scholarly journals Associations of serum low-density lipoprotein and systolic blood pressure levels with type 2 diabetic patients with and without peripheral neuropathy: Systemic review, meta-analysis and meta-regression analysis of observational studies

2019 ◽  
Author(s):  
Syed Shah Zaman Haider Naqvi ◽  
Saber imani(Former Corresponding Author) ◽  
Hossein Hosseinifard ◽  
QingLian Wen ◽  
M. Naveed Shahzad ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Peripheral Neuropathy ◽  
Systolic Blood Pressure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Systemic Review ◽  
Low Density ◽  
Collision Risk ◽  
Meta Regression

Abstract Background:Compositional abnormalities in lipoproteins and cardiovascular risk factors play an important role in the progression of diabetic peripheral neuropathy (DPN). This systematic review aimed to estimate the predicting value of low-density lipoprotein (LDL) and systolic blood pressure (SBP) level in type-2 diabetes mellitus (T2DM) patients with and without peripheral neuropathy. We also tried to determine whether LDL and SBP are associated with an increased collision risk of DPN. Materials and Methods:A systematic search was conducted for eligible publications which explored the LDL and SBP level in T2DM patients with and without peripheral neuropathy. The quality of the included studies was assessed by the QUADAS-2 tool. The standardized mean difference (SMD) with 95% CI of LDL and SBP level were pooled to assess the correlation between LDL and SBP level with DPN. We performed random effects meta-regression analyses to investigate factors associated with an increased collision risk of DPN. Results:There was a significant association between LDL and SBP with poor prognosis of DPN in those included studies (I2= 88.1% and I2= 84.9%, respectively, Both P < 0.001). European T2DM patients have higher serum level of LDL in compare with the European DPN patients (SMD = 0.16, 95 % CI: -0.06 - 0.38; P <0.001). SBP level was associated with a 2.6-fold decrease in non-DPN patients of T2DM (SMD = -2.63, 95% CI: -4.00 - -1.27, P <0.001). Old age European T2DM patients have significantly high risk for diabetes drivers. Furthermore, the results of the case-control study design model are more precise to show the accuracy of SBP in Asian T2DM patients. Conclusion:Our finding supports the LDL and SBP status could be associated with increased risk of peripheral neuropathy in T2DM patients.

scholarly journals Associations of serum low-density lipoprotein and systolic blood pressure levels with type 2 diabetic patients with and without peripheral neuropathy: Systemic review, meta-analysis and meta-regression analysis of observational studies

2019 ◽  
Author(s):  
Syed Shah Zaman Haider Naqvi ◽  
Saber imani ◽  
Hossein Hosseinifard ◽  
QingLian Wen ◽  
M. Naveed Shahzad ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Peripheral Neuropathy ◽  
Systolic Blood Pressure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Systemic Review ◽  
Low Density ◽  
Collision Risk ◽  
Meta Regression

Abstract Background: Compositional abnormalities in lipoproteins and cardiovascular risk factors play an important role in the progression of diabetic peripheral neuropathy (DPN). This systematic review aimed to estimate the predicting value of low-density lipoprotein (LDL) and systolic blood pressure (SBP) level in type-2 diabetes mellitus (T2DM) patients with and without peripheral neuropathy. We also tried to determine whether LDL and SBP are associated with an increased collision risk of DPN. Materials: A systematic search was conducted for eligible publications which explored the LDL and SBP level in T2DM patients with and without peripheral neuropathy. The quality of the included studies was assessed by the QUADAS-2 tool. The standardized mean difference (SMD) with 95% CI of LDL and SBP level were pooled to assess the correlation between LDL and SBP level with DPN. We performed random effects meta-regression analyses to investigate factors associated with an increased collision risk of DPN. Results: There was a significant association between LDL and SBP with poor prognosis of DPN in those included studies (I 2 = 88.1% and I 2 = 84.9%, respectively, Both P < 0.001 ). European T2DM patients have higher serum level of LDL in compare with the European DPN patients (SMD = 0.16, 95 % CI: -0.06 - 0.38; P < 0.001). SBP level was associated with a 2.6-fold decrease in non-DPN patients of T2DM (SMD = -2.63, 95% CI: -4.00 - -1.27, P < 0.001). Old age European T2DM patients have significantly high risk for diabetes drivers. Furthermore, the results of the case-control study design model are more precise to show the accuracy of SBP in Asian T2DM patients. Conclusion: Our finding supports the LDL and SBP status could be associated with increased risk of peripheral neuropathy in T2DM patients.

