Temporal Trends in Incidence and Mortality Rates for Colorectal Cancer by Tumor Location: 1975–2007

Abstract Purpose: Incidence and mortality of colorectal cancer (CRC) declined over the last decades. However, survival depends on the primary tumor location. It is unknown if all progress in outcomes vary depending on left-sided (LCRC) versus right sided (RCC) colorectal cancer. We compare incidence and mortality rates over time according to the primary tumor location. Methods: Data from the Austrian National Cancer Registry spanning from 1983 to 2018 were used to calculate annual incidence and mortality rates and survival stratified by primary tumor localization and stage. Joinpoint regression with linear regression models were used on different subgroups to identify significant changes of incidence- and mortality slopes.Results: A total of 168,260 (incidence-data set) and 87,355 cases (mortality data-set) were identified. Survival of disseminated RCC was worse compared to LCRC (HR 1.14; CI 1.106 – 1.169). Total and LCRC incidence- and mortality-rates declined steadily over time, whereas the rates of RCC did not. Incidence of disseminated RCC declined significantly less (slope -0.07; CI -0.086; -0.055) than in LCRC (slope -0.159; CI -0.183; -0.136); mortality rate of RCC was unchanged over time. Incidence and mortality of localized RCC remained unchanged over time, whereas both rates declined independently of stage in LCRC. Conclusion: Colorectal cancer outcomes during the last 35 years have preferentially improved in LCRC but not in RCC, indicating that the progress made is limited to LCRC. It is necessary to define RCC as a distinct form of CRC and to focus on specific strategies for its early detection and treatment.

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Colorectal Cancer in Lebanon: Incidence, Temporal Trends, and Comparison to Regional and Western Countries

Cancer Control ◽

10.1177/1073274821996869 ◽

2021 ◽

Vol 28 ◽

pp. 107327482199686

Author(s):

Najla A. Lakkis ◽

Ola El-Kibbi ◽

Mona H. Osman

Keyword(s):

Colorectal Cancer ◽

Cancer Incidence ◽

Temporal Trends ◽

Incidence Rates ◽

Steady Increase ◽

P Value ◽

Western Countries ◽

Incidence And Mortality ◽

Colorectal Cancer Incidence ◽

Males And Females

Global trends in the incidence and mortality rates of colorectal cancer show a steady increase with significant predilection to western developed countries, possibly linking it to westernized lifestyles among other risk factors. This study aims to investigate the incidence and trends of colorectal cancer in Lebanon, a country in the Middle East and North Africa region, and to compare these rates to those in regional and western countries. Colorectal cancer incidence data were extracted from the Lebanese National Cancer Registry for the currently available years 2005 to 2016. The calculated age-standardized incidence rates and age-specific rates were expressed as per 100,000 population. The age-standardized incidence rates of colorectal cancer in Lebanon increased from 16.3 and 13.0 per 100,000 in 2005 to 23.2 and 20.2 per 100,000 in 2016, among males and females, respectively. The incidences were higher for males, and they increased with age. The annual percent change was +4.36% and +4.45%, in males and females respectively (p-value < 0.05). There was a non-statistically significant trend of decrease in recent years (since 2012 in males and since 2011 in females). The age-standardized incidence rates in Lebanon were higher than those in the majority of the regional countries, but lower than the rates in developed western countries. There were high age-specific incidence rates at age groups 40-44 and 45-49 years in Lebanon in both males and females (with significant rising temporal trend) compared to other countries, including the ones reported to have the highest colorectal cancer age-standardized incidence rate worldwide. Therefore, the burden of colorectal cancer is significant in Lebanon. This raises the necessity to develop national strategies tailored to reduce colorectal cancer incidence through promoting healthy lifestyles, raising awareness, and early detection as of 40 years of age.

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Colorectal Cancer Incidence and Mortality Trends by Sex and Population Group in South Africa: 2002-2014.

10.21203/rs.3.rs-79442/v1 ◽

2020 ◽

Author(s):

Lactatia Matsie Motsuku ◽

Wenlong Carl Chen ◽

Mazvita Molleen Muchengeti ◽

Tamlyn Mac Quene ◽

Patricia Kellett ◽

...

Keyword(s):

