scholarly journals LipoDDx: a mobile application for identification of rare lipodystrophy syndromes

2020 ◽  
Author(s):  
David Araujo-Vilar ◽  
Antia Fernández-Pombo ◽  
Gemma Rodríguez-Carnero ◽  
Miguel Angel Martínez-Olmos ◽  
Ana Cantón ◽  
...  
Keyword(s):  
Success Rate ◽  
Mobile Application ◽  
Clinical Signs ◽  
Nutritional Deprivation ◽  
Small Cohort ◽  
Clinical Records ◽  
Delays In Diagnosis ◽  
Low Prevalence ◽  
User Friendly ◽  
Score Table

Abstract Background: Lipodystrophy syndromes are a group of disorders characterized by a loss of adipose tissue once other situations of nutritional deprivation or exacerbated catabolism have been ruled out. With the exception of the HIV-associated lipodystrophy, they have a very low prevalence, which together with their large phenotypic heterogeneity makes their identification difficult, even for endocrinologists and pediatricians. This leads to significant delays in diagnosis or even to misdiagnosis. Our group has developed an algorithm that identifies the more than 40 rare lipodystrophy subtypes described to date. This algorithm has been implemented in a free mobile application, LipoDDx®. Our aim was to establish the effectiveness of LipoDDx®.40 clinical records of patients with a diagnosis of certainty of most lipodystrophy subtypes were analyzed, including subjects without lipodystrophy. The medical records, blinded for diagnosis, were evaluated by 13 physicians, 1 biochemist and 1 dentist. Each evaluator first gave his/her results based on his/her own criteria. Then, a second diagnosis was given using LipoDDx®. The results were analysed based on a score table according to the complexity of each case and the prevalence of the disease.Results: LipoDDx® provides a user-friendly environment, based on usually dichotomous questions or choice of clinical signs from drop-down menus. The final result provided by this app for a particular case can be a low/high probability of suffering a particular lipodystrophy subtype. Without using LipoDDx® the success rate was 17 ± 20%, while with LipoDDx® the success rate was 79 ± 20% (p <0.01).Conclusions: LipoDDx® is a free app that enables the identification of subtypes of rare lipodystrophies, which in this small cohort has around 80% effectiveness, which will be of help to doctors who are not experts in this field. However, it will be necessary to analyze more cases in order to obtain a more accurate efficiency value.

scholarly journals LipoDDx: a mobile application for identification of rare lipodystrophy syndromes

2020 ◽  
Author(s):  
David Araujo-Vilar ◽  
Antia Fernández-Pombo ◽  
Gemma Rodríguez-Carnero ◽  
Miguel Angel Martínez-Olmos ◽  
Ana Cantón ◽  
...  
Keyword(s):  
Success Rate ◽  
Medical Records ◽  
Mobile Application ◽  
Clinical Signs ◽  
Nutritional Deprivation ◽  
Clinical Records ◽  
Delays In Diagnosis ◽  
Low Prevalence ◽  
User Friendly ◽  
Score Table

Abstract Background: Lipodystrophy syndromes are a group of disorders characterized by a loss of adipose tissue once other situations of nutritional deprivation or exacerbated catabolism have been ruled out. With the exception of the HIV-associated lipodystrophy, they have a very low prevalence, which together with their large phenotypic heterogeneity makes their identification difficult, even for endocrinologists and pediatricians. This leads to significant delays in diagnosis or even to misdiagnosis. Our group has developed an algorithm that identifies the more than 40 rare lipodystrophy subtypes described to date. This algorithm has been implemented in a free mobile application, LipoDDx®. Our aim was to establish the effectiveness of LipoDDx®.40 clinical records of patients with a diagnosis of certainty of most lipodystrophy subtypes were analyzed, including subjects without lipodystrophy. The medical records, blinded for diagnosis, were evaluated by 13 physicians, 1 biochemist and 1 dentist. Each evaluator first gave his/her results based on his/her own criteria. Then, a second diagnosis was given using LipoDDx®. The results were analysed based on a score table according to the complexity of each case and the prevalence of the disease. Results: LipoDDx® provides a user-friendly environment, based on usually dichotomous questions or choice of clinical signs from drop-down menus. The final result provided by this app for a particular case can be a low/high probability of suffering a particular lipodystrophy subtype. Without using LipoDDx® the success rate was 17 ± 20%, while with LipoDDx® the success rate was 79 ± 20% (p <0.01). Conclusions: LipoDDx® is a free app that enables the identification of subtypes of rare lipodystrophies with around 80% effectiveness, which will be of help to doctors who are not experts in this field.