scholarly journals Associations of serum low-density lipoprotein and systolic blood pressure levels with type 2 diabetic patients with and without peripheral neuropathy: systemic review, meta-analysis and meta-regression analysis of observational studies

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Syed Shah Zaman Haider Naqvi ◽  
Saber Imani ◽  
Hossein Hosseinifard ◽  
Qing-Lian Wen ◽  
M. Naveed Shahzad ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Peripheral Neuropathy ◽  
Systolic Blood Pressure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Systemic Review ◽  
Low Density ◽  
Collision Risk ◽  
Meta Regression

Abstract Background Compositional abnormalities in lipoproteins and cardiovascular risk factors play an important role in the progression of diabetic peripheral neuropathy (DPN). This systematic review aimed to estimate the predicting value of low-density lipoprotein (LDL) and systolic blood pressure (SBP) level in type-2 diabetes mellitus (T2DM) patients with and without peripheral neuropathy. We also tried to determine whether LDL and SBP are associated with an increased collision risk of DPN. Methods A systematic search was conducted for eligible publications which explored the LDL and SBP level in T2DM patients with and without peripheral neuropathy. The quality of the included studies was assessed by the QUADAS-2 tool. The standardized mean difference (SMD) with 95% CI of LDL and SBP level were pooled to assess the correlation between LDL and SBP level with DPN. We performed random effects meta-regression analyses to investigate factors associated with an increased collision risk of DPN. Results There was a significant association between LDL and SBP with poor prognosis of DPN in those included studies (I2 = 88.1% and I2 = 84.9%, respectively, Both P < 0.001). European T2DM patients have higher serum level of LDL in compare with the European DPN patients (SMD = 0.16, 95% CI: − 0.06 - 0.38; P < 0.001). SBP level was associated with a 2.6-fold decrease in non-DPN patients of T2DM (SMD = − 2.63, 95% CI: − 4.00 - -1.27, P < 0.001). Old age European T2DM patients have significantly high risk for diabetes drivers. Furthermore, the results of the case-control study design model are more precise to show the accuracy of SBP in Asian T2DM patients. Conclusion Our finding supports the LDL and SBP status could be associated with increased risk of peripheral neuropathy in T2DM patients.

scholarly journals Associations of serum low-density lipoprotein and systolic blood pressure levels with type 2 diabetic patients with and without peripheral neuropathy: Systemic review, meta-analysis and meta-regression analysis of observational studies

2019 ◽  
Author(s):  
Syed Shah Zaman Haider Naqvi ◽  
Saber imani ◽  
Hossein Hosseinifard ◽  
M. Naveed Shahzad ◽  
Iqra Ijaz ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Clinical Practice ◽  
Peripheral Neuropathy ◽  
Low Density Lipoprotein ◽  
Real Life ◽  
Density Lipoprotein ◽  
Low Density ◽  
Collision Risk ◽  
Meta Regression

