scholarly journals Clinical and histologic tissue responses of skin incisions closed with glycomer 631 and lactomer 9-1 using a subcuticular technique in pigs

2020 ◽  
Author(s):  
Tanja Plavec ◽  
Tanja Švara ◽  
Irena Zdovc ◽  
Mitja Gombač ◽  
Marija Damjanovska ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Suture Material ◽  
Giant Cells ◽  
Tissue Reaction ◽  
Absorbable Suture ◽  
Suture Materials ◽  
Tissue Samples ◽  
Trueperella Pyogenes ◽  
Cumulative Score ◽  
Tissue Reactions

Abstract Background : Glycomer 631 and lactomer 9-1 are absorbable suture materials indicated for soft tissue approximation in non-infected wounds. Pigs are often used as surgical models in translational research; however, reports of tissue reactions to both suture materials in pigs are limited. The aim of this study was to assess clinical and histologic responses of skin incisions closed with a subcuticular technique using glycomer 631 and lactomer 9-1 in pigs. Results: Skin incisions on 17 pigs were closed with glycomer 631 and lactomer 9-1, and a clinical reactive score (CRS) including erythema, swelling, discharge and dehiscence was calculated on postoperative days 7 and 14. Subcuticular tissue reaction was assessed histologically on postoperative day 14 (the presence of extravascular neutrophils, macrophages, multinucleated giant cells, lymphocytes, fibroblasts, bacterial colonies and the overall severity of the inflammatory response to the suture material), and the cumulative score of the variables was calculated as an aggregate tissue irritation score (ATIS). Tissue samples were examined for suture extrusion and evaluated microbiologically. The clinical reactive score did not differ between the suture materials. Only one ATIS variable, namely the overall severity of the inflammatory response, was lower ( p = 0.029) when glycomer 631 was used. Suture extrusion was found in 10/17 of the incisions closed by glycomer 631 and in 7/13 of the incisions closed by lactomer 9-1. Trueperella pyogenes was isolated from the skin and from the area of tissue reaction in six pigs. Conclusions: No difference in CRS between the suture materials was observed, and thus both materials may be used for the subcuticular technique in pigs. Glycomer 631 induced less tissue reaction only in terms of the overall severity of the inflammatory response. Suture extrusion was observed in more than 50% of incisions regardless of the suture material, possibly due to a large amount of suture material in the wound. Trueperella pyogenes was the only pathogen isolated from the tissue surrounding the suture material.

scholarly journals Clinical and histologic tissue responses of skin incisions closed with glycomer 631 and lactomer 9-1 using subcuticular technique in pigs

2019 ◽  
Author(s):  
Tanja Plavec ◽  
Tanja Švara ◽  
Irena Zdovc ◽  
Mitja Gombač ◽  
Marija Damjanovska ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Suture Material ◽  
Giant Cells ◽  
Tissue Reaction ◽  
Absorbable Suture ◽  
Suture Materials ◽  
Tissue Samples ◽  
Trueperella Pyogenes ◽  
Cumulative Score ◽  
Tissue Reactions

Abstract Background: Glycomer 631 and lactomer 9-1 are absorbable suture materials indicated for soft tissue approximation in non-infected wounds. Pigs are often used as surgical models in translational research, however, the reports of tissue reactions to both suture materials in pigs are lacking. The aim of this study was to assess clinical and histologic responses of skin incisions closed with subcuticular technique using glycomer 631 and lactomer 9-1 in pigs. Results: Skin incisions of 17 pigs were closed with glycomer 631 and lactomer 9-1 and clinical reactive score (CRS) including erythema, swelling, discharge, and dehiscence was calculated on postoperative days 7 and 14. Subcuticular tissue reaction was assessed histologically on postoperative day 14 (the presence of extravascular neutrophils, macrophages, multinucleated giant cells, lymphocytes, fibroblasts, bacterial colonies, overall severity of inflammatory response to suture material), and the cumulative score of variables calculated as aggregate tissue irritation score (ATIS). Tissue samples were examined for suture extrusion and evaluated microbiologically. Clinical reactive score did not differ between the suture materials. Only one variable of ATIS, overall severity of inflammatory response, was lower ( p = 0.029) when glycomer 631 was used. Suture extrusion was found in 10/17 of incisions closed by glycomer 631 and in 7/13 of incisions closed by lactomer 9-1. Trueperella pyogenes was isolated from the skin and from the area of tissue reaction in six pigs. Conclusions: No difference in CRS between the suture materials was observed. Glycomer 631 induced less tissue reaction only in terms of overall severity of inflammatory response. Suture extrusion was observed in more than 50% of incisions regardless of the suture material. Trueperella pyogenes was the only pathogen isolated from the tissue surrounding the suture material.