scholarly journals LipoDDx: a mobile application for identification of rare lipodystrophy syndromes

2019 ◽  
Author(s):  
David Araujo-Vilar ◽  
Antia Fernández-Pombo ◽  
Gemma Rodríguez-Carnero ◽  
Miguel Angel Martínez-Olmos ◽  
Ana Cantón ◽  
...  
Keyword(s):  
Success Rate ◽  
Medical Records ◽  
Mobile Application ◽  
Clinical Signs ◽  
Nutritional Deprivation ◽  
Clinical Records ◽  
Delays In Diagnosis ◽  
Low Prevalence ◽  
User Friendly ◽  
Score Table

Abstract Lipodystrophy syndromes are a group of disorders characterized by a loss of adipose tissue once other situations of nutritional deprivation or exacerbated catabolism have been ruled out. With the exception of the HIV-associated lipodystrophy, they have a very low prevalence, which together with their large phenotypic heterogeneity makes their identification difficult, even for endocrinologists and pediatricians. This leads to significant delays in diagnosis or even to misdiagnosis. Objective: Our group has developed an algorithm that identifies the more than 40 rare lipodystrophy subtypes described to date. This algorithm has been implemented in a free mobile application, LipoDDx®. Our aim was to establish the effectiveness of LipoDDx®.Design and participants: 40 clinical records of patients with a diagnosis of certainty of most lipodystrophy subtypes were analyzed, including subjects without lipodystrophy. The medical records, blinded for diagnosis, were evaluated by 15 people. Each evaluator first gave his/her results based on his/her own criteria. Then, a second diagnosis was given using LipoDDx®. The results were analysed based on a score table according to the complexity of each case and the prevalence of the disease.Results: LipoDDx® provides a user-friendly environment, based on usually dichotomous questions or choice of clinical signs from drop-down menus. The final result provided by this app for a particular case can be a low/high probability of suffering a particular lipodystrophy subtype. Without using LipoDDx® the success rate was 17 ± 20%, while with LipoDDx® the success rate was 79 ± 20% (p <0.01).Conclusions: LipoDDx® is a free app that enables the identification of subtypes of rare lipodystrophies with around 80% effectiveness, which will be of help to doctors who are not experts in this field.

scholarly journals Trichuris spp. in Animals, with Specific Reference to Neo-Tropical Rodents

2021 ◽  
Vol 8 (2) ◽  
pp. 15
Author(s):  
Kegan Romelle Jones
Keyword(s):  
Guinea Pig ◽  
Guinea Pigs ◽  
Clinical Signs ◽  
Molecular Techniques ◽  
Meat Production ◽  
Specific Reference ◽  
Hydrochoerus Hydrochaeris ◽  
Present Information ◽  
Low Prevalence ◽  
A New Species

Trichuriasis is the clinical disease of animals infected with the parasite of the genus Trichuris. This review attempts to present information on Trichuris spp. infestation in neo-tropical rodents that are utilized for meat consumption by humans. Neo-tropical rodents utilized for meat production can be divided into two categories: those that have been domesticated, which include the guinea pig (Cavia porcellus), and those that are on the verge of domestication, such as the capybara (Hydrochoerus hydrochaeris), lappe (Cuniculus paca/Agouti paca), and agouti (Dasyprocta leporina). This document reviews the literature on the species of Trichuris that affects the rodents mentioned above, as well as the clinical signs observed. The literature obtained spans over sixty years, from 1951 to 2020. Trichuris spp. was found in these neo-tropical rodents mentioned. However, there is a dearth of information on the species of Trichuris that parasitize these animals. The capybara was the only rodent where some molecular techniques were used to identify a new species named T. cutillasae. In most cases, Trichuris spp. was found in combination with other endoparasites, and was found at a low prevalence in the lappe and guinea pig. The presence of Trichuris spp. ranged from 4.62–53.85% in the agouti, 4.21–10.00% in the lappe, 50% in the capybaras, and 1–31% in guinea pigs. Further work must be done towards molecular identification of various Trichuris spp. present in these rodents, as well as the clinical effect of infection on the performance of agouti, lappe, capybara, and guinea pigs.

