scholarly journals Trajectory of serum uric acid as a predictor for renal outcome and mortality in stage -3 chronic kidney disease patients

2019 ◽  
Author(s):  
Shangfeng Tsai ◽  
Cheng-Hsu Chen ◽  
Ming-Ju Wu ◽  
Chia-Lin Lee
Keyword(s):  
Renal Outcome ◽  
Long Term Effects ◽  
Patient Death ◽  
Renal Protection ◽  
Subdistribution Hazard ◽  
Mean Values ◽  
Xanthine Oxidase Inhibitors ◽  
Three Samples ◽  
Control Trajectory

Abstract IntroductionUric acid (UA) is associate with renal and patient survival but the association is causal in nature remains unclear. Also, no finding is yet available regarding longitudinal UA control (trajectory). Methods We enrolled 808 subjects diagnosed with stage 3 CKD from 2007 to 2017. We plotted based on follow-ups the mean UA over a period of 6 months with a minimum of three samples of UA was required. From the sampled points, we generated for each patient an interpolated line by joining mean values of the UA levels over time. And from the lines from all patients, we classified them into three groups of trajectories (low, medium and high UA) through group-based trajectory modeling, and then further separated into either a treatment or no-treatment subgroups. Using the univariate competing-risks regression, we calculated the competing risk analysis with subdistribution hazard ratio of possible confounders.Results All of the 6 trajectories appeared as gradually falling functions with time without any of the curves crossed over one another. For all-cause mortality risk, none of the variables was statistically significant. Patients with DM were statistically more likely to undergo dialysis. There was also a trend that the on-treatment trajectories, compared to their no-treatment trajectories, had lower risks for dialysis.Conclusions Initial treatment of UA is utterly important. Xanthine oxidase inhibitors may lead to renal protection without effects on patient death, independent from the UA-lowering effects. This is the first study on the long-term effects of UA trajectory on patient survivals and renal outcomes.

scholarly journals Protective Effect of Daikenchuto on Dextran Sulfate Sodium-Induced Colitis in Mice

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Takaharu Matsunaga ◽  
Shinichi Hashimoto ◽  
Naoki Yamamoto ◽  
Ryo Kawasato ◽  
Tomohiro Shirasawa ◽  
...  
Keyword(s):  
Survival Time ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Expression Profiles ◽  
Experimental Colitis ◽  
Long Term Effects ◽  
Mean Values ◽  
Model Mouse ◽  
Necrosis Factor

Aim. To investigate the effect of daikenchuto (TJ-100; DKT) for ulcerative colitis (UC) model mouse and assess its anti-inflammatory mechanisms. Methods. We evaluated the effects of DKT on dextran sulfate sodium- (DSS-) induced experimental colitis. First, we assessed the short-term effects of DKT using two groups: 5% DSS group and 5% DSS with DKT group. Colon length; histological scores; and interleukin- (IL-) 10, IL-1β, and tumor necrosis factor-α mRNA expression profiles were analyzed using real-time PCR. Second, we assessed the long-term effects of DKT, by comparing survival time between 2% DSS and 2% DSS with DKT groups. Results. After 7 days, the colon lengths of DSS + DKT group were longer than those of the DSS group (mean values: 6.11 versus 5.69 cm, p<0.05). Furthermore, compared to DSS group, the DSS + DKT group maintained significantly higher levels of serum hemoglobin (13.1 versus 10.7 g/dL, p<0.05) and exhibited significantly higher expression levels of IL-10 (p<0.05). The 2% DSS + DKT group exhibited significantly longer survival time than the 2% DSS group (70 versus 44 days, p<0.01). Conclusion. Our results indicate that DKT prevented inflammation in the colon, indicating its potential as a new therapeutic agent for UC.

Vascularity Outcomes of Lingual Artery Ligation in Transoral Robotic Base of Tongue Resections

2021 ◽  
pp. 019459982110174
Author(s):  
Quinn Dunlap ◽  
William M. Mitchell ◽  
James Reed Gardner ◽  
Deanne King ◽  
Rohan Samant ◽  
...  
Keyword(s):  
Contralateral Side ◽  
Transoral Robotic Surgery ◽  
Lingual Artery ◽  
Long Term Effects ◽  
Artery Ligation ◽  
Mean Values ◽  
Base Of Tongue ◽  
Significant Difference ◽  
Intrinsic Muscles

To explore the effect of lingual artery ligation on tongue vascularity, we performed an analysis of 25 patients who underwent transoral robotic surgery for base of tongue cancers (May 2011 to December 2019). Hounsfield units of the intrinsic muscles (IMs) and genioglossus muscles (GGs) were measured in postoperative imaging (mean 4 months) as a surrogate for vascularity. In ligated patients (n = 15), the values from the ligated/resected side of the tongue were compared with the contralateral side and the nonligated side of resection. Individually, IMs and GGs on the ligated side demonstrated no significant difference to the contralateral side ( P = .662 and .618, respectively). Ligation produced a significant decrease in IM measurements but no difference between GG values vs nonligated patients ( P = .050 and .818, respectively). No difference was appreciated in mean values for combined IMs and GGs between cohorts ( P = .212). No gross tongue atrophy or complications were incurred. Future studies are warranted to delineate long-term effects.