scholarly journals Clinical and histologic tissue responses of skin incisions closed with glycomer 631 and lactomer 9-1 using subcuticular technique in pigs

2019 ◽  
Author(s):  
Tanja Plavec ◽  
Tanja Švara ◽  
Irena Zdovc ◽  
Mitja Gombač ◽  
Marija Damjanovska ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Suture Material ◽  
Giant Cells ◽  
Tissue Reaction ◽  
Absorbable Suture ◽  
Suture Materials ◽  
Tissue Samples ◽  
Trueperella Pyogenes ◽  
Cumulative Score ◽  
Tissue Reactions

Abstract Background: Glycomer 631 and lactomer 9-1 are absorbable suture materials indicated for soft tissue approximation in non-infected wounds. Pigs are often used as surgical models in translational research, however, the reports of tissue reactions to both suture materials in pigs are limited. The aim of this study was to assess clinical and histologic responses of skin incisions closed with subcuticular technique using glycomer 631 and lactomer 9-1 in pigs. Results: Skin incisions of 17 pigs were closed with glycomer 631 and lactomer 9-1 and clinical reactive score (CRS) including erythema, swelling, discharge, and dehiscence was calculated on postoperative days 7 and 14. Subcuticular tissue reaction was assessed histologically on postoperative day 14 (the presence of extravascular neutrophils, macrophages, multinucleated giant cells, lymphocytes, fibroblasts, bacterial colonies, overall severity of inflammatory response to suture material), and the cumulative score of variables calculated as aggregate tissue irritation score (ATIS). Tissue samples were examined for suture extrusion and evaluated microbiologically. Clinical reactive score did not differ between the suture materials. Only one variable of ATIS, overall severity of inflammatory response, was lower (p = 0.029) when glycomer 631 was used. Suture extrusion was found in 10/17 of incisions closed by glycomer 631 and in 7/13 of incisions closed by lactomer 9-1. Trueperella pyogenes was isolated from the skin and from the area of tissue reaction in six pigs. Conclusions: No difference in CRS between the suture materials was observed. Glycomer 631 induced less tissue reaction only in terms of overall severity of inflammatory response. Suture extrusion was observed in more than 50% of incisions regardless of the suture material. Trueperella pyogenes was the only pathogen isolated from the tissue surrounding the suture material. Thinner suture material with less knots should be used for subcuticular closure in pigs.

scholarly journals Clinical and histologic tissue responses of skin incisions closed with glycomer 631 and lactomer 9-1 using subcutaneous and subcuticular techniques in pigs

2019 ◽  
Author(s):  
Tanja Plavec ◽  
Tanja Švara ◽  
Irena Zdovc ◽  
Mitja Gombač ◽  
Marija Damjanovska ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Suture Material ◽  
Giant Cells ◽  
Tissue Reaction ◽  
Absorbable Suture ◽  
Suture Materials ◽  
Tissue Samples ◽  
Trueperella Pyogenes ◽  
Cumulative Score ◽  
Tissue Reactions

Abstract Background: Glycomer 631 and lactomer 9-1 are absorbable suture materials indicated for soft tissue approximation in non-infected wounds. Pigs are often used as surgical models in translational research, however, the reports of tissue reactions to both suture materials in pigs are deficient. The aim of this study was to assess clinical and histologic responses of skin incisions closed with subcutaneous and subcuticular techniques using glycomer 631 and lactomer 9-1 in pigs. Results: Skin incisions of 17 pigs were closed with glycomer 631 and lactomer 9-1 and clinical reactive score (CRS) including erythema, swelling, discharge, and dehiscence was calculated on postoperative days 7 and 14. Tissue reaction was assessed histologically on postoperative day 14 (the presence of extravascular neutrophils, macrophages, multinucleated giant cells, lymphocytes, fibroblasts, bacterial colonies, overall severity of inflammatory response to suture material), and the cumulative score of variables calculated as aggregate tissue irritation score (ATIS). Tissue samples were examined for suture extrusion and evaluated microbiologically. Clinical reactive score did not differ between the suture materials. Only one variable of ATIS, overall severity of inflammatory response, was lower (p = 0.029) when glycomer 631 was used. Suture extrusion was found in 10/17 of incisions closed by glycomer 631 and in 7/13 of incisions closed by lactomer 9-1. Trueperella pyogenes was isolated from the skin and from the area of tissue reaction in six pigs. Conclusions: No difference in CRS between the suture materials was observed. Glycomer 631 induced less tissue reaction only in terms of overall severity of inflammatory response. Suture extrusion was observed in more than 50% of incisions regardless of the suture material. Trueperella pyogenes was the only pathogen isolated from the tissue surrounding the suture material.