scholarly journals AB1048 RHUPUS SYNDROME IN A TERTIARY HOSPITAL

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1815.1-1815
Author(s):  
I. Martínez Cordellat ◽  
R. Gonzalez Mazario ◽  
M. De la Rubia Navarro ◽  
C. Pávez Perales ◽  
S. Leal Rodriguez ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Tertiary Hospital ◽  
Jak Inhibitors ◽  
Systematic Revision ◽  
Erosive Arthritis ◽  
Rheumatoid Nodules ◽  
Clinical Records ◽  
Low Prevalence ◽  
First Diagnosis

Background:Rhupus syndrome (RhS) is a rare combination of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Different studies describe RhS cases that begin with erosive arthritis and the presence of rheumatoid factor (RF) and/or anti CCP and then the SLE symptoms.Objectives:Despite the fact that RhS shows a low prevalence, it would be useful to know clinical characteristics of RhS patients since their therapy and outcome differ from those having RA or SLE alone.Methods:Retrospective study with systematic revision of electronic clinical records of RhS patients was performed. Demographic, clinical and immunological data were collected.Results:Eight RhS patients were included (all fulfilled SLICC 2012 criteria for SLE and ACR 2010 for RA). Mean age was 67.3 (45-84) years (7 were female).In 3 cases RA was the first diagnosis with a mean evolution of 4.5 years until SLE diagnosis. In contrast, in 5 cases SLE was the first diagnosis with a mean evolution of 7.2 years until RA diagnosis. Photosensitivity and arthritis were the predominant clinical manifestations. One patient presents pericarditis and other case showed rheumatoid nodules in elbows. Renal, pulmonary or neurological affection was no reported.4 patients were under biological/JAK inhibitors therapies (2 abatacept, 1 rituximab and 1 baricitinib) with favorable response of treatment.Conclusion:In contrast to other series, only the 37.5% of our RhS cases begins with polyarticular seropositive arthritis. The 62.5% started with SLE symptoms as haematological alterations, cutaneous and serological manifestation, and showed longer progression to have polyarticular affection. Thus, RhS diagnosis is earlier in patients that begin with RA symptoms. 4 RhS patients were refractory to DMARd treatments, where biological/JAK inhibitors therapies are needed.Disclosure of Interests:None declared

scholarly journals Vitamin A Supplementation and Child Morbidity and Mortality in Developing Countries

1994 ◽  
Vol 15 (4) ◽  
pp. 1-9 ◽  
Author(s):  
George H. Beaton ◽  
Reynaldo Martorell ◽  
Kristan A. Aronson ◽  
Barry Edmonston ◽  
George McCabe. A. Catharine Ross ◽  
...  
Keyword(s):  
Vitamin A ◽  
Respiratory Infections ◽  
Vitamin A Deficiency ◽  
Meta Analysis ◽  
Clinical Signs ◽  
Vitamin A Status ◽  
Child Morbidity ◽  
Age Profile ◽  
Mortality Trials ◽  
Low Prevalence

A meta-analysis of eight mortality trials indicates that improving the vitamin A status of children aged six months to five years reduced mortality rates by about 23% in populations with at least low prevalence of clinical signs of vitamin A deficiency. The observed effect of supplementation, described in terms of relative risk (RR), was RR =0.77 (95% confidence interval 0.68–0.88; p < .001) and did not differ by sex or age. However, the number of lives saved was greater at younger ages because of higher mortality. A significant RR was shown for deaths attributed to diarrhoea and measles, but not for respiratory infection. Variability among the trials in effects was apparent, but attempts to explain it by descriptors of the population (baseline anthropometric status, prevalence of xerophthalmia, age profile, baseline mortality) were unsuccessful. Owing to the lack of data, firm conclusions could not be reached about effectiveness in children of less than six months and in settings where biochemical but not clinical evidence of vitamin A deficiency exists. Information about morbidity outcomes from about two dozen studies was reviewed. No consistent effects on frequency or prevalence of diarrhoeal and respiratory infections were found. Improvement in vitamin A status did appear to reduce severe morbidity, particularly in children with measles.

scholarly journals Real-Time Heart Pulse Monitoring Technique Using Wireless Sensor Network and Mobile Application

