scholarly journals RADIOPROTECTIVE EFFECT OF HUMAN LACTOFERRIN AGAINST GAMMA-IRRADIATION WITH SUBLETHAL DOSE

2020 ◽  
Author(s):  
Marina Yu. Kopaeva ◽  
Irina B. Alchinova ◽  
Mikhail V. Nesterenko ◽  
Anton B. Cherepov ◽  
Marina S. Demorzhi ◽  
...  
Keyword(s):  
Gamma Irradiation ◽  
Radioprotective Effect ◽  
Human Lactoferrin ◽  
Sublethal Dose

scholarly journals Lactoferrin beneficially influences the recovery of physiological and behavioral indexes in mice exposed to acute gamma-irradiation

2020 ◽  
pp. 29-33 ◽  
Author(s):  
М.Ю. Копаева ◽  
И.Б. Алчинова ◽  
М.В. Нестеренко ◽  
А.Б. Черепов ◽  
И.Ю. Зарайская ◽  
...  
Keyword(s):  
Body Weight ◽  
Survival Rate ◽  
Gamma Irradiation ◽  
Life Span ◽  
Open Field Test ◽  
Whole Body ◽  
Sublethal Dose ◽  
Male Mice ◽  
Research Activity ◽  
Compensatory Effect

Целью настоящей работы стало исследование эффектов лактоферрина (Лф) человека у мышей после острого гамма-облучения в сублетальной дозе. Методы. Исследование было проведено на 2-2,5-месячных самцах мышей линии C57Bl/6. Животные из экспериментальных групп были подвергнуты общему воздействию гамма-излучения в дозе 7,5 Гр. Сразу после облучения и повторно через 24 часа после него часть животных получила инъекцию Лф (внутрибрюшинно, 4 мг на животное). Было изучено влияние Лф на выживаемость и среднюю продолжительность жизни мышей. Для оценки общей двигательной и исследовательской активности использовали тест «Открытое поле». Результаты. Введение Лф позволило увеличить выживаемость и среднюю продолжительность жизни облученных мышей в течение эксперимента. Происходила более быстрая нормализация динамики изменения массы тела. Кроме того, Лф оказал компенсаторное действие на исследовательскую активность облученных животных. The aim of this study was to investigate effects of human lactoferrin (Lf) in mice exposed to acute gamma-irradiation at a sublethal dose. Methods. C57Вl/6 2-2.5-month-old male mice were used for the experiments. Animals from experimental groups were exposed to whole-body gamma-radiation at a dose of 7.5 Gy. Some animals received an intraperitoneal injection of Lf (4 mg per animal) immediately and then at 24 hours after the irradiation. The effect of Lf on survival rate and life span was studied. The open field test was used to assess locomotor and research activity. Results. The Lf administration increased the survival rate and life span of irradiated mice during the experiment. The dynamics of body weight normalized faster. In addition, Lf exerted a compensatory effect on the research activity of irradiated animals.

Investigating the radioprotective effect of sesamol oral consumption against gamma irradiation in mice by micronucleus and alkaline comet assays

2020 ◽  
Vol 159 ◽  
pp. 109091
Author(s):  
Mehrsa Majdaeen ◽  
Amin Banaei ◽  
Razzagh Abedi-Firouzjah ◽  
Kourosh Ebrahimnejad Gorji ◽  
Gholamreza Ataei ◽  
...  
Keyword(s):  
Gamma Irradiation ◽  
Radioprotective Effect ◽  
Oral Consumption

Radioprotective effect of Curcuma longa extract on γ-irradiation-induced oxidative stress in rats

2012 ◽  
Vol 90 (4) ◽  
pp. 415-423 ◽  
Author(s):  
Ahmed S. Nada ◽  
Asrar M. Hawas ◽  
Nour El-Din Amin ◽  
Magdy M. Elnashar ◽  
Zakaria Y. Abd Elmageed
Keyword(s):  
Oxidative Stress ◽  
Aqueous Extract ◽  
Antioxidant Status ◽  
Curcuma Longa ◽  
Radioprotective Effect ◽  
Male Rats ◽  
Sublethal Dose ◽  
Γ Irradiation ◽  
Protein Levels ◽  
Radiation Induced

