scholarly journals Risk Based Improvement Performance Strategy for Operation and Maintenance Activities of River and River Infrastructure (BBWS Ciliwung-Cisadane Authority)

2021 ◽  
Vol 1 ◽  
Author(s):  
Isni Septima Anindhita

The Ministry of Public Works and Public Housing (PUPR) has the duty and responsibility to carry out effective and efficient river operation activities and river infrastructure including overcoming floods during the rainy season, but these activities are deemed necessary for improvement in planning procedures. To realize this goal, it is necessary to manage risks that can reduce river performance and river infrastructure as flood control. With risk management in this activity, it is possible to apply the sequence of risks that occur which are then used as recommendations for action (risk response) and risk-based development strategies to improve river performance and river infrastructure to control floods through operation and maintenance activities to build a functional and sustainable system. Suitable for long-term planning and short-term maintenance needs.

2019 ◽  
Vol 30 (5) ◽  
pp. 2997-3014 ◽  
Author(s):  
Benjamin Kowialiewski ◽  
Laurens Van Calster ◽  
Lucie Attout ◽  
Christophe Phillips ◽  
Steve Majerus

Abstract An influential theoretical account of working memory (WM) considers that WM is based on direct activation of long-term memory knowledge. While there is empirical support for this position in the visual WM domain, direct evidence is scarce in the verbal WM domain. This question is critical for models of verbal WM, as the question of whether short-term maintenance of verbal information relies on direct activation within the long-term linguistic knowledge base or not is still debated. In this study, we examined the extent to which short-term maintenance of lexico-semantic knowledge relies on neural activation patterns in linguistic cortices, and this by using a fast encoding running span task for word and nonword stimuli minimizing strategic encoding mechanisms. Multivariate analyses showed specific neural patterns for the encoding and maintenance of word versus nonword stimuli. These patterns were not detectable anymore when participants were instructed to stop maintaining the memoranda. The patterns involved specific regions within the dorsal and ventral pathways, which are considered to support phonological and semantic processing to various degrees. This study provides novel evidence for a role of linguistic cortices in the representation of long-term memory linguistic knowledge during WM processing.


2008 ◽  
Vol 82 (6) ◽  
pp. 3135-3138 ◽  
Author(s):  
Sarah E. Blutt ◽  
Kelly L. Warfield ◽  
Mary K. Estes ◽  
Margaret E. Conner

ABSTRACT Correlates of protection from rotavirus infection are controversial. We compared the roles of B and T lymphocytes in protective immunity induced either by intranasally administered nonreplicating viruslike particles or inactivated virus or by orally administered murine rotavirus. We found that protection induced by nonreplicating vaccines requires CD4+ T cells and CD40/CD40L. In contrast, T cells were not required for short-term protective immunity induced by infection, but both T-cell-dependent and -independent mechanisms contributed to long-term maintenance of protection. Our findings indicate that more than one marker of protective immunity exists and that these markers depend on the vaccine that is administered.


Water ◽  
2017 ◽  
Vol 9 (6) ◽  
pp. 424 ◽  
Author(s):  
Wen-Ming Cheng ◽  
Chien-Lin Huang ◽  
Nien-Sheng Hsu ◽  
Chih-Chiang Wei

2020 ◽  
Vol 4 (23) ◽  
pp. 5951-5957
Author(s):  
Alden A. Moccia ◽  
Christian Taverna ◽  
Sämi Schär ◽  
Anna Vanazzi ◽  
Stéphanie Rondeau ◽  
...  

Abstract The Swiss Group for Clinical Cancer Research (SAKK) conducted the SAKK 35/03 randomized trial (NCT00227695) to investigate different rituximab monotherapy schedules in patients with follicular lymphoma (FL). Here, we report their long-term treatment outcome. Two-hundred and seventy FL patients were treated with 4 weekly doses of rituximab monotherapy (375 mg/m2); 165 of them, achieving at least a partial response, were randomly assigned to maintenance rituximab (375 mg/m2 every 2 months) on a short-term (4 administrations; n = 82) or a long-term (up to a maximum of 5 years; n = 83) schedule. The primary end point was event-free survival (EFS). At a median follow-up period of 10 years, median EFS was 3.4 years (95% confidence interval [CI], 2.1-5.5) in the short-term arm and 5.3 years (95% CI, 3.5-7.5) in the long-term arm. Using the prespecified log-rank test, this difference is not statistically significant (P = .39). There also was not a statistically significant difference in progression-free survival or overall survival (OS). Median OS was 11.0 years (95% CI, 11.0-NA) in the short-term arm and was not reached in the long-term arm (P = .80). The incidence of second cancers was similar in the 2 arms (9 patients after short-term maintenance and 10 patients after long-term maintenance). No major late toxicities emerged. No significant benefit of prolonged maintenance became evident with longer follow-up. Notably, in symptomatic patients in need of immediate treatment, the 10-year OS rate was 83% (95% CI, 73-89%). These findings indicate that single-agent rituximab may be a valid first-line option for symptomatic patients with advanced FL.