2018 ◽  
Vol 8 (6) ◽  
pp. 5118 ◽  
Author(s):  
Nabeel Salih Ali ◽  
Zaid Abdi Alkaream Alyasseri ◽  
Abdulhussein Abdulmohson
Keyword(s):  
Real Time ◽  
Mobile Application ◽  
Electronic Circuit ◽  
Healthcare Services ◽  
Wireless Sensor ◽  
Sensor Technology ◽  
Medical Monitoring ◽  
Monitoring Technique ◽  
Arduino Microcontroller ◽  
User Friendly

Wireless Sensor Networks (WSNs) for healthcare have emerged in the recent years. Wireless technology has been developed and used widely for different medical fields. This technology provides healthcare services for patients, especially who suffer from chronic diseases. Services such as catering continuous medical monitoring and get rid of disturbance caused by the sensor of instruments. Sensors are connected to a patient by wires and become bed-bound that less from the mobility of the patient. In this paper, proposed a real-time heart pulse monitoring system via conducted an electronic circuit architecture to measure Heart Pulse (HP) for patients and display heart pulse measuring via smartphone and computer over the network in real-time settings. In HP measuring application standpoint, using sensor technology to observe heart pulse by bringing the fingerprint to the sensor via used Arduino microcontroller with Ethernet shield to connect heart pulse circuit to the internet and send results to the web server and receive it anywhere. The proposed system provided the usability by the user (user-friendly) not only by the specialist. Also, it offered speed andresults accuracy, the highest availability with the user on an ongoing basis, and few cost.

scholarly journals Developing A Comprehensive Tool to Support Requirements Analyst During Elicitation Interviews [Kennesaw State University]

2019 ◽  
Author(s):  
Norah Jean-Charles ◽  
Paola Spoletini
Keyword(s):  
Mobile Application ◽  
State University ◽  
Research Project ◽  
Ongoing Research ◽  
Need Support ◽  
Voice Data ◽  
User Friendly ◽  
The Voice ◽  
Data Requirements ◽  
Voice Recording

This research is being conducted to provide requirements analysts with a supportive tool to use during elicitation interviews. In these interviews that were conducted as part of the overall project, stakeholders were asked a series of questions while wearing the Empatica E4 wristband and being recorded through various voice recording platforms. As a part of an ongoing research project, stakeholders have been interviewed using voice recordings and the Empatica E4 wristband to gather biofeedback data. Requirements analyst need support during elicitation interviews because of the ambiguity that arises during communication making it harder to collect proper requirements. In order to provide features such as visualizing the biofeedback collected from the Empatica E4 wristband and the voice waves, questions such as how to create a user-friendly application and how to synchronize the biofeedback and voice data must be researched. In conclusion, creating this mobile application would to assist requirements analysts in carrying out assessments during elicitation interviews.

Molecular detection of visceral leishmaniasis in dogs from Barão de Melgaço, Pantanal region of Mato Grosso, Brazil

2021 ◽  
Vol 41 ◽  
Author(s):  
Álvaro Felipe L.R. Dias ◽  
Arleana B.P.F. Almeida ◽  
Luciano Nakazato ◽  
Valéria R.F. Sousa
Keyword(s):  
Visceral Leishmaniasis ◽  
Molecular Detection ◽  
Clinical Signs ◽  
Conventional Polymerase Chain Reaction ◽  
Epidemiological Survey ◽  
Mato Grosso ◽  
Canine Infection ◽  
Polymerase Chain ◽  
Comparison Of The Results ◽  
Low Prevalence

ABSTRACT: The increasing expansion of visceral leishmaniasis (VL) in the Brazilian territory evidences the need for studies focused on the main reservoir of this parasite: the dog. This study aimed to conduct an epidemiological survey in the municipality of Barão de Melgaço, Pantanal region of the state of Mato Grosso (MT), Brazil. Conventional polymerase chain reaction (PCR) and qualitative SYBR®Green real-time PCR (qPCR) were used to diagnose canine VL (CVL) and characterize the factors associated with this infection. Of the 402 dogs that had blood samples collected, 31 presented the parasite DNA, representing a prevalence of 7.71% in the population studied. Positivity indices for PCR and qPCR were 3.48 (14/402) and 7.21% (29/402), respectively. Comparison of the results obtained by both techniques showed moderate agreement (Kappa = 0.5364). Of the independent variables analyzed, presence of clinical signs (p≤0.05) was the only one associated with CVL. Based on this study, we conclude that VL is a circulating disease, with relatively low prevalence, in dogs of Barão de Melgaço/MT, and that the presence of clinical signs is the only variable associated with canine infection.