Abstract Background: Compositional abnormalities in lipoproteins and cardiovascular risk factors play an important role in the progression of diabetic peripheral neuropathy (DPN). This systematic review aimed to estimate the predicting value of low-density lipoprotein (LDL) and systolic blood pressure (SBP) level in type-2 diabetes mellitus (T2DM) patients with and without peripheral neuropathy. We also tried to determine whether LDL and SBP are associated with an increased collision risk of DPN. Materials and Methods: A systematic search was conducted for eligible publications which explored the LDL and SBP level in T2DM patients with and without peripheral neuropathy. The quality of the included studies was assessed by the QUADAS-2 tool. The standardized mean difference (SMD) with 95% CI of LDL and SBP level were pooled to assess the correlation between LDL and SBP level with DPN. We performed random effects meta-regression analyses to investigate factors associated with an increased collision risk of DPN. Results: There was a significant association between LDL and SBP with poor prognosis of DPN in those included studies (I2 = 88.1% and I2 = 84.9%, respectively, Both P < 0.001). European T2DM patients have higher serum level of LDL in compare with the European DPN patients (SMD = 0.16, 95 % CI: -0.06 - 0.38; P < 0.001). SBP level was associated with a 2.6 fold reduce in non-DPN patients of T2DM (SMD = -2.63, 95% CI: -4.00 - -1.27, P < 0.001). Furthermore, the results of the case-control study design model are more precise to show the accuracy of SBP in Asian T2DM patients. Old age European T2DM patients have significantly low collision risk in the last 30 years for diabetes drivers that indicates that LDL and SBP levels could be a promising vulnerability biomarker for early detection and effective intervention of DPN in real-life clinical practice of individuals with T2DM. Conclusion: Our finding supports the LDL and SBP status could be a promising prognostic biomarker for early detection and effective intervention of DPN in real-life clinical practice of individuals with T2DM.

scholarly journals Hubungan Antara Tekanan Darah Sistolik Dengan Kadar Ldl (Low Density Lipoprotein) Padapasien Diabetes Melitus Tipe 2 Di Klinik Arafah, Lampung Tengah

2021 ◽  
Vol 1 (3) ◽  
pp. 134-141
Author(s):  
Avi Hurriyatus Sholihah ◽  
Firhat Esfandiari ◽  
Sandhy Arya Pratama ◽  
Resti Arania
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Systolic Blood Pressure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Diabetes Melitus

ABSTRACT: RELATIONSHIP BETWEEN SYSTOLIC BLOOD PRESSURE WITH LDL (LOW DENSITY LIPOPROTEIN) IN DIABETES MELLITUS TYPE 2 PATIENTS IN ARAFAH CLINIC, CENTRAL LAMPUNG  Background: According to the 2017 World Health Organization (WHO), type 2 diabetes mellitus and hypertension ( HT) is a common disease among older adults aged> 60 years in developing and developed countries. One of the factors of hypertension is high levels of fat at high levels of fat, levels of LDL (Low Density Lipoprotein) are very influential and can lead to atherosclerosis that triggers hypertension. Of the 46 subjects, the frequency distribution of the sexes was male as many as 16 people (34.8%), female 30 people (65.2%). According to age <30 years as many as 2 people (4.3%), 30-50 years as many as 8 people (17.4%),> 50 years as many as 36 (78.3%). According to normal systolic blood pressure <140 mmHg as many as 34 people (73.9%), Height> 140 mmHg as many as 12 people (26.1%). And according to normal LDL levels <100 mg / dl as many as 8 people (17.4%), height> 100 mmHg as many as 38 people (2.6%). Objectives: to determine the relationship between systolic blood pressure and LDL (Low Density Lipoprotein) levels in patients with type 2 diabetes mellitus at the Arafah clinic, Central Lampung, 2020. Methods: This study used a cross sectional approach, namely by collecting data at the same time as one time. The data will be processed and analyzed with the help of a computer using the SPSS for Windows version 20.0 program. Results: Based on the Chi-Square analysis, it was found that there was no relationship with the value of p = 0.336 (p> 0.05). Conclusion: There is no relationship between systolic blood pressure and LDL (Low Density Lipoprotein) levels in patients with type 2 diabetes mellitus.                                                                                                 Keywords: Systolic blood pressure, LDL Levels, Diabetes Mellitus type 2.        INTISARI: HUBUNGAN ANTARA TEKANAN DARAH SISTOLIK DENGAN KADAR LDL (LOW DENSITY LIPOPROTEIN) PADA PASIEN DIABETES MELITUS TIPE 2 DI KLINIK ARAFAH, LAMPUNG TENGAH.Latar Belakang: Menurut World Health Organization tahun 2017 (WHO), diabetes melitus tipe 2 dan hipertensi (HT) adalah penyakit yang umum dikalangan orang dewasa tua berusia > 60 tahun di negara berkembang dan negara maju. Salah satu faktor hipertensi ialah tingginya kadar lemak pada tingginya kadar lemak, kadar LDL (Low Density Lipoprotein) sangat berpengaruh dan dapat mengakibatkan sebuah aterosklerosis pemacu hipertensi. Dari 46 subjek didapatkan distribusi frekuensi jenis kelaminnya laki laki sebanyak 16 orang (34,8%), perempuan 30 orang (65,2%). Menurut umurnya <30 tahun sebanyak 2 orang (4,3%), 30 – 50 tahun sebanyak 8 orang (17,4%), >50 tahun sebanyak 36 (78,3%). Menurut Tekanan darah sistoliknya Normal <140 mmHg sebanyak 34 orang (73,9%), Tinggi >140 mmHg sebanyak 12 orang (26,1%). Dan Menurut Kadar LDLnya normal <100 mg/dl sebanyak 8 orang (17,4%), tinggi >100 mmHg sebanyak 38 orang (2,6%).Tujuan: untuk mengetahui hubunganan antara tekanan darah sistolik dengan kadar LDL (Low Density Lipoprotein) pada pasien diabetes melitus tipe 2 di klinik Arafah, Lampung tengah tahun 2020.Metode: Penelitian ini menggunakan pendekatan cross sectional, yaitu dengan cara pengumpulan data sekaligus pada satu waktu. Data akan diolah dan dianalisa dengan bantuan komputer dengan menggunakan program SPSS for Windows versi 20,0.Hasil: Berdasarkan analisa Chi-Square didapatkan tidak adanya hubungan dengan nilai nilai p =0,336 (p>0,05).Kesimpulan: Tidak terdapat hubungan antara tekanan darah sistolik dengan kadar LDL (Low Density Lipoprotein) pada pasien diabetes melitus tipe 2. Kata Kunci : Tekanan darah sistolik, Kadar LDL, Diabetes Melitus tipe 2.

