults (54% men; aged 21–70 years) were included. The atrial volumes: maximum, minimum, and pre-atrial contraction (Vmax, Vmin, and Vpac); atrial phasic emptying fractions: total, passive, and booster (EF total, EF passive, and EF booster); atrial phasic emptying volumes: total, passive, and active (TEV, PEV, and AEV); and atrial expansion index (EI) were measured. Normal reference values were calculated and were stratified by sex (men and women) and age decades. The absolute LA and RA volumes and the indexed RA volumes were all greater in men. Women demonstrated higher LAEF total, LAEF booster, LAEI, RAEF total, RAEF passive, RAEF booster, and RAEI, while men had greater RATEV and RAAEV. Aging was positively correlated with the absolute and indexed LA and RA volumes, except for LA Vmax. LA and RA reservoir and conduit function including EF total, EI, EF passive, and PEV increased with age, while the atrial booster function (EF booster and AEV) decreased. We systematically provide age- and sex-specific CMR reference values for LA, RA volumes and phasic function based on a large sample of healthy Chinese adults with a wide age range. Both age and sex are closely associated with atrial volumes and function.

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