Pulmonary Langerhans cell histiocytosis in cats and a literature review of feline histiocytic diseases

2019 ◽  
Vol 22 (4) ◽  
pp. 305-312 ◽  
Author(s):  
Fernando Froner Argenta ◽  
Fernanda Cristina de Britto ◽  
Paula Reis Pereira ◽  
Daniel Ricardo Rissi ◽  
Cristiano Gomes ◽  
...  
Keyword(s):  
Literature Review ◽  
Langerhans Cell Histiocytosis ◽  
Clinical Signs ◽  
Clinical Information ◽  
Langerhans Cell ◽  
Fungal Culture ◽  
Pulmonary Langerhans Cell Histiocytosis ◽  
Pulmonary Parenchyma ◽  
Clinical Records ◽  
E Cadherin

Objectives The aim of this study was to report the clinical, radiographic and pathological features of pulmonary Langerhans cell histiocytosis in four cats, and carry out a literature review of feline histiocytic diseases. Methods Necropsy reports archived at the Department of Veterinary Pathology of the Federal University of Rio Grande do Sul were reviewed. The clinical information was then obtained from the clinical records at the Veterinary Hospital. Routine samples had been collected during necropsy, fixed in 10% formalin, routinely processed for histology, and stained with hematoxylin and eosin. Samples of lung were submitted for bacterial and fungal culture. Tissue sections of lung underwent immunohistochemical testing for vimentin, pancytokeratin, CD18, CD3, CD79αcy, E-cadherin and Iba1. Results This disease affected mixed breed cats aged 7–14 years. Clinical signs consisted of severe mixed inspiratory and expiratory restrictive dyspnea, lethargy and anorexia. Thoracic radiographs revealed different lesion profiles, predominantly of an interstitial and alveolar pattern. Grossly, the lungs were diffusely firm and did not collapse. The pleural surface was bright and irregular due to multifocal-to-coalescent, well-demarcated, white, firm nodules that also extended into and obliterated the pulmonary parenchyma. Histological changes were characterized by poorly demarcated infiltration with histiocytic cells arranged in cohesive groups within the alveolar, bronchiolar and bronchial spaces. Histiocytic cells had intense cytoplasmic immunolabeling for vimentin and Iba1, and robust membrane immunolabeling with CD18 and E-cadherin; these cells were negative for CD3, CD79αcy and pancytokeratin in all cases. Conclusions and relevance This article confirms that pulmonary Langerhans cell histiocytosis is a rare disease that occurs in middle-aged to older cats and causes widespread involvement of the pulmonary parenchyma, inducing acute or chronic, progressive respiratory disease characterized by mixed restrictive dyspnea that eventually leads to death. While a definitive clinical diagnosis is challenging, the nodular appearance of the pulmonary changes, together with the histological and immunohistochemistry findings, suffice for diagnostic confirmation of pulmonary Langerhans cell histiocytosis.

The Concept of the Receipts & Promotions Cloud Service: a New Level of Communication between Bank, Store, and Customer

2020 ◽  
Vol 26 (12) ◽  
pp. 697-700
Author(s):  
V. I. Belovitskiy ◽  
Keyword(s):  
Mobile Application ◽  
Cloud Service ◽  
Complete Information ◽  
Cloud Services ◽  
Software Products ◽  
Wide Range ◽  
Software Product ◽  
Plastic Card ◽  
User Friendly ◽  
To Receive

The development of cloud services improving the interaction of banks, stores and customers becomes high-demanded by digitalized society, that is ready to use innovative software products. The Receipts & Promotions cloud service, developed at the concept level, allows to realize the idea of providing complete information of a receipt in electronic form along with printed receipt for the Mir plastic card holders through the "Privet, Mir!" mobile application. Information from electronic receipts accumulated in the Mir cloud will allow the customer to receive personalized bonus offers from the stores — partners of the program, as well as manage the family budget. The introduction of the service opens up the wide opportunities to the stores for communication with customers. The Receipts & Promotions service is able to become the first software product based on the collection and analysis of information from electronic receipts linked to a specific user. The system of flexible personalization of bonus offers and their assessment by customers is unique and not implemented in other software products. It will be possible to consider the display of electronic receipts in the "Privet, Mir!" mobile application in a user-friendly interface as the first fully automated option of providing electronic receipts to a wide range of users.

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