scholarly journals Anthracycline therapy and 24-hour blood-pressure profile in long-term survivors of childhood cancer

2010 ◽  
pp. S97-S102
Author(s):  
Z Nováková ◽  
J Šťastná ◽  
K Honzíková ◽  
H Hrstková ◽  
N Honzíková ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Holter Monitoring ◽  
Pressure Profile ◽  
Mean Value ◽  
Long Term Effects ◽  
Mean Values ◽  
Pressure Profiles ◽  
Least Squares Fit ◽  
Mean Pressure

In our previous studies, a decreased blood pressure was reported in children treated by anthracycline (AC). The aim of this study was to assess the long-term effects of AC anticancer therapy in 45 subjects aged 13-22 years by repeated 24-hour Holter monitoring of blood pressure. Sixty four aged-matched subjects served as controls. The differences between mean values of systolic (SBP) and diastolic blood pressure (DBP) in each hour of both groups were evaluated by Mann-Whitney test. Also the parameters of the least-squares fit of the sinusoidal curve in each subject were estimated (M – mesor, midline-estimating, a mean value of sinusoidal curve corresponds to 24-hours mean pressure; A – amplitude, double amplitude corresponds to nightday difference; Acr – acrophase is a time of maximal value of a sinusoidal curve). SBP and DBP was significantly lower only during night hours in anthracycline patients 19-22 years old. Also M was lower in this age subgroup of patients comparing to age matched controls (SBP: 112±6 mm Hg versus 117±7 mm Hg, p<0.05; DBP: 67±3 mm Hg versus 69±6 mm Hg, p<0.05), A was not different, Acr in patients was shifted one hour earlier (SBP: 2.4 p.m. versus 3.6 p.m., p<0.05; DBP: 2.1 p.m. versus 3.3 p.m., p<0.01). This corresponds to the shift of the morning blood-pressure increase seen on 24-hours blood pressure profiles. M correlated with age in controls (SBP: r=0.374, p<0.01; regression coefficient b=1.34 mm Hg/1 year; DBP: r=0.365, p<0.01; b=0.95 mm Hg/1 year), but not in patients (SBP: r=0.182, DBP: r=0.064). A and Acr were age-independent in all subjects. It is concluded that blood pressure in 19-22 years old AC patients is lower during night hours, the age-dependent increase of blood pressure seen in healthy controls between 13 and 22 years of age does not occur in patients. This finding is consistent with the long-lasting impairment of the sympathetic nervous system caused by anthracyclines.

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

Long-Term Effects of Head Lice Tx Unknown

2012 ◽  
Vol 43 (3) ◽  
pp. 42
Author(s):  
MITCHEL L. ZOLER
Keyword(s):  
Head Lice ◽  
Long Term Effects

The response of skin perfusion and of rheological and immunological variables to intravenous prostanoid administration in Raynaud’s phenomenon secondary to collagenosis

VASA ◽  
2005 ◽  
Vol 34 (4) ◽  
pp. 243-249 ◽  
Author(s):  
Drinda ◽  
Neumann ◽  
Pöhlmann ◽  
Vogelsang ◽  
Stein ◽  
...  
Keyword(s):  
Laser Doppler Flowmetry ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Plasma Viscosity ◽  
Laser Doppler ◽  
Erythrocyte Aggregation ◽  
Control Group ◽  
Long Term Effects ◽  
Doppler Flowmetry

Background: Prostanoids are used in the treatment of Raynaud’s phenomenon and acral perfusion disorders secondary to collagenosis. In subjective terms, intravenous administration of these agents produces success in more than 50% of patients. The therapeutic outcome of clinical administration of alprostadil or iloprost may vary from individual to individual. Patients and methods: The following variables were analysed in a cross-over study in 27 patients with collagenosis and Raynaud’s phenomenon: plasma viscosity and erythrocyte aggregation (rheological variables), partial pressure of oxygen and laser Doppler flowmetry in the finger region, and lymphocyte phenotyping and interleukin (IL) determinations (immunological variables). Results: Laser Doppler flowmetry revealed significant differences between patients with secondary Raynaud’s phenomenon and a control group of 25 healthy subjects. Laser Doppler readings did not change significantly as a result of the treatments. Therapy with iloprost produced a reduction in IL-1beta, L-selectin (CD 62 L) and IL-6. Conclusion: The change in immunological variables due to iloprost may explain the long-term effects of prostaglandins in the treatment of Raynaud’s phenomenon. From our results it is not possible to infer any preference for iloprost or alprostadil.

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