2014 ◽  
Vol 05 (S 01) ◽  
pp. S053-S054 ◽  
Author(s):  
Lekhansh Shukla ◽  
Arun Kandasamy ◽  
Muralidharan Kesavan ◽  
Vivek Benegal

ABSTRACTBenzodiazepine (BZD) dependence is a significant public health problem. Apart from the long-term tapering doses of BZD, no others drugs are available for the maintenance treatment of BZD dependence. Baclofen has been used in alcohol and other drug dependence as long-term anti-craving agent. Since alcohol and BZD act through the GABA receptor, we attempted to study the effect of Baclofen as maintenance treatment in a series of five cases with BZD dependence.


2021 ◽  
Vol 13 (9) ◽  
Author(s):  
Andrea Junge ◽  
Zachary C. Dunseth ◽  
Ruth Shahack-Gross ◽  
Israel Finkelstein ◽  
Markus Fuchs

AbstractThe Negev Highlands (Israel) are characterized by a rich settlement history over the last millennia. To sustain life in this arid environment, measures to collect and store water were introduced. Two types of installations to collect and store runoff water were built in the region: open reservoirs, and more elaborate subterranean rock-cut cisterns. This article focuses on the latter. Based on a few inscriptions found in rock-cut cisterns, it is assumed that the majority were constructed in the Hellenistic (Nabatean) to Byzantine period. To evaluate this age assessment, this study was carried out at the Borot Hazaz cisterns system, using optically stimulated luminescence (OSL) dating together with micromorphological analyses. Both were applied to sediments that were relocated during the cistern’s construction and usage and after the maintenance activities ended. Despite unfavourable conditions for resetting the OSL signal, including fluvial transport over short distances and sediment deposition by humans in large quantities, it was possible to reconstruct the life cycle of the cistern system. The present study places the construction of the system during the late Roman to Byzantine period, with utilization and long-term maintenance during the following centuries. Maintenance ceased at the Borot Hazaz cistern system gradually over the course of the last 500 years.


Author(s):  
shengli liao ◽  
yitong song ◽  
benxi liu ◽  
zhanwei liu ◽  
zhou fang

Mid-long term inflow forecasting plays an important supporting role in reservoir production planning, drought and flood control, comprehensive utilization and water resource management. Although the inflow data have some periodicity and predictability characteristics, the inflow sequence has complex nonlinearity due to the comprehensive influence of climate, underlying surfaces, human activities and other factors. Therefore, it is difficult to achieve accurate inflow forecasting. In this study, a new hybrid inflow forecast framework that uses previous inflows and monthly factors as inputs, and that adopts Long Short-Term Memory (LSTM) and the Jonckheere-Terpstra test (J-T test) is developed for mid-long term inflow forecasting. First, the J-T test can test whether the monthly average inflow sequence set exhibits significant differences due to climate, underlying surfaces, human activities and other factors to ensure the effectiveness of the framework. Second, the LSTM, which is good at determining the nonlinearity law of the time sequence and finding the best solution, is chosen as the framework algorithm. Finally, due to the periodicity of the inflow sequence, adding monthly factors into the framework can provide more information for the framework to improve the accuracy of the forecast. Xiaowan Hydropower Station in the Lancang River of China is selected as the research area. Six evaluation criteria are used to evaluate established framework using historical monthly inflow data (January 1954-December 2016). The performance of the framework is compared with that of the Back Propagation Neural Network (BPNN) and Support Vector Regression (SVR) models. The results show that the introduction of monthly factors greatly improves the accuracy of the inflow forecast studied, and the proposed method is also better than other frameworks.


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