Jumpstarting Health With a 15-Day Whole-Food Plant-Based Program

2021 ◽  
pp. 155982762110063
Author(s):  
Susan M. Friedman ◽  
Carol Hee Barnett ◽  
Robert Franki ◽  
Bruce Pollock ◽  
Beth Garver ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Blood Sugar ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Food Plant ◽  
Fasting Blood Sugar ◽  
Average Weight ◽  
Low Density ◽  
Average Drop

The 15-day Jumpstart was developed as an evidence-based, affordable, standardized, replicable, and scalable program, designed to demonstrate quickly to patients that changing what they eat can improve their health. The program was designed using the principles of the self-determination theory of motivation and personality. Patients were instructed to eat an Esselstyn-compliant, whole-food plant-based diet consisting of vegetables, fruits, whole grains, and legumes. Of the 389 participants in the program from September 2018 to February 2020, average weight loss was 5.8 pounds (7.3 for those whose body mass index was >30), average systolic blood pressure drop was 6.8 points (16.8 points for those with systolic blood pressure >140), average drop in cholesterol was 26 points (44 points for those with a cholesterol >200), average drop in low-density lipoprotein was 19 points (33 points for those with a low-density lipoprotein >100), and average drop in fasting blood sugar was 5.1 points (28.4 points for those starting in the diabetic range); P value was <.005 for fasting blood sugar and <.001 for all other comparisons. A 15-day program that helps patients adopt an Esselstyn-style whole-food plant-based diet, through education, individualized medical feedback, social support, and facilitated small group work, rapidly improves health.

scholarly journals Cardiometabolic risk factors are associated with immune cell mitochondrial respiration in humans

2020 ◽  
Vol 319 (2) ◽  
pp. H481-H487
Author(s):  
Theodore M. DeConne ◽  
Eric R. Muñoz ◽  
Faria Sanjana ◽  
Joshua C. Hobson ◽  
Christopher R. Martens
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Mitochondrial Respiration ◽  
Cardiometabolic Risk ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