Colorectal Cancer ◽

South Africa ◽

Black Males ◽

Population Group ◽

Black Population ◽

Mortality Rates ◽

P Value ◽

Mortality Trends ◽

Population Groups ◽

Incidence And Mortality

Abstract BackgroundSouth Africa (SA) has experienced a rapid transition in the Human Development Index (HDI) over the past decade, which had an effect on the incidence and mortality rates of colorectal cancer (CRC). This study aims to provide CRC incidence and mortality trends by population group and sex in SA from 2002 to 2014.MethodsIncidence data were extracted from the South African National Cancer Registry and mortality data obtained from Statistics South Africa (STATS SA), for the period 2002 to 2014. Age-standardised incidence rates (ASIR) and age-standardised mortality rates (ASMR) were calculated using the STATS SA mid-year population as the denominator and the Segi world standard population data for standardisation. A Joinpoint regression analysis was computed for the CRC ASIR and ASMR by population group and sex.ResultsA total of 33,232 incident CRC cases and 26,836 CRC deaths were reported during the study period. Of the CRC cases reported, 54% were males and 46% were females, and among deaths reported, 47% were males and 53% were females. Overall, there was a 2.5% annual average percentage change (AAPC) increase in ASIR from 2002 to 2014 (95% CI: 0.6- 4.5, p-value <0.001). For ASMR overall, there was 1.3% increase from 2002 to 2014 (95% CI: 0.1- 2.6, p-value <0.001). The ASIR and ASMR among population groups were stable, with the exception of the Black population group. The ASIR increased consistently at 4.3% for black males (95% CI: 1.9- 6.7, p-value <0.001) and 3.4% for black females (95% CI: 1.5- 5.3, p-value <0.001) from 2002 to 2014, respectively. Similarly, ASMR for black males and females increased by 4.2% (95% CI: 2.0- 6.5, p-value <0.001) and 3.4% (, 95%CI: 2.0- 4.8, p-value <0.01) from 2002 to 2014, respectively.ConclusionsThe disparities in the CRC incidence and mortality trends may reflect socioeconomic inequalities across different population groups in SA. The rapid increase in CRC trends among the Black population group is concerning and requires further investigation and increased efforts for cancer prevention, early screening and diagnosis, as well as better access to cancer treatment.

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Recent advances in clinical practice: colorectal cancer chemoprevention in the average-risk population

Gut ◽

10.1136/gutjnl-2020-320990 ◽

2020 ◽

Vol 69 (12) ◽

pp. 2244-2255 ◽

Cited By ~ 2

Author(s):

Nicolas Chapelle ◽

Myriam Martel ◽

Esther Toes-Zoutendijk ◽

Alan N Barkun ◽

Marc Bardou

Keyword(s):

Colorectal Cancer ◽

Fruits And Vegetables ◽

Healthy Lifestyle ◽

Mortality Rates ◽

Preliminary Evidence ◽

Dietary Factors ◽

Normal Colonic Mucosa ◽

Average Risk ◽

Level Of Evidence ◽

Incidence And Mortality

Colorectal cancer (CRC) is one of the most common and lethal malignancies in Western countries. Its development is a multistep process that spans more than 15 years, thereby providing an opportunity for prevention and early detection. The high incidence and mortality rates emphasise the need for prevention and screening. Many countries have therefore introduced CRC screening programmes. It is expected, and preliminary evidence in some countries suggests, that this screening effort will decrease CRC-related mortality rates. CRC prevention involves a healthy lifestyle and chemoprevention—more specifically, oral chemoprevention that can interfere with progression from a normal colonic mucosa to adenocarcinoma. This preventive effect is important for individuals with a genetic predisposition, but also in the general population. The ideal chemopreventive agent, or combination of agents, remains unknown, especially when considering safety during long-term use. This review evaluates the evidence across 80 meta-analyses of interventional and observational studies of CRC prevention using medications, vitamins, supplements and dietary factors. This review suggests that the following factors are associated with a decreased incidence of CRC: aspirin, non-steroidal anti-inflammatory drugs, magnesium, folate, a high consumption of fruits and vegetables, fibre and dairy products. An increased incidence of CRC was observed with frequent alcohol or meat consumption. No evidence of a protective effect for tea, coffee, garlic, fish and soy products was found. The level of evidence is moderate for aspirin, β-carotene and selenium, but is low or very low for all other exposures or interventions.

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Colorectal Cancer Incidence and Mortality Rates Among New York City Adults Ages 20–54 years during 1976–2015

JNCI Cancer Spectrum ◽

10.1093/jncics/pky048 ◽

2018 ◽

Vol 2 (4) ◽

Author(s):

Kellie C Van Beck ◽

John Jasek ◽

Kristi Roods ◽

Jennifer J Brown ◽

Shannon M Farley ◽

...

Keyword(s):

Colorectal Cancer ◽

New York ◽

New York City ◽

York City ◽

New York State ◽

Mortality Rates ◽

Registry Data ◽

Mortality Trends ◽

Annual Percent Change ◽

Incidence And Mortality

Abstract Colorectal cancer (CRC) incidence rates are rising in younger Americans and mortality rates are increasing among younger white Americans. We used New York State Cancer Registry data to examine New York City CRC incidence and mortality trends among adults ages 20–54 years by race from 1976 to 2015. Annual percent change (APC) was considered statistically significant at P less than .05 using a two-sided test. CRC incidence increased among those ages 20–49 years, yet blacks had the largest APC of 2.2% (1993–2015; 95% confidence interval [CI] = 1.4% to 3.1%) compared with 0.5% in whites (1976–2015; 95% CI = 0.2% to 0.7%). Among those aged 50–54 years, incidence increased among blacks by 0.8% annually (1976–2015; 95% CI = 0.4% to 1.1%), but not among whites. CRC mortality decreased among both age and race groups. These findings emphasize the value of local registry data to understand trends locally, the importance of timely screening, and the need for clinicians to consider CRC among all patients with compatible signs and symptoms.