Absorbable suture material in carotid surgery

VASA ◽  
2015 ◽  
Vol 44 (6) ◽  
pp. 451-457 ◽  
Author(s):  
Vincenzo Gasbarro ◽  
Luca Traina ◽  
Francesco Mascoli ◽  
Vincenzo Coscia ◽  
Gianluca Buffone ◽  
...  
Keyword(s):  
Suture Material ◽  
Absorbable Suture ◽  
Paediatric Surgery ◽  
Carotid Surgery ◽  
Suture Materials ◽  
Absorbable Suture Material ◽  
Absorbable Sutures ◽  
Group A ◽  
Group B

Abstract. Background: Absorbable sutures are not generally accepted by most vascular surgeons for the fear of breakage of the suture line and the risk of aneurysmal formation, except in cases of paediatric surgery or in case of infections. Aim of this study is to provide evidence of safety and efficacy of the use of absorbable suture materials in carotid surgery. Patients and methods: In an 11 year period, 1126 patients (659 male [58.5 %], 467 female [41.5 %], median age 72) underwent carotid endarterectomy for carotid stenosis by either conventional with primary closure (cCEA) or eversion (eCEA) techniques. Patients were randomised into two groups according to the type of suture material used. In Group A, absorbable suture material (polyglycolic acid) was used and in Group B non-absorbable suture material (polypropylene) was used. Primary end-point was to compare severe restenosis and aneurysmal formation rates between the two groups of patients. For statistical analysis only cases with a minimum period of follow-up of 12 months were considered. Results: A total of 868 surgical procedures were considered for data analysis. Median follow-up was 6 years (range 1-10 years). The rate of postoperative complications was better for group A for both cCEA and eCEA procedures: 3.5 % and 2.0 % for group A, respectively, and 11.8 % and 12.9 % for group B, respectively. Conclusions: In carotid surgery, the use of absorbable suture material seems to be safe and effective and with a general lower complications rate compared to the use of non-absorbable materials.

scholarly journals Obstructive pneumonia owing to migration of a Teflon pledget at 8 years after surgery for a pulmonary carcinoid tumor: a case report

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Hikaru Watanabe ◽  
Kohei Abe ◽  
Naoki Kanauchi
Keyword(s):  
General Anesthesia ◽  
Carcinoid Tumor ◽  
Suture Material ◽  
Rare Complication ◽  
Absorbable Suture ◽  
Suture Materials ◽  
Bronchial Stump ◽  
Flexible Bronchoscope ◽  
Pulmonary Carcinoid ◽  
Bronchial Lumen

Abstract Background It is uncommon for a bronchial stump-related complication to develop during the remote postoperative period in a case of obstructive pneumonia owing to migration of the suture material. Here, we describe a case of bronchial obstructive pneumonia that developed owing to migration of the suture material in the airway 8 years after pulmonary resection. Case presentation A 34-year-old woman underwent left lower lobectomy for a pulmonary carcinoid tumor (pT1bN0M0-stage IA) in 2010. She experienced obstructive pneumonia, and chest computed tomography revealed a mass protruding from the bronchial stump to the bronchial lumen in 2018. After treatment for pneumonia, flexible bronchoscopy showed the presence of a fibrous suture material (Teflon pledget) completely obstructing the left second carina. A week later, the Teflon pledget obstructing the bronchial lumen was removed using a flexible bronchoscope with the patient under general anesthesia. The procedure was completed without removing the small amount of granulation tissue because the bronchial lumen opened after removing the Teflon pledget. She has remained asymptomatic for 1 year after removal. Conclusions In this case, the complication of obstructive pneumonia developed owing to migration of the non-absorbable suture materials used to suture the bronchial stump. Bronchoscopic management of this rare complication comprised endobronchial removal with the patient under general anesthesia. Given our experience with this case, we believe that such conservative management should allow for excellent results in most instances and avoid the need for reoperation.