Independent of other cardiometabolic risk factors, low-density lipoprotein cholesterol, and systolic blood pressure were found to be negatively associated with several parameters of mitochondrial respiration in peripheral blood mononuclear cells of healthy adults. These data suggest that low-density lipoprotein cholesterol and systolic blood pressure may induce metabolic reprogramming of immune cells, contributing to increased cardiovascular disease risk and impaired immune health.

scholarly journals Hubungan antara Kadar Low Density Lipoprotein dengan Tekanan Darah Sistolik saat Puncak Exercise pada Personil Kepolisian Daerah Sulawesi Tenggara (The Relationship between Low Density Lipoprotein Levels and Systolic Blood Pressure during Peak Exercise of Police Personnel in Southeast Sulawesi)

MEDULA ◽  
2020 ◽  
Vol 7 (2) ◽  
Author(s):  
Dina Fitriana ◽  
Hilma Yuniar ◽  
Jamaluddin Jamaluddin
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Peak Exercise ◽  
P Value ◽  
Low Density ◽  
Cross Sectional ◽  
Police Personnel ◽  
The Relationship

Background: Systolic blood pressure during exercise is the blood pressure as measured by aneroid sphygmomanometer at the peak exercise (treadmill), namely when the subject has experienced fatigue or heart rate has reached > 85% of Maximum Heart Rate. Purpose:This research purpose is to determine the relationship between LDL level and systolic blood pressure at the exercise peak of  police personnel in Southeast Sulawesi. Methods: This research used analytical-observasional study with cross sectional aproach. The independent variables used in this research are LDL level while the dependent variables was systolic blood pressure during the peak exercise. Research location is in Maxima Laboratory Kendari.The subjects of this study were 95 people based on the inclusion and exclusion criteria that selected by Purposive Sampling method. Data collection was gained by taking the secondary data and was processed by using statistical test data of Independent T-test with a significance p-value <0.05. Result: The result of bivariate analysis showed that there was a relationship between LDL level and systolic blood pressure at the exercise peak on the police personnel in Southeast Sulawesi with a p-value = 0,000 (<0.05). Conclusion: This study can be conlcuded that there was a relationship between LDL level and systolic blood pressure at the peak exercise of police personnel in Southeast Sulawesi.Keywords: low density lipoprotein, systolic blood pressure, peak exercise. ABSTRAKLatar belakang : Puncak tekanan darah sistolik pada saat exercise adalah tekanan darah sistolik yang diukur dengan menggunakan sfignomanometer air raksa pada saat puncak exercise, dimana subyek sudah mengalami kelelahan atau denyut jantung telah mencapai 85% dari denyut jantung maximal. Tujuan: Tujuan penelitian ini adalah untuk mengetahui hubungan antara kadar LDL plasma dengan tekanan darah sistolik pada puncak exercise pada personil Kepolisian Daerah Sulawesi Tenggara. Metode: penelitian ini merupakan penelitian analitik-observasional dengan metode cross sectional. variabel independen adalah kadar LDL plasma dan dependen variabel adalah tekanan darah sistol pada puncak exercise. penelitian dilakukan di Laboratorium Klinik Maxima Kendari. sebanyak 95 sampel penelitian yang memenuhi kriteria inklusi dan eksklusi diambil dengan metode purposive sampling. Data tekanan darah saat puncak exercise dan kadar LDL plasma diambil dari data sekunder rekam medik pasien. Data kemudian dianalisa dengan uji statistik Independent T-test dan bermakna bila nilai p <0,05. Hasil: Analisa statistik menunjukkan adanya hubungan antara kadar LDL plasma dengan tekanan darah sistolik pada puncak exercise pada personil POLDA Sulawesi Tenggara, dengan nilai p=0,000. Simpulan : Pada penelitian ini dapat disimpulkan bahwa terdapat hubungan antara kadar LDL plasma dengan tekanan darah sistolik pada puncak exercise pada personil POLDA Sulawesi Tenggara.Kata Kunci: low density lipoprotein, tekanan darah sistolik, puncak exercise

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