This study was conducted to evaluate the modulatory effect of aqueous extract of Curcuma longa (L.) against γ-irradiation (GR), which induces biochemical disorders in male rats. The sublethal dose of GR was determined in primary hepatocytes. Also, the effect of C. longa extract was examined for its activity against GR. In rats, C. longa extract was administered daily (200 mg/kg body mass) for 21 days before, and 7 days after GR exposure (6.5 Gy). The lipid profile and antioxidant status, as well as levels of transaminases, interleukin-6 (IL-6), and tumour necrosis factor α (TNFα) were assessed. The results showed that in hepatocytes, the aqueous extract exhibited radioprotective activity against exposure to GR. Exposure of untreated rats to GR resulted in transaminase disorders, lipid abnormalities, elevation of lipid peroxidation, trace element alterations, release of IL-6 and TNF, and decrease in glutathione and protein level of superoxide dismutase-1 (SOD-1) and peroxiredoxin-1 (PRDX-1). However, treatment of rats with this extract before and after GR exposure improved antioxidant status and minimized the radiation-induced increase in inflammatory cytokines. Changes occurred in the tissue levels of trace elements, and the protein levels of SOD-1 and PRDX-1 were also modulated by C. longa extract. Overall, C. longa exerted a beneficial radioprotective effect against radiation-induced oxidative stress in male rats by alleviating pathological disorders and modulating antioxidant enzymes.

scholarly journals Antioxidant potential and radioprotective effect of soy isoflavone against gamma irradiation induced oxidative stress

2012 ◽  
Vol 4 (1) ◽  
pp. 197-206 ◽  
Author(s):  
Amit Kumar Dixit ◽  
Deepti Bhatnagar ◽  
Vineet Kumar ◽  
D. Chawla ◽  
K. Fakhruddin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gamma Irradiation ◽  
Radioprotective Effect ◽  
Antioxidant Potential ◽  
Soy Isoflavone

scholarly journals Radiation protection by an isoflavone, genistein: A study on the survivability of mice

2007 ◽  
Vol 22 (1) ◽  
pp. 34-39 ◽  
Author(s):  
Lal Bhatia ◽  
Ajay Gaur ◽  
Avadhesh Sharma
Keyword(s):  
Body Weight ◽  
Gamma Irradiation ◽  
Radiation Protection ◽  
Radioprotective Effect ◽  
Optimum Dose ◽  
Acute Administration ◽  
Male Mice ◽  
Different Doses

The radioprotective effects of an acute administration of the isoflavone genistein (4?, 5, 7-trihydroxyflavone), have been investigated in the present study. Male mice were administered with different doses (100, 200, 300, and 400 mg/kg body weight) of genistein 24 hours prior to 8 Gy gamma irradiation and the 200 mg/kg dose of genistein was determined to offer the maximum survivability and was used as an optimum dose for further experimentation. The 0.5 ml dose of genistein (200 mg/kg) was administered intraperitoneally to 2 different groups of mice, 15 minutes and 24 hours prior to gamma irradiation. In the mice treated with genistein with the optimum dose 24 hours before irradiation, a significant increase in 30 day survival has been recorded in contrast to the mice treated with genistein 15 minutes before the irradiation. The longer survivability (i. e. 20% for a period of more than 30 days) has been observed in the 24 hour group as compared to that of 15 minutes (i. e. 20% for 22 days). Although the radioprotective effect of genistein was evident in both groups, it was of greater magnitude in the group with a longer interval, indicating thereby an efficacy with longer retention with the possible minimum toxicity, unlike hitherto known other radioprotective agents.

scholarly journals Radioprotective effect of ergothioneine on .GAMMA.-irradiation of metmyoglobin: Comparison with cysteine on sulfmyoglobin-formation.

1977 ◽  
Vol 25 (10) ◽  
pp. 2516-2523 ◽  
Author(s):  
NORIKO MOTOHASHI ◽  
ITSUHIKO MORI ◽  
YUKIO SUGIURA ◽  
HISASHI TANAKA
Keyword(s):  
Gamma Irradiation ◽  
Radioprotective Effect
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