Effectiveness of cerclage for the prevention of premature birth depending on the suture material used

2020 ◽  
Vol 18 (6) ◽  
pp. 30-33
Author(s):  
O. V. YAKOVLEVA ◽  
◽  
A. G. YASHCHUK ◽  
A. V. MASLENNIKOV ◽  
A. A. TYURINA ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Suture Material ◽  
Neonatal Outcomes ◽  
Absorbable Suture ◽  
Silk Thread ◽  
Suture Materials ◽  
Significant Difference ◽  
Suture Complications ◽  
Group 2 ◽  
Duration Of Pregnancy

The purpose — to compare the effectiveness of cerclage to reduce the frequency of preterm birth when using non-absorbable suture material in the form of a braided silk thread (4 mm) and a braided tape (5 mm), as well as to identify the frequency of complications when using them. Material and methods. A retrospective analysis of cases and childbirth was conducted, as well as the analysis of own experience of applying cerclage with various suture materials in patients with isthmic-cervical insufficiency. A total of 157 patients were examined. Pregnancy outcomes, neonatal outcomes, and post-suture complications were evaluated. Results. 157 women were given cerclage at gestation periods of 14 to 23 weeks. There was no significant difference in the choice of suture material relative to the duration of pregnancy. Cerclage with thread was performed in 92 patients (58,6%) — group 1 and 65 patients were sutured with tape (41,4%) — group 2. Preterm birth occurred in 28 patients of the 2nd comparison group (18%) and 45 patients of the 1st group (29%). The duration of pregnancy in preterm birth was comparable in both groups. Conclusions. The study found that preterm birth after cerclage using a braided tape occurred less frequently than with the use of a braided silk thread. There were no significant differences in neonatal outcomes in the comparison groups. Complications after cerclage, such as suture and cervical rupture, were found only in the group of women who underwent surgery using a woven silk thread.

Use of Vicrуl Rapide in Hand and Upper Extremity Surgery

2010 ◽  
Vol 17 (4) ◽  
pp. 80-83
Author(s):  
Aleksandr Sergeevich Zolotov ◽  
Yu A Zolotova ◽  
A S Zolotov ◽  
Yu A Zolotova
Keyword(s):  
Surgical Treatment ◽  
Upper Extremity ◽  
Suture Material ◽  
Tissue Reaction ◽  
Complete Loss ◽  
Absorbable Suture ◽  
Local Response ◽  
Local Tissue Reaction ◽  
Post Operative Period ◽  
Loss Of Strength

Quick-Absorbable Suture Vicryl Rapide was used at surgical treatment of 112 patients with various injuries and diseases of the hand and upper extremity for wounds closure. Wounds were closed by intradermal (34 patients) and external (78) sutures. Time of ligatures resorption and loss of strength as well as local response of tissues to suture material were analyzed in post-operative period. Complications that developed in 2 (1.8%) cases were not specific to Vicryl Rapide. External knots of intradermal suture were easily removed in all patients on day 14 after surgery. In 72 patients with external sutures complete loss of ligatures strength was noted during the period from 13th to 21st postoperative day (mean in 15.8±2.3 days). No local tissue reaction was observed. In external sutures the time of ligatures resorption and loss of strength was slightly higher than indicated in instruction. Use of Vicrуl Rapide in hand and upper extremity surgery is effective and safe.

Porcine Dermis and Pericardium-Based, Non–Cross-Linked Materials Induce Multinucleated Giant Cells After Their In Vivo Implantation: A Physiological Reaction?

2015 ◽  
Vol 41 (6) ◽  
pp. e267-e281 ◽  
Author(s):  
Mike Barbeck ◽  
Jonas Lorenz ◽  
Marzellus Grosse Holthaus ◽  
Nina Raetscho ◽  
Alica Kubesch ◽  
...  
Keyword(s):  
Mononuclear Cells ◽  
Giant Cells ◽  
Cellular Tissue ◽  
Tissue Reaction ◽  
Material Surface ◽  
Multinucleated Giant Cells ◽  
Barrier Membrane ◽  
Tissue Reactions ◽  
Early Degradation