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Temporal Trends in Sepsis Incidence and Mortality in Patients With Cancer in the US Population

American Journal of Critical Care ◽

10.4037/ajcc2021632 ◽

2021 ◽

Vol 30 (4) ◽

pp. e71-e79

Author(s):

Michael A. Liu ◽

Brianna R. Bakow ◽

Tzu-Chun Hsu ◽

Jia-Yu Chen ◽

Ke-Ying Su ◽

...

Keyword(s):

Propensity Score ◽

Hospital Mortality ◽

Propensity Score Matching ◽

Cox Regression ◽

Temporal Trends ◽

Mortality Rates ◽

Hazard Ratio ◽

Patients With Cancer ◽

Incidence And Mortality ◽

The Impact

Background Few population-based studies assess the impact of cancer on sepsis incidence and mortality. Objectives To evaluate epidemiological trends of sepsis in patients with cancer. Methods This retrospective cohort study included adults (≥20 years old) identified using sepsis-indicator International Classification of Diseases codes from the Nationwide Inpatient Sample database (2006-2014). A generalized linear model was used to trend incidence and mortality. Outcomes in patients with cancer and patients without cancer were compared using propensity score matching. Cox regression modeling was used to calculate hazard ratios for mortality rates. Results The study included 13 996 374 patients, 13.6% of whom had cancer. Gram-positive infections were most common, but the incidence of gram-negative infections increased at a greater rate. Compared with patients without cancer, those with cancer had significantly higher rates of lower respiratory tract (35.0% vs 31.6%), intra-abdominal (5.5% vs 4.6%), fungal (4.8% vs 2.9%), and anaerobic (1.2% vs 0.9%) infections. Sepsis incidence increased at a higher rate in patients with cancer than in those without cancer, but hospital mortality rates improved equally in both groups. After propensity score matching, hospital mortality was higher in patients with cancer than in those without cancer (hazard ratio, 1.25; 95% CI, 1.24-1.26). Of patients with sepsis and cancer, those with lung cancer had the lowest survival (hazard ratio, 1.65) compared with those with breast cancer, who had the highest survival. Conclusions Cancer patients are at high risk for sepsis and associated mortality. Research is needed to guide sepsis monitoring and prevention in patients with cancer.

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Early effect of screening programmes on incidence and mortality rates of colorectal cancer

Gut ◽

10.1136/gutjnl-2014-308970 ◽

2014 ◽

Vol 64 (6) ◽

pp. 1007.1-1007 ◽

Cited By ~ 3

Author(s):

Manuel Zorzi ◽

Ugo Fedeli

Keyword(s):

Colorectal Cancer ◽

Mortality Rates ◽

Early Effect ◽

Incidence And Mortality

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Temporal trends in incidence and mortality rates of laryngeal cancer at the global, regional and national levels, 1990–2017

BMJ Open ◽

10.1136/bmjopen-2021-050387 ◽

2021 ◽

Vol 11 (10) ◽

pp. e050387

Author(s):

Jing-Yuan Wang ◽

Qiang-Wei Zhang ◽

Kaixue Wen ◽

Chen Wang ◽

Xiaolin Ji ◽

...

Keyword(s):

Laryngeal Cancer ◽

Disease Burden ◽

Temporal Trends ◽

Mortality Rates ◽

Population Based ◽

Mortality Data ◽

Average Percentage ◽

Incidence And Mortality ◽

Disease Study ◽

Incident Cases

ObjectivesLaryngeal cancer is the most prevalent entity of head and neck cancer. Knowing the trends of incidence and mortality of laryngeal cancer is important for the reduction in related disease burden.DesignPopulation-based observational study.Main outcomes and measuresThe incidence and mortality data of laryngeal cancer were retrieved from the Global Burden of Disease study 2017 online database. The estimated average percentage change was used to quantify the trends of laryngeal cancer incidence and mortality at the global, regional and national levels.ResultsGlobally, the numbers of incident cases and deaths due to laryngeal cancer increased 58.7% and 33.9%, respectively, from 1990 to 2017. However, the overall age-standardised incidence rate (ASIR) and age-standardised mortality rate decreased by 0.99% (95% CI 0.83% to 1.14%) and 1.62% (95% CI 1.50% to 1.74%) per year, respectively. These decreases were ubiquitous worldwide. However, unfavourable trends in the ASIR of laryngeal cancer were also observed in a total of 51 developing countries.ConclusionsThe incidence and mortality rates of laryngeal cancer have significantly decreased at the global level and in most countries over the past three decades. The regions that showed an increasing incidence trend deserve more attention.

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