Vascularity Outcomes of Lingual Artery Ligation in Transoral Robotic Base of Tongue Resections

2021 ◽  
pp. 019459982110174
Author(s):  
Quinn Dunlap ◽  
William M. Mitchell ◽  
James Reed Gardner ◽  
Deanne King ◽  
Rohan Samant ◽  
...  
Keyword(s):  
Contralateral Side ◽  
Transoral Robotic Surgery ◽  
Lingual Artery ◽  
Long Term Effects ◽  
Artery Ligation ◽  
Mean Values ◽  
Base Of Tongue ◽  
Significant Difference ◽  
Intrinsic Muscles

To explore the effect of lingual artery ligation on tongue vascularity, we performed an analysis of 25 patients who underwent transoral robotic surgery for base of tongue cancers (May 2011 to December 2019). Hounsfield units of the intrinsic muscles (IMs) and genioglossus muscles (GGs) were measured in postoperative imaging (mean 4 months) as a surrogate for vascularity. In ligated patients (n = 15), the values from the ligated/resected side of the tongue were compared with the contralateral side and the nonligated side of resection. Individually, IMs and GGs on the ligated side demonstrated no significant difference to the contralateral side ( P = .662 and .618, respectively). Ligation produced a significant decrease in IM measurements but no difference between GG values vs nonligated patients ( P = .050 and .818, respectively). No difference was appreciated in mean values for combined IMs and GGs between cohorts ( P = .212). No gross tongue atrophy or complications were incurred. Future studies are warranted to delineate long-term effects.

scholarly journals Transitional Cell Carcinomas of the Urinary Tract in a Colony of Beagle Dogs

1989 ◽  
Vol 26 (6) ◽  
pp. 455-461 ◽  
Author(s):  
K. J. Nikula ◽  
S. A. Benjamin ◽  
G. M. Angleton ◽  
A. C. Lee
Keyword(s):  
Urinary Tract ◽  
Transitional Cell ◽  
Clinical Signs ◽  
Conclusive Evidence ◽  
Whole Body ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Significant Difference ◽  
Microscopic Features

Gross and light microscopic features of transitional cell carcinomas (TCC) of the urinary tract were examined in Beagle dogs used for the study of the long-term effects of low-dose, whole-body, 60Co gamma radiation. Thirty-eight cases of TCC occurred among 990 dogs that were from 0 to 14 years of age. There was no conclusive evidence of a radiation effect. The 38 TCC were equally divided between male and female dogs, but there was a significant difference in the sex distribution of urethra-origin TCC. Eleven males had a primary urethral TCC compared to only two females. There was no significant difference between the urethra-origin and bladder-origin TCCs in the number of tumors that caused clinical signs, metastasized, or that contributed to the death of the dog. All cases of urethral TCC in male dogs occurred in the prostatic urethra. The majority of these cases were not recognized to be neoplasms at gross necropsy, but microscopic examination revealed the TCC. Our findings differ from previous reports stating that TCC occurs more frequently in female than male dogs, and they especially differ from reports claiming that urethra-origin TCC is predominately a disease of female dogs.

scholarly journals Impact of chronic khat (Catha edulis Forsk) chewing on pulmonary function test and oxygen saturation in humans: A comparative study

2019 ◽  
Vol 7 ◽  
pp. 205031211882461 ◽  
Author(s):  
Gashaw Garedew Woldeamanuel ◽  
Teshome Gensa Geta
Keyword(s):  
Lung Function ◽  
Pulmonary Function ◽  
Oxygen Saturation ◽  
Vital Capacity ◽  
Forced Expiratory Volume ◽  
Mean Values ◽  
Khat Chewing ◽  
Significant Difference ◽  
The Mean

Background: Chronic consumption of khat affects many organ systems and leads to various health disturbances in the chewers. Few studies examined the acute effects of khat ingestion on lung function parameters. However, studies which assessed the long-term effects of khat chewing on pulmonary function parameters and oxygen saturation are lacking. Objective: The aim of this study was to assess the impact of chronic Khat chewing on pulmonary function parameters and oxygen saturation among chronic Khat chewers in Wolkite, Ethiopia. Methods: A community-based comparative cross-sectional study was conducted in Wolkite, Ethiopia from 1 June 2018 to 15 August 2018. A total of 324 participants, 162 khat chewers and 162 non-chewers were included in the study. The data were collected through face-to-face interview by trained data collectors. British Medical Research Council respiratory questionnaire was used to assess respiratory symptoms. A spirometer was used to assess various lung function parameters. Moreover, oxygen saturation of hemoglobin was measured using pulse oximeter. Data were entered into CSPro version 6.2 and analyzed using SPSS version 23. Results: This study showed statistically significant (p < 0.05) reduction in the mean values of forced vital capacity, forced expiratory volume in first second and maximum ventilation volume among khat chewers as compared to non-chewers. There was no significant difference in the mean values of other lung function parameters between the two groups. Similarly, there was no significant difference (p = 0.642) in mean oxygen saturation of hemoglobin (SaO2) across the two groups. Conclusion: It is evident from this study that long-term khat consumption is associated with decreased mean forced vital capacity, forced expiratory volume in first second and maximum ventilation volume. Hence, there is a need for further study to strengthen the current findings and to explore the mechanisms of khat chewing effect on lung function parameters.

scholarly journals Short- and Long-Term Reduction of Door-to-Needle Time in Thrombolysis for Acute Stroke

2016 ◽  
Vol 44 (3) ◽  
pp. 255-260 ◽  
Author(s):  
Bing Yu Chen ◽  
Aimen Moussaddy ◽  
Mark R. Keezer ◽  
Yan Deschaintre ◽  
Alexandre Y. Poppe
Keyword(s):  
Computed Tomography ◽  
Intracerebral Hemorrhage ◽  
Acute Stroke ◽  
Hospital Treatment ◽  
Long Term Effects ◽  
Symptomatic Intracerebral Hemorrhage ◽  
Significant Difference ◽  
Clinical Benefits ◽  
Short And Long Term

AbstractBackground: More timely administration of tissue plasminogen activator (alteplase) for patients with acute ischemic stroke yields greater clinical benefits. We implemented door-to-needle (DTN) time reduction strategies at our center and evaluated their short- and long-term effects on in-hospital treatment delays and clinical outcomes. Methods: Strategies, including stroke team prenotification, direct computed tomography transfer, not routinely waiting for laboratory results and alteplase delivery on the computed tomography table, were implemented in June 2013. We included all thrombolysed patients admitted directly to our hospital between January 2012 and March 2015. In-hospital delays and symptomatic intracerebral hemorrhage rates were compared between patients pre- and postmodification, and the latter period was divided into early (first 6 months) and late (beyond 6 months) phases to assess the durability of our modifications. Results: Forty-eight individuals were treated premodification compared with 58 postmodification. The median DTN time was reduced from 75 to 46 minutes (p<0.0001). The median DTN time in the early and late postmodification phases was not significantly different (41 vs 46 minutes, p=0.4085). There was no significant difference in rates of symptomatic intracerebral hemorrhage (4.2 vs 1.7%, p=0.361) or stroke mimics (2.1 ves 5.2%, p=0.625) Conclusions: We were able to decrease our DTN time for acute stroke thrombolysis by implementing relatively simple modifications and these improvements persisted over time.

Differentiation Between Ischemic and Hemorrhagic Strokes – A Pilot Study with Transtemporal Investigation of Brain Parenchyma Elasticity Using Ultrasound Shear Wave Elastography

2020 ◽  
Author(s):  
Michael Ertl ◽  
Margarethe Woeckel ◽  
Christoph Maurer
Keyword(s):  
Shear Wave ◽  
Acoustic Radiation ◽  
Pearson Correlation ◽  
Shear Wave Elastography ◽  
Contralateral Side ◽  
Brain Parenchyma ◽  
Acoustic Radiation Force Impulse ◽  
Mean Values ◽  
Mass Effects ◽  
Significant Difference

Abstract Introduction Ultrasound shear wave elastography is well established in diagnostics of several parenchymatous organs and is recommended by respective guidelines. So far, research about applications in relevant neurological conditions is missing, especially in adults. Here we aimed to examine the method for the differentiation of ischemic (IS) and hemorrhagic strokes (HS) and cerebral mass effects. Materials & Methods 50 patients with a confirmed diagnosis of HS or IS were enrolled in this prospective study. 2D shear wave elastography was performed on the ipsilateral and the contralateral side with a modified acoustic radiation force impulse (ARFI) technique (ElastPQ mode, Philips). Lesion volumetry was conducted based on computed tomography data for correlation with elastography results. Results Elastography measurements (EM) revealed a highly significant difference between IS and HS with mean values of 1.94 and 5.50 kPa, respectively (p < 0.00 001). Mean values of brain tissue on the non-affected side were almost identical (IS 3.38 (SD = 0.63); HS 3.35 (SD = 0.66); p = 0.91). With a sensitivity of 0.98 and a specificity of 0.99, a cut-off value of 3.52 kPa for discrimination could be calculated. There was a significant correlation of mass effect represented by midline shift and EM values on the contralateral side (Pearson correlation coefficient = 0.68, p < 0.0003). Conclusion Ultrasound brain parenchyma elastography seems to be a reliable sonographic method for discriminating between large IS and HS and for detecting and tracking conditions of intracerebral mass effects.

scholarly journals Oncological and quality of life outcomes following extralevator versus standard abdominoperineal excision for rectal cancer

2017 ◽  
Vol 99 (5) ◽  
pp. 402-409 ◽  
Author(s):  
D Kamali ◽  
A Sharpe ◽  
A Musbahi ◽  
A Reddy
Keyword(s):  
Quality Of Life ◽  
Rectal Cancer ◽  
Abdominoperineal Excision ◽  
Long Term Effects ◽  
Recurrence Rates ◽  
Oncological Outcomes ◽  
Significant Difference

INTRODUCTION There is increasing and conflicting research debating the oncological benefits of extralevator abdominoperineal excision (ELAPE) compared with standard abdominoperineal excision (SAPE). However, there is very little in the literature on the long-term effects on patients’ wellbeing following the two procedures. The aim of this study was to determine the oncological outcomes and long-term quality of life (QoL) of patients at two hospitals having undergone ELAPE or SAPE. METHODS Consecutive patients with rectal cancer who underwent either ELAPE or SAPE between January 2009 and June 2015 at a single centre were analysed. Oncological outcomes were determined by histology and follow-up imaging. QoL data were obtained prospectively using the QLQ-C30 and QLQ-CR29 questionnaires. RESULTS A total of 48 patients (36 male, 12 female; 27 ELAPE, 21 SAPE) were reviewed. The mean age was 67.4 years and the median follow-up duration was 44 months (range: 6–79 months). Four patients (2 ELAPE, 2 SAPE) developed local recurrence. Rates of distant metastasis were similar (ELAPE: 11%, SAPE: 14%). There was no significant difference in mean global health status score (ELAPE: 77.3, SAPE: 65.3). Impotence was the most frequently reported problem (mean symptom scores of 89.7 and 78.8 for ELAPE and SAPE respectively). CONCLUSIONS This is the largest study with the longest follow-up period that compares QoL after ELAPE with that after SAPE. Although more radical in nature, ELAPE did not demonstrate any significant impact on QoL compared with SAPE. There was no significant difference in long-term oncological outcome between the groups. Impotence remains a significant problem for all patients and they should be well informed of this risk prior to surgery.

Acute and long-term effects of grape and pomegranate juice consumption on vascular reactivity in paediatric metabolic syndrome

2010 ◽  
Vol 20 (1) ◽  
pp. 73-77 ◽  
Author(s):  
Mohammad Hashemi ◽  
Roya Kelishadi ◽  
Mahin Hashemipour ◽  
Afshin Zakerameli ◽  
Noushin Khavarian ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Endothelial Function ◽  
Grape Juice ◽  
Pomegranate Juice ◽  
Controlled Clinical Trial ◽  
Flow Mediated Dilation ◽  
Long Term Effects ◽  
Daily Consumption ◽  
Significant Difference

AbstractObjectivesThis study, which to the best of our knowledge is the first of its kind, aimed to determine the acute and long-term effects of the consumption of grape and pomegranate juices on endothelium function in adolescents with metabolic syndrome, and to compare the effects of these two kinds of juices.MethodsThis randomised controlled clinical trial was conducted in 2008 among 30 adolescents, aged 12–15 years, with metabolic syndrome. Participants were randomly assigned to two groups of equal number; one group was asked to drink 18 millilitre per kilogram per day of natural grape juice and the other group was asked to drink 240 millilitre per day of natural pomegranate juice once daily for 1 month. Juices were homemade without any added sweetener. Basal brachial artery dimension and flow-mediated dilation as an index of endothelial function and endothelial-dependent dilation after receiving nitoglycerin spray were evaluated by high-resolution B mode ultrasonography before juice consumption, 4 hours and 30 days after regular daily consumption.ResultsFlow-mediated dilation at 90 seconds and after nitoglycerin significantly improved at 4 hours and at 1 month after drinking both kinds of juices, without significant difference between the two groups. The change at 1 month versus 4 hours was significant only in the grape juice group.ConclusionDaily consumption of diets rich in antioxidants might improve endothelial function in adolescents with metabolic syndrome. These effects began as soon as 4 hours after juice consumption. Such beneficial effects should be considered in dietary recommendations for the paediatric age group, notably in obese individuals.

scholarly journals Trajectory of serum uric acid as a predictor for renal outcome and mortality in stage -3 chronic kidney disease patients

2019 ◽  
Author(s):  
Shangfeng Tsai ◽  
Cheng-Hsu Chen ◽  
Ming-Ju Wu ◽  
Chia-Lin Lee
Keyword(s):  
Renal Outcome ◽  
Long Term Effects ◽  
Patient Death ◽  
Renal Protection ◽  
Subdistribution Hazard ◽  
Mean Values ◽  
Xanthine Oxidase Inhibitors ◽  
Three Samples ◽  
Control Trajectory

Abstract IntroductionUric acid (UA) is associate with renal and patient survival but the association is causal in nature remains unclear. Also, no finding is yet available regarding longitudinal UA control (trajectory). Methods We enrolled 808 subjects diagnosed with stage 3 CKD from 2007 to 2017. We plotted based on follow-ups the mean UA over a period of 6 months with a minimum of three samples of UA was required. From the sampled points, we generated for each patient an interpolated line by joining mean values of the UA levels over time. And from the lines from all patients, we classified them into three groups of trajectories (low, medium and high UA) through group-based trajectory modeling, and then further separated into either a treatment or no-treatment subgroups. Using the univariate competing-risks regression, we calculated the competing risk analysis with subdistribution hazard ratio of possible confounders.Results All of the 6 trajectories appeared as gradually falling functions with time without any of the curves crossed over one another. For all-cause mortality risk, none of the variables was statistically significant. Patients with DM were statistically more likely to undergo dialysis. There was also a trend that the on-treatment trajectories, compared to their no-treatment trajectories, had lower risks for dialysis.Conclusions Initial treatment of UA is utterly important. Xanthine oxidase inhibitors may lead to renal protection without effects on patient death, independent from the UA-lowering effects. This is the first study on the long-term effects of UA trajectory on patient survivals and renal outcomes.

scholarly journals Long-Term Effects of Ketoanalogues on Mortality and Renal Outcomes in Advanced Chronic Kidney Disease Patients Receiving a Low-Protein Diet

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2708
Author(s):  
Yi-Chun Wang ◽  
Shu-Hui Juan ◽  
Chu-Lin Chou ◽  
Tsung-Cheng Hsieh ◽  
Jung-Lun Wu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Research Database ◽  
Long Term Effects ◽  
Low Protein ◽  
Significant Difference ◽  
Patients With Diabetes

The effects of ketoanalogues (KA) supplementation on mortality and progression to dialysis in patients with pre-dialysis stage 5 chronic kidney disease (CKD) receiving a low-protein diet (LPD) remain ambiguous. From Taiwan’s National Health Insurance Research Database during 1996–2011, 165 patients with pre-dialysis CKD on an LPD (0.6 g/kg/day) with KA supplementation were matched with 165 patients with pre-dialysis CKD on an LPD without KA supplementation. Of the 165 patients with advanced CKD receiving KA supplementation, 34 (20.6%) died, and 124 (75.2%) underwent long-term dialysis during the study period. There was no significant difference in mortality between the KA-user group and the KA-nonuser group (adjusted hazard ratio [HR], 1.41; 95% confidence interval [CI], 0.68–2.93; p = 0.355). KA supplementation significantly increased long-term dialysis risk (adjusted HR, 1.41; 95% CI, 1.04–1.90; p = 0.025) and combined outcome risk (defined as long-term dialysis and death; adjusted HR, 1.37; 95% CI, 1.02–1.83; p = 0.034). KA supplementation also increased long-term dialysis risk (adjusted HR, 1.49; 95% CI, 1.00–2.20; p = 0.048) in the subgroup of pre-dialysis patients with diabetes mellitus (DM), but not in those patients without DM. In conclusion, KA supplementation might increase long-term dialysis risk in patients with advanced CKD receiving an LPD, but it did not increase mortality.

The Influence of Self-rated Health on the Development of Change in the Level of Physical Activity for Participants in Prescribed Exercise

2011 ◽  
Vol 20 (5-6) ◽  
pp. 73-94
Author(s):  
Thomas Bredahl ◽  
John Singhammer
Keyword(s):  
Physical Activity ◽  
Drop Out ◽  
Long Term Effects ◽  
National Guidelines ◽  
Exercise Interventions ◽  
Self Rated Health ◽  
Metabolic Equivalents ◽  
Significant Difference ◽  
The Impact

The Influence of Self-rated Health on the Development of Change in the Level of Physical Activity for Participants in Prescribed Exercise Background: Knowledge is needed concerning whether intense prescribed exercise interventions are effective in regards to long term effects on physical activity levels. A successful and lasting outcome of a behaviour-change intervention is believed to be contingent on the inclusion of psychological issues such as self-rated quality of life and self-rated health. This study extends previous research conducted on the long-term influence of prescribed exercise on psychosocial issues. Specifically, it was hypothesized that participants' level of self-rated health (good or poor) at baseline was decisive for level of physical activity in the long term. Methods: This study is based on a secondary analysis of a quasi-experimental study of the impact of counseling on level of physical activity. The study included a baseline analysis of participants in a treatment group (TG) and follow-up after 4, 10 and 16 months. The TG included individuals with lifestyle diseases who followed supervised group-based training and received motivational counselling. The TG was divided into "good" and "poor" self-rated health at baseline. Linear growth curve analyses (multilevel linear regression) were used to examine the data. Results: The results yielded a statistical significant difference of 1.71 metabolic equivalents (MET) between participants with good versus poor health at baseline. Also, a difference of MET was observed at 10 months. MET increased by 0.85 units for participants with good self-rated health (SE = 0.094) from baseline to 16 months, though the increase between subsequent points in time was small and non-significant. In contrast, considerably more variation in the development of MET over time was observed among participants with poor self-rated health. Overall, MET increased by 2.53 units across the whole time span. Results were influenced by the overall proportion of drop-out for participants with good and poor self-rated health with values of 28% and 79%, respectively. Conclusions: Exercise on Prescription (EoP) improves levels of physical activity (MET) of participants with good and poor self-rated health in the long term enough to accommodate national guidelines of levels of physical activity. Participants with poor self-rated health will improve their level of physical activity to a clinical relevant level in the long term, if they manage to stay compliant during the observation period. An assessment of good and poor self-rated health supplemented by a discussion of psychical and physical domains of self-rated health as barriers by the general practitioner (GP), could possibly enhance compliance and thereby long-term adherence to physical activity.

Effects of gastrocnemius stretching with talus-stabilizing taping on ankle dorsiflexion and balance in individuals with limited ankle dorsiflexion: A randomized controlled trial

2021 ◽  
pp. 1-9
Author(s):  
Jong-Chul Jung ◽  
Yong-Il Shin ◽  
Da-In An ◽  
Won-Young Park ◽  
Soo-Yong Kim
Keyword(s):  
Repeated Measures ◽  
Controlled Trial ◽  
Ankle Dorsiflexion ◽  
Long Term Effects ◽  
Post Intervention ◽  
Balance Test ◽  
Randomized Controlled ◽  
Repeated Measures Analysis ◽  
Significant Difference

BACKGROUND: Various interventions have been recommended to increase ankle dorsiflexion range of motion (DFROM); however, few studies have investigated the long-term effects of applying gastrocnemius stretching with talus-stabilizing taping (GSTST). OBJECTIVE: To compare the effects of gastrocnemius stretching (GS) and GSTST on DFROM and balance in subjects with limited DFROM. METHODS: Twenty-six subjects with limited DFROM were randomly allocated to either the GS group (n= 13) or GSTST group (n= 13) for 6 weeks. Maximum DFROM before heel-off during gait, passive DFROM, posterior talar glide, flexibility of the gastrocnemius, and the lower-quarter Y-balance test (YBT-LQ) were assessed pre-intervention and post-intervention. Two-way repeated-measures analysis of variance was used to compare the changes in variables. RESULTS: The GSTST group had greater maximum DFROM before heel-off, passive DFROM, and posterior talar glide than the GS group. Gastrocnemius flexibility and YBT-LQ scores increased significantly post-intervention in both groups; however, there was no significant difference between the groups. CONCLUSIONS: GSTST is recommend for improving ankle DFROM and balance in subjects with limited DFROM.

Sign in / Sign up

Export Citation Format

Share Document