The present study analyzed the tissue reaction to 2 novel porcine-derived collagen materials: pericardium versus dermis. By means of the subcutaneous implantation model in mice, the tissue reactions were investigated at 5 time points: 3, 10, 15, 30, and 60 days after implantation. Histologic, histochemical, immunhistologic, and histomorphometric analysis methodologies were applied. The dermis-derived material underwent an early degradation while inducing mononuclear cells together with some multinucleated giant cells and mild vascularization. The pericardium-derived membrane induced 2 different cellular tissue reactions. The compact surface induced mononuclear cells and multinucleated giant cells, and underwent a complete degradation until day 30. The spongy surface of the membrane induced mainly mononuclear cells, and served as a stable barrier membrane for up to 60 days. No transmembranous vascularization was observed within the spongy material surface layer. The present data demonstrate the diversity of the cellular tissue reaction toward collagen-based materials from different tissues. Furthermore, it became obvious that the presence of multinucleated giant cells was associated with the material breakdown/degradation and vascularization. Further clinical data are necessary to assess extent to which the presence of multinucleated giant cells observed here will influence the materials stability, integration, and, correspondingly, tissue regeneration within human tissue.

scholarly journals Influence of different types of surgical suture material on the intensity of tissue reaction in oral cavity

2008 ◽  
pp. 91-99
Author(s):  
Sinisa Mirkovic ◽  
Ljubisa Dzambas ◽  
Srecko Selakovic
Keyword(s):  
Suture Material ◽  
Oral Surgery ◽  
Fibrous Tissue ◽  
Tissue Reaction ◽  
Routine Practice ◽  
Suture Materials ◽  
Experimental Conditions ◽  
Monofilament Suture ◽  
Surgical Suture ◽  
Basic Features

Throughout the history the most diverse suture material have been used for closing and suturing surgical wounds. The four basic features of suture material are described: knot safety, stretch capacity, tissue reactivity and wound safety. Tissue reaction, even the minimum one, which develops during the first to seven days after applying the suture in the tissue. The aim of this study was to investigate influence of a monofilament suture material (nylon) on the intensity of local tissue reaction in experimental conditions, and to compare it with the multifilament suture used in the routine practice of oral surgery (silk). This investigation is a prospective experimental study carried out on Wistar rats. The experiment included 30 animals, in which Black Silk (thickness 4-1) and Nylon (thickness 4-0) were applied in the upper and lower jaw, respectively. To monitor tissue reaction on different suture materials the following parameters were used: coagulum formation, presence of polymorphonuclear leukocytes, presence of macrophages and granuloma, formation of epithelial bridge and connective tissue, collagen synthesis, granulomatous tissue formation and presence of fibrous tissue. After comparing parameters for the intensity of tissue reaction to the investigate suture materials by suturing the oral mucosa, certain advantage could be given to the monofilament suture materials.

scholarly journals Iliofemoral technique modification using an anchor screw as treatment of canine traumatic hip luxation - case report

2020 ◽  
Vol 72 (6) ◽  
pp. 2252-2258
Author(s):  
A.G. Rocha ◽  
R.C. Costa ◽  
G.O. Morato ◽  
D.G. Chung ◽  
J.G. Padilha-Filho ◽  
...  
Keyword(s):  
Surgical Intervention ◽  
Suture Material ◽  
Clinical Results ◽  
Suture Technique ◽  
Absorbable Suture ◽  
Suture Materials ◽  
Absorbable Sutures ◽  
Surgical Difficulty ◽  
Hip Luxation ◽  
Joint Congruence

ABSTRACT Twelve dogs with traumatic hip luxation were selected for surgical intervention with a modified iliofemoral suture technique using an anchor screw to substitute the passage of suture material through a perforated tunnel in the ilium. Six procedures were performed with non-absorbable suture and other six with absorbable suture materials. These cases were evaluated at 15, 30, 60, and 90 days after surgery by performing an ambulation analysis and palpation of the joint. In all cases, there was a return of partial and total limb support in an average of 3 and 19 postoperative, respectively. The fixation strategy of the suture material in the ilium using an anchor screw proved to be efficient with a smaller surgical approach and lesser surgical difficulty, maintaining joint congruence in acute as chronic luxation cases. The use of absorbable and non-absorbable sutures had excellent clinical results, but there was a subjective superiority of the first ones, once 4 dogs of the non-absorbable group presented some discomfort during the postoperative palpation of the joint, 90 days